General Information of Drug (ID: DMDGCQP)

Drug Name
Norethindrone acetate Drug Info
Synonyms
Noresthisterone; Norethadrone; Norethisteron; Norethisterone; Norethisteronum; Norethyndron; Norethynodron; Norethynodrone; Noretisterona; Norfor; Norgestin; Noriday; Norluten; Norlutin; Norluton; Norpregneninlone; Norpregneninolone; Primolut-N; Proluteasi; Synphase; Triella; Utovlan; Utovlar; norethindrone; 19-Nor-ethindrone; 19-Norethisterone; 68-22-4; Anovulatorio; Anovule; Camila; Ciclovulan; Conludaf; Conludag; Ethinylnortestosterone; Gestest; Microneth; Micronett; Micronor; Micronovum; Mini-Pe; Mini-pill; Minovlar; Nor-QD; Noralutin; Norcolut; 1-(Ethylsulfonyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-3-azetidineacetonitrile
Cross-matching ID
PubChem CID
5832
ChEBI ID
CHEBI:7628
CAS Number
CAS 51-98-9
TTD Drug ID
DMDGCQP
INTEDE Drug ID
DR1750

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [7]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [8]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [9]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [10]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [11]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [12]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [13]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [14]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [8]
Verapamil DMA7PEW Angina pectoris BA40 Approved [15]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [16]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [17]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [18]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [19]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [20]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [21]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [13]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [22]
Verapamil DMA7PEW Angina pectoris BA40 Approved [23]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [24]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 2A6 (CYP2A6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [16]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [25]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [26]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [11]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [27]
Metronidazole DMTIVEN Abscess Approved [28]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [29]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [30]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [25]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 3A5 (CYP3A5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [31]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [32]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [33]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [2]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [34]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [35]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [36]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [37]
Verapamil DMA7PEW Angina pectoris BA40 Approved [38]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [2]
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Drug(s) Metabolized By Cytochrome P450 3A7 (CYP3A7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [39]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [2]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [2]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [2]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [25]
Verapamil DMA7PEW Angina pectoris BA40 Approved [40]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [2]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [2]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [2]
Metronidazole DMTIVEN Abscess Approved [28]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Mephenytoin 4-hydroxylase (CYP2C19)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [41]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [42]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [43]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [44]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [25]
Verapamil DMA7PEW Angina pectoris BA40 Approved [45]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [46]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [47]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [48]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [29]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Aldo-keto reductase 1C4 (AKR1C4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nabumetone DMAT2XH Osteoarthritis FA00-FA05 Approved [49]
Trastuzumab emtansine DMU1LXS HER2-positive breast cancer 2C60-2C65 Phase 2 [50]
BRN-3548355 DM4KXT0 N. A. N. A. Investigative [51]
Drug Name Drug ID Indication ICD 11 Highest Status REF
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [52]
Tibolone DM78XFG Anabolic metabolism 5C50-5C8Z Approved [53]
Pregnenolone DM6VFO1 Schizophrenia 6A20 Phase 4 [54]
17alpha-hydroxypregnenolone DMT2EPG Discovery agent N.A. Investigative [54]
Drug(s) Metabolized By Aldo-keto reductase 1D1 (AKR1D1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydroxy-cholesten-one DM6IEKW N. A. N. A. Investigative [55]
Drug(s) Affected By Lutropin subunit beta (LHB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [56]
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [6]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [57]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [58]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [59]
Alprazolam DMC7XDN Anxiety Approved [60]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [61]
Metoclopramide DMFA5MY Nausea MD90 Approved [58]
Cetrorelix DMFD9Q6 Ovarian stimulation LB45.1 Approved [62]
Ganirelix DMGMB30 Ovulation dysfunction 5A80 Approved [63]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 1B1 (CYP1B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [5]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [64]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [65]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [66]
Estrone DM5T6US Acne vulgaris ED80 Approved [67]
Melatonin DMKWFBT Depression 6A70-6A7Z Approved [68]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [69]
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [70]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [71]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [72]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) Main DME DE4LYSA CP3A4_HUMAN Substrate [1]
Mephenytoin 4-hydroxylase (CYP2C19) DEGTFWK CP2CJ_HUMAN Substrate [2]
Cytochrome P450 2A6 (CYP2A6) DEJVYAZ CP2A6_HUMAN Substrate [1]
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Substrate [1]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Substrate [3]
Beta-HSD adrenal and gonadal type (HSD3B2) DEN0GVQ 3BHS2_HUMAN Substrate [4]
Cytochrome P450 3A7 (CYP3A7) DERD86B CP3A7_HUMAN Substrate [3]
Aldo-keto reductase 1C4 (AKR1C4) DEAJN47 AK1C4_HUMAN Substrate [4]
Aldo-keto reductase 1D1 (AKR1D1) DEVON3M AK1D1_HUMAN Substrate [4]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Cytochrome P450 1B1 (CYP1B1) OTYXFLSD CP1B1_HUMAN Gene/Protein Processing [5]
Lutropin subunit beta (LHB) OT5GBOVJ LSHB_HUMAN Protein Interaction/Cellular Processes [6]

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