Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMCY9PO)

• Drug Name: Itarnafloxin Drug Info
• Synonyms: Quarfloxin; CX-3385; CX-3543; Quadruplex DNA oncogene inhibitor (cancer), Cylene; C-Myc/VEGF oncogene inhibitor (cancer), Cylene

Indication

Disease Entry	ICD 11	Status	REF
leukaemia	2A60-2B33	Phase 2	[1]

• Cross-matching ID:
  PubChem CID: 11635763
  CAS Number: CAS 865311-47-3
  TTD Drug ID: DMCY9PO

Molecule-Related Drug Atlas

Drug(s) Targeting Nucleolin (NCL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ACT-GRO-777	DMMG61B	Solid tumour/cancer	2A00-2F9Z	Phase 2	[4]
IPP-204106	DM8E3N6	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[5]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[6]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[7]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[8]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[9]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[10]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[11]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[10]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[12]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[13]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[14]

Drug(s) Affected By Histone H2AX (H2AX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[15]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[16]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[18]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[19]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[20]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[21]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[22]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[23]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[24]

Drug(s) Affected By TP53-binding protein 1 (TP53BP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[27]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[29]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[30]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[31]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[32]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[33]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[34]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Nucleolin (NCL)	TTCSZH7	NUCL_HUMAN	Inhibitor	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Histone H2AX (H2AX)	OT18UX57	H2AX_HUMAN	Gene/Protein Processing	[2]
Poly polymerase 1 (PARP1)	OT310QSG	PARP1_HUMAN	Protein Interaction/Cellular Processes	[3]
TP53-binding protein 1 (TP53BP1)	OTL8879S	TP53B_HUMAN	Gene/Protein Processing	[2]

References

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