Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM1237M)

Drug Name

Alfacalcidol Drug Info

Synonyms

Alfacalcidol [INN:BAN:JAN]; Alfacalcidolum; Alfacalcidolum [INN-Latin]; Alfarol; Alpha D 3; Alphacalcidol; Alsiodol; Bondiol; EinsAlpha; One-Alpha; Oxydevit; Sinovul; URQ2517572; Un-Alpha; Vitamin D3, 1alpha-Hydroxy-; alfacalcidol; alpha-Calcidol; (5Z,7E)-9,10-Seco-5,7,10(19)-cholestatrien-1alpha,3beta-diol; 1-Hydroxycholecalciferol; 1-Hydroxyvitamin D3; 1alpha-Hydroxy-vitamin D3; 1alpha-Hydroxycholecalciferol; 1alpha-Hydroxyvitamin D3; 1alpha-OH-D3; 41294-56-8; CCRIS 3341; CHEBI:31186; UNII-URQ2517572

Indication

Disease Entry	ICD 11	Status	REF
Hyperparathyroidism	5A51	Approved	[1]
Hypoparathyroidism	5A50	Approved	[2]
Renal osteodystrophy		Approved	[3]

Cross-matching ID

PubChem CID: 5282181
ChEBI ID: CHEMBL1601669
CAS Number: CAS 41294-56-8
TTD Drug ID: DM1237M
INTEDE Drug ID: DR0060

Molecule-Related Drug Atlas

Molecule Type:

DME

DOT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Download the Complete Related Drug List

Drug(s) Metabolized By Vitamin D(3) 25-hydroxylase (CYP27A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxercalciferol	DM6FG1P	Chronic kidney disease	GB61	Approved	[10]
Vitamin D	DMWQUC9	N. A.	N. A.	Approved	[11]
ANW-32821	DMMJOZD	N. A.	N. A.	Phase 2	[12]
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Drug(s) Metabolized By Cytochrome P450 2J2 (CYP2J2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Riociguat	DMXBLMP	Chronic thromboembolic pulmonary hypertension		Approved	[13]
Rivaroxaban	DMQMBZ1	Deep vein thrombosis	BD71	Approved	[14]
Ergocalciferol	DMHO0AR	Hypoparathyroidism	5A50	Approved	[5]
Vorapaxar	DMA16BR	Myocardial infarction	BA41-BA43	Approved	[15]
Vitamin D	DMWQUC9	N. A.	N. A.	Approved	[5]
Ebastine	DMH21D9	N. A.	N. A.	Phase 4	[16]
MANIDIPINE	DMJPGUA	N. A.	N. A.	Phase 3	[17]
Carebastine	DMUVMWZ	Ocular allergy	4A81	Phase 3	[18]
Eperisone	DM1SMAI	Muscle spasm	MB47.3	Phase 3	[19]
H3B-6545	DMIFCY2	Breast cancer	2C60-2C65	Phase 1/2	[20]
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Drug(s) Affected By 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (CYP24A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[21]
Calcidiol	DMN4CV5	Hypophosphatemia		Approved	[22]
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[23]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[24]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[27]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[28]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[29]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[30]
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Drug(s) Affected By Albumin (ALB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[31]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[32]
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[33]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[34]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[35]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[36]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[37]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[38]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[39]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
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Drug(s) Affected By Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[41]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[42]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[43]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[44]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[45]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[46]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[48]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[49]
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Drug(s) Affected By Transforming growth factor beta-1 proprotein (TGFB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[50]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[32]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[51]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[52]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[53]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[54]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[55]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[56]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[57]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[58]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Vitamin D(3) 25-hydroxylase (CYP27A1)	DEBS639	CP27A_HUMAN	Substrate	[4]
Cytochrome P450 2J2 (CYP2J2)	DERSX5P	CP2J2_HUMAN	Substrate	[5]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (CYP24A1)	OTG2T749	CP24A_HUMAN	Gene/Protein Processing	[6]
Albumin (ALB)	OTVMM513	ALBU_HUMAN	Gene/Protein Processing	[7]
Transforming growth factor beta-1 proprotein (TGFB1)	OTV5XHVH	TGFB1_HUMAN	Drug Response	[8]
Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B)	OTDS2EAR	TNR1B_HUMAN	Gene/Protein Processing	[7]
Vitamin D3 receptor	OTFC7K35	VDR_HUMAN	Gene/Protein Processing	[9]

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