Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMM1IAU)

Drug Name
PHENYLTHIOUREA Drug Info
Synonyms
Phenylthiourea; N-Phenylthiourea; 1-Phenylthiourea; 103-85-5; 1-PHENYL-2-THIOUREA; Phenylthiocarbamide; Thiourea, phenyl-; Phenyl-2-thiourea; Urea, 1-phenyl-2-thio-; phenyl-thiourea; Thiourea, N-phenyl-; Fenylthiomocovina; USAF EK-1569; RCRA waste number P093; NCI-C02017; CCRIS 514; Fenylthiomocovina [Czech]; NSC 5779; N-Phenyl-Thiourea; N-phenylisothiourea; alpha-Phenylthiourea; U 6324; UNII-6F82C6Q54C; HSDB 4105; .alpha.-Phenylthiourea; EINECS 203-151-2; RCRA waste no. P093; AI3-07549; CHEMBL263376; CHEBI:46261
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
676454
ChEBI ID
CHEMBL263376
CAS Number
CAS 103-85-5
TTD Drug ID
DMM1IAU

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Tyrosinase (TYR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [6]
Monobenzone DMVJS2K Vitiligo ED63.0 Approved [6]
Multi-epitope peptide melanoma vaccine DMZPEHY Melanoma 2C30 Phase 3 [7]
Melanoma vaccine DMQEC6Z Melanoma 2C30 Phase 3 [8]
Polynoma-1 DM3QDA6 Melanoma 2C30 Phase 2 [9]
MKC-1106-MT DMXKOW6 Melanoma 2C30 Phase 2 [10]
Multi-epitope tyrosinase/gp100 vaccine DMN68ZL Melanoma 2C30 Phase 2 [11]
PMID29130358-Compound-Figure11(3) DMSME2B N. A. N. A. Patented [12]
Benzothiazole analog 1 DMHXFCQ Albinism EC23.2 Patented [13]
Monoamine derivative 2 DMAZ6DI Albinism EC23.2 Patented [13]
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Drug(s) Affected By Taste receptor type 2 member 38 (TAS2R38)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Propylthiouracil DM6D7N8 Hyperthyroidism 5A02 Approved [4]
Probenecid DMMFWOJ Acute gonococcal cervicitis Approved [4]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [14]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [15]
Drug(s) Affected By Protein c-Fos (FOS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [16]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [17]
Verapamil DMA7PEW Angina pectoris BA40 Approved [18]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [19]
Acebutolol DM0TI4U Hypertension BA00-BA04 Approved [18]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [20]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [21]
Methotrexate DM2TEOL Anterior urethra cancer Approved [22]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [23]
Quercetin DM3NC4M Obesity 5B81 Approved [24]
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Drug(s) Affected By Transcription factor p65 (RELA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [25]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [26]
Selenium DM25CGV N. A. N. A. Approved [27]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [28]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [29]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [30]
Quercetin DM3NC4M Obesity 5B81 Approved [31]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [32]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [33]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [34]
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Drug(s) Affected By Flavin-containing monooxygenase 3 (FMO3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [35]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [36]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [37]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [38]
Perazine DM2AOTZ Psychotic disorder 6A20-6A25 Approved [39]
Almogran DM7I64Z Migraine 8A80 Approved [40]
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [41]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [42]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [43]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [44]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Tyrosinase (TYR) TTULVH8 TYRO_HUMAN Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Flavin-containing monooxygenase 3 (FMO3) OT1G2EV3 FMO3_HUMAN Drug Response [2]
Protein c-Fos (FOS) OTJBUVWS FOS_HUMAN Gene/Protein Processing [3]
Taste receptor type 2 member 38 (TAS2R38) OTX5MM36 T2R38_HUMAN Gene/Protein Processing [4]
Transcription factor p65 (RELA) OTUJP9CN TF65_HUMAN Gene/Protein Processing [5]

References

1 Analogues of N-hydroxy-N'-phenylthiourea and N-hydroxy-N'-phenylurea as inhibitors of tyrosinase and melanin formation. Bioorg Med Chem Lett. 2008 Jun 15;18(12):3607-10.
