Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM9J6C2)

Drug Name
Tetracaine Drug Info
Synonyms
Amethocaine; Anetain; Contralgin; Dicain; Dicaine; Dikain; Fissucain; Intercain; Laudocaine; Medicaine; Meethobalm; Metraspray; Mucaesthin; Niphanoid; Pontocaine; Rexocaine; Tetracaina; Tetracainum; Tetrakain; Uromucaesthin; Tetrakain [Czech]; Amethocaine (TN); Diaethylaminoaethanol ester der p-butylaminobenzoesaeure;Diaethylaminoaethanol ester der p-butylaminobenzoesaeure [German]; Medihaler-Tetracaine; Pontocaine (TN); Tetracaina [INN-Spanish]; Tetracaine [USAN:INN]; Tetracainum [INN-Latin]; Dimethylaminoethyl p-butyl-aminobenzoate; Tetracaine (USP/INN); P-Butylaminobenzoyl-2-dimethylaminoethanol; BENZOIC ACID,4-BUTYLAMINO,2-DIMETHYLAMINOETHYL ESTER PANTOCAIN BASE; P-(Butylamino)benzoic acid, 2-(dimethylamino)ethyl ester; BENZOIC ACID, p-(BUTYLAMINO)-, 2-(DIMETHYLAMINO)ETHYL ESTER; Benzoic acid, 4-(butylamino)-, 2-(dimethylamino)ethyl ester; 2-(Dimethylamino)ethyl 4-(butylamino)benzoate; 2-(Dimethylamino)ethyl p-(butylamino)benzoate; 2-Dimethylaminoethylester kyseliny p-butylaminobenzoove; 2-Dimethylaminoethylester kyseliny p-butylaminobenzoove [Czech]; 2-dimethylaminoethyl 4-(butylamino)benzoate; 4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester; 4-[Butylamino]benzoic acid-2-[dimethylamino]ethyl ester
Indication
Disease Entry ICD 11 Status REF
Spinal anesthesia MB40.3 Approved [1]
Pain MG30-MG3Z Phase 2 [2]
Pruritus EC90 Investigative [3]
Therapeutic Class
Anesthetics
Cross-matching ID
PubChem CID
5411
ChEBI ID
CHEBI:9468
CAS Number
CAS 94-24-6
TTD Drug ID
DM9J6C2
VARIDT Drug ID
DR00562
ACDINA Drug ID
D01479

