Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMFIWAN)

Drug Name
NPPB Drug Info
Synonyms
5-Nitro-2-(3-phenylpropylamino)benzoic acid; 107254-86-4; UNII-3A35O9G3YZ; 5-nitro-2-[(3-phenylpropyl)amino]benzoic acid; 3A35O9G3YZ; CHEBI:34457; Benzoic acid,5-nitro-2-[(3-phenylpropyl)amino]-; Benzoic acid, 5-nitro-2-((3-phenylpropyl)amino)-; 5-NITRO-2-PHENYLPROPYLAMINOBENZOIC ACID [NPPB]; 5-NITRO-2-(3-PHENYLPROPYLAMINO)-BENZOIC ACID; 5-Nitro-2-(3-phenylpropylamino)benzoic Acid (NPPB); SR-01000075336; HOE-144; HOE 144; Tocris-0593; Spectrum_001814; ACMC-20c9kv; AC1L1IEV; Spectrum4_000338; Spectrum2_001477; HOE 144; 5-nitro-2-(3-phenylpropylamino) benzoic acid
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
4549
ChEBI ID
CHEMBL1256759
CAS Number
CAS 107254-86-4
TTD Drug ID
DMFIWAN

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Investigative Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Calcium-dependent chloride channel anoctamin (ANO)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Benzbromarone DMC3YUA Gout FA25 Approved [9]
Crofelemer DM4AMQZ HIV-associated diarrhoea 1A2Z Approved [10]
DIDS DMKSQUB Discovery agent N.A. Investigative [2]
9-anthroic acid DMGCVT2 Discovery agent N.A. Investigative [2]
SITS DMCMIUG Discovery agent N.A. Investigative [2]
DCDPC DMG9BFR Discovery agent N.A. Investigative [2]
tannic acid DM52WGH Discovery agent N.A. Investigative [2]
Ins(3,4,5,6)P4 DMAQU71 Discovery agent N.A. Investigative [2]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Targeting Chloride channel protein 7 (ClC-7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
DIDS DMKSQUB Discovery agent N.A. Investigative [4]
diphenylamine-2-carboxylic acid DMBV19T Discovery agent N.A. Investigative [11]
SITS DMCMIUG Discovery agent N.A. Investigative [11]
GTPgammaS DMJUXKY Discovery agent N.A. Investigative [11]
NS5818 DM629TD Discovery agent N.A. Investigative [4]
Drug(s) Targeting Chloride channel protein 2 (CLC-2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lubiprostone DMJTEMW Chronic idiopathic constipation DC32 Approved [12]
RK-023 DM2VO97 Alopecia ED70 Phase 2 [13]
diphenylamine-2-carboxylic acid DMBV19T Discovery agent N.A. Investigative [3]
Acid-activated omeprazole DMTOEJX Discovery agent N.A. Investigative [14]
Drug(s) Targeting Volume regulated chloride channel (VRAC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
DIDS DMKSQUB Discovery agent N.A. Investigative [6]
9-anthroic acid DMGCVT2 Discovery agent N.A. Investigative [6]
GTPgammaS DMJUXKY Discovery agent N.A. Investigative [6]
1,9-dideoxyforskolin DMW613U Discovery agent N.A. Investigative [6]
diBA-(5)-C4 DM9KPHZ Discovery agent N.A. Investigative [6]
IAA-94 DMFSAK3 Discovery agent N.A. Investigative [6]
DCPIB DM9NMIY Discovery agent N.A. Investigative [6]
⏷ Show the Full List of 7 Drug(s)
Drug(s) Targeting Transformation-sensitive protein p120 (TRPA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Menthol DMG2KW7 Back pain ME84.Z Approved [15]
LY3526318 DMFXNQM Chronic low-back pain MG30 Phase 2 [16]
HX-100 DMFRM15 Diabetic neuropathy 8C0Z Phase 1 [17]
acetaldehyde DMJFKG4 Discovery agent N.A. Investigative [18]
[3H]resolvin D1 DMFT0HU Discovery agent N.A. Investigative [19]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [20]
icilin DMYVOL9 Discovery agent N.A. Investigative [21]
4-oxo-nonenal DMPX1J9 Discovery agent N.A. Investigative [22]
dibutyl phthalate DMEDGKO Discovery agent N.A. Investigative [23]
prostaglandin A2 DMWC4X8 Discovery agent N.A. Investigative [24]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Permeability pathway (NP pathway)
Drug Name Drug ID Indication ICD 11 Highest Status REF
7-tert-butyl-2, 3-dihydro-3, 3-dimethyl substituted dihydrofuran 30 (DHDMBF30) DMSU06X Discovery agent N.A. Investigative [1]
Decyltrimethylammonium DM1ITJ5 Discovery agent N.A. Investigative [1]
Drug(s) Affected By Secretin (SCT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [25]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [26]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [27]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [28]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [29]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [30]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [31]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [32]
Pentagastrin DMRCLZB Diagnostic imaging N.A. Approved [33]
CHLORIDE DM1TJXA Solid tumour/cancer 2A00-2F9Z Phase 3 [34]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By H(+)/Cl(-) exchange transporter 3 (CLCN3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [35]
Selenium DM25CGV N. A. N. A. Approved [36]
Quercetin DM3NC4M Obesity 5B81 Approved [37]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [38]
Leflunomide DMR8ONJ Arthritis FA20 Approved [39]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [40]
Testosterone enanthate DMB6871 N. A. N. A. Approved [41]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [27]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [42]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [43]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Calcium-dependent chloride channel anoctamin (ANO) TTOJI4S ANO1_HUMAN Blocker (channel blocker) [2]
Chloride channel protein 2 (CLC-2) TT30NW6 CLCN2_HUMAN Blocker (channel blocker) [3]
Chloride channel protein 7 (ClC-7) TTST1AJ CLCN7_HUMAN Blocker (channel blocker) [4]
Permeability pathway (NP pathway) TTT1MCF NOUNIPROTAC Inhibitor [1]
Transformation-sensitive protein p120 (TRPA1) TTELV3W TRPA1_HUMAN Activator [5]
Volume regulated chloride channel (VRAC) TT0FC1V NOUNIPROTAC Blocker (channel blocker) [6]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
H(+)/Cl(-) exchange transporter 3 (CLCN3) OTEEXNMU CLCN3_HUMAN Gene/Protein Processing [7]
Secretin (SCT) OTV3MLOO SECR_HUMAN Gene/Protein Processing [8]

