Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM346EU)

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Patented Agent(s)

Investigative Drug(s)

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Drug(s) Targeting Bromodomain-containing protein 4 (BRD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CPI-0610	DMPXOYJ	Myelofibrosis	2A20.2	Phase 3	[2]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[2]
PLX2853	DMX168L	Acute myeloid leukaemia	2A60	Phase 1/2	[3]
RVX-208	DM1LO8K	Alzheimer disease	8A20	Phase 1/2	[2]
INCB57643	DMBGU7V	Advanced malignancy	2A00-2F9Z	Phase 1/2	[3]
ABBV-744	DMTEA9C	Acute myeloid leukaemia	2A60	Phase 1	[3]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[4]
GSK525762	DMPAWBN	Haematological malignancy	2B33.Y	Phase 1	[2]
TEN010	DM4UOY5	Advanced solid tumour	2A00-2F9Z	Phase 1	[2]
AZD5153	DMW4GM2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[3]
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Drug(s) Targeting Bromodomain-containing protein 3 (BRD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ABBV-744	DMTEA9C	Acute myeloid leukaemia	2A60	Phase 1	[3]
PMID26924192-Compound-102	DMEJ107	N. A.	N. A.	Patented	[1]
PMID26924192-Compound-103	DMWOCP7	N. A.	N. A.	Patented	[1]
PMID26924192-Compound-105	DMAWLGI	N. A.	N. A.	Patented	[1]
Pyrrolo-pyrrolone derivative 1	DMN4SE5	N. A.	N. A.	Patented	[1]
XD14	DMUMACD	Discovery agent	N.A.	Investigative	[5]
GW841819X	DMRL9IN	Discovery agent	N.A.	Investigative	[6]
PMID24000170C36	DMHUWZS	Discovery agent	N.A.	Investigative	[7]
PMID24000170C38	DMOLRIY	Discovery agent	N.A.	Investigative	[7]
I-BET151	DMYRUH2	Discovery agent	N.A.	Investigative	[8]
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Drug(s) Targeting Bromodomain-containing protein 2 (BRD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[2]
ABBV-744	DMTEA9C	Acute myeloid leukaemia	2A60	Phase 1	[3]
PMID26924192-Compound-102	DMEJ107	N. A.	N. A.	Patented	[1]
PMID26924192-Compound-103	DMWOCP7	N. A.	N. A.	Patented	[1]
PMID26924192-Compound-105	DMAWLGI	N. A.	N. A.	Patented	[1]
Pyrrolo-pyrrolone derivative 1	DMN4SE5	N. A.	N. A.	Patented	[1]
PMID26924192-Compound-106	DM9HRZJ	N. A.	N. A.	Patented	[1]
XD14	DMUMACD	Discovery agent	N.A.	Investigative	[5]
GW841819X	DMRL9IN	Discovery agent	N.A.	Investigative	[6]
PMID24000170C36	DMHUWZS	Discovery agent	N.A.	Investigative	[7]
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Drug(s) Targeting Bromodomain testis-specific protein (BRDT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[9]
PMID26924192-Compound-102	DMEJ107	N. A.	N. A.	Patented	[1]
PMID26924192-Compound-103	DMWOCP7	N. A.	N. A.	Patented	[1]
PMID26924192-Compound-105	DMAWLGI	N. A.	N. A.	Patented	[1]
XD14	DMUMACD	Discovery agent	N.A.	Investigative	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bromodomain testis-specific protein (BRDT)	TT7CPI5	BRDT_HUMAN	Inhibitor	[1]
Bromodomain-containing protein 2 (BRD2)	TTDP48B	BRD2_HUMAN	Inhibitor	[1]
Bromodomain-containing protein 3 (BRD3)	TTHE657	BRD3_HUMAN	Inhibitor	[1]
Bromodomain-containing protein 4 (BRD4)	TTRA6BO	BRD4_HUMAN	Inhibitor	[1]

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References

1	BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22.
2	Targeting bromodomains: epigenetic readers of lysine acetylation.Nat Rev Drug Discov.2014 May;13(5):337-56.
3	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4	Selective inhibition of BET bromodomains. Nature. 2010 Dec 23;468(7327):1067-73.
5	4-Acyl pyrroles: mimicking acetylated lysines in histone code reading. Angew Chem Int Ed Engl. 2013 Dec 23;52(52):14055-9.
6	Discovery and characterization of small molecule inhibitors of the BET family bromodomains. J Med Chem. 2011 Jun 9;54(11):3827-38.
7	Naphthyridines as novel BET family bromodomain inhibitors. ChemMedChem. 2014 Mar;9(3):580-9.
8	Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia. Nature. 2011 Oct 2;478(7370):529-33.
9	Small-molecule inhibition of BRDT for male contraception. Cell. 2012 Aug 17;150(4):673-84.