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Voltage-gated sodium channel alpha Nav1.8 (SCN10A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rilpivirine DMJ0QOW Human immunodeficiency virus infection 1C62 Approved [8]
Ropivacaine DMSPJG2 Anaesthesia 9A78.6 Approved [9]
Bupivacaine DM4PRFC Anaesthesia 9A78.6 Approved [9]
Tiapride DMN6CAG Alcohol dependence 6C40.2 Approved [10]
Proparacaine DMLS39E Anaesthesia 9A78.6 Approved [9]
Conatumumab DM2UOSN Colorectal cancer 2B91.Z Phase 2 [11]
VX-150 DMGDB21 Neuropathic pain 8E43.0 Phase 2 [12]
DSP-2230 DM0WTMD Neuropathic pain 8E43.0 Phase 1 [13]
PF-01247324 DM93LMS Pain MG30-MG3Z Phase 1 [14]
VX-128 DMC8J0G Pain MG30-MG3Z Phase 1 [12]
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Drug(s) Affected By Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRNPC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [15]
Methotrexate DM2TEOL Anterior urethra cancer Approved [16]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [17]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [18]
Testosterone enanthate DMB6871 N. A. N. A. Approved [19]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [20]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [21]
Folic Acid DMEMBJC Colorectal carcinoma Approved [22]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [23]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [24]
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Drug(s) Affected By 72 kDa type IV collagenase (MMP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [25]
Selenium DM25CGV N. A. N. A. Approved [26]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [27]
Quercetin DM3NC4M Obesity 5B81 Approved [28]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [29]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [30]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [31]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [32]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [33]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [34]
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Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [35]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [36]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [37]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [38]
Testosterone DM7HUNW Hot flushes GA30 Approved [39]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [39]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [20]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [21]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [40]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [41]
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Drug(s) Affected By Cyclin-dependent kinase 4 (CDK4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [42]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [43]
Selenium DM25CGV N. A. N. A. Approved [44]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [45]
Methotrexate DM2TEOL Anterior urethra cancer Approved [46]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [47]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [48]
Quercetin DM3NC4M Obesity 5B81 Approved [49]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [36]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [50]
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Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [51]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [52]
Gefitinib DM15F0X Colon adenocarcinoma Approved [53]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [54]
Selenium DM25CGV N. A. N. A. Approved [26]
Pentosan Polysulfate DM2HRKE Interstitial cystitis GC00.3 Approved [55]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [56]
Methotrexate DM2TEOL Anterior urethra cancer Approved [57]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [58]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [59]
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Drug(s) Affected By Metalloproteinase inhibitor 2 (TIMP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [60]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [61]
Selenium DM25CGV N. A. N. A. Approved [26]
Quercetin DM3NC4M Obesity 5B81 Approved [62]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [63]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [32]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [64]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [65]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [66]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [67]
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Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [68]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [69]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [70]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [71]
Gefitinib DM15F0X Colon adenocarcinoma Approved [72]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [73]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [74]
Selenium DM25CGV N. A. N. A. Approved [75]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [76]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [77]
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Drug(s) Affected By G1/S-specific cyclin-E1 (CCNE1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [78]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [79]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [80]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [81]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [82]
Quercetin DM3NC4M Obesity 5B81 Approved [83]
Fluoxetine DM3PD2C Bipolar depression Approved [84]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [85]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [86]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [87]
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Drug(s) Affected By Cyclin-dependent kinase 2 (CDK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [88]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [89]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [79]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [90]
Selenium DM25CGV N. A. N. A. Approved [44]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [81]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [91]
Methotrexate DM2TEOL Anterior urethra cancer Approved [57]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [47]
Quercetin DM3NC4M Obesity 5B81 Approved [49]
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Drug(s) Affected By Cyclin-dependent kinase 6 (CDK6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [43]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [92]
Gefitinib DM15F0X Colon adenocarcinoma Approved [93]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [82]
Methotrexate DM2TEOL Anterior urethra cancer Approved [16]
Quercetin DM3NC4M Obesity 5B81 Approved [94]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [95]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [36]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [17]
Panobinostat DM58WKG Chronic graft versus host disease Approved [96]
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Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein A0 (HNRNPA0)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [97]
Quercetin DM3NC4M Obesity 5B81 Approved [62]
Leflunomide DMR8ONJ Arthritis FA20 Approved [98]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [18]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [20]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [21]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [99]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [100]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [101]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [102]
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Drug(s) Affected By Histamine H1 receptor (HRH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Desloratadine DM56YN7 Allergic rhinitis CA08.0 Approved [103]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [103]
Gabapentin DM6T924 Complex partial seizure 8A68.0 Approved [104]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [105]
Methotrexate DM2TEOL Anterior urethra cancer Approved [106]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [107]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [108]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [109]
Clozapine DMFC71L Schizophrenia 6A20 Approved [110]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [111]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Voltage-gated sodium channel alpha Nav1.8 (SCN10A) TT90XZ8 SCNAA_HUMAN Inhibitor [4]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
72 kDa type IV collagenase (MMP2) OT5NIWA2 MMP2_HUMAN Gene/Protein Processing [5]
Cyclin-dependent kinase 2 (CDK2) OTB5DYYZ CDK2_HUMAN Post-Translational Modifications [6]
Cyclin-dependent kinase 4 (CDK4) OT7EP05T CDK4_HUMAN Post-Translational Modifications [6]
Cyclin-dependent kinase 6 (CDK6) OTR95N0X CDK6_HUMAN Post-Translational Modifications [6]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Gene/Protein Processing [6]
G1/S-specific cyclin-E1 (CCNE1) OTLD7UID CCNE1_HUMAN Gene/Protein Processing [6]
Heterogeneous nuclear ribonucleoprotein A0 (HNRNPA0) OTCP792K ROA0_HUMAN Gene/Protein Processing [6]
Heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1) OTIRPN6B ROA1_HUMAN Gene/Protein Processing [6]
Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRNPC) OT47AK4C HNRPC_HUMAN Gene/Protein Processing [6]
Histamine H1 receptor (HRH1) OT8F9FV6 HRH1_HUMAN Drug Response [7]

References

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56 Investigation of molecular mechanisms underlying the antiproliferative effects of colchicine against PC3 prostate cancer cells. Toxicol In Vitro. 2021 Jun;73:105138. doi: 10.1016/j.tiv.2021.105138. Epub 2021 Mar 6.
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