Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM0UADK)

Drug Name
OCTOCLOTHEPIN Drug Info
Synonyms
Clorotepine; Octoclothepin; Octoclothepine; Clotepin; Clothepin; 13448-22-1; Clorotepine [INN]; Clorotepinum [INN-Latin]; Clorotepina [INN-Spanish]; CHEMBL64249; 1-(8-Chloro-10,11-dihydrodibenzo(b,f)thiepin-10-yl)-4-methylpiperazine; Piperazine, 1-(8-chloro-10,11-dihydrodibenzo(b,f)thiepin-10-yl)-4-methyl-; clothepine; clorothepin; Clorotepinum; Clorotepina; 1-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl)-4-methylpiperazine; VUFB-6281; Octoclothepin maleate; CLOROTEPINE(-); AC1Q3SXZ; CLOROTEPINE (+); OCTOCLOTHEPIN,(-)
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
1238
ChEBI ID
CHEMBL135459
CAS Number
CAS 13448-22-1
TTD Drug ID
DM0UADK

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Approved Drug(s)
Discontinued Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting 5-HT 6 receptor (HTR6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
LU AE58054 DMWGRQD Schizophrenia 6A20 Phase 3 [3]
SB-742457 DM6L4ZT Alzheimer disease 8A20 Phase 3 [4]
AVN 211 DMVB4OS Schizophrenia 6A20 Phase 2/3 [5]
SYN120 DMDF7XB Parkinson disease 8A00.0 Phase 2 [6]
AVN 101 DMJFLBC Alzheimer disease 8A20 Phase 2 [5]
SYN-120 DMPW0UL Alzheimer disease 8A20 Phase 2 [7]
PF-05212377 DMPVQYR Alzheimer disease 8A20 Phase 2 [8]
AVN 322 DMK2LGM Cognitive impairment 6D71 Phase 2 [4]
SAM-531 DMHVJZ6 Alzheimer disease 8A20 Phase 2 [9]
SUVN-502 DMQD753 Alzheimer disease 8A20 Phase 2 [10]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Adrenergic receptor alpha-1B (ADRA1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methamphetamine DMPM4SK Anxiety Approved [11]
Propericiazine DME9JNL Psychiatric disorder 6E8Z Approved [12]
Methoxamine DMF5XQH Hypertension BA00-BA04 Approved [13]
Phendimetrazine DM6TS1N Obesity 5B81 Approved [14]
MEDETOMIDINE DMX9Y7V Pain MG30-MG3Z Phase 2 [15]
TIOSPIRONE DME5QDP N. A. N. A. Discontinued in Phase 3 [16]
Sunepitron DM6M8ZX N. A. N. A. Discontinued in Phase 3 [17]
MAZAPERTINE DMRHYAU N. A. N. A. Discontinued in Phase 2 [18]
SOU-001 DMPAEK5 Urinary incontinence MF50.2 Discontinued in Phase 2 [19]
SNAP-5089 DMROJEN Heart arrhythmia BC65 Terminated [20]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Adrenergic receptor alpha-1D (ADRA1D)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxazosin DM9PLRH Benign prostatic hyperplasia GA90 Approved [21]
Armodafinil DMGB035 Malignant glioma 2A00.0 Approved [22]
Alfuzosin DMZVMKF Benign prostatic hyperplasia GA90 Approved [23]
Moxisylyte DMFCLYW Erectile dysfunction HA01.1 Approved [24]
Terazosin DM3JCVS Benign prostatic hyperplasia GA90 Approved [25]
Bunazosin DM4I8O7 Glaucoma/ocular hypertension 9C61 Approved [26]
Trimazosin DM1QLST Congestive heart failure BD10 Approved [27]
MEDETOMIDINE DMX9Y7V Pain MG30-MG3Z Phase 2 [15]
DL-017 DMM8GZT Hypertension BA00-BA04 Phase 1 [28]
PMID30124346-Compound-LDT8 DM5MUNG Benign prostatic hyperplasia GA90 Patented [29]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Dopamine D2 receptor (D2R)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [30]
Haloperidol DM96SE0 Delirium Approved [31]
