Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM6T0IQ)

• Drug Name: PSAMMAPLIN A Drug Info
• Synonyms: Psammaplin A; 110659-91-1; Bisprasin; NSC614495; AC1O46WI; SCHEMBL364511; ZINC150352860; NSC-614495; B723735K022; J-002461; Benzenepropanamide, N,N'-(dithiodi-2,1-ethanediyl)bis(3-bromo-4-hydroxy-alpha-(hydroxyimino)-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 6400741
  CAS Number: CAS 110659-91-1
  TTD Drug ID: DM6T0IQ

Molecule-Related Drug Atlas

Drug(s) Targeting Histone deacetylase 6 (HDAC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Citarinostat	DMQLODU	Multiple myeloma	2A83	Phase 1	[3]
KA2507	DMW0H9Y	Solid tumour/cancer	2A00-2F9Z	Phase 1	[3]
PMID29671355-Compound-62	DMWRS34	N. A.	N. A.	Patented	[4]
PMID29671355-Compound-43	DMVPMWJ	N. A.	N. A.	Patented	[4]
PMID29671355-Compound-25	DMPV0KZ	N. A.	N. A.	Patented	[4]
PMID29671355-Compound-21	DMPJN0M	N. A.	N. A.	Patented	[4]
PMID29671355-Compound-31	DM3H78D	N. A.	N. A.	Patented	[4]
PMID29671355-Compound-56	DM0VBMI	N. A.	N. A.	Patented	[4]
PMID29671355-Compound-67	DM1RPL4	N. A.	N. A.	Patented	[4]
PMID29671355-Compound-23	DMUBOEX	N. A.	N. A.	Patented	[4]

Drug(s) Targeting Histone deacetylase 8 (HDAC8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
NBM-BMX	DM5OWXA	Solid tumour/cancer	2A00-2F9Z	Phase 1	[5]
PMID29671355-Compound-62	DMWRS34	N. A.	N. A.	Patented	[4]
PMID29671355-Compound-43	DMVPMWJ	N. A.	N. A.	Patented	[4]
PMID29671355-Compound-25	DMPV0KZ	N. A.	N. A.	Patented	[4]
PMID29671355-Compound-21	DMPJN0M	N. A.	N. A.	Patented	[4]
PMID29671355-Compound-31	DM3H78D	N. A.	N. A.	Patented	[4]
PMID29671355-Compound-56	DM0VBMI	N. A.	N. A.	Patented	[4]
PMID29671355-Compound-67	DM1RPL4	N. A.	N. A.	Patented	[4]
PMID29671355-Compound-23	DMUBOEX	N. A.	N. A.	Patented	[4]
PMID29671355-Compound-44	DM80A3V	N. A.	N. A.	Patented	[4]

Drug(s) Targeting Histone deacetylase 2 (HDAC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CHR-3996	DMIXPNG	Lymphoma	2A80-2A86	Phase 1/2	[6]
PMID29671355-Compound-62	DMWRS34	N. A.	N. A.	Patented	[4]
PMID29671355-Compound-43	DMVPMWJ	N. A.	N. A.	Patented	[4]
PMID29671355-Compound-25	DMPV0KZ	N. A.	N. A.	Patented	[4]
PMID29671355-Compound-21	DMPJN0M	N. A.	N. A.	Patented	[4]
PMID29671355-Compound-31	DM3H78D	N. A.	N. A.	Patented	[4]
PMID29671355-Compound-56	DM0VBMI	N. A.	N. A.	Patented	[4]
PMID29671355-Compound-67	DM1RPL4	N. A.	N. A.	Patented	[4]
PMID29671355-Compound-23	DMUBOEX	N. A.	N. A.	Patented	[4]
PMID29671355-Compound-44	DM80A3V	N. A.	N. A.	Patented	[4]

