Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMM0KOJ)

Drug Name
2-arachidonoylglycerol Drug Info
Synonyms
2-arachidonoylglycerol; 2-AG; 2-Arachidonylglycerol; 2-Arachidonyl-glycerol; 53847-30-6; 2-Arachidonoyl-glycerol; 2-Arachidonoyl Glycerol; 2-Ara-Gl; 2-Monoarachidonoylglycerol; UNII-8D239QDW64; 1,3-dihydroxypropan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate; CHEMBL122972; CHEBI:52392; RCRCTBLIHCHWDZ-DOFZRALJSA-N; 8D239QDW64; MG(20:4); MG(0:0/20:4(5Z,8Z,11Z,14Z)/0:0); 5,8,11,14-Eicosatetraenoic acid, 2-hydroxy-1-(hydroxymethyl)ethyl ester, (5Z,8Z,11Z,14Z)-; 5,8,11,14-Eicosatetraenoic acid, 2-hydroxy-1-(hydroxymethyl)ethy
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
5282280
ChEBI ID
CHEMBL122972
CAS Number
CAS 53847-30-6
TTD Drug ID
DMM0KOJ

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting Fatty acid amide hydrolase (FAAH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [8]
Thiopental DMGP8AX Anaesthesia 9A78.6 Approved [9]
JNJ-42165279 DM72GZO Anxiety disorder 6B00-6B0Z Phase 2 [10]
SSR411298 DMGTB2Q Major depressive disorder 6A70.3 Phase 2 [11]
IW-6118 DMP42W1 Inflammation 1A00-CA43.1 Phase 2 [12]
PF-04457845 DMPRYU1 Liver disease DB90-BD99 Phase 2 [13]
IPI-940 DMEIM5G Pain MG30-MG3Z Phase 1 [14]
PMID29053063-Compound-11d DMDRK68 N. A. N. A. Patented [15]
Piperazine carbamic compound 1 DMZSYU4 N. A. N. A. Patented [15]
Piperazine carbamic compound 2 DMMQ0ZO N. A. N. A. Patented [15]
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Drug(s) Affected By Sterol 26-hydroxylase, mitochondrial (CYP27A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Clavulanate DM2FGRT Bacteremia 1A73 Approved [16]
Methotrexate DM2TEOL Anterior urethra cancer Approved [17]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [18]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [19]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [20]
Testosterone DM7HUNW Hot flushes GA30 Approved [21]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [22]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [23]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [24]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [25]
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Drug(s) Affected By Cyclic AMP-responsive element-binding protein 3-like protein 3 (CREB3L3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [26]
Quercetin DM3NC4M Obesity 5B81 Approved [27]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [18]
Leflunomide DMR8ONJ Arthritis FA20 Approved [28]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [23]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [30]
Ampicillin DMHWE7P Acute epiglottitis Approved [27]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [31]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [32]
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Drug(s) Affected By 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase (CYP8B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Chenodiol DMQ8JIK Cholelithiasis DC11 Approved [33]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [16]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [33]
Quercetin DM3NC4M Obesity 5B81 Approved [27]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [18]
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [33]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [23]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [24]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Arsenic DMTL2Y1 N. A. N. A. Approved [34]
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Drug(s) Affected By Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [35]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [36]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [37]
Quercetin DM3NC4M Obesity 5B81 Approved [27]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [38]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [39]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [40]
Pyrazinamide DM4IF32 Meningeal tuberculosis Approved [41]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [42]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [43]
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Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [44]
Gefitinib DM15F0X Colon adenocarcinoma Approved [45]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [46]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [47]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [48]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [49]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [48]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [50]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [51]
Methotrexate DM2TEOL Anterior urethra cancer Approved [52]
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Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [53]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [54]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [55]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [56]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [57]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [58]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [59]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [60]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [61]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [59]
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Drug(s) Affected By C-C motif chemokine 2 (CCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [62]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [63]
Gefitinib DM15F0X Colon adenocarcinoma Approved [64]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [65]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [66]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [67]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [68]
Methotrexate DM2TEOL Anterior urethra cancer Approved [69]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [70]
Quercetin DM3NC4M Obesity 5B81 Approved [71]
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Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-4 (ATF4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [35]
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [72]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [73]
Selenium DM25CGV N. A. N. A. Approved [74]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [75]
Pyrazinamide DM4IF32 Meningeal tuberculosis Approved [41]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [76]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [77]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [78]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [79]
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Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [80]
Triacetin DM0AEPG Onychomycosis EE12.1 Approved [81]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [35]
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [72]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [82]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [83]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [84]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [85]
Methotrexate DM2TEOL Anterior urethra cancer Approved [86]
Quercetin DM3NC4M Obesity 5B81 Approved [27]
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Drug(s) Affected By Cocaine esterase (CES2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [87]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [88]
Dextropropoxyphene DM23HCX Pain MG30-MG3Z Approved [89]
Methotrexate DM2TEOL Anterior urethra cancer Approved [90]
Quercetin DM3NC4M Obesity 5B81 Approved [27]
Tacrine DM51FY6 Alzheimer disease 8A20 Approved [91]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [92]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [23]
Testosterone enanthate DMB6871 N. A. N. A. Approved [93]
Cantharidin DMBP5N3 Molluscum contagiosum infection 1E76 Approved [94]
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Drug(s) Affected By Transient receptor potential cation channel subfamily V member 1 (TRPV1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [95]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [96]
Quercetin DM3NC4M Obesity 5B81 Approved [27]
Leflunomide DMR8ONJ Arthritis FA20 Approved [28]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [23]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [97]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [98]
Menthol DMG2KW7 Back pain ME84.Z Approved [99]
Capsaicin DMGMF6V Back pain ME84.Z Approved [100]
Lidocaine DML4ZOT Anaesthesia 9A78.6 Approved [101]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Fatty acid amide hydrolase (FAAH) TTDP1UC NOUNIPROTAC Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase (CYP8B1) OTRI4UR1 CP8B1_HUMAN Gene/Protein Processing [3]
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Gene/Protein Processing [4]
Cocaine esterase (CES2) OTC647SQ EST2_HUMAN Biotransformations [5]
Cyclic AMP-dependent transcription factor ATF-4 (ATF4) OTRFV19J ATF4_HUMAN Gene/Protein Processing [6]
Cyclic AMP-responsive element-binding protein 3-like protein 3 (CREB3L3) OTDMU3GP CR3L3_HUMAN Gene/Protein Processing [3]
DNA damage-inducible transcript 3 protein (DDIT3) OTI8YKKE DDIT3_HUMAN Gene/Protein Processing [6]
Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1) OTM0GDTP IF2A_HUMAN Post-Translational Modifications [6]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Gene/Protein Processing [4]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Protein Interaction/Cellular Processes [7]
Sterol 26-hydroxylase, mitochondrial (CYP27A1) OT649C01 CP27A_HUMAN Gene/Protein Processing [3]