References

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2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 708).
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 699).
4 The G215R mutation in the Cl-/H+-antiporter ClC-7 found in ADO II osteopetrosis does not abolish function but causes a severe trafficking defect. PLoS One. 2010 Sep 7;5(9):e12585.
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6 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 710).
7 5-Nitro-2-(3-phenylpropylamino) benzoic acid induced drug resistance to cisplatin in human erythroleukemia cell lines. Anat Rec (Hoboken). 2011 Jun;294(6):945-52. doi: 10.1002/ar.21392. Epub 2011 Apr 28.
8 Activation of transepithelial ion transport by secretin in human intestinal Caco-2 cells. Jpn J Physiol. 2000 Apr;50(2):215-25. doi: 10.2170/jjphysiol.50.215.
9 Anoctamin Channels in Human Myometrium: A Novel Target for Tocolysis.Reprod Sci. 2018 Nov;25(11):1589-1600.
10 Nat Rev Drug Discov. 2013 Feb;12(2):87-90.
11 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 709).
12 Lubiprostone stimulates secretion from tracheal submucosal glands of sheep, pigs, and humans. Am J Physiol Lung Cell Mol Physiol. 2009 May;296(5):L811-24.
13 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
14 ClC-2 Cl- channels in human lung epithelia: activation by arachidonic acid, amidation, and acid-activated omeprazole. Am J Physiol Cell Physiol. 2001 Jul;281(1):C46-54.
15 TRPV1-mediated itch in seasonal allergic rhinitis. Allergy. 2009 May;64(5):807-10.
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17 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
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19 Resolvin D1 attenuates activation of sensory transient receptor potential channels leading to multiple anti-nociception. Br J Pharmacol. 2010 Oct;161(3):707-20.
20 An ion channel essential for sensing chemical damage. J Neurosci. 2007 Oct 17;27(42):11412-5.
21 ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell. 2003 Mar 21;112(6):819-29.
22 Transient receptor potential A1 is a sensory receptor for multiple products of oxidative stress. J Neurosci. 2008 Mar 5;28(10):2485-94.
23 TRPA1 and TRPV1 activation is a novel adjuvant effect mechanism in contact hypersensitivity. J Neuroimmunol. 2009 Feb 15;207(1-2):66-74.
24 Cox-dependent fatty acid metabolites cause pain through activation of the irritant receptor TRPA1. Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):12045-50.
25 Retinoic acid-induced human secretin gene expression in neuronal cells is mediated by cyclin-dependent kinase 1. Ann N Y Acad Sci. 2006 Jul;1070:393-8. doi: 10.1196/annals.1317.051.
26 Arsenic suppresses gene expression in promyelocytic leukemia cells partly through Sp1 oxidation. Blood. 2005 Jul 1;106(1):304-10.
27 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
28 Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
29 Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
30 Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: application to acetaminophen injury. Toxicol Appl Pharmacol. 2012 Mar 15;259(3):270-80.
31 Transcriptome and DNA methylome dynamics during triclosan-induced cardiomyocyte differentiation toxicity. Stem Cells Int. 2018 Oct 29;2018:8608327.
32 Administration of secretin for autism alters dopamine metabolism in the central nervous system. Brain Dev. 2006 Mar;28(2):99-103. doi: 10.1016/j.braindev.2005.05.005. Epub 2005 Sep 15.
33 Secretin inhibits canine gastric acid secretion in response to pentagastrin by modulating gastric histamine release. J Pharmacol Exp Ther. 1996 Nov;279(2):718-23.
34 The influence of secretin on ion transport in the human jejunum. Gut. 1973 Jun;14(6):485-90. doi: 10.1136/gut.14.6.485.
35 Oxidative stress modulates theophylline effects on steroid responsiveness. Biochem Biophys Res Commun. 2008 Dec 19;377(3):797-802.
36 Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
37 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
38 Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermatoendocrinol. 2009 May;1(3):177-87.
39 Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
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41 Transcriptional profiling of testosterone-regulated genes in the skeletal muscle of human immunodeficiency virus-infected men experiencing weight loss. J Clin Endocrinol Metab. 2007 Jul;92(7):2793-802. doi: 10.1210/jc.2006-2722. Epub 2007 Apr 17.
42 Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
43 Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.