Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMNOSWU)

• Drug Name: Anisodine Drug Info
• Synonyms: anisodine; 52646-92-1; SCHEMBL474045; AC1N31M8; 2,3-Dihydroxy-2-phenylpropanoic acid 9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonane-7alpha-yl ester

Indication

Disease Entry	ICD 11	Status	REF
Central and peripheral nervous disease	8A04-8E7Z	Approved	[1]

• Cross-matching ID:
  PubChem CID: 11616712
  CAS Number: CAS 52646-92-1
  TTD Drug ID: DMNOSWU

Molecule-Related Drug Atlas

Drug(s) Targeting Adrenergic receptor beta-1 (ADRB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[3]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[4]
Norepinephrine	DMOUC09	Alopecia	ED70	Approved	[5]
Atenolol	DMNKG1Z	Angina pectoris	BA40	Approved	[6]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[6]
Metoprolol	DMOJ0V6	Acute coronary syndrome	BA41	Approved	[6]
Timolol	DM3NXRU	High blood pressure	BA00	Approved	[7]
Isoproterenol	DMK7MEY	Atrioventricular block		Approved	[8]
Betaxolol	DM6EUL5	Hypertension	BA00-BA04	Approved	[9]
Sotalol	DML60TN	Sinus rhythm disorder	BC9Y	Approved	[10]

Drug(s) Targeting Muscarinic acetylcholine receptor M5 (CHRM5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Promazine	DMZAL7W	Acute intermittent hepatic porphyria	5C58.11	Approved	[11]
ACECLIDINE	DMOLNCZ	Glaucoma/ocular hypertension	9C61	Approved	[12]
Pilocarpine	DMV9ADG	Glaucoma/ocular hypertension	9C61	Approved	[13]
Atropine	DMEN6X7	Organophosphate poisoning	NE6Z	Approved	[14]
Propiverine	DMUWBIJ	Urinary incontinence	MF50.2	Approved	[15]
Umeclidinium	DM4E8O9	Chronic obstructive pulmonary disease	CA22	Approved	[16]
Cimetropium bromide	DMZHPNE	Gastric motility disorder	DA21	Approved	[17]
Butylscopolamine	DMZKXB7	Dysmenorrhea	GA34.3	Approved	[18]
Trospium	DMX6RTG	Overactive bladder	GC50.0	Approved	[19]
Choline alfoscerate	DMOI1ZF	Amnesia	MB21.1	Approved	[20]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adrenergic receptor beta-1 (ADRB1)	TTR6W5O	ADRB1_HUMAN	Modulator	[2]
Muscarinic acetylcholine receptor M5 (CHRM5)	TTH18TF	ACM5_HUMAN	Modulator	[2]

References

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• [3] Beta-blockers in the treatment of hypertension: are there clinically relevant differences Postgrad Med. 2009 May;121(3):90-8.
• [4] Adrenergic activation of electrogenic K+ secretion in guinea pig distal colonic epithelium: involvement of beta1- and beta2-adrenergic receptors. Am J Physiol Gastrointest Liver Physiol. 2009 Aug;297(2):G269-77.
• [5] Impact of exogenous beta-adrenergic receptor stimulation on hepatosplanchnic oxygen kinetics and metabolic activity in septic shock. Crit Care Med. 1999 Feb;27(2):325-31.
• [6] Prediction and experimental validation of acute toxicity of beta-blockers in Ceriodaphnia dubia. Environ Toxicol Chem. 2005 Oct;24(10):2470-6.
• [7] Topical dorzolamide 2%/timolol 0.5% ophthalmic solution: a review of its use in the treatment of glaucoma and ocular hypertension. Drugs Aging. 2006;23(12):977-95.
• [8] Current therapeutic uses and potential of beta-adrenoceptor agonists and antagonists. Eur J Clin Pharmacol. 1998 Feb;53(6):389-404.
• [9] beta-adrenergic enhancement of brain kynurenic acid production mediated via cAMP-related protein kinase A signaling. Prog Neuropsychopharmacol Biol Psychiatry. 2009 Apr 30;33(3):519-29.
• [10] beta(2)-adrenoceptors are critical for antidepressant treatment of neuropathic pain. Ann Neurol. 2009 Feb;65(2):218-25.
• [11] Muscarinic cholinergic and histamine H1 receptor binding of phenothiazine drug metabolites. Life Sci. 1988;43(5):405-12.
• [12] Design, synthesis, and neurochemical evaluation of 5-(3-alkyl-1,2,4- oxadiazol-5-yl)-1,4,5,6-tetrahydropyrimidines as M1 muscarinic receptor agonists. J Med Chem. 1993 Apr 2;36(7):842-7.
• [13] Retinoic acid prevents virus-induced airway hyperreactivity and M2 receptor dysfunction via anti-inflammatory and antiviral effects. Am J Physiol Lung Cell Mol Physiol. 2009 Aug;297(2):L340-6.
• [14] Additive protective effects of donepezil and nicotine against salsolinol-induced cytotoxicity in SH-SY5Y cells. Neurotox Res. 2009 Oct;16(3):194-204.
• [15] Affinity profiles of various muscarinic antagonists for cloned human muscarinic acetylcholine receptor (mAChR) subtypes and mAChRs in rat heart and submandibular gland. Life Sci. 1999;64(25):2351-8.
• [16] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7354).
• [17] Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77.
• [18] Comparison of pharmacological effects of L- and DL-n-butyl-scopolamine in rat uterus. Yao Xue Xue Bao. 1994;29(1):24-7.
• [19] Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.
• [20] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 467).