Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMF8Y74)

Drug Name
Hydroxyzine Drug Info
Synonyms
Atara; Atarax; Ataraxoid; Atarazoid; Atarox; Atazina; Aterax; Deinait; Durrax; Hidroxizina; Hychotine; Hydroksyzyny; Hydroxine; Hydroxizine; Hydroxizinum; Hydroxycine; Hydroxyzin; Hydroxyzinum; Hydroxyzyne; Idrossizina; Neurozina; Nevrolaks; Orgatrax; Pamazone; Parenteral; Paxistil; Placidol; Plaxidol; Tranquizine; Traquizine; Vistaril; Atarax base; Hydroksyzyny [Polish]; Hydroxyzine Hcl; Hydroxyzine base; Hydroxyzine hydrochloride; Idrossizina [DCIT]; NP 212; UCB 4492; UCB 492; Atarax (TN); Hidroxizina [INN-Spanish]; Hy-Pam 25; Hydroxyzine (INN); Hydroxyzine [INN:BAN]; Hydroxyzinum [INN-Latin]; Marex (TN); Neo-Calma; Tran-Q; U.CB 4492; Vesparaz-Wirkstoff; Vistaril (TN); U.C.B 4492; N-(4-Chlorobenzhydryl)-N'-(hydroxyethoxyethyl)piperazine; N-(4-Chlorobenzhydryl)-N'-(hydroxyethyloxyethyl)piperazine; Ethanol, 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-(9CI); 1-(p-Chloro-.alpha.-phenylbenzyl)-4-[2-[(2-hydroxyethoxy)ethyl]piperazine; 1-(p-Chloro-alpha-phenylbenzyl)-4-(2-(2-hydroxyethoxy)ethyl)piperazine; 1-(p-Chloro-alpha-phenylbenzyl)-4-(2-hydroxyethoxyethyl)piperazine; 1-(p-Chlorobenzhydryl)-4-(2-(2-hydroxyethoxy)ethyl)diethylenediamine; 1-(p-Chlorobenzhydryl)-4-(2-(2-hydroxyethoxy)ethyl)piperazine; 1-(p-Chlorobenzhydryl)-4-[2-(2-hydroxyethoxy)ethyl]diethylenediamine; 1-(p-Chlorobenzhydryl)-4-[2-(2-hydroxyethoxy)ethyl]piperazine; 1-(p-Chlorodiphenylmethyl)-4-(2-(2-hydroxyethoxy)ethyl)piperazine; 1-(p-Chlorodiphenylmethyl)-4-[2-(2-hydroxyethoxy)ethyl]piperazine; 2-(2-(4-((4-Chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)ethanol; 2-(2-(4-(p-Chloro-alpha-phenylbenzyl)-1-piperazinyl)ethoxy)ethanol; 2-(2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)ethanol; 2-[(2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethyl)oxy]ethanol; 2-[2-[4-(p-Chloro-.alpha.-phenylbenzyl)-1-piperazinyl]ethoxy]ethanol; 2-[2-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]ethanol
Indication
Disease Entry ICD 11 Status REF
Allergic rhinitis CA08.0 Approved [1]
Anxiety disorder 6B00-6B0Z Approved [2]
Urticaria EB00-EB05 Approved [1]
Pruritus EC90 Investigative [1]
Therapeutic Class
Hypnotics and Sedatives
Cross-matching ID
PubChem CID
3658
ChEBI ID
CHEBI:5818
CAS Number
CAS 68-88-2
TTD Drug ID
DMF8Y74
INTEDE Drug ID
DR0840
ACDINA Drug ID
D00318

