Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM27U4Y)

Drug Name
Desogestrel Drug Info
Synonyms
Cerazette; Desogen; Desogestrelum; Organon Brand of Desogestrel; ORG 2969; Desogestrelum [INN-Latin]; Desogestrel (USAN/INN); Desogestrel [USAN:BAN:INN]; Alpha-pregn-4-en-20-yn-17-ol, 13-Ethyl-11-methylene-18,19-dinor-17; (17alpha)-13-Ethyl-11-methylene-18,19-dinorpregn-4-en-20-yn-17-ol; (8S,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-11-methylidene-1,2,3,6,7,8,9,10,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-ol; 13 Ethyl 11 methylene 18,19 dinor 17 alpha pregn 4 en 20 yn 17 ol; 13-Ethyl-11-methylene-18,19-dinor-17 alpha-pregn-4-en-20-yn-17-ol; 13-Ethyl-11-methylene-18,19-dinor-17alpha-pregn-4-en-20-yn-17-ol; 17alpha-ethynyl-11-methylidene-18a-homo-estr-4-en-17beta-ol
Indication
Disease Entry ICD 11 Status REF
Contraception QA21 Approved [1]
Therapeutic Class
Contraceptive Agents
Cross-matching ID
PubChem CID
40973
ChEBI ID
CHEMBL1533
CAS Number
CAS 54024-22-5
TTD Drug ID
DM27U4Y
INTEDE Drug ID
DR0438

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Progesterone receptor (PGR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [7]
Ulipristal DMBNI20 Contraception QA21 Approved [8]
Etonogestrel DMKA8J4 Contraception QA21 Approved [9]
Megestrol DMDH9KX Breast cancer 2C60-2C65 Approved [10]
Segesterone acetate; ethinyl estradiol DMFEGB0 Contraception QA21 Approved [11]
Norgestimate DMYP4XC Acne vulgaris ED80 Approved [9]
Dydrogesterone DMAKIDV Menstrual disorder GA20.3 Approved [12]
Medroxyprogesterone DMBGWPH Solid tumour/cancer 2A00-2F9Z Approved [12]
Ethynodiol Diacetate DMZM84R Contraception QA21 Approved [13]
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [14]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [15]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [16]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [17]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [18]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [19]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [20]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [21]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [22]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [16]
Verapamil DMA7PEW Angina pectoris BA40 Approved [23]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [24]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [25]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [26]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [27]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [28]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [27]
Verapamil DMA7PEW Angina pectoris BA40 Approved [29]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [30]
Estrone DM5T6US Acne vulgaris ED80 Approved [31]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [32]
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Drug(s) Metabolized By Mephenytoin 4-hydroxylase (CYP2C19)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [33]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [24]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [34]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [35]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [27]
Verapamil DMA7PEW Angina pectoris BA40 Approved [36]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [37]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [32]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [38]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [39]
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Drug(s) Affected By Aldo-keto reductase family 1 member C3 (AKR1C3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [40]
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [41]
Diazepam DM08E9O Alcohol withdrawal Approved [42]
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [5]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [41]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [41]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [43]
Quercetin DM3NC4M Obesity 5B81 Approved [44]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [45]
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [46]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Vitamin K-dependent protein S (PROS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [47]
Quercetin DM3NC4M Obesity 5B81 Approved [48]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [49]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [50]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [51]
Testosterone enanthate DMB6871 N. A. N. A. Approved [52]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [53]
Folic Acid DMEMBJC Colorectal carcinoma Approved [54]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [55]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [56]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Progesterone receptor (PGR) TTUV8G9 PRGR_HUMAN Modulator [2]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [3]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Substrate [4]
Mephenytoin 4-hydroxylase (CYP2C19) DEGTFWK CP2CJ_HUMAN Substrate [4]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Aldo-keto reductase family 1 member C3 (AKR1C3) OTU2SXBA AK1C3_HUMAN Gene/Protein Processing [5]
Vitamin K-dependent protein S (PROS1) OTXQWNOI PROS_HUMAN Gene/Protein Processing [6]

References

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26 Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms. Endocrinology. 2003 Aug;144(8):3382-98.
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47 The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
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