References

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28 Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
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32 Gene expression analysis of precision-cut human liver slices indicates stable expression of ADME-Tox related genes. Toxicol Appl Pharmacol. 2011 May 15;253(1):57-69.
33 Potency of individual bile acids to regulate bile acid synthesis and transport genes in primary human hepatocyte cultures. Toxicol Sci. 2014 Oct;141(2):538-46. doi: 10.1093/toxsci/kfu151. Epub 2014 Jul 23.
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39 D-Penicillamine targets metastatic melanoma cells with induction of the unfolded protein response (UPR) and Noxa (PMAIP1)-dependent mitochondrial apoptosis. Apoptosis. 2012 Oct;17(10):1079-94.
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45 Evidence of securin-mediated resistance to gefitinib-induced apoptosis in human cancer cells. Chem Biol Interact. 2013 Apr 25;203(2):412-22. doi: 10.1016/j.cbi.2013.03.011. Epub 2013 Mar 22.
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50 Investigation of molecular mechanisms underlying the antiproliferative effects of colchicine against PC3 prostate cancer cells. Toxicol In Vitro. 2021 Jun;73:105138. doi: 10.1016/j.tiv.2021.105138. Epub 2021 Mar 6.
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53 Monomeric and oligomeric flavanols maintain the endogenous glucocorticoid response in human macrophages in pro-oxidant conditions in vitro. Chem Biol Interact. 2018 Aug 1;291:237-244.
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55 Ca(2+) Signaling and IL-8 Secretion in Human Testicular Peritubular Cells Involve the Cation Channel TRPV2. Int J Mol Sci. 2018 Sep 19;19(9):2829. doi: 10.3390/ijms19092829.
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57 Nitrogen mustard prevents transport of Fra-1 into the nucleus to promote c-Fos- and FosB-dependent IL-8 induction in injured mouse epidermis. Toxicol Lett. 2020 Feb 1;319:256-263. doi: 10.1016/j.toxlet.2019.10.006. Epub 2019 Oct 19.
58 ERE-independent ERalpha target genes differentially expressed in human breast tumors. Mol Cell Endocrinol. 2005 Dec 21;245(1-2):53-9. doi: 10.1016/j.mce.2005.10.003. Epub 2005 Nov 17.
59 An in vitro coculture system of human peripheral blood mononuclear cells with hepatocellular carcinoma-derived cells for predicting drug-induced liver injury. Arch Toxicol. 2021 Jan;95(1):149-168. doi: 10.1007/s00204-020-02882-4. Epub 2020 Aug 20.
60 Gypenosides protect retinal pigment epithelium cells from oxidative stress. Food Chem Toxicol. 2018 Feb;112:76-85.
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62 Some HIV antiretrovirals increase oxidative stress and alter chemokine, cytokine or adiponectin production in human adipocytes and macrophages. Antivir Ther. 2007;12(4):489-500.
63 Arsenite and cadmium promote the development of mammary tumors. Carcinogenesis. 2020 Jul 14;41(7):1005-1014. doi: 10.1093/carcin/bgz176.
64 Crosstalk between alveolar macrophages and alveolar epithelial cells/fibroblasts contributes to the pulmonary toxicity of gefitinib. Toxicol Lett. 2021 Mar 1;338:1-9. doi: 10.1016/j.toxlet.2020.11.011. Epub 2020 Nov 25.
65 Oxidative Stress Alters miRNA and Gene Expression Profiles in Villous First Trimester Trophoblasts. Biomed Res Int. 2015;2015:257090. doi: 10.1155/2015/257090. Epub 2015 Aug 3.
66 Cannabidiol selectively modulates interleukin (IL)-1 and IL-6 production in toll-like receptor activated human peripheral blood monocytes. Toxicology. 2021 Dec;464:153016. doi: 10.1016/j.tox.2021.153016. Epub 2021 Nov 2.
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