Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMN7Y9K)

Drug Name
Alpidem Drug Info
Synonyms
ALPIDEM; 82626-01-5; Ananxyl; Alpidemum [Latin]; UNII-I93SC245QZ; SL 80.0342-00; 2-(6-Chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)-N,N-dipropylacetamide; 6-Chloro-2-(p-chlorophenyl)-N,N-dipropylimidazo(1,2-a)pyridine-3-acetamide; CHEMBL54349; I93SC245QZ; S-800342; NCGC00182850-01; 6-Chlor-2-(4-chlorphenyl)-N,N-dipropylimidazol(1,2-a)pyridin-3-acetamid; DSSTox_RID_83237; DSSTox_CID_28972; DSSTox_GSID_49046; Alpidemum; 6-Chloro-2-(4-chlorophenyl)-N,N-dipropyl-imidazo[1,2-a]pyridine-3-acetamide
Indication
Disease Entry ICD 11 Status REF
Anxiety disorder 6B00-6B0Z Approved [1]
Cross-matching ID
PubChem CID
54897
ChEBI ID
CHEBI:135649
CAS Number
CAS 82626-01-5
TTD Drug ID
DMN7Y9K

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Gamma-aminobutyric acid receptor (GAR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [7]
Allopregnanolone DMNLHAC Depression 6A70-6A7Z approved [8]
THIOCOLCHICOSIDE DMEPWYA Muscle spasm MB47.3 Approved [9]
Clonazepam DMTO13J Absence epilepsy Approved [10]
Piperazine DMTY9LU Ascariasis 1F62 Approved [11]
Moxidectin DMYGHX5 Onchocerciasis 1F6A Approved [12]
DP-VPA DMGOXPQ Bipolar disorder 6A60 Approved [13]
ANDROSTERONE DMITJAK N. A. N. A. Phase 3 [8]
ZK-93423 DMFWMKZ Epileptic seizures 8A61-8A6Z Phase 3 [14]
GSK683699 DMTW79H Inflammatory bowel disease DD72 Phase 2 [9]
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Drug(s) Targeting Translocator protein (TSPO)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Diazepam DM08E9O Alcohol withdrawal Approved [15]
Flunitrazepam DMGR5Z3 Insomnia 7A00-7A0Z Approved [16]
Oxazepam DMXNZM4 Alcohol withdrawal delirium Approved [17]
Midazolam DMXOELT Agitation 6A70.3 Approved [18]
Temazepam DM02A65 Insomnia 7A00-7A0Z Approved [18]
Flumazenil DMPCG2L Benzodiazepine overdose PC91 Approved [19]
Alprazolam DMC7XDN Anxiety Approved [16]
Clotiazepam DM59AZT Anxiety disorder 6B00-6B0Z Approved [20]
Quazepam DMY4D87 Insomnia 7A00-7A0Z Approved [18]
Eszopiclone DM8RZ9H Insomnia 7A00-7A0Z Approved [21]
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Drug(s) Affected By Proepiregulin (EREG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [22]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [4]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [23]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [4]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [4]
Methotrexate DM2TEOL Anterior urethra cancer Approved [24]
Quercetin DM3NC4M Obesity 5B81 Approved [25]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [26]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [27]
Penbutolol DM4ES8F Hypertension BA00-BA04 Approved [4]
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Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [28]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [29]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [30]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [31]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [32]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [33]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [4]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [34]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [35]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [4]
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Drug(s) Affected By Bone morphogenetic protein 6 (BMP6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [4]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [4]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [36]
Penbutolol DM4ES8F Hypertension BA00-BA04 Approved [4]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [4]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [4]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [4]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [37]
Etodolac DM6WJO9 Osteoarthritis FA00-FA05 Approved [4]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [38]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [39]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [40]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [41]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [42]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [43]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [44]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [45]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [46]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [47]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [48]
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Drug(s) Affected By Caspase-7 (CASP7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [49]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [50]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [51]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [52]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [5]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [5]
Methotrexate DM2TEOL Anterior urethra cancer Approved [24]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [53]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [54]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [55]
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Drug(s) Affected By Tumor necrosis factor-inducible gene 6 protein (TNFAIP6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [56]
Selenium DM25CGV N. A. N. A. Approved [57]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [4]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [26]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [58]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [59]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [4]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [4]
Trihexyphenidyl DMB19L8 Dystonia 8A02 Approved [4]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [4]
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Drug(s) Affected By Potassium voltage-gated channel subfamily H member 2 (KCNH2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Metoclopramide DMFA5MY Nausea MD90 Approved [60]
Quinidine DMLPICK N. A. N. A. Approved [61]
Verapamil DMA7PEW Angina pectoris BA40 Approved [62]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [6]
Clarithromycin DM4M1SG Acute maxillary sinusitis Approved [6]
Disopyramide DM5SYZP Long QT syndrome BC65.0 Approved [63]
Propranolol DM79NTF Angina pectoris BA40 Approved [64]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [65]
Dofetilide DMPN1TW Sinus rhythm disorder BC9Y Approved [66]
Flecainide DMSQDLE Tachyarrhythmias BC71 Approved [6]
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Drug(s) Affected By Interleukin-24 (IL24)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [67]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [4]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [33]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [4]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [4]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [68]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [26]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Penbutolol DM4ES8F Hypertension BA00-BA04 Approved [4]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [69]
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Drug(s) Affected By PTB-containing, cubilin and LRP1-interacting protein (PID1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [4]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [4]
Penbutolol DM4ES8F Hypertension BA00-BA04 Approved [4]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [4]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [4]
Amikacin DM5PDRB Bacteremia 1A73 Approved [4]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [4]
Promethazine DM6I5GR Hyperemesis gravidarum Approved [4]
Etodolac DM6WJO9 Osteoarthritis FA00-FA05 Approved [4]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [70]
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Drug(s) Affected By Cystine/glutamate transporter (SLC7A11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [71]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [4]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [72]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [4]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [4]
Methotrexate DM2TEOL Anterior urethra cancer Approved [73]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [74]
Quercetin DM3NC4M Obesity 5B81 Approved [25]
Fluoxetine DM3PD2C Bipolar depression Approved [75]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Gamma-aminobutyric acid receptor (GAR) TTNJYV2 NOUNIPROTAC Inhibitor [2]
Translocator protein (TSPO) TTPTXIN TSPO_HUMAN Inhibitor [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Bone morphogenetic protein 6 (BMP6) OT9WN536 BMP6_HUMAN Gene/Protein Processing [4]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [5]
Caspase-7 (CASP7) OTAPJ040 CASP7_HUMAN Gene/Protein Processing [5]
Cystine/glutamate transporter (SLC7A11) OTKJ6PXW XCT_HUMAN Gene/Protein Processing [4]
Interleukin-24 (IL24) OT4VUWH1 IL24_HUMAN Gene/Protein Processing [4]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Gene/Protein Processing [4]
Potassium voltage-gated channel subfamily H member 2 (KCNH2) OTZX881H KCNH2_HUMAN Gene/Protein Processing [6]
Proepiregulin (EREG) OTRM4NQY EREG_HUMAN Gene/Protein Processing [4]
PTB-containing, cubilin and LRP1-interacting protein (PID1) OT5YJ7FI PCLI1_HUMAN Gene/Protein Processing [4]
Tumor necrosis factor-inducible gene 6 protein (TNFAIP6) OT1SLUZH TSG6_HUMAN Gene/Protein Processing [4]

