Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM9NJ52)

Drug Name
Fosinopril Drug Info
Synonyms
Acecor; Fosenopril; Monopril; Staril; FOSINOPRIL SODIUM; Fosinopril (INN); Fosinopril [INN:BAN]; Monopril (TN); SQ-28555; SQ-28,555; Fosinopril, (1(S*(R*)),2 alpha,4 beta)-Isomer; (2S,4S)-4-cyclohexyl-1-[2-[(2-methyl-1-propanoyloxypropoxy)-(4-phenylbutyl)phosphoryl]acetyl]pyrrolidine-2-carboxylic acid; (2S,4S)-4-cyclohexyl-1-[2-[[(1S)-2-methyl-1-propanoyloxypropoxy]-(4-phenylbutyl)phosphoryl]acetyl]pyrrolidine-2-carboxylic acid; (2S,4S)-4-cyclohexyl-1-{2-[(2-methyl-1-propionyloxy-propoxy)-(4-phenyl-butyl)-phosphinoyl]-acetyl}-pyrrolidine-2-carboxylic acid; (4S)-4-cyclohexyl-1-({[2-methyl-1-(propanoyloxy)propoxy](4-phenylbutyl)phosphoryl}acetyl)-L-proline; (4S)-4-cyclohexyl-1-{[{[2-methyl-1-(propanoyloxy)propyl]oxy}(4-phenylbutyl)phosphoryl]acetyl}-L-proline; 4-cyclohexyl-1-[2-[(2-methyl-1-propanoyloxypropoxy)-(4-phenylbutyl)phosphoryl]acetyl]pyrrolidine-2-carboxylic acid
Indication
Disease Entry ICD 11 Status REF
Chronic heart failure BD1Z Approved [1]
Hypertension BA00-BA04 Approved [2]
Malignant essential hypertension BA00 Approved [1]
Therapeutic Class
Antihypertensive Agents
Cross-matching ID
PubChem CID
55891
ChEBI ID
CHEBI:5163
CAS Number
CAS 98048-97-6
TTD Drug ID
DM9NJ52
VARIDT Drug ID
DR00701
ACDINA Drug ID
D00293

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Angiotensin-converting enzyme (ACE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Enalapril DMNFUZR Congestive heart failure BD10 Approved [8]
Spirapril DM5XLTY Hypertension BA00-BA04 Approved [9]
Captopril DM458UM Chronic heart failure BD1Z Approved [10]
Benazepril DMH1M9B Hypertension BA00-BA04 Approved [11]
Moexipril DM26E4B Hypertension BA00-BA04 Approved [12]
Ramipril DM2R68E Acute heart failure BD10-BD13 Approved [13]
Perindopril DMOPZDT Hypertension BA00-BA04 Approved [14]
Trandolapril DM4L6EU Chronic heart failure BD1Z Approved [15]
Lisinopril DMUOK4C Chronic heart failure BD1Z Approved [16]
Enalaprilat DMFYAM1 Congestive heart failure BD10 Approved [17]
Trandolapril DM4L6EU Chronic heart failure BD1Z Approved [6]
Quinapril DMR8H31 Chronic heart failure BD1Z Approved [6]
Cilazapril DM4V6JA Congestive heart failure BD10 Approved [31]
Perindopril DMOPZDT Hypertension BA00-BA04 Approved [32]
Lisinopril DMUOK4C Chronic heart failure BD1Z Approved [33]
Testosterone DM7HUNW Hot flushes GA30 Approved [34]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [35]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [36]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [37]
Cenestin DMXQS7K Menopause symptom GA30.0 Approved [38]
⏷ Show the Full List of 20 Drug(s)
Drug(s) Transported By Peptide transporter 1 (SLC15A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [18]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [19]
Ampicillin DMHWE7P Acute epiglottitis Approved [20]
Losartan DM72JXH Diabetic kidney disease GB61.Z Approved [21]
Enalapril DMNFUZR Congestive heart failure BD10 Approved [22]
Cefazolin DMPDYFR Bacteremia 1A73 Approved [23]
Ceftriaxone DMCEW64 Acute gonococcal cervicitis Approved [24]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [19]
Cefadroxil DMMC345 Bacterial infection 1A00-1C4Z Approved [21]
Irbesartan DMTP1DC Diabetic kidney disease GB61.Z Approved [21]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Transported By Peptide transporter 2 (SLC15A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [18]
Ampicillin DMHWE7P Acute epiglottitis Approved [25]
Enalapril DMNFUZR Congestive heart failure BD10 Approved [26]
Entecavir DM7VTQO Hepatitis B virus infection 1E51.0 Approved [27]
Cefadroxil DMMC345 Bacterial infection 1A00-1C4Z Approved [28]
Cephalexin DMD5JU8 Acute otitis media AB00 Approved [25]
Valaciclovir DMHKS94 Genital herpes 1A94 Approved [29]
Cefaclor DMJXDGC Bacterial infection 1A00-1C4Z Approved [18]
Aminolevulinic acid hci DMS4BLQ Acne vulgaris ED80 Approved [30]
Spirapril DM5XLTY Hypertension BA00-BA04 Approved [5]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Multidrug resistance-associated protein 1 (ABCC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [39]
Folic Acid DMEMBJC Colorectal carcinoma Approved [40]
Methotrexate DM2TEOL Anterior urethra cancer Approved [41]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [43]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [44]
Epirubicin DMPDW6T Solid tumour/cancer 2A00-2F9Z Approved [45]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [46]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [47]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [47]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ATP-binding cassette sub-family C member 2 (ABCC2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lopinavir DMITQS0 Human immunodeficiency virus infection 1C62 Approved [48]
Sulfinpyrazone DMEV954 Gout FA25 Approved [49]
Probenecid DMMFWOJ Acute gonococcal cervicitis Approved [50]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [51]
Methotrexate DM2TEOL Anterior urethra cancer Approved [41]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [52]
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [53]
Epirubicin DMPDW6T Solid tumour/cancer 2A00-2F9Z Approved [45]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [54]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [55]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By B2 bradykinin receptor (BDKRB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [6]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [56]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [57]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [35]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [58]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [59]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [60]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [61]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [62]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [63]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Angiotensin-converting enzyme (ACE) TTL69WB ACE_HUMAN Inhibitor [3]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Peptide transporter 2 (SLC15A2) DT8QKNP S15A2_HUMAN Substrate [4]
Peptide transporter 1 (SLC15A1) DT9G7XN S15A1_HUMAN Substrate [5]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Angiotensin-converting enzyme (ACE) OTDF1964 ACE_HUMAN Drug Response [6]
ATP-binding cassette sub-family C member 2 (ABCC2) OTJSIGV5 MRP2_HUMAN Drug Response [7]
B2 bradykinin receptor (BDKRB2) OTOA9D3W BKRB2_HUMAN Drug Response [6]
Multidrug resistance-associated protein 1 (ABCC1) OTGUN89S MRP1_HUMAN Drug Response [7]

