Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM0VBUL)

Drug Name

Aprophen Drug Info

Synonyms

Aprofene; Aprophen; Aprofen; Aprophenum; Aprofene [INN]; 3563-01-7; 2-Diethylaminoethyl 2,2-diphenylpropionate; Aprofenum [INN-Latin]; Aprofeno [INN-Spanish]; UNII-PL791XXJ7B; PL791XXJ7B; CHEMBL26505; 2-(Diethylamino)ethyl 2,2-diphenylpropanoate; 2,2-Diphenylpropionic acid 2-diethylaminoethyl ester; BRN 2509326; NCGC00160676-01; Propionic acid, 2,2-diphenyl-, 2-(diethylamino)ethyl ester; DSSTox_CID_26294; DSSTox_RID_81519; DSSTox_GSID_46294; alpha,alpha-Diphenylpropionic acid beta-diethylaminoethyl ester

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 71128
ChEBI ID: CHEMBL26505
CAS Number: CAS 3563-01-7
TTD Drug ID: DM0VBUL

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Muscarinic acetylcholine receptor M5 (CHRM5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Promazine	DMZAL7W	Acute intermittent hepatic porphyria	5C58.11	Approved	[2]
ACECLIDINE	DMOLNCZ	Glaucoma/ocular hypertension	9C61	Approved	[3]
Pilocarpine	DMV9ADG	Glaucoma/ocular hypertension	9C61	Approved	[4]
Anisodine	DMNOSWU	Central and peripheral nervous disease	8A04-8E7Z	Approved	[5]
Atropine	DMEN6X7	Organophosphate poisoning	NE6Z	Approved	[6]
Propiverine	DMUWBIJ	Urinary incontinence	MF50.2	Approved	[7]
Umeclidinium	DM4E8O9	Chronic obstructive pulmonary disease	CA22	Approved	[8]
Cimetropium bromide	DMZHPNE	Gastric motility disorder	DA21	Approved	[9]
Butylscopolamine	DMZKXB7	Dysmenorrhea	GA34.3	Approved	[10]
Trospium	DMX6RTG	Overactive bladder	GC50.0	Approved	[11]
------------------------------------------------------------------------------------


⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Muscarinic acetylcholine receptor M5 (CHRM5)	TTH18TF	ACM5_HUMAN	Antagonist	[1]

------------------------------------------------------------------------------------

References

1	The muscarinic antagonists aprophen and benactyzine are noncompetitive inhibitors of the nicotinic acetylcholine receptor. Mol Pharmacol. 1987 Nov;32(5):678-85.
2	Muscarinic cholinergic and histamine H1 receptor binding of phenothiazine drug metabolites. Life Sci. 1988;43(5):405-12.
3	Design, synthesis, and neurochemical evaluation of 5-(3-alkyl-1,2,4- oxadiazol-5-yl)-1,4,5,6-tetrahydropyrimidines as M1 muscarinic receptor agonists. J Med Chem. 1993 Apr 2;36(7):842-7.
4	Retinoic acid prevents virus-induced airway hyperreactivity and M2 receptor dysfunction via anti-inflammatory and antiviral effects. Am J Physiol Lung Cell Mol Physiol. 2009 Aug;297(2):L340-6.
5	Medicinal plants in therapy. Bull World Health Organ. 1985;63(6):965-81.
6	Additive protective effects of donepezil and nicotine against salsolinol-induced cytotoxicity in SH-SY5Y cells. Neurotox Res. 2009 Oct;16(3):194-204.
7	Affinity profiles of various muscarinic antagonists for cloned human muscarinic acetylcholine receptor (mAChR) subtypes and mAChRs in rat heart and submandibular gland. Life Sci. 1999;64(25):2351-8.
8	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7354).
9	Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77.
10	Comparison of pharmacological effects of L- and DL-n-butyl-scopolamine in rat uterus. Yao Xue Xue Bao. 1994;29(1):24-7.
11	Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.