Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMB19L8)

Drug Name
Trihexyphenidyl Drug Info
Synonyms
trihexyphenidyl; Benzhexol; Triphenidyl; Trihexyphenidyle; Parkinane retard; Benzhexolum; 144-11-6; Trihexyphenidylum; Sedrena (free base); Trihexifenidilo; Trihexyphenidyle [INN-French]; Trihexifenidilo [INN-Spanish]; Trihexyphenidylum [INN-Latin]; Artane; Trihexylphenizyl; Trihexylphenidyl; Trihexylphenidyle; Trihexyphenidyl [INN:BAN]; Trihexylphenedyl; HSDB 3196; EINECS 205-614-4; NSC 12268; 1-Piperidinepropanol, alpha-cyclohexyl-alpha-phenyl-; 1-cyclohexyl-1-phenyl-3-piperidin-1-ylpropan-1-ol; BRN 0088959; Benzhexol; Trihexane; Trihexy; Artane Sequels; PMS Trihexyphenidyl; Apo-Trihex; Artane (TN); Trihexyphenidyl (INN); Apo-Trihex (TN); Apo-trihex (TN); SWR-0342SA
Indication
Disease Entry ICD 11 Status REF
Dystonia 8A02 Approved [1]
Parkinson disease 8A00.0 Approved [1]
Parkinsonian disorder Approved [2]
Postencephalitic Parkinson disease Approved [2]
Obesity 5B81 Investigative [3]
Therapeutic Class
Antiparkinson Agents
Cross-matching ID
PubChem CID
5572
ChEBI ID
CHEBI:9720
CAS Number
CAS 144-11-6
TTD Drug ID
DMB19L8
VARIDT Drug ID
DR00982
INTEDE Drug ID
DR2309
ACDINA Drug ID
D00704

