Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM8KN2M)

Drug Name

ONO-2231 Drug Info

Synonyms

ONO-1924H; PARP inhibitor (intravenous, stroke), ONO; Poly ADP ribose polymerase inhibitors (intravenous formulation, stroke), ONO

Indication

Disease Entry	ICD 11	Status	REF
Cerebrovascular ischaemia	8B1Z	Discontinued in Phase 1	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Poly [ADP-ribose] polymerase (PARP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Olaparib	DM8QB1D	Ovarian cancer	2C73	Approved	[3]
Rucaparib	DM9PVX8	Ovarian cancer	2C73	Approved	[4]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[5]
MK-4827	DMLYGH4	Ovarian cancer	2C73	Phase 3	[6]
BSI-201	DMM0VO3	Solid tumour/cancer	2A00-2F9Z	Phase 3	[7]
Rubraca rucaparib	DM25TMP	Ovarian cancer	2C73	Phase 3	[8]
ABT-888	DM4HYMS	Breast cancer	2C60-2C65	Phase 3	[6]
INO-1001	DM5L8QT	Brain cancer	2A00	Phase 3	[9]
BGP-15	DMYDM68	Type-2 diabetes	5A11	Phase 2	[10]
BGB-290	DMRO6XT	Ovarian cancer	2C73	Phase 2	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Poly [ADP-ribose] polymerase (PARP)	TTEBCY8	NOUNIPROTAC	Modulator	[2]

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800022742)
2	Company report (ONO PHARMACEUTICAL)
3	2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81.
4	2016 FDA drug approvals. Nat Rev Drug Discov. 2017 Feb 2;16(2):73-76.
5	2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89.
6	Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
7	Failure of iniparib to inhibit poly(ADP-Ribose) polymerase in vitro. Clin Cancer Res. 2012 Mar 15;18(6):1655-62.
8	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
9	Therapeutic injection of PARP inhibitor INO-1001 preserves cardiac function in porcine myocardial ischemia and reperfusion without reducing infarct size. Shock. 2010 May;33(5):507-12.
10	BGP-15, a PARP-inhibitor, prevents imatinib-induced cardiotoxicity by activating Akt and suppressing JNK and p38 MAP kinases. Mol Cell Biochem. 2012 Jun;365(1-2):129-37.