Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMC1NBW)

Drug Name
Thiazolidinedione Drug Info
Synonyms
2295-31-0; 1,3-Thiazolidine-2,4-dione; thiazolidine-2,4-dione; 2,4-Dioxothiazolidine; 2,4(3H,5H)-Thiazoledione; USAF EK-5496; Thiazolidindione; UNII-AA68LXK93C; Thiazolidinedione-2,4; NSC 6745; EINECS 218-941-2; BRN 0110700; AA68LXK93C; AI3-61185; CHEBI:50992; NSC6745; ZOBPZXTWZATXDG-UHFFFAOYSA-N; MFCD00005478; 2,4-Thiazolidinedione, 99%; C3H3NO2S; thiazolidine-dione; 2,4-thiazolidindione; 2,5H)-Thiazoledione; PubChem17487
Indication
Disease Entry ICD 11 Status REF
Alzheimer disease 8A20 Approved [1]
Cross-matching ID
PubChem CID
5437
ChEBI ID
CHEBI:50992
CAS Number
CAS 2295-31-0
TTD Drug ID
DMC1NBW

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Peroxisome proliferator-activated receptor gamma (PPAR-gamma)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [5]
Pioglitazone DMKJ485 Amyotrophic lateral sclerosis 8B60.0 Approved [2]
Lobeglitazone DMHY3IP Type-2 diabetes 5A11 Approved [6]
Rosiglitazone XR DMT45MU Type-2 diabetes 5A11 Approved [7]
Glitazone DMDN4A1 N. A. N. A. Phase 4 [8]
MURAGLITAZAR DMG3NFZ N. A. N. A. Phase 3 [9]
Rivoglitazone DMBY31K Ocular inflammation 9C61.24 Phase 3 [10]
Balaglitazone DMXBHR6 Type-1 diabetes 5A10 Phase 3 [11]
Ragaglitazar DMFSHEM Type-1 diabetes 5A10 Phase 3 [12]
CS-038 DM67P0F Type-2 diabetes 5A11 Phase 3 [13]
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Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [14]
Riluzole DMECBWN Amyotrophic lateral sclerosis 8B60.0 Approved [15]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [16]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [17]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [18]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [19]
Ethacrynic acid DM60QMR Edema MG29 Approved [20]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [21]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [22]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [4]
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Drug(s) Affected By Retinoblastoma-associated protein (RB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [23]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [24]
Gefitinib DM15F0X Colon adenocarcinoma Approved [25]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [26]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [27]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [28]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [29]
Methotrexate DM2TEOL Anterior urethra cancer Approved [30]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [31]
Quercetin DM3NC4M Obesity 5B81 Approved [32]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [33]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [34]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [35]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [36]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [37]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [38]
Verapamil DMA7PEW Angina pectoris BA40 Approved [39]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [40]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [41]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [42]
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Drug(s) Affected By Cyclin-dependent kinase 4 (CDK4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [43]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [44]
Selenium DM25CGV N. A. N. A. Approved [45]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [46]
Methotrexate DM2TEOL Anterior urethra cancer Approved [47]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [48]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [49]
Quercetin DM3NC4M Obesity 5B81 Approved [32]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [50]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [51]
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Drug(s) Affected By Proliferating cell nuclear antigen (PCNA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [38]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [52]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [53]
Selenium DM25CGV N. A. N. A. Approved [45]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [54]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [55]
Meloxicam DM2AR7L Arthritis FA20 Approved [56]
Methotrexate DM2TEOL Anterior urethra cancer Approved [47]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [57]
Epinephrine DM3KJBC Acute asthma CA23 Approved [58]
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Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [59]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [60]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [42]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [61]
Gefitinib DM15F0X Colon adenocarcinoma Approved [62]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [26]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [63]
Selenium DM25CGV N. A. N. A. Approved [64]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [65]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [66]
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Drug(s) Affected By Peroxisome proliferator-activated receptor gamma (PPARG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [67]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [68]
Quercetin DM3NC4M Obesity 5B81 Approved [69]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [70]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [71]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [72]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [73]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [74]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [75]
Stavudine DM6DEK9 Human immunodeficiency virus infection 1C62 Approved [76]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [77]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [78]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [79]
Gefitinib DM15F0X Colon adenocarcinoma Approved [80]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [26]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [81]
Etretinate DM2CZFA Keratosis ED56 Approved [82]
Prednisone DM2HG4X Acute asthma CA23 Approved [83]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [84]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [85]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [24]
Gefitinib DM15F0X Colon adenocarcinoma Approved [62]
Prednisone DM2HG4X Acute asthma CA23 Approved [83]
Methotrexate DM2TEOL Anterior urethra cancer Approved [86]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [87]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [88]
Quercetin DM3NC4M Obesity 5B81 Approved [89]
Fluoxetine DM3PD2C Bipolar depression Approved [90]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [91]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [92]
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Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [33]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [93]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [38]
Verapamil DMA7PEW Angina pectoris BA40 Approved [39]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [94]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [95]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [26]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [27]
Meloxicam DM2AR7L Arthritis FA20 Approved [56]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [84]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Peroxisome proliferator-activated receptor gamma (PPAR-gamma) TTZMAO3 PPARG_HUMAN Agonist [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [3]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [3]
Cyclin-dependent kinase 4 (CDK4) OT7EP05T CDK4_HUMAN Gene/Protein Processing [3]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Gene/Protein Processing [3]
Cyclin-dependent kinase inhibitor 1B (CDKN1B) OTNY5LLZ CDN1B_HUMAN Gene/Protein Processing [3]
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Gene/Protein Processing [4]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Gene/Protein Processing [3]
Peroxisome proliferator-activated receptor gamma (PPARG) OTHMARHO PPARG_HUMAN Protein Interaction/Cellular Processes [3]
Proliferating cell nuclear antigen (PCNA) OTHZ1RIA PCNA_HUMAN Gene/Protein Processing [3]
Retinoblastoma-associated protein (RB1) OTQJUJMZ RB_HUMAN Gene/Protein Processing [3]

References

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30 Melanoma coordinates general and cell-specific mechanisms to promote methotrexate resistance. Exp Cell Res. 2012 Jun 10;318(10):1146-59.
31 HMG-CoA reductase inhibitor simvastatin inhibits cell cycle progression at the G1/S checkpoint in immortalized lymphocytes from Alzheimer's disease patients independently of cholesterol-lowering effects. J Pharmacol Exp Ther. 2008 Jan;324(1):352-9. doi: 10.1124/jpet.107.128959. Epub 2007 Oct 10.
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33 4.8% sevoflurane induces activation of autophagy in human neuroblastoma SH-SY5Y cells by the AMPK/mTOR signaling pathway. Neurotoxicology. 2022 May;90:256-264. doi: 10.1016/j.neuro.2022.04.008. Epub 2022 Apr 23.
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