Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM7J2TA)

Drug Name
Methazolamide Drug Info
Synonyms Methazolamide (oral, sustained release)
Indication
Disease Entry ICD 11 Status REF
Glaucoma/ocular hypertension 9C61 Approved [1]
Cross-matching ID
PubChem CID
4100
ChEBI ID
CHEBI:6822
CAS Number
CAS 554-57-4
TTD Drug ID
DM7J2TA
VARIDT Drug ID
DR00599
ACDINA Drug ID
D00408

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Carbonic anhydrase I (CA-I)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [5]
Ethoxzolamide DMVO4ED Glaucoma/ocular hypertension 9C61 Approved [6]
Dichlorphenamide DMH7IDQ Chronic glaucoma 9C61.0Z Approved [6]
Acetazolamide DM1AF5U Absence epilepsy Approved [6]
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [7]
PARABEN DMEW5Z8 N. A. N. A. Phase 3 [8]
CG-100649 DMIKMA9 Arthritis FA20 Phase 3 [9]
PHENOL DM1QSM3 N. A. N. A. Phase 2/3 [7]
Coumate DMVKW0N Breast cancer 2C60-2C65 Phase 2 [10]
SULFAMIDE DMMAS3K N. A. N. A. Phase 1 [11]
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Drug(s) Affected By Carbonic anhydrase 2 (CA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetazolamide DM1AF5U Absence epilepsy Approved [12]
Epinephrine DM3KJBC Acute asthma CA23 Approved [13]
Quercetin DM3NC4M Obesity 5B81 Approved [14]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [15]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [16]
Topiramate DM82Z30 Alcohol dependence 6C40.2 Approved [17]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [18]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [19]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [20]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [21]
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Drug(s) Affected By Metalloproteinase inhibitor 1 (TIMP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Pentoxifylline DMU3DNC Alcoholic hepatitis DB94.1 Approved [22]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [23]
Verapamil DMA7PEW Angina pectoris BA40 Approved [4]
Selenium DM25CGV N. A. N. A. Approved [24]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [4]
Quercetin DM3NC4M Obesity 5B81 Approved [25]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [26]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [27]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [28]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [29]
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Drug(s) Affected By Proto-oncogene tyrosine-protein kinase receptor Ret (RET)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [4]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [30]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [4]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [31]
Irbesartan DMTP1DC Diabetic kidney disease GB61.Z Approved [32]
Estrone DM5T6US Acne vulgaris ED80 Approved [30]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [33]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [18]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
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Drug(s) Affected By Clusterin (CLU)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [4]
Selenium DM25CGV N. A. N. A. Approved [36]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [4]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [37]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [38]
Panobinostat DM58WKG Chronic graft versus host disease Approved [39]
Levamisole DM5EN79 Parasitic infection 1D0Y-1G2Z Approved [40]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [41]
Testosterone DM7HUNW Hot flushes GA30 Approved [42]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [37]
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Drug(s) Affected By Neuromodulin (GAP43)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [4]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [4]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [43]
Panobinostat DM58WKG Chronic graft versus host disease Approved [39]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [44]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [18]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [45]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [46]
Megestrol DMDH9KX Breast cancer 2C60-2C65 Approved [4]
Scopolamine DMOM8AL Addictive disorder 6C50-6C5Z Approved [47]
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Drug(s) Affected By Galanin peptides (GAL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [4]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [48]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [4]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [49]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [50]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [51]
Testosterone DM7HUNW Hot flushes GA30 Approved [52]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Carbonic anhydrase I (CA-I) TTHQPL7 CAH1_HUMAN Modulator [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Carbonic anhydrase 2 (CA2) OTJRMUAG CAH2_HUMAN Gene/Protein Processing [3]
Clusterin (CLU) OTQGG0JM CLUS_HUMAN Gene/Protein Processing [4]
Galanin peptides (GAL) OTB3VPTO GALA_HUMAN Gene/Protein Processing [4]
Metalloproteinase inhibitor 1 (TIMP1) OTOXC51H TIMP1_HUMAN Gene/Protein Processing [4]
Neuromodulin (GAP43) OT2OTGGV NEUM_HUMAN Gene/Protein Processing [4]
Proto-oncogene tyrosine-protein kinase receptor Ret (RET) OTLU040A RET_HUMAN Gene/Protein Processing [4]

References

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2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2597).
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23 Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1. FASEB J. 2012 Apr;26(4):1535-48. doi: 10.1096/fj.11-198184. Epub 2011 Dec 23.
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26 Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicol In Vitro. 2017 Mar;39:93-103.
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29 Aspirin inhibits MMP-2 and MMP-9 expressions and activities through upregulation of PPARalpha/gamma and TIMP gene expressions in ox-LDL-stimulated macrophages derived from human monocytes. Pharmacology. 2009;83(1):18-25. doi: 10.1159/000166183. Epub 2008 Oct 30.
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31 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
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35 A Gene Expression Biomarker Identifies Chemical Modulators of Estrogen Receptor in an MCF-7 Microarray Compendium. Chem Res Toxicol. 2021 Feb 15;34(2):313-329. doi: 10.1021/acs.chemrestox.0c00243. Epub 2021 Jan 6.
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