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Histamine H1 receptor (H1R)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [8]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [9]
Azelastine DMXTMBJ Allergic conjunctivitis 9A60.02 Approved [10]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [11]
Cinnarizine DM7U5QJ Meniere disease AB31.0 Approved [12]
Diphenhydramine DMKQTBA Hyperemesis gravidarum Approved [10]
Doxepin DMPI98T Anxiety Approved [13]
Chlorpheniramine DM5URA2 Allergic rhinitis CA08.0 Approved [10]
Epinastine DMX0K3Q Allergic conjunctivitis 9A60.02 Approved [14]
Desloratadine DM56YN7 Allergic rhinitis CA08.0 Approved [15]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [16]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [17]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [18]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [19]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [20]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [21]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [22]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [23]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [17]
Verapamil DMA7PEW Angina pectoris BA40 Approved [24]
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Drug(s) Metabolized By Cytochrome P450 3A5 (CYP3A5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [25]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [26]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [27]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [28]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [29]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [30]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [31]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [32]
Verapamil DMA7PEW Angina pectoris BA40 Approved [33]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [28]
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Drug(s) Affected By Potassium voltage-gated channel subfamily H member 2 (KCNH2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Metoclopramide DMFA5MY Nausea MD90 Approved [34]
Quinidine DMLPICK N. A. N. A. Approved [35]
Verapamil DMA7PEW Angina pectoris BA40 Approved [36]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [37]
Clarithromycin DM4M1SG Acute maxillary sinusitis Approved [37]
Disopyramide DM5SYZP Long QT syndrome BC65.0 Approved [38]
Propranolol DM79NTF Angina pectoris BA40 Approved [39]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [40]
Dofetilide DMPN1TW Sinus rhythm disorder BC9Y Approved [41]
Flecainide DMSQDLE Tachyarrhythmias BC71 Approved [37]
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Drug(s) Affected By Transmembrane protease serine 2 (TMPRSS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [5]
Diazepam DM08E9O Alcohol withdrawal Approved [5]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [42]
Selenium DM25CGV N. A. N. A. Approved [43]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [5]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [5]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [5]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [5]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [5]
Fluphenazine DMIT8LX Psychotic disorder 6A20-6A25 Approved [5]
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Drug(s) Affected By Interleukin-1 beta (IL1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [44]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [45]
Gefitinib DM15F0X Colon adenocarcinoma Approved [46]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [6]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [47]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [6]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [48]
Selenium DM25CGV N. A. N. A. Approved [49]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [50]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [51]
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Drug(s) Affected By Antileukoproteinase (SLPI)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [6]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [6]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [42]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [6]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [6]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [6]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [6]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [52]
Penbutolol DM4ES8F Hypertension BA00-BA04 Approved [6]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [6]
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Drug(s) Affected By Phosphatidylcholine translocator ABCB4 (ABCB4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [53]
Verapamil DMA7PEW Angina pectoris BA40 Approved [54]
Methysergide DM1EF73 Migraine 8A80 Approved [7]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [55]
Methotrexate DM2TEOL Anterior urethra cancer Approved [56]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [7]
Quercetin DM3NC4M Obesity 5B81 Approved [57]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [58]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [59]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [60]
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Drug(s) Affected By Interleukin-24 (IL24)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [61]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [6]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [45]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [6]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [6]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [62]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [63]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [64]
Penbutolol DM4ES8F Hypertension BA00-BA04 Approved [6]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [64]
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Drug(s) Affected By PTB-containing, cubilin and LRP1-interacting protein (PID1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [6]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [6]
Penbutolol DM4ES8F Hypertension BA00-BA04 Approved [6]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [6]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [6]
Amikacin DM5PDRB Bacteremia 1A73 Approved [6]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [6]
Promethazine DM6I5GR Hyperemesis gravidarum Approved [6]
Etodolac DM6WJO9 Osteoarthritis FA00-FA05 Approved [6]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [65]
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Drug(s) Affected By Angiotensin-converting enzyme 2 (ACE2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Captopril DM458UM Chronic heart failure BD1Z Approved [66]
Diazepam DM08E9O Alcohol withdrawal Approved [5]
Dantrolene DM1D8XY Hyperthermia MG26 Approved [5]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [5]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [5]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [5]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [5]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [5]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [5]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Histamine H1 receptor (H1R) TTTIBOJ HRH1_HUMAN Antagonist [3]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) Main DME DE4LYSA CP3A4_HUMAN Substrate [4]
Cytochrome P450 3A5 (CYP3A5) Main DME DEIBDNY CP3A5_HUMAN Substrate [4]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Angiotensin-converting enzyme 2 (ACE2) OTTRZGU7 ACE2_HUMAN Gene/Protein Processing [5]
Antileukoproteinase (SLPI) OTUNFUU8 SLPI_HUMAN Gene/Protein Processing [6]
Interleukin-1 beta (IL1B) OT0DWXXB IL1B_HUMAN Gene/Protein Processing [6]
Interleukin-24 (IL24) OT4VUWH1 IL24_HUMAN Gene/Protein Processing [6]
Phosphatidylcholine translocator ABCB4 (ABCB4) OTE6PY83 MDR3_HUMAN Gene/Protein Processing [7]
Potassium voltage-gated channel subfamily H member 2 (KCNH2) OTZX881H KCNH2_HUMAN Gene/Protein Processing [3]
PTB-containing, cubilin and LRP1-interacting protein (PID1) OT5YJ7FI PCLI1_HUMAN Gene/Protein Processing [6]
Transmembrane protease serine 2 (TMPRSS2) OTN44YQ5 TMPS2_HUMAN Gene/Protein Processing [5]

References

1 Hydroxyzine FDA Label
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34 Comparison of the effects of metoclopramide and domperidone on HERG channels. Pharmacology. 2005 Apr;74(1):31-6. doi: 10.1159/000083234. Epub 2005 Jan 7.
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36 Automated tight seal electrophysiology for assessing the potential hERG liability of pharmaceutical compounds. Assay Drug Dev Technol. 2004 Oct;2(5):497-506. doi: 10.1089/adt.2004.2.497.
37 Refining the human iPSC-cardiomyocyte arrhythmic risk assessment model. Toxicol Sci. 2013 Dec;136(2):581-94. doi: 10.1093/toxsci/kft205. Epub 2013 Sep 19.
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46 Reactive metabolite of gefitinib activates inflammasomes: implications for gefitinib-induced idiosyncratic reaction. J Toxicol Sci. 2020;45(11):673-680. doi: 10.2131/jts.45.673.
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52 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
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58 Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicol In Vitro. 2017 Mar;39:93-103.
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60 Evaluation of gene induction of drug-metabolizing enzymes and transporters in primary culture of human hepatocytes using high-sensitivity real-time reverse transcription PCR. Yakugaku Zasshi. 2002 May;122(5):339-61.
61 Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.
62 Sulindac enhances adenoviral vector expressing mda-7/IL-24-mediated apoptosis in human lung cancer. Mol Cancer Ther. 2005 Feb;4(2):291-304.
63 Effects of ciglitazone and troglitazone on the proliferation of human stomach cancer cells. World J Gastroenterol. 2009 Jan 21;15(3):310-20.
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66 Polymorphisms of ACE2 gene are associated with essential hypertension and antihypertensive effects of Captopril in women. Clin Pharmacol Ther. 2007 Aug;82(2):187-96. doi: 10.1038/sj.clpt.6100214. Epub 2007 May 2.