Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMBKVJY)

• Drug Name: PMEA Drug Info
• Synonyms: ADEFOVIR; 106941-25-7; PMEA; ((2-(6-Amino-9H-purin-9-yl)ethoxy)methyl)phosphonic acid; 9-(2-Phosphonylmethoxyethyl)adenine; GS-0393; GS 0393; GS 393; 9-(2-(Phosphonomethoxy)ethyl)adenine; N-(2-Phosphonylmethoxyethyl)adenine; DRG-0156; UNII-6GQP90I798; C8H12N5O4P; HSDB 8079; CHEMBL484; 2-(6-aminopurin-9-yl)ethoxymethylphosphonic acid; BRN 3561094; {[2-(6-Amino-9h-Purin-9-Yl)ethoxy]methyl}phosphonic Acid; N-(2-Phophonomethoxyethyl-2,6-diaminopurine); Phosphonic acid, [[2-(6-amino-9H-purin-9-yl)ethoxy]methyl]-; 6GQP90I798

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 60172
  ChEBI ID: CHEMBL484
  CAS Number: CAS 106941-25-7
  TTD Drug ID: DMBKVJY

Molecule-Related Drug Atlas

Drug(s) Targeting Herpes simplex virus DNA polymerase UL30 (HSV UL30)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[6]
Aciclovir	DMYLOVR	Genital herpes	1A94	Approved	[7]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[8]
Valaciclovir	DMHKS94	Genital herpes	1A94	Approved	[9]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[7]
Valganciclovir	DMS2IUH	Virus infection	1A24-1D9Z	Approved	[10]
Penciclovir	DMOUMDV	Herpes simplex labialis	1F00.01	Approved	[11]
Famciclovir	DMJHLSD	Meniere disease	AB31.0	Approved	[12]
Valacyclovir Hydrochloride	DM5I1CE	Herpes simplex virus infection	1F00	Approved	[7]
Foscavir	DM9KJLZ	Cytomegalovirus retinitis	9B72.00	Approved	[10]

Drug(s) Affected By Methylmalonyl-CoA mutase, mitochondrial (MMUT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[13]
Selenium	DM25CGV	N. A.	N. A.	Approved	[14]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[3]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[15]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[16]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[19]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[20]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[3]

Drug(s) Affected By Organic anion transporter 3 (SLC22A8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valsartan	DMREUQ6	Chronic heart failure	BD1Z	Approved	[21]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[22]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[4]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[23]
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[24]
Cimetidine	DMH61ZB	Acid-reflux disorder	DA22	Approved	[24]
Cefdinir	DMJ7A0H	Bacterial infection	1A00-1C4Z	Approved	[25]
Cefaclor	DMJXDGC	Bacterial infection	1A00-1C4Z	Approved	[25]
Famotidine	DMRL3AB	Gastric ulcer	DA60	Approved	[26]
Tetracycline	DMZA017	Acne vulgaris	ED80	Approved	[27]

Drug(s) Affected By Solute carrier family 22 member 6 (SLC22A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[22]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[28]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[28]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[28]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[28]
Succinic acid	DMDWICP	Malnutrition	5B50-5B71	Approved	[30]
Mefenamic acid	DMK7HFI	Dysmenorrhea	GA34.3	Approved	[28]
Probenecid	DMMFWOJ	Acute gonococcal cervicitis		Approved	[31]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[28]

Drug(s) Affected By ATP-binding cassette sub-family C member 4 (ABCC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[32]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[34]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[35]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[36]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[37]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[38]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[16]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Herpes simplex virus DNA polymerase UL30 (HSV UL30)	TTIU7X1	DPOL_HHV11	Inhibitor	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
ATP-binding cassette sub-family C member 4 (ABCC4)	OTO27PAL	MRP4_HUMAN	Regulation of Drug Effects	[2]
Methylmalonyl-CoA mutase, mitochondrial (MMUT)	OTBBBV70	MUTA_HUMAN	Gene/Protein Processing	[3]
Organic anion transporter 3 (SLC22A8)	OT8BY933	S22A8_HUMAN	Drug Response	[4]
Solute carrier family 22 member 6 (SLC22A6)	OTKRCBVM	S22A6_HUMAN	Drug Response	[5]

References

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