Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM5AOFW)

Drug Name
DIGITOXIGENIN Drug Info
Synonyms
Uzarigenin; 466-09-1; UNII-K9ZR7LI283; EINECS 207-373-0; NSC 119993; BRN 0095446; K9ZR7LI283; 3-beta-14-beta-5-Allo-cardenolid [German]; 3beta,14-Dihydroxy-5alpha-card-20(22)-enolide; 3-beta,14-Dihydroxy-5-alpha-card-20(22)-enolide; 4-18-00-01470 (Beilstein Handbook Reference); Urarigenin; Odorigeni; 3-beta-14-beta-5-Allo-cardenolid; AC1L3OS7; CHEMBL109863; SCHEMBL1152953; XZTUSOXSLKTKJQ-CIXPXFMPSA-N; MolPort-006-111-351; ZINC4073972; MCULE-2541512222; NCGC00384854-01; BC271971; 3,14-Dihydroxycard-20(22)-enolide #
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
4369270
ChEBI ID
CHEBI:42219
CAS Number
CAS 143-62-4
TTD Drug ID
DM5AOFW
VARIDT Drug ID
DR01376

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Sodium pump subunit alpha-1 (ATP1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Artemether DM48QOT Malaria 1F40-1F45 Approved [3]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [4]
Lumefantrine DM29GAD Malaria 1F40-1F45 Approved [3]
Chloroprocaine DMSOQK1 Anaesthesia 9A78.6 Approved [5]
Deslanoside DMB3ZSK Arrhythmia BC9Z Approved [4]
Almitrine DM0SYAN Chronic obstructive pulmonary disease CA22 Approved [6]
Acetyldigitoxin DMHAUO0 Congestive heart failure BD10 Approved [7]
Aluminium DM6ECN9 Hyperhidrosis EE00 Approved [8]
UNBS-1450 DMR38M4 Solid tumour/cancer 2A00-2F9Z Phase 1 [9]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Interleukin-6 receptor subunit alpha (IL6R)
Drug Name Drug ID Indication ICD 11 Highest Status REF
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [10]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [11]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [12]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [13]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [14]
Testosterone enanthate DMB6871 N. A. N. A. Approved [15]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [16]
Emetine DMCT2YF Hepatitis virus infection 1E50-1E51 Approved [2]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [17]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [18]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [19]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [20]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [21]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [22]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [23]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [24]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [25]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [26]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [27]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [25]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By C-C motif chemokine 4 (CCL4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [28]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [29]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [30]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [31]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [32]
Betamethasone DMAHJEF Acute adrenal insufficiency Approved [2]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [33]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Emetine DMCT2YF Hepatitis virus infection 1E50-1E51 Approved [2]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [35]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By C-C motif chemokine 2 (CCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [36]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [37]
Gefitinib DM15F0X Colon adenocarcinoma Approved [38]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [39]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [40]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [41]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [42]
Methotrexate DM2TEOL Anterior urethra cancer Approved [43]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [44]
Quercetin DM3NC4M Obesity 5B81 Approved [45]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By C-C motif chemokine 5 (CCL5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [46]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [47]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [48]
Methotrexate DM2TEOL Anterior urethra cancer Approved [43]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [49]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [50]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [30]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [51]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [31]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [52]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Sodium pump subunit alpha-1 (ATP1A1) TTWK8D0 AT1A1_HUMAN Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Gene/Protein Processing [2]
C-C motif chemokine 4 (CCL4) OT6B8P25 CCL4_HUMAN Gene/Protein Processing [2]
C-C motif chemokine 5 (CCL5) OTSCA5CK CCL5_HUMAN Gene/Protein Processing [2]
Interleukin-6 receptor subunit alpha (IL6R) OTCQL07Z IL6RA_HUMAN Gene/Protein Processing [2]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Gene/Protein Processing [2]
Vascular endothelial growth factor A, long form OTIM9MZ3 VEGFA_HUMAN Gene/Protein Processing [2]

References

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