2 Thiourea toxicity in mouse C3H/10T1/2 cells expressing human flavin-dependent monooxygenase 3. Biochem Pharmacol. 2002 Jun 1;63(11):1941-8. doi: 10.1016/s0006-2952(02)00978-4.
3 Role of CCK1 and Y2 receptors in activation of hindbrain neurons induced by intragastric administration of bitter taste receptor ligands. Am J Physiol Regul Integr Comp Physiol. 2008 Jan;294(1):R33-8. doi: 10.1152/ajpregu.00675.2007. Epub 2007 Nov 14.
4 Probenecid inhibits the human bitter taste receptor TAS2R16 and suppresses bitter perception of salicin. PLoS One. 2011;6(5):e20123.
5 Human glioblastoma ADF cells express tyrosinase, L-tyrosine hydroxylase and melanosomes and are sensitive to L-tyrosine and phenylthiourea. J Cell Physiol. 2006 Jun;207(3):675-82. doi: 10.1002/jcp.20603.
6 Identification of an Alkylhydroquinone from Rhus succedanea as an Inhibitor of Tyrosinase and Melanogenesis. J Agric Food Chem. 2009 Mar 25;57(6):2200-5.
7 Safety and immunogenicity of vaccination with MART-1 (26-35, 27L), gp100 (209-217, 210M), and tyrosinase (368-376, 370D) in-adjuvant with PF-3512676 and GM-CSF in metastatic melanoma. Correction in: volume 35 on page 650.
8 National Cancer Institute Drug Dictionary (drug id 685201).
9 An immuno-oncology company developing a novel polyvalent antigen therapy for the treatment of melanoma. Polynoma. 2015.
10 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
11 ClinicalTrials.gov (NCT00003362) Vaccine Therapy Plus Immune Adjuvants in Treating Patients With Advanced Melanoma. U.S. National Institutes of Health.
12 Gelatinase inhibitors: a patent review (2011-2017).Expert Opin Ther Pat. 2018 Jan;28(1):31-46.
13 Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62.
14 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
15 Cellular reactions to long-term volatile organic compound (VOC) exposures. Sci Rep. 2016 Dec 1;6:37842. doi: 10.1038/srep37842.
16 Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol. 2011 Dec;28(4):1225-54.
17 Cannabidiol Activates Neuronal Precursor Genes in Human Gingival Mesenchymal Stromal Cells. J Cell Biochem. 2017 Jun;118(6):1531-1546. doi: 10.1002/jcb.25815. Epub 2016 Dec 29.
18 Selection of drugs to test the specificity of the Tg.AC assay by screening for induction of the gadd153 promoter in vitro. Toxicol Sci. 2003 Aug;74(2):260-70. doi: 10.1093/toxsci/kfg113. Epub 2003 May 2.
19 Sertraline induces endoplasmic reticulum stress in hepatic cells. Toxicology. 2014 Aug 1;322:78-88. doi: 10.1016/j.tox.2014.05.007. Epub 2014 May 24.
20 Estrogen regulation in human breast cancer cells of new downstream gene targets involved in estrogen metabolism, cell proliferation and cell transformation. J Mol Endocrinol. 2004 Apr;32(2):397-414.
21 Microarray analysis of H2O2-, HNE-, or tBH-treated ARPE-19 cells. Free Radic Biol Med. 2002 Nov 15;33(10):1419-32.
22 Methotrexate induces production of IL-1 and IL-6 in the monocytic cell line U937. Arthritis Res Ther. 2014 Jan 20;16(1):R17. doi: 10.1186/ar4444.
