Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMLFSTR)

Drug Name
Ticrynafen Drug Info
Synonyms
Ticrynafen; Tienilic acid; 40180-04-9; Thienylic acid; Selacryn; Diflurex; Ticrex; Acido tienilico; Acide tienilique; Acidum tienilicum; Tienilico acido; Tienilico acido [Spanish]; Ticrynafen [USAN]; Acido tienilico [INN-Spanish]; Acide tienilique [INN-French]; Acidum tienilicum [INN-Latin]; ANP 3624; C13H8Cl2O4S; SKF 62698; UNII-HC95205SY4; 2-(2,3-dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid; (2,3-Dichloro-4-(2-thenoyl)phenoxy)acetic acid; CCRIS 5489; 4-(2-Thienylketo)-2,3-dichlorophenoxyacetic acid
Indication
Disease Entry ICD 11 Status REF
Congestive heart failure BD10 Withdrawn from market [1]
Cross-matching ID
PubChem CID
38409
ChEBI ID
CHEMBL9590
CAS Number
CAS 40180-04-9
TTD Drug ID
DMLFSTR
INTEDE Drug ID
DR1593

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DME
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [7]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [8]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [9]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [10]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [11]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [10]
Verapamil DMA7PEW Angina pectoris BA40 Approved [12]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [13]
Estrone DM5T6US Acne vulgaris ED80 Approved [14]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [15]
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Drug(s) Affected By Proepiregulin (EREG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [16]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [3]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [17]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [3]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [3]
Methotrexate DM2TEOL Anterior urethra cancer Approved [18]
Quercetin DM3NC4M Obesity 5B81 Approved [19]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [20]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [21]
Penbutolol DM4ES8F Hypertension BA00-BA04 Approved [3]
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Drug(s) Affected By Renin (REN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [22]
Acebutolol DM0TI4U Hypertension BA00-BA04 Approved [23]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [24]
Reboxetine DM26PRD Depression 6A70-6A7Z Approved [25]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [26]
Ramipril DM2R68E Acute heart failure BD10-BD13 Approved [27]
Rhucin DM3ADGP Erectile dysfunction HA01.1 Approved [28]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [29]
Epinephrine DM3KJBC Acute asthma CA23 Approved [30]
Chlorthalidone DM4DMBT Edema MG29 Approved [31]
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Drug(s) Affected By Antileukoproteinase (SLPI)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [3]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [3]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [17]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [3]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [3]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [3]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [3]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Penbutolol DM4ES8F Hypertension BA00-BA04 Approved [3]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [3]
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Drug(s) Affected By Hepatocyte growth factor receptor (MET)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cabozantinib DMIYDT4 Medullary thyroid gland carcinoma Approved [33]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [34]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [3]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [3]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [3]
Methotrexate DM2TEOL Anterior urethra cancer Approved [35]
Quercetin DM3NC4M Obesity 5B81 Approved [19]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [3]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [36]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [35]
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Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [37]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [38]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [39]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [40]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [41]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [42]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [3]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [43]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [44]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [3]
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Drug(s) Affected By Solute carrier family 12 member 2 (SLC12A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [17]
Quercetin DM3NC4M Obesity 5B81 Approved [19]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Estrone DM5T6US Acne vulgaris ED80 Approved [45]
Ethacrynic acid DM60QMR Edema MG29 Approved [5]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [46]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [47]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [48]
Furosemide DMMQ8ZG Congestive heart failure BD10 Approved [5]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [45]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 2C9 (CYP2C9) Main DME DE5IED8 CP2C9_HUMAN Substrate [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Antileukoproteinase (SLPI) OTUNFUU8 SLPI_HUMAN Gene/Protein Processing [3]
Hepatocyte growth factor receptor (MET) OT7K55MU MET_HUMAN Gene/Protein Processing [3]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Gene/Protein Processing [3]
Proepiregulin (EREG) OTRM4NQY EREG_HUMAN Gene/Protein Processing [3]
Renin (REN) OT52GZR2 RENI_HUMAN Gene/Protein Processing [4]
Solute carrier family 12 member 2 (SLC12A2) OT3ZJ3LH S12A2_HUMAN Gene/Protein Processing [5]
UDP-glucuronosyltransferase 1A1 OTH1C8OJ UD11_HUMAN Gene/Protein Processing [6]

References

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