Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM0TI4U)

Drug Name
Acebutolol Drug Info
Synonyms
Acebrutololum; Acebutololo; Acebutololum; Acetobutolol; Neptal; Prent; Sectral; Acebutolol HCL; RP 21823; Acebrutololum [INN-Latin]; Acebutololum [INN-Latin]; Acetobutolol [INN-Spanish]; Dl-Acebutolol; M & B 17803A; Prent (TN); Sectral (TN); Acebutolol (USAN/INN); Acebutolol [USAN:INN:BAN]; M&B-17803 A; N-(3-Acetyl-4-[2-hydroxy-3-(isopropylamino)propoxy]phenyl)butanamide; N-[3-acetyl-4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]butanamide; N-[3-acetyl-4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]butanamide; N-{3-acetyl-4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl}butanamide; (+-)-3'-Acetyl-4'-(2-hydroxy-3-(isopropylamino)propoxy)butyranilide; (+-)-Acebutolol; (+-)-N-(3-Acetyl-4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)phenyl)butanamide; 1-(2-Acetyl-4-n-butyramidophenoxy)-2-hydroxy-3-isopropylaminopropane; 3'-(Acetyl-4'-(2-hydroxy-3-(isopropylamino)propoxy)butyranilide; 3'-Acetyl-4'-(2-hydroxy-3-(isopropylamino)propoxy)butyranilide; 3'-Acetyl-4'-(2-hydroxy-3-isopropylaminopropoxy)butyranilid; 5'-Butyramido-2'-(2-hydroxy-3-isopropylaminopropoxy)acetophenone
Indication
Disease Entry ICD 11 Status REF
Hypertension BA00-BA04 Approved [1]
Malignant essential hypertension BA00 Approved [2]
Therapeutic Class
Antihypertensive Agents
Cross-matching ID
PubChem CID
1978
ChEBI ID
CHEBI:2379
CAS Number
CAS 37517-30-9
TTD Drug ID
DM0TI4U
VARIDT Drug ID
DR00627
INTEDE Drug ID
DR0032
ACDINA Drug ID
D00008

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Adrenergic receptor beta-1 (ADRB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Propranolol DM79NTF Angina pectoris BA40 Approved [11]
Epinephrine DM3KJBC Acute asthma CA23 Approved [12]
Norepinephrine DMOUC09 Alopecia ED70 Approved [13]
Atenolol DMNKG1Z Angina pectoris BA40 Approved [3]
Metoprolol DMOJ0V6 Acute coronary syndrome BA41 Approved [3]
Timolol DM3NXRU High blood pressure BA00 Approved [14]
Isoproterenol DMK7MEY Atrioventricular block Approved [15]
Betaxolol DM6EUL5 Hypertension BA00-BA04 Approved [16]
Sotalol DML60TN Sinus rhythm disorder BC9Y Approved [17]
Nadolol DMW6GVL Angina pectoris BA40 Approved [18]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Transported By P-glycoprotein 1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [6]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [19]
Methotrexate DM2TEOL Anterior urethra cancer Approved [20]
Folic Acid DMEMBJC Colorectal carcinoma Approved [21]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [20]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [20]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [22]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [20]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [23]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [24]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Transported By Organic cation transporter 1 (SLC22A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [25]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [26]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [27]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [28]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [6]
Verapamil DMA7PEW Angina pectoris BA40 Approved [4]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [29]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [30]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [31]
Propranolol DM79NTF Angina pectoris BA40 Approved [32]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Transported By Organic anion transporting polypeptide 1A2 (SLCO1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [33]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [34]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [35]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [36]
PITAVASTATIN CALCIUM DM1UJO0 Dyslipidemia 5C80-5C81 Approved [37]
Rosuvastatin DMMIQ7G Arteriosclerosis BD40 Approved [38]
Saquinavir DMG814N Human immunodeficiency virus infection 1C62 Approved [39]
Enalapril DMNFUZR Congestive heart failure BD10 Approved [40]
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [41]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [42]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [43]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [44]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [45]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [46]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [47]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [48]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [49]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [50]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [51]
Propranolol DM79NTF Angina pectoris BA40 Approved [52]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [53]
Paliperidone DM7NPJS Psychotic disorder 6A20-6A25 Approved [54]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [55]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [56]
Oxatomide DM1F42Z Hay fever CA08.00 Approved [57]
Cinacalcet DMCX0K3 Hyperparathyroidism 5A51 Approved [58]
Capsaicin DMGMF6V Back pain ME84.Z Approved [59]
Pentamidine DMHZJCG African trypanosomiasis 1F51 Approved [60]
Quinidine DMLPICK N. A. N. A. Approved [61]
Buprenorphine DMPRI8G Opioid dependence 6C43.2Z Approved [62]
⏷ Show the Full List of 20 Drug(s)
Drug(s) Affected By Renin (REN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [63]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [64]
Reboxetine DM26PRD Depression 6A70-6A7Z Approved [65]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [66]
Ramipril DM2R68E Acute heart failure BD10-BD13 Approved [67]
Rhucin DM3ADGP Erectile dysfunction HA01.1 Approved [68]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [69]
Epinephrine DM3KJBC Acute asthma CA23 Approved [70]
Chlorthalidone DM4DMBT Edema MG29 Approved [71]
Trandolapril DM4L6EU Chronic heart failure BD1Z Approved [72]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein c-Fos (FOS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [73]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [74]
Verapamil DMA7PEW Angina pectoris BA40 Approved [9]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [75]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [76]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [77]
Methotrexate DM2TEOL Anterior urethra cancer Approved [78]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [79]
Quercetin DM3NC4M Obesity 5B81 Approved [80]
Fluoxetine DM3PD2C Bipolar depression Approved [81]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Adrenergic receptor beta-1 (ADRB1) TTR6W5O ADRB1_HUMAN Antagonist [3]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Organic cation transporter 1 (SLC22A1) DTT79CX S22A1_HUMAN Substrate [4]
Organic anion transporting polypeptide 1A2 (SLCO1A2) DTE2B1D SO1A2_HUMAN Substrate [5]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [6]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 2D6 (CYP2D6) Main DME DECB0K3 CP2D6_HUMAN Substrate [7]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Cytochrome P450 2D6 (CYP2D6) OTZJC802 CP2D6_HUMAN Drug Response [8]
Protein c-Fos (FOS) OTJBUVWS FOS_HUMAN Gene/Protein Processing [9]
Renin (REN) OT52GZR2 RENI_HUMAN Gene/Protein Processing [10]

References

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2 Acebutolol FDA Label
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