Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMGRZW2)

• Drug Name: Betaine Drug Info
• Synonyms: Cystadane

Indication

Disease Entry	ICD 11	Status	REF
Cystitis	GC00	Approved	[1]
Homocystinuria	5C50.B	Approved	[1]
Inborn error of metabolism	5C50-5C59	Approved	[2]

• Cross-matching ID:
  PubChem CID: 247
  ChEBI ID: CHEBI:17750
  CAS Number: CAS 107-43-7
  TTD Drug ID: DMGRZW2
  VARIDT Drug ID: DR00314

Molecule-Related Drug Atlas

Drug(s) Transported By Na(+)/Cl(-) betaine/GABA transporter (SLC6A12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[8]
Glycine	DMIOZ29	Allergic rhinitis	CA08.0	Approved	[9]
L-Proline	DMKSTWR	Malnutrition	5B50-5B71	Approved	[9]
CHOLINE	DM5D9YK	Insomnia	7A00-7A0Z	Investigative	[9]

Drug(s) Affected By E3 ubiquitin-protein ligase MARCHF6 (MARCHF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[10]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[7]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[11]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[12]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[13]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[14]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[15]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[10]
ANW-32821	DMMJOZD	N. A.	N. A.	Phase 2	[7]
CB-5083	DM12GN7	Multiple myeloma	2A83	Phase 1	[7]

Drug(s) Affected By Coagulation factor VIII (F8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[16]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[17]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[18]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[19]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[20]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[21]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[22]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[23]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[24]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[25]

Drug(s) Affected By Coagulation factor IX (F9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[18]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[19]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[20]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[26]
Warfarin	DMJYCVW	Atrial fibrillation	BC81.3	Approved	[27]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[28]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[29]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[30]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[31]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[32]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[33]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[34]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[35]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[36]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[37]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[38]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[39]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[40]

Drug(s) Affected By Betaine--homocysteine S-methyltransferase 1 (BHMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[18]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[11]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[44]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[45]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[46]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[28]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[47]

Molecular Interaction Atlas of This Drug

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Na(+)/Cl(-) betaine/GABA transporter (SLC6A12)	DTBPTJF	S6A12_HUMAN	Substrate	[3]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Protein Interaction/Cellular Processes	[4]
Betaine--homocysteine S-methyltransferase 1 (BHMT)	OTYB6PXZ	BHMT1_HUMAN	Regulation of Drug Effects	[5]
Coagulation factor IX (F9)	OTT0CX3Q	FA9_HUMAN	Protein Interaction/Cellular Processes	[6]
Coagulation factor VIII (F8)	OTH6XHDU	FA8_HUMAN	Protein Interaction/Cellular Processes	[6]
E3 ubiquitin-protein ligase MARCHF6 (MARCHF6)	OTBTA03N	MARH6_HUMAN	Protein Interaction/Cellular Processes	[7]

References

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