Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM54OKX)

• Drug Name: Thenoyltrifluoroacetone Drug Info
• Synonyms: thenoyl trifluoro acetone; MolPort-001-660-116; STK312921; AKOS005437067; ST45092067; (2E)-1,1,1-trifluoro-4-oxo-4-(thiophen-2-yl)but-2-en-2-olate

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 5601
  ChEBI ID: CHEMBL1236433
  CAS Number: CAS 326-91-0
  TTD Drug ID: DM54OKX

Molecule-Related Drug Atlas

Drug(s) Targeting Liver carboxylesterase (CES1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[4]
PACTIMIBE	DM0NZDT	Arteriosclerosis	BD40	Phase 2/3	[5]
K-604	DMQVN6P	Arteriosclerosis	BD40	Phase 2	[6]
Eldacimibe	DML7WP0	Hyperlipidaemia	5C80	Phase 2	[7]
GR148672X	DM7W6YN	Acute lymphoblastic leukaemia	2A85	Clinical trial	[8]
Avasimibe	DMFG4OM	Peripheral vascular disease	BD4Z	Discontinued in Phase 3	[9]
E-5324	DM562BM	Hyperlipidaemia	5C80	Discontinued in Phase 2	[10]
RP-64477	DMTQ3BS	Hyperlipidaemia	5C80	Discontinued in Phase 2	[11]
CI-976	DMBO28J	Hyperlipidaemia	5C80	Discontinued in Phase 2	[12]
CL-283796	DM7LIDT	Hyperlipidaemia	5C80	Discontinued in Phase 2	[13]

Drug(s) Affected By Autophagy protein 5 (ATG5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[14]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[15]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[16]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[17]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[18]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[19]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[20]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]

Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[24]
Selenium	DM25CGV	N. A.	N. A.	Approved	[25]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[26]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[27]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[28]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[30]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[31]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[32]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[33]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Liver carboxylesterase (CES1)	TTMF541	EST1_HUMAN	Inhibitor	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Autophagy protein 5 (ATG5)	OT4T5SMS	ATG5_HUMAN	Drug Response	[2]
Serine/threonine-protein kinase ULK1	OTXNP0N5	ULK1_HUMAN	Gene/Protein Processing	[3]
Superoxide dismutase , mitochondrial (SOD2)	OTIWXGZ9	SODM_HUMAN	Drug Response	[2]

References

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