References

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6 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
7 Mrp2 is involved in the efflux and disposition of fosinopril. J Appl Toxicol. 2013 Jun;33(6):458-65. doi: 10.1002/jat.1767. Epub 2011 Nov 17.
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18 Interactions of amoxicillin and cefaclor with human renal organic anion and peptide transporters. Drug Metab Dispos. 2006 Apr;34(4):547-55.
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24 Intestinal transport of beta-lactam antibiotics: analysis of the affinity at the H+/peptide symporter (PEPT1), the uptake into Caco-2 cell monolayers and the transepithelial flux. Pharm Res. 1999 Jan;16(1):55-61.
25 Transport characteristics of a novel peptide transporter 1 substrate, antihypotensive drug midodrine, and its amino acid derivatives. J Pharmacol Exp Ther. 2006 Jul;318(1):455-60.
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27 The oligopeptide transporter 2-mediated reabsorption of entecavir in rat kidney. Eur J Pharm Sci. 2014 Feb 14;52:41-7.
28 Species Differences in Human and Rodent PEPT2-Mediated Transport of Glycylsarcosine and Cefadroxil in Pichia Pastoris Transformants. Drug Metab Dispos. 2017 Feb;45(2):130-136.
29 Valacyclovir: a substrate for the intestinal and renal peptide transporters PEPT1 and PEPT2. Biochem Biophys Res Commun. 1998 May 19;246(2):470-5.
30 PEPT2-mediated transport of 5-aminolevulinic acid and carnosine in astrocytes. Brain Res. 2006 Nov 29;1122(1):18-23.
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33 Targeted catalytic inactivation of angiotensin converting enzyme by lisinopril-coupled transition-metal chelates. J Am Chem Soc. 2012 Feb 22;134(7):3396-410. doi: 10.1021/ja208791f. Epub 2012 Feb 10.
34 The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
35 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
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37 Nicotine induced changes in gene expression by human coronary artery endothelial cells. Atherosclerosis. 2001 Feb 1;154(2):277-83.
38 Relationship between the angiotensin-converting enzyme genotype and the forearm vasodilator response to estrogen replacement therapy in postmenopausal women. J Am Coll Cardiol. 2001 May;37(6):1529-35. doi: 10.1016/s0735-1097(01)01191-3.
39 Characterization of multidrug transporter-mediated efflux of avermectins in human and mouse neuroblastoma cell lines. Toxicol Lett. 2015 Jun 15;235(3):189-98. doi: 10.1016/j.toxlet.2015.04.005. Epub 2015 Apr 9.
40 Folate concentration dependent transport activity of the Multidrug Resistance Protein 1 (ABCC1). Biochem Pharmacol. 2004 Apr 15;67(8):1541-8.
41 Methotrexate normalizes up-regulated folate pathway genes in rheumatoid arthritis. Arthritis Rheum. 2013 Nov;65(11):2791-802.
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52 In vitro study of transporters involved in intestinal absorption of inorganic arsenic. Chem Res Toxicol. 2012 Feb 20;25(2):446-53. doi: 10.1021/tx200491f. Epub 2012 Jan 26.
53 Potency of individual bile acids to regulate bile acid synthesis and transport genes in primary human hepatocyte cultures. Toxicol Sci. 2014 Oct;141(2):538-46. doi: 10.1093/toxsci/kfu151. Epub 2014 Jul 23.
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55 Gene expression analysis of precision-cut human liver slices indicates stable expression of ADME-Tox related genes. Toxicol Appl Pharmacol. 2011 May 15;253(1):57-69.
56 Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
57 THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders. Transl Psychiatry. 2018 Apr 25;8(1):89. doi: 10.1038/s41398-018-0137-3.
58 Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
59 Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
60 Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
61 Long-term estrogen exposure promotes carcinogen bioactivation, induces persistent changes in gene expression, and enhances the tumorigenicity of MCF-7 human breast cancer cells. Toxicol Appl Pharmacol. 2009 Nov 1;240(3):355-66.
62 Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
63 Reproducible chemical-induced changes in gene expression profiles in human hepatoma HepaRG cells under various experimental conditions. Toxicol In Vitro. 2009 Apr;23(3):466-75. doi: 10.1016/j.tiv.2008.12.018. Epub 2008 Dec 30.