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Muscarinic acetylcholine receptor M1 (CHRM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
ACECLIDINE DMOLNCZ Glaucoma/ocular hypertension 9C61 Approved [7]
Fesoterodine fumarate DM13495 Overactive bladder GC50.0 Approved [8]
SMT-D002 DM1I93C Seborrhea ED91.2 Approved [9]
Clidinium DMUMQZ0 Abdominal stomach pain DD91.4 Approved [10]
Oxyphenonium DMMQHOZ Visceral spasms MD81.4 Approved [11]
Benztropine DMGZOVN Parkinson disease 8A00.0 Approved [12]
Glycopyrrolate DM2M3ZA Anaesthesia 9A78.6 Approved [13]
Pirenzepine DMP6M1N Peptic ulcer DA61 Approved [14]
Cycrimine DM8C43Q Parkinson disease 8A00.0 Approved [15]
Dicyclomine DMZSDGX Functional bowel syndrome DD91.0 Approved [16]
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Drug(s) Targeting Adrenergic receptor beta-3 (ADRB3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mirabegron DMS1GYT Overactive bladder GC50.0 Approved [17]
Amosulalol DML8QSZ Hypertension BA00-BA04 Approved [18]
Bopindolol DMIFYLX Hypertension BA00-BA04 Approved [19]
Mepindolol DMUDWP9 Angina pectoris BA40 Approved [20]
Rimiterol DMA47C6 Asthma CA23 Approved [21]
Bitolterol DMK6XAV Chronic obstructive pulmonary disease CA22 Approved [22]
Nipradilol DMA65ER Angina pectoris BA40 Approved [23]
Vibegron DMFR201 Overactive bladder GC50.0 Approved [24]
ONO-2506 DMCA2PJ Stroke 8B20 Phase 2/3 [25]
CL-316,243 DMXH1KC Obesity 5B81 Phase 2 [26]
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Drug(s) Affected By Proepiregulin (EREG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [27]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [5]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [28]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [5]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [5]
Methotrexate DM2TEOL Anterior urethra cancer Approved [29]
Quercetin DM3NC4M Obesity 5B81 Approved [30]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [31]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Penbutolol DM4ES8F Hypertension BA00-BA04 Approved [5]
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Drug(s) Affected By Interleukin-1 alpha (IL1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [33]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [5]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [5]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [34]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [5]
Methotrexate DM2TEOL Anterior urethra cancer Approved [35]
Quercetin DM3NC4M Obesity 5B81 Approved [36]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [5]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [37]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [38]
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Drug(s) Affected By Interleukin-1 beta (IL1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [39]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [40]
Gefitinib DM15F0X Colon adenocarcinoma Approved [41]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [5]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [42]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [5]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [43]
Selenium DM25CGV N. A. N. A. Approved [44]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [45]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [46]
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Drug(s) Affected By Antileukoproteinase (SLPI)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [5]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [5]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [28]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [5]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [5]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [5]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [5]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [38]
Penbutolol DM4ES8F Hypertension BA00-BA04 Approved [5]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [5]
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Drug(s) Affected By Hepatocyte growth factor receptor (MET)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cabozantinib DMIYDT4 Medullary thyroid gland carcinoma Approved [47]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [48]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [5]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [5]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [5]
Methotrexate DM2TEOL Anterior urethra cancer Approved [49]
Quercetin DM3NC4M Obesity 5B81 Approved [30]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [5]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [50]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [49]
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Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [51]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [52]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [53]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [54]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [55]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [40]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [5]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [42]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [56]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [5]
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Drug(s) Affected By Bone morphogenetic protein 6 (BMP6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [5]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [5]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [57]
Penbutolol DM4ES8F Hypertension BA00-BA04 Approved [5]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [5]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [5]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [5]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [58]
Etodolac DM6WJO9 Osteoarthritis FA00-FA05 Approved [5]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [59]
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Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [60]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [61]
Gamolenic acid DMQN30Z Allergy 4A80-4A85 Approved [62]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [63]
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [64]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [65]
Ibandronate DM0QZBN Hypercalcaemia 5B91.0 Approved [66]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [67]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [5]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [68]
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Drug(s) Affected By Tumor necrosis factor-inducible gene 6 protein (TNFAIP6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [69]
Selenium DM25CGV N. A. N. A. Approved [44]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [5]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [31]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [71]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [5]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [5]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [5]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [72]
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Drug(s) Affected By Interleukin-24 (IL24)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [33]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [5]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [40]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [5]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [5]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [73]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [31]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [74]
Penbutolol DM4ES8F Hypertension BA00-BA04 Approved [5]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [74]
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Drug(s) Affected By PTB-containing, cubilin and LRP1-interacting protein (PID1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [5]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [5]
Penbutolol DM4ES8F Hypertension BA00-BA04 Approved [5]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [5]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [5]
Amikacin DM5PDRB Bacteremia 1A73 Approved [5]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [5]
Promethazine DM6I5GR Hyperemesis gravidarum Approved [5]
Etodolac DM6WJO9 Osteoarthritis FA00-FA05 Approved [5]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [75]
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Drug(s) Affected By Cystine/glutamate transporter (SLC7A11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [76]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [5]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [77]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [5]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [5]
Methotrexate DM2TEOL Anterior urethra cancer Approved [49]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [78]
Quercetin DM3NC4M Obesity 5B81 Approved [30]
Fluoxetine DM3PD2C Bipolar depression Approved [79]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [5]
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Drug(s) Affected By Apolipoprotein E (APOE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [80]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [81]
Selenium DM25CGV N. A. N. A. Approved [82]
Quercetin DM3NC4M Obesity 5B81 Approved [30]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [83]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [31]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [84]
LY2835219 DM93VBZ Breast cancer 2C60-2C65 Approved [85]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [75]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Adrenergic receptor beta-3 (ADRB3) TTMXGCW ADRB3_HUMAN Agonist [3]
Muscarinic acetylcholine receptor M1 (CHRM1) TTZ9SOR ACM1_HUMAN Antagonist [4]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Antileukoproteinase (SLPI) OTUNFUU8 SLPI_HUMAN Gene/Protein Processing [5]
Apolipoprotein E (APOE) OTFOWL2H APOE_HUMAN Drug Response [6]
Bone morphogenetic protein 6 (BMP6) OT9WN536 BMP6_HUMAN Gene/Protein Processing [5]
Cystine/glutamate transporter (SLC7A11) OTKJ6PXW XCT_HUMAN Gene/Protein Processing [5]
Hepatocyte growth factor receptor (MET) OT7K55MU MET_HUMAN Gene/Protein Processing [5]
Interleukin-1 alpha (IL1A) OTPSGILV IL1A_HUMAN Gene/Protein Processing [5]
Interleukin-1 beta (IL1B) OT0DWXXB IL1B_HUMAN Gene/Protein Processing [5]
Interleukin-24 (IL24) OT4VUWH1 IL24_HUMAN Gene/Protein Processing [5]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Gene/Protein Processing [5]
Proepiregulin (EREG) OTRM4NQY EREG_HUMAN Gene/Protein Processing [5]

References

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