Drug(s) Targeting Histone deacetylase 4 (HDAC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID29671355-Compound-62	DMWRS34	N. A.	N. A.	Patented	[4]
PMID29671355-Compound-43	DMVPMWJ	N. A.	N. A.	Patented	[4]
PMID29671355-Compound-25	DMPV0KZ	N. A.	N. A.	Patented	[4]
PMID29671355-Compound-21	DMPJN0M	N. A.	N. A.	Patented	[4]
PMID29671355-Compound-31	DM3H78D	N. A.	N. A.	Patented	[4]
PMID29671355-Compound-56	DM0VBMI	N. A.	N. A.	Patented	[4]
PMID29671355-Compound-67	DM1RPL4	N. A.	N. A.	Patented	[4]
PMID29671355-Compound-23	DMUBOEX	N. A.	N. A.	Patented	[4]
PMID29671355-Compound-61	DMXH1G3	N. A.	N. A.	Patented	[4]
PMID29671355-Compound-45a	DM5LYKR	N. A.	N. A.	Patented	[4]

Drug(s) Targeting Histone deacetylase (HDAC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[7]
Sodium phenylbutyrate	DMXLBCQ	Spinal muscular atrophy	8B61	Approved	[8]
HBI-8000	DMDWYUN	Non-small-cell lung cancer	2C25.Y	Registered	[3]
ITF2357	DMFZBNE	Duchenne dystrophy	8C70	Phase 3	[9]
Pracinostat	DMTD7AB	Acute myeloid leukaemia	2A60	Phase 3	[10]
NVP-LAQ824	DM8JWNA	Mood disorder	6A60-6E23	Phase 3	[11]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[3]
CMS-024-02	DMC4X7L	Solid tumour/cancer	2A00-2F9Z	Phase 3	[12]
Abexinostat	DM91LGU	Follicular lymphoma	2A80	Phase 3	[13]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[14]

Drug(s) Targeting Histone deacetylase 1 (HDAC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[15]
Romidepsin	DMT5GNL	Cutaneous T-cell lymphoma	2B01	Approved	[16]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[15]
HBI-8000	DMDWYUN	Non-small-cell lung cancer	2C25.Y	Registered	[14]
ITF2357	DMFZBNE	Duchenne dystrophy	8C70	Phase 3	[17]
NVP-LAQ824	DM8JWNA	Mood disorder	6A60-6E23	Phase 3	[18]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[11]
Phenylbutyrate	DMBHPDW	Urea cycle disorder	5C50.A	Phase 2	[19]
MGCD-0103	DM726HX	Non-small-cell lung cancer	2C25.Y	Phase 2	[15]
Resminostat	DMNE1FR	Hepatocellular carcinoma	2C12.02	Phase 2	[20]

Drug(s) Targeting Histone deacetylase 10 (HDAC10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID29671355-Compound-62	DMWRS34	N. A.	N. A.	Patented	[4]
PMID29671355-Compound-43	DMVPMWJ	N. A.	N. A.	Patented	[4]
PMID29671355-Compound-25	DMPV0KZ	N. A.	N. A.	Patented	[4]
PMID29671355-Compound-21	DMPJN0M	N. A.	N. A.	Patented	[4]
PMID29671355-Compound-56	DM0VBMI	N. A.	N. A.	Patented	[4]
PMID29671355-Compound-44	DM80A3V	N. A.	N. A.	Patented	[4]
PMID29671355-Compound-8	DM7YQJK	N. A.	N. A.	Patented	[4]
9,9,9-Trifluoro-8-oxo-nonanoic acid phenylamide	DMVBCID	Discovery agent	N.A.	Investigative	[2]
7-Mercapto-heptanoic acid phenylamide	DM4912P	Discovery agent	N.A.	Investigative	[21]
6-benzenesulfinylhexanoic acid hydroxamide	DM2I95Z	Discovery agent	N.A.	Investigative	[22]