23 Simvastatin inhibits NOR-1 expression induced by hyperlipemia by interfering with CREB activation. Cardiovasc Res. 2005 Aug 1;67(2):333-41. doi: 10.1016/j.cardiores.2005.03.016. Epub 2005 Apr 21.
24 The G protein-coupled receptor GPR30 mediates c-fos up-regulation by 17beta-estradiol and phytoestrogens in breast cancer cells. J Biol Chem. 2004 Jun 25;279(26):27008-16. doi: 10.1074/jbc.M403588200. Epub 2004 Apr 16.
25 Cannabidiol Modulates the Immunophenotype and Inhibits the Activation of the Inflammasome in Human Gingival Mesenchymal Stem Cells. Front Physiol. 2016 Nov 24;7:559. doi: 10.3389/fphys.2016.00559. eCollection 2016.
26 -Carotene Induces Apoptosis in Human Esophageal Squamous Cell Carcinoma Cell Lines via the Cav-1/AKT/NF-B Signaling Pathway. J Biochem Mol Toxicol. 2016 Mar;30(3):148-57. doi: 10.1002/jbt.21773. Epub 2016 Jan 6.
27 Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
28 Differential gene expression of sulindac-treated human breast epithelial cells. Int J Oncol. 2005 Dec;27(6):1727-36.
29 Suppression of RAGE as a basis of simvastatin-dependent plaque stabilization in type 2 diabetes. Arterioscler Thromb Vasc Biol. 2006 Dec;26(12):2716-23.
30 Prevention of deoxycholate-induced gastric apoptosis by aspirin: roles of NF-kappaB and PKC signaling. J Surg Res. 2008 Mar;145(1):66-73. doi: 10.1016/j.jss.2007.04.039. Epub 2007 Jul 20.
31 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
32 Peroxisome proliferator-activated receptor-gamma agonists inhibit respiratory syncytial virus-induced expression of intercellular adhesion molecule-1 in human lung epithelial cells. Immunology. 2007 May;121(1):71-81. doi: 10.1111/j.1365-2567.2006.02539.x.
33 Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and Am80-induced HL-60 cell differentiation revealed by DNA microarray analysis. Biochem Pharmacol. 2004 Dec 1;68(11):2177-86.
34 Glucosamine regulation of LPS-mediated inflammation in human bronchial epithelial cells. Eur J Pharmacol. 2010 Jun 10;635(1-3):219-26. doi: 10.1016/j.ejphar.2010.02.044. Epub 2010 Mar 20.
35 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
36 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
37 Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
38 Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
39 Cytochrome P-450 enzymes and FMO3 contribute to the disposition of the antipsychotic drug perazine in vitro. Psychopharmacology (Berl). 2000 Sep;151(4):312-20.
40 Identification of the human liver enzymes involved in the metabolism of the antimigraine agent almotriptan. Drug Metab Dispos. 2003 Apr;31(4):404-11.
41 Evaluation of fresh and cryopreserved hepatocytes as in vitro drug metabolism tools for the prediction of metabolic clearance. Drug Metab Dispos. 2004 Nov;32(11):1247-53. doi: 10.1124/dmd.104.000026. Epub 2004 Jul 30.
42 Identification and functional analysis of common human flavin-containing monooxygenase 3 genetic variants. J Pharmacol Exp Ther. 2007 Jan;320(1):266-73. doi: 10.1124/jpet.106.112268. Epub 2006 Oct 18.
43 Genetic polymorphisms of human flavin monooxygenase 3 in sulindac-mediated primary chemoprevention of familial adenomatous polyposis. Clin Cancer Res. 2004 Dec 15;10(24):8357-62. doi: 10.1158/1078-0432.CCR-04-1073.
44 Pharmacogenomics variation in drug metabolizing enzymes and transporters in relation to docetaxel toxicity in Lebanese breast cancer patients: paving the way for OMICs in low and middle income countries. OMICS. 2013 Jul;17(7):353-67. doi: 10.1089/omi.2013.0019. Epub 2013 Jun 11.