References

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31 Calcium pantothenate modulates gene expression in proliferating human dermal fibroblasts. Exp Dermatol. 2009 Nov;18(11):969-78. doi: 10.1111/j.1600-0625.2009.00884.x. Epub 2009 Apr 8.
32 Nitrogen mustard prevents transport of Fra-1 into the nucleus to promote c-Fos- and FosB-dependent IL-8 induction in injured mouse epidermis. Toxicol Lett. 2020 Feb 1;319:256-263. doi: 10.1016/j.toxlet.2019.10.006. Epub 2019 Oct 19.
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49 Cannabidiol Effectively Promoted Cell Death in Bladder Cancer and the Improved Intravesical Adhesion Drugs Delivery Strategy Could Be Better Used for Treatment. Pharmaceutics. 2021 Sep 7;13(9):1415. doi: 10.3390/pharmaceutics13091415.
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54 Simvastatin induces apoptosis and alters cytoskeleton in endometrial stromal cells. J Clin Endocrinol Metab. 2010 Jul;95(7):3453-9. doi: 10.1210/jc.2010-0072. Epub 2010 Apr 28.
55 The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib. Toxicol Sci. 2023 Dec 21;197(1):69-78. doi: 10.1093/toxsci/kfad099.
56 Unique signatures of stress-induced senescent human astrocytes. Exp Neurol. 2020 Dec;334:113466. doi: 10.1016/j.expneurol.2020.113466. Epub 2020 Sep 17.
57 Changes in gene expression profiles in response to selenium supplementation among individuals with arsenic-induced pre-malignant skin lesions. Toxicol Lett. 2007 Mar 8;169(2):162-76. doi: 10.1016/j.toxlet.2007.01.006. Epub 2007 Jan 19.
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59 Global effects of inorganic arsenic on gene expression profile in human macrophages. Mol Immunol. 2009 Feb;46(4):649-56.
60 Comparison of the effects of metoclopramide and domperidone on HERG channels. Pharmacology. 2005 Apr;74(1):31-6. doi: 10.1159/000083234. Epub 2005 Jan 7.
61 Further insights into the effect of quinidine in short QT syndrome caused by a mutation in HERG. J Cardiovasc Electrophysiol. 2005 Jan;16(1):54-8. doi: 10.1046/j.1540-8167.2005.04470.x.
62 Automated tight seal electrophysiology for assessing the potential hERG liability of pharmaceutical compounds. Assay Drug Dev Technol. 2004 Oct;2(5):497-506. doi: 10.1089/adt.2004.2.497.
63 Pharmacology of the short QT syndrome N588K-hERG K+ channel mutation: differential impact on selected class I and class III antiarrhythmic drugs. Br J Pharmacol. 2008 Nov;155(6):957-66. doi: 10.1038/bjp.2008.325. Epub 2008 Aug 25.
64 Comparison of HERG channel blocking effects of various beta-blockers-- implication for clinical strategy. Br J Pharmacol. 2006 Mar;147(6):642-52. doi: 10.1038/sj.bjp.0706508.
65 Inhibitory effects of the class III antiarrhythmic drug amiodarone on cloned HERG potassium channels. Naunyn Schmiedebergs Arch Pharmacol. 1999 Mar;359(3):212-9. doi: 10.1007/pl00005344.
66 Redox state dependency of HERGS631C channel pharmacology: relation to C-type inactivation. FEBS Lett. 2000 May 26;474(1):111-5. doi: 10.1016/s0014-5793(00)01586-6.
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