Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMPFD6Y)

Drug Name

Oxindole 94 Drug Info

Synonyms

SB 202190; 152121-30-7; SB202190; SB-202190; FHPI; SB202190 (FHPI); UNII-PVX798P8GI; 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole; CHEBI:79090; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole; PVX798P8GI; SB 202190, Immobilized; C20H14FN3O; Phenol, 4-[4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-; 4-[4-(4-fluorophenyl)-5-(pyridin-4-yl)-1H-imidazol-2-yl]phenol; 4-[5-(4-fluorophenyl)-4-(pyridin-4-yl)-1H-imidazol-2-yl]phenol

Indication

Disease Entry	ICD 11	Status	REF
Pain	MG30-MG3Z	Investigative	[1]

Cross-matching ID

PubChem CID: 5169
ChEBI ID: CHEBI:79090
CAS Number: CAS 152121-30-7
TTD Drug ID: DMPFD6Y

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Clinical Trial Drug(s)

Patented Agent(s)

Preclinical Drug(s)

Investigative Drug(s)

Approved Drug(s)

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Drug(s) Targeting Cyclin-dependent kinase 8 (CDK8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
SEL120	DMHCUZV	Acute myeloid leukaemia	2A60	Phase 1	[13]
Tricyclic benzimidazole derivative 1	DM5SD9E	N. A.	N. A.	Patented	[14]
Macrocycle derivative 14	DMXSRPH	N. A.	N. A.	Patented	[14]
CCT251545	DMNA9KW	Colorectal cancer	2B91.Z	Preclinical	[15]
Oxindole 16 (compound 3)	DMM5208	Discovery agent	N.A.	Investigative	[2]
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Drug(s) Targeting Stress-activated protein kinase 2a (p38 alpha)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ozagrel	DMIGKA1	Xerophthalmia	5B55.Y	Phase 4	[16]
Losmapimod	DMIL37Z	Acute coronary syndrome	BA41	Phase 3	[16]
VX-702	DMKJDR6	Coronary artery disease	BA80	Phase 2a	[17]
VX-745	DMJAEG6	Alzheimer disease	8A20	Phase 2	[18]
Dilmapimod	DMBYJ92	Acute lung injury	NB32.3	Phase 2	[16]
PMID25991433-Compound-A1	DM89LF0	N. A.	N. A.	Patented	[19]
PMID25991433-Compound-F2	DM37VIQ	N. A.	N. A.	Patented	[19]
PMID25991433-Compound-L2	DM58UO9	N. A.	N. A.	Patented	[19]
PMID25991433-Compound-L3	DM3LWUR	N. A.	N. A.	Patented	[19]
PMID25991433-Compound-L1	DM2135Y	N. A.	N. A.	Patented	[19]
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Drug(s) Targeting Prostaglandin G/H synthase 2 (COX-2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[20]
Naproxen	DMZ5RGV	Bursitis		Approved	[21]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[22]
Indomethacin	DMSC4A7	Bursitis		Approved	[23]
Celecoxib	DM6LOQU	Dysmenorrhea	GA34.3	Approved	[24]
Nabumetone	DMAT2XH	Osteoarthritis	FA00-FA05	Approved	[25]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[26]
Flurbiprofen	DMGN4BY	Osteoarthritis	FA00-FA05	Approved	[27]
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[28]
Aminosalicylic Acid	DMENSL5	Crohn disease	DD70	Approved	[23]
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Drug(s) Affected By Mitogen-activated protein kinase 11 (MAPK11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[29]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[30]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[31]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[32]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[33]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[34]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[34]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[37]
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Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[38]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[39]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[40]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[41]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[42]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[43]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[44]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[45]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[46]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[47]
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Drug(s) Affected By Defensin beta 4A (DEFB4A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[48]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[49]
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Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[50]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[51]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[52]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[53]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[54]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[53]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[55]
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[57]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[58]
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Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[59]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[60]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[61]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[62]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[63]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[64]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[65]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[66]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[67]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[68]
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Drug(s) Affected By Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[69]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[70]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[71]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[72]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[73]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[51]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[74]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[55]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[75]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[69]
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Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[76]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[77]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[72]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[78]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[51]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[81]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[82]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[30]
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Drug(s) Affected By C-C chemokine receptor type 2 (CCR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[83]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[84]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[85]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[86]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[88]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[89]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[5]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[90]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[91]
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Drug(s) Affected By NAD-dependent protein deacetylase sirtuin-1 (SIRT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[92]
Selenium	DM25CGV	N. A.	N. A.	Approved	[29]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[93]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[94]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[95]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[96]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[97]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[98]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[99]
Olaparib	DM8QB1D	Ovarian cancer	2C73	Approved	[100]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cyclin-dependent kinase 8 (CDK8)	TTBJR4L	CDK8_HUMAN	Inhibitor	[2]
Prostaglandin G/H synthase 2 (COX-2)	TTVKILB	PGH2_HUMAN	Inhibitor	[3]
Stress-activated protein kinase 2a (p38 alpha)	TTQBR95	MK14_HUMAN	Inhibitor	[4]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
C-C chemokine receptor type 2 (CCR2)	OTQ7T10J	CCR2_HUMAN	Gene/Protein Processing	[5]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Post-Translational Modifications	[6]
Cytochrome P450 1A1 (CYP1A1)	OTE4EFH8	CP1A1_HUMAN	Gene/Protein Processing	[7]
Defensin beta 4A (DEFB4A)	OTQEI15K	DFB4A_HUMAN	Gene/Protein Processing	[8]
Heme oxygenase 1 (HMOX1)	OTC1W6UX	HMOX1_HUMAN	Gene/Protein Processing	[9]
Interleukin-1 beta (IL1B)	OT0DWXXB	IL1B_HUMAN	Protein Interaction/Cellular Processes	[10]
Interleukin-6 (IL6)	OTUOSCCU	IL6_HUMAN	Gene/Protein Processing	[11]
Mitogen-activated protein kinase 11 (MAPK11)	OT0AS010	MK11_HUMAN	Gene/Protein Processing	[12]
NAD-dependent protein deacetylase sirtuin-1 (SIRT1)	OTAYZMOY	SIR1_HUMAN	Gene/Protein Processing	[8]

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References

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