Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM1ROU7)

Drug Name
D-xylulose Drug Info
Synonyms
D-threo-2-Pentulose; D-threo-pent-2-ulose; D-xylulose; HY-W010256; Lyxulose; Threo-2-pentulose (9CI); Threo-2-pentulose(9ci); Threo-2-pentulose, D-; Xylulose D-isomer [MI]; Xylulose, D-; YSC9WAF8X1; ZAQJHHRNXZUBTE-WUJLRWPWSA-N; ZINC100028356; threo-2-Pentulose; xylulose; (3S,4R)-1,3,4,5-tetrahydroxypentan-2-one; 551-84-8; 5962-29-8; AC1NRDJS; AKOS027320628; CHEBI:17140; CHEMBL195094; CS-W010972; CTK5A3156; D-Xul; DTXSID70415364; FCH4007851; FT-0625634; SCHEMBL37387; UNII-YSC9WAF8X1; XUL
Cross-matching ID
PubChem CID
5289590
ChEBI ID
CHEBI:17140
CAS Number
CAS 551-84-8
TTD Drug ID
DM1ROU7
INTEDE Drug ID
DR2093

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DME
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Affected By L-xylulose reductase (DCXR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [3]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [5]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [6]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [7]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [8]
Ethanol DMDRQZU Chronic pain MG30 Approved [9]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [10]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [11]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [12]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Xylulose kinase (XYLB) Main DME DECFU6W XYLB_HUMAN Substrate [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
L-xylulose reductase (DCXR) OTYVXRXB DCXR_HUMAN Regulation of Drug Effects [2]

References

1 Structure and function of human xylulokinase, an enzyme with important roles in carbohydrate metabolism. J Biol Chem. 2013 Jan 18;288(3):1643-52.
2 Diacetyl/l-xylulose reductase mediates chemical redox cycling in lung epithelial cells. Chem Res Toxicol. 2017 Jul 17;30(7):1406-1418.
3 Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
4 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
5 Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermatoendocrinol. 2009 May;1(3):177-87.
6 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
7 Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
8 Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
9 Gene expression signatures after ethanol exposure in differentiating embryoid bodies. Toxicol In Vitro. 2018 Feb;46:66-76.
10 Transcriptomic analysis of untreated and drug-treated differentiated HepaRG cells over a 2-week period. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):27-35.
11 Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
12 CXCL14 downregulation in human keratinocytes is a potential biomarker for a novel in vitro skin sensitization test. Toxicol Appl Pharmacol. 2020 Jan 1;386:114828. doi: 10.1016/j.taap.2019.114828. Epub 2019 Nov 14.