Details of the Drug-Related molecule(s) Interaction Atlas

Chondroitin sulfate Drug Info

Chondritinsulfate; Chondritinsulphate; Chondroitin 4 and 6 sulfate; Chondroitin 4-sulfate; Chondroitin 6-sulfate; Chondroitin polysulfate; Chondroitin sulfate; Chondroitin sulfuric acid; Chondroitin sulfuric acids; Chondroitin sulphate; Chondroitin, CHONDROITIN SULFATES; hydrogen sulfate; Chondroitine sulfate; Chondroitinsulfate C; Chondroitinsulfuric acids; Chondron; Chonsurid; Condrosan; Condrosulf; Sodium chondroitin sulfate; Structum; Uropol S; chondroitin sulfate C; 9007-28-7; EINECS 232-696-9; Gepan; UNII-6IC1M3OG5Z

Cross-matching ID

PubChem CID

24766

CAS Number

CAS 9007-28-7

TTD Drug ID

DM0N19Y

INTEDE Drug ID

DR0317

General Information of Drug (ID: DM0N19Y)

Molecule-Related Drug Atlas

Molecule Type:

DME

DOT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

Approved Drug(s)

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Drug(s) Metabolized By Beta-glucuronidase (GUSB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
MK-4827	DMLYGH4	Ovarian cancer	2C73	Phase 3	[11]
Tyropanoic acid	DM91UKB	N. A.	N. A.	Investigative	[12]
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Drug(s) Metabolized By Hyaluronate lyase (hyaL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hyaluronate sodium	DMX8M26	Joint lubricant	FA30-FA38	Approved	[5]
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Drug(s) Metabolized By Hyaluronoglucosaminidase (nagH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hyaluronic acid	DMABXOZ	N. A.	N. A.	Phase 4	[3]
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Drug(s) Affected By Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[13]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[14]
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[15]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[16]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[17]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[18]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[19]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[20]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[21]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[22]
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Drug(s) Affected By Tumor necrosis factor ligand superfamily member 11 (TNFSF11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[15]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[23]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[17]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[9]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[22]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[24]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[25]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[26]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
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Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[29]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[14]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[30]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[31]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[32]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[33]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[34]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[35]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[36]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
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Drug(s) Affected By Midkine (MDK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[38]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[43]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[44]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[45]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[46]
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Drug(s) Affected By Tyrosine-protein phosphatase non-receptor type 11 (PTPN11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[47]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[48]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[50]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[51]
Bortezomib	DMNO38U	Leukemia		Approved	[52]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[53]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[54]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[55]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[56]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Arylsulfatase B (ARSB)	DEHKRDS	ARSB_HUMAN	Substrate	[1]
Iduronate 2-sulfatase (IDS)	DEL45C2	IDS_HUMAN	Substrate	[1]
N-acetyl-beta-glucosaminidase beta (HEXB)	DE6AY40	HEXB_HUMAN	Substrate	[1]
Beta-glucuronidase (GUSB)	DEP54UE	BGLR_HUMAN	Substrate	[1]
Alpha-L-iduronidase (IDUA)	DELTYX6	IDUA_HUMAN	Substrate	[1]
Chondroitin 6-sulfotransferase (CHST3)	DEQIZP2	CHST3_HUMAN	Substrate	[2]
Hyaluronoglucosaminidase (nagH)	DEV7UZD	NAGH_CLOPE	Substrate	[3] , [4]
Hyaluronate lyase (hyaL)	DEH31BC	D1AWD4_STRM9	Substrate	[5] , [6]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
C-C motif chemokine 2 (CCL2)	OTAD2HEL	CCL2_HUMAN	Protein Interaction/Cellular Processes	[7]
Midkine (MDK)	OTF24HKC	MK_HUMAN	Protein Interaction/Cellular Processes	[8]
Tumor necrosis factor ligand superfamily member 11 (TNFSF11)	OTJEPKEQ	TNF11_HUMAN	Gene/Protein Processing	[9]
Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B)	OTQ4W7MT	TR11B_HUMAN	Gene/Protein Processing	[9]
Tyrosine-protein phosphatase non-receptor type 11 (PTPN11)	OTFH9M73	PTN11_HUMAN	Drug Response	[10]

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References

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