Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMP5I47)

• Drug Name: Dimethylallyl Diphosphate Drug Info
• Synonyms: di-CH3-allyl-PPi; dimethylallyl-PP; prenyl diphosphate trianion; delta-Prenyl diphosphate; prenyl-diphosphate; delta2-isopentenyl-diphosphate; prenyl diphosphate(3-); prenyl pyrophosphate trianion; polycis-polyprenyl diphosphate; GTPL3049; CHEBI:83374; CHEBI:57623; CTK4H5497; CHEBI:58914; CBIDRCWHNCKSTO-UHFFFAOYSA-K; Dimethylallyl pyrophosphate trianion; an all-trans-polyprenyl diphosphate; 3-methylbut-2-en-1-yl diphosphate; all-cis-polyprenyl diphosphate(3-); poly-cis-polyprenyl diphosphate(3-); all-trans-polyprenyl diphospha

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 647
  ChEBI ID: CHEMBL343480
  CAS Number: CAS 358-72-5
  TTD Drug ID: DMP5I47

Molecule-Related Drug Atlas

Drug(s) Targeting Geranyltranstransferase (FDPS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[4]
Minodronate	DM50PMY	Osteoporosis	FB83.0	Approved	[5]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[4]
Alendronate	DMY2KX9	Bone Paget disease		Approved	[4]
Pamidronate	DMB4AVP	Bone Paget disease		Approved	[6]
Incadronate	DM3DSVJ	Hypercalcaemia	5B91.0	Approved	[7]
Risedronate	DM5FLTY	Bone Paget disease		Approved	[8]
NERIDRONIC ACID	DMMPG5V	Bone disease	FC0Z	Approved	[9]
Zarnestra	DMF30HL	Acute myeloid leukaemia	2A60	Phase 3	[10]
GERANYLGERANYL DIPHOSPHATE	DMJZ0AM	Discovery agent	N.A.	Investigative	[2]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[11]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[12]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[13]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[14]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[15]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[16]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[16]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[18]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[19]

Drug(s) Affected By Interleukin-12 receptor subunit beta-1 (IL12RB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[20]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[21]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[22]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[20]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[23]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[24]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[25]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[26]
4-hydroxy-2-nonenal	DM2LJFZ	Discovery agent	N.A.	Investigative	[27]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[28]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Geranyltranstransferase (FDPS)	TTIKWV4	FPPS_HUMAN	Inhibitor	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Interleukin-12 receptor subunit beta-1 (IL12RB1)	OTM1IJO2	I12R1_HUMAN	Gene/Protein Processing	[3]
Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B)	OTDS2EAR	TNR1B_HUMAN	Gene/Protein Processing	[3]

References

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• [2] The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
• [3] Vgamma9/Vdelta2 T lymphocytes in Italian patients with Beh?et's disease: evidence for expansion, and tumour necrosis factor receptor II and interleukin-12 receptor beta1 expression in active disease. Arthritis Res Ther. 2003;5(5):R262-8. doi: 10.1186/ar785. Epub 2003 Jun 30.
• [4] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
• [5] Synthesis, chiral high performance liquid chromatographic resolution and enantiospecific activity of a potent new geranylgeranyl transferase inhibitor, 2-hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosphonopropionic acid. J Med Chem. 2010 May 13;53(9):3454-64.
• [6] Detection of nonsterol isoprenoids by HPLC-MS/MS. Anal Biochem. 2008 Dec 1;383(1):18-24.
• [7] Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates. J Pharmacol Exp Ther. 2001 Feb;296(2):235-42.
• [8] Activity of bisphosphonates against Trypanosoma brucei rhodesiense. J Med Chem. 2002 Jul 4;45(14):2904-14.
• [9] Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of hu... J Med Chem. 2008 Apr 10;51(7):2187-95.
• [10] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [11] Identification of genes linked to gefitinib treatment in prostate cancer cell lines with or without resistance to androgen: a clue to application of gefitinib to hormone-resistant prostate cancer. Oncol Rep. 2006 Jun;15(6):1453-60.
• [12] Integrated assessment by multiple gene expression analysis of quercetin bioactivity on anticancer-related mechanisms in colon cancer cells in vitro. Eur J Nutr. 2005 Mar;44(3):143-56. doi: 10.1007/s00394-004-0503-1. Epub 2004 Apr 30.
• [13] Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicol In Vitro. 2017 Mar;39:93-103.
• [14] Arsenic suppresses gene expression in promyelocytic leukemia cells partly through Sp1 oxidation. Blood. 2005 Jul 1;106(1):304-10.
• [15] Hydroquinone Exposure Worsens Rheumatoid Arthritis through the Activation of the Aryl Hydrocarbon Receptor and Interleukin-17 Pathways. Antioxidants (Basel). 2021 Jun 7;10(6):929. doi: 10.3390/antiox10060929.
• [16] Circulating endothelial progenitor cells in multiple myeloma: implications and significance. Blood. 2005 Apr 15;105(8):3286-94. doi: 10.1182/blood-2004-06-2101. Epub 2004 Dec 23.
• [17] Stem cell transcriptome responses and corresponding biomarkers that indicate the transition from adaptive responses to cytotoxicity. Chem Res Toxicol. 2017 Apr 17;30(4):905-922.
• [18] Alcohol and Cannabinoids Differentially Affect HIV Infection and Function of Human Monocyte-Derived Dendritic Cells (MDDC). Front Microbiol. 2015 Dec 22;6:1452. doi: 10.3389/fmicb.2015.01452. eCollection 2015.
• [19] Repurposing L-menthol for systems medicine and cancer therapeutics? L-menthol induces apoptosis through caspase 10 and by suppressing HSP90. OMICS. 2016 Jan;20(1):53-64.
• [20] Prostaglandin E2 and dexamethasone inhibit IL-12 receptor expression and IL-12 responsiveness. J Immunol. 1998 Sep 15;161(6):2723-30.
• [21] Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
• [22] Prenatal arsenic exposure and the epigenome: identifying sites of 5-methylcytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes. Toxicol Sci. 2015 Jan;143(1):97-106. doi: 10.1093/toxsci/kfu210. Epub 2014 Oct 10.
• [23] Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen. Clin Pharmacol Ther. 2016 Apr;99(4):432-41.
• [24] Functional expression of IL-12 receptor by human eosinophils: IL-12 promotes eosinophil apoptosis. J Immunol. 2001 Jul 15;167(2):1039-46. doi: 10.4049/jimmunol.167.2.1039.
• [25] Bromodomain-containing protein 4 (BRD4) regulates RNA polymerase II serine 2 phosphorylation in human CD4+ T cells. J Biol Chem. 2012 Dec 14;287(51):43137-55.
• [26] Effect of aflatoxin B(1), benzo[a]pyrene, and methapyrilene on transcriptomic and epigenetic alterations in human liver HepaRG cells. Food Chem Toxicol. 2018 Nov;121:214-223. doi: 10.1016/j.fct.2018.08.034. Epub 2018 Aug 26.
• [27] Microarray analysis of H2O2-, HNE-, or tBH-treated ARPE-19 cells. Free Radic Biol Med. 2002 Nov 15;33(10):1419-32.
• [28] Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.