Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM9NSWT)

• Drug Name: Guanethidine Drug Info
• Synonyms: Abapresin; Dopam; Dopom; Eutensol; Guanethidinum; Guanetidina; Ismelin; Isobarin; Octadin; Octadine; Octatensin; Octatensine; Oktadin; Oktatensin; Oktatenzin; Sanotensin; Guanethidine Sulphae; Guanethidine sulfate; Ismelin sulfate; Apo-Guanethidine; Guanethidine (INN); Guanethidine [INN:BAN]; Guanethidinum [INN-Latin]; Guanetidina [INN-Spanish]; Apo-Guanethidine (TN); Beta-1-Azacyclooctylethylguanidine; Guanethidine Sulfate (1:1); Guanethidine Sulfate (2:1); Su 5864 sulfate (1:1); N-(2-Perhydroazocin-1-ylethyl)guanidine; ((2-Hexahydro-1(2H)-azocinyl)ethyl)guanidine; (2-(Octahydro-1-azocinyl)ethyl)guanidine; 1-(2-azocan-1-ylethyl)guanidine; 1-[2-(azocan-1-yl)ethyl]guanidine; 2-(1'-Azacyclooctyl)ethylguanidine; 2-(1-N,N-Heptamethyleneimino)ethylguanidine; 2-[2-(azocan-1-yl)ethyl]guanidine

Indication

Disease Entry	ICD 11	Status	REF
Moderate and severe hypertension	BA00.Z	Approved	[1]

• Therapeutic Class: Antihypertensive Agents
• Cross-matching ID:
  PubChem CID: 3518
  ChEBI ID: CHEBI:5557
  CAS Number: CAS 55-65-2
  TTD Drug ID: DM9NSWT

Molecule-Related Drug Atlas

Drug(s) Targeting Adrenergic neuron (AD neuro)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Debrisoquin	DMC50ME	Hypertension	BA00-BA04	Approved	[5]

Drug(s) Affected By Pro-neuropeptide Y (NPY)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[6]
Reserpine	DM6VM38	Hypertension	BA00-BA04	Approved	[6]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[7]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[8]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[9]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[10]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[11]
Orlistat	DMRJSP8	Obesity	5B81	Approved	[12]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[13]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[8]

Drug(s) Affected By Phosphatidylcholine translocator ABCB4 (ABCB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[14]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[15]
Methysergide	DM1EF73	Migraine	8A80	Approved	[3]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[16]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[17]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[3]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[19]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[20]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[21]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adrenergic neuron (AD neuro)	TTT04VN	NOUNIPROTAC	Blocker	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Phosphatidylcholine translocator ABCB4 (ABCB4)	OTE6PY83	MDR3_HUMAN	Gene/Protein Processing	[3]
Pro-neuropeptide Y (NPY)	OT4ICV3P	NPY_HUMAN	Protein Interaction/Cellular Processes	[4]

References

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• [12] [Effect of orlistat therapy on carbohydrate, lipid, vitamin and hormone plasma levels in obese subjects]. Pol Arch Med Wewn. 2004 Dec;112(6):1415-23.
• [13] Coordinate up-regulation of TMEM97 and cholesterol biosynthesis genes in normal ovarian surface epithelial cells treated with progesterone: implications for pathogenesis of ovarian cancer. BMC Cancer. 2007 Dec 11;7:223.
• [14] [Reversal effect of MDR1 and MDR3 gene silencing on resistance of A2780/taxol cells to paclitaxel]. Zhonghua Fu Chan Ke Za Zhi. 2007 Jun;42(6):412-6.
• [15] 8-Methoxypsoralen disrupts MDR3-mediated phospholipids efflux and bile acid homeostasis and its relevance to hepatotoxicity. Toxicology. 2017 Jul 1;386:40-48. doi: 10.1016/j.tox.2017.05.011. Epub 2017 May 24.
• [16] Molecular mechanisms of hepatotoxic cholestasis by clavulanic acid: Role of NRF2 and FXR pathways. Food Chem Toxicol. 2021 Dec;158:112664. doi: 10.1016/j.fct.2021.112664. Epub 2021 Nov 9.
• [17] Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
• [18] Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
• [19] Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicol In Vitro. 2017 Mar;39:93-103.
• [20] Species-specific toxicity of diclofenac and troglitazone in primary human and rat hepatocytes. Chem Biol Interact. 2009 Apr 15;179(1):17-24.
• [21] Evaluation of gene induction of drug-metabolizing enzymes and transporters in primary culture of human hepatocytes using high-sensitivity real-time reverse transcription PCR. Yakugaku Zasshi. 2002 May;122(5):339-61.