Drug(s) Targeting UDP-glucose 4-epimerase (GALE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nicotinamide-Adenine-Dinucleotide	DM9LRKB	N. A.	N. A.	Investigative	[23]
UDP-glucose	DMLT4JA	Discovery agent	N.A.	Investigative	[23]
Uridine Diphosphate Galactose	DMPA0BJ	Discovery agent	N.A.	Investigative	[24]
Uridine-Diphosphate-N-Acetylgalactosamine	DMXHO6J	N. A.	N. A.	Investigative	[23]
Uridine-Diphosphate-N-Acetylglucosamine	DMEQSTP	Discovery agent	N.A.	Investigative	[25]
Tetramethylammonium Ion	DMLEPYN	Discovery agent	N.A.	Investigative	[23]
Uridine-5'-Diphosphate	DMDQKJB	Discovery agent	N.A.	Investigative	[23]
Phenyl-Uridine-5'-Diphosphate	DM7J0YG	Discovery agent	N.A.	Investigative	[23]
Uridine-5'-Diphosphate-Mannose	DMAYCQU	Discovery agent	N.A.	Investigative	[23]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Histone deacetylase (HDAC)	TTBH0VX	NOUNIPROTAC	Inhibitor	[2]
Histone deacetylase 1 (HDAC1)	TT6R7JZ	HDAC1_HUMAN	Inhibitor	[2]
Histone deacetylase 10 (HDAC10)	TTYHPU6	HDA10_HUMAN	Inhibitor	[2]
Histone deacetylase 2 (HDAC2)	TTSHTOI	HDAC2_HUMAN	Inhibitor	[2]
Histone deacetylase 4 (HDAC4)	TTTQGH8	HDAC4_HUMAN	Inhibitor	[2]
Histone deacetylase 6 (HDAC6)	TT5ZKDI	HDAC6_HUMAN	Inhibitor	[2]
Histone deacetylase 8 (HDAC8)	TTT6LFV	HDAC8_HUMAN	Inhibitor	[2]
UDP-glucose 4-epimerase (GALE)	TTGRHIB	GALE_HUMAN	Inhibitor	[1]

References

• [1] Identification of novel inhibitors of UDP-Glc 4'-epimerase, a validated drug target for african sleeping sickness. Bioorg Med Chem Lett. 2006 Nov 15;16(22):5744-7.
• [2] Histone deacetylase inhibitors. J Med Chem. 2003 Nov 20;46(24):5097-116.
• [3] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [4] HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17.
• [5] Clinical pipeline report, company report or official report of NatureWise Biotech & Medicals.
• [6] A phase I pharmacokinetic and pharmacodynamic study of CHR-3996, an oral class I selective histone deacetylase inhibitor in refractory solid tumors. Clin Cancer Res. 2012 May 1;18(9):2687-94.
• [7] Transcription-independent heritability of induced histone modifications in the mouse preimplantation embryo. PLoS One. 2009 Jun 30;4(6):e6086.
• [8] Histone Deacetylase inhibitors: new promise in the treatment of immune and inflammatory diseases. Curr Drug Targets. 2010 Nov;11(11):1430-8.
• [9] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [10] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8365).
• [11] Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127.
• [12] US patent application no. 2012,0302,505, Cyclodextrin-based polymers for therapeutic delivery.
• [13] Phase 1 study of the oral histone deacetylase inhibitor abexinostat in patients with Hodgkin lymphoma, non-Hodgkin lymphoma, or chronic lymphocytic leukaemia. Invest New Drugs. 2015 Apr;33(2):423-31.
• [14] Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
• [15] Protein methyltransferases as a target class for drug discovery. Nat Rev Drug Discov. 2009 Sep;8(9):724-32.
• [16] Hughes B: 2009 FDA drug approvals. Nat Rev Drug Discov. 2010 Feb;9(2):89-92.
• [17] Emerging drugs for the therapy of primary and post essential thrombocythemia, post polycythemia vera myelofibrosis. Expert Opin Emerg Drugs. 2009 Sep;14(3):471-9.
• [18] NVP-LAQ824 is a potent novel histone deacetylase inhibitor with significant activity against multiple myeloma. Blood. 2003 Oct 1;102(7):2615-22.
• [19] Emerging disease-modifying therapies for the treatment of motor neuron disease/amyotropic lateral sclerosis. Expert Opin Emerg Drugs. 2007 May;12(2):229-52.
• [20] 2011 Pipeline of 4SC AG.
• [21] Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32.
• [22] Aromatic sulfide inhibitors of histone deacetylase based on arylsulfinyl-2,4-hexadienoic acid hydroxyamides. J Med Chem. 2006 Jan 26;49(2):800-5.
• [23] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [24] Crystal structure of beta1,4-galactosyltransferase complex with UDP-Gal reveals an oligosaccharide acceptor binding site. J Mol Biol. 2002 Apr 26;318(2):491-502.
• [25] DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.