Perphenazine DMA4MRX Schizophrenia 6A20 Approved [32]
Perazine DM2AOTZ Psychotic disorder 6A20-6A25 Approved [33]
Domperidone DMBDPY0 Gastrointestinal disease DE2Z Approved [34]
Levodopa DMN3E57 Parkinson disease 8A00.0 Approved [35]
Quetiapine DM1N62C Anorexia nervosa cachexia 6B80 Approved [36]
Pimozide DMW83TP Schizophrenia 6A20 Approved [37]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [38]
Iloperidone DM6AUFY Schizophrenia 6A20 Approved [39]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Histamine H1 receptor (H1R)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [40]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [41]
Azelastine DMXTMBJ Allergic conjunctivitis 9A60.02 Approved [42]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [43]
Cinnarizine DM7U5QJ Meniere disease AB31.0 Approved [44]
Diphenhydramine DMKQTBA Hyperemesis gravidarum Approved [42]
Doxepin DMPI98T Anxiety Approved [45]
Chlorpheniramine DM5URA2 Allergic rhinitis CA08.0 Approved [42]
Epinastine DMX0K3Q Allergic conjunctivitis 9A60.02 Approved [46]
Desloratadine DM56YN7 Allergic rhinitis CA08.0 Approved [47]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting 5-HT 2C receptor (HTR2C)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Metergolin DMJFP6G Hyperprolactinaemia 5A60.1 Approved [48]
Lorcaserin DMG6OYJ Obesity 5B81 Approved [49]
Tramadol DMRQD04 Osteoarthritis FA00-FA05 Approved [50]
Mirtazapine DML53ZJ Depression 6A70-6A7Z Approved [51]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [52]
Methysergide DM1EF73 Migraine 8A80 Approved [53]
Eltoprazine DMW6C81 Attention deficit hyperactivity disorder 6A05.Z Phase 3 [54]
M100907 DM7ZFBA Sleep-wake disorder 7A00-7B2Z Phase 3 [55]
SR46349B DM1ODMR Primary insomnia 7A00 Phase 3 [56]
Vabicaserin DM9GZW6 Psychotic disorder 6A20-6A25 Phase 2 [57]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Adrenergic receptor alpha-1A (ADRA1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
SILODOSIN DMJSBT6 Benign prostatic hyperplasia GA90 Approved [58]
NAFTOPIDIL DMQ8R4E Hypertension BA00-BA04 Approved [58]
Tamsulosin DM5QF9V Benign prostatic hyperplasia GA90 Approved [59]
Xatral DMLHOA0 Benign prostatic hyperplasia GA90 Approved [60]
Dutasteride + tamsulosin DM6P8HU Benign prostatic hyperplasia GA90 Phase 3 [61]
Besipirdine DMLVNTA Cognitive impairment 6D71 Phase 3 [62]
MEDETOMIDINE DMX9Y7V Pain MG30-MG3Z Phase 2 [15]
PMID30124346-Compound-LDT8 DM5MUNG Benign prostatic hyperplasia GA90 Patented [29]
PMID30124346-Compound-LDT66 DMJMTNL Benign prostatic hyperplasia GA90 Patented [29]
TIOSPIRONE DME5QDP N. A. N. A. Discontinued in Phase 3 [16]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
5-HT 2C receptor (HTR2C) TTWJBZ5 5HT2C_HUMAN Inhibitor [1]
5-HT 6 receptor (HTR6) TTJS8PY 5HT6R_HUMAN Inhibitor [2]
Adrenergic receptor alpha-1A (ADRA1A) TTNGILX ADA1A_HUMAN Inhibitor [1]
Adrenergic receptor alpha-1B (ADRA1B) TTBRKXS ADA1B_HUMAN Inhibitor [1]
Adrenergic receptor alpha-1D (ADRA1D) TT34BHT ADA1D_HUMAN Inhibitor [1]
Dopamine D2 receptor (D2R) TTEX248 DRD2_HUMAN Inhibitor [1]
Histamine H1 receptor (H1R) TTTIBOJ HRH1_HUMAN Inhibitor [1]

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