Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMPV1LU)

• Drug Name: 2'-deoxyuridylic acid Drug Info
• Synonyms: dUMP; 2'-deoxyuridylic acid; Deoxyuridine monophosphate; Deoxyuridylic acid; 2'-Deoxyuridine 5'-monophosphate; 2'-deoxy-5'-uridylic acid; Deoxyuridine 5'-phosphate; 2'-Deoxyuridine 5'-phosphate; Deoxy-UMP; 2'-Deoxyuridylate; 964-26-1; 2'-DEOXYURIDINE-5'-MONOPHOSPHATE; Deoxyuridine 5'-monophosphate; 5'-Uridylic acid, 2'-deoxy-; deoxyuridylate; Uridine, 2'-deoxy-, 5'-phosphate; EINECS 213-518-9; Uridine, 2'-deoxy-, 5'-(dihydrogen phosphate); BRN 0042143; CHEMBL211312; CHEBI:17622; JSRLJPSBLDHEIO-SHYZEUOFSA-N; 42155-08-8; 1tsy; 1tsv

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 65063
  ChEBI ID: CHEBI:17622
  CAS Number: CAS 964-26-1
  TTD Drug ID: DMPV1LU
  INTEDE Drug ID: DR2009

Molecule-Related Drug Atlas

Drug(s) Targeting Bacterial Deoxyuridine triphosphate nucleotidohydrolase (Bact dut)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetate Ion	DMD08RH	Discovery agent	N.A.	Investigative	[1]
Deoxyuridine-5'-Triphosphate	DMCG5V2	Discovery agent	N.A.	Investigative	[1]
1-[(Z)-4-trityloxy-2-butenyl]uracil	DMIHBFO	Discovery agent	N.A.	Investigative	[5]
2'-deoxyuridine 5'-alpha,beta-imido-diphosphate	DMXV27U	Discovery agent	N.A.	Investigative	[6]
1-[2-(trityloxy)ethoxymethyl]uracil	DM98F0U	Discovery agent	N.A.	Investigative	[5]
1-[4-hydroxy-3-(tritylaminomethyl)butyl]uracil	DMHXAMR	Discovery agent	N.A.	Investigative	[5]
Deoxyuridine-5'-Diphosphate	DMIFMDC	Discovery agent	N.A.	Investigative	[6]
1-(3-tritylaminopropyl)uracil	DMZPJM4	Discovery agent	N.A.	Investigative	[5]
2'-Deoxyuridine 5'-Alpha,Beta-Imido-Triphosphate	DMOHABR	Discovery agent	N.A.	Investigative	[1]

Drug(s) Targeting Candida Thymidylate synthase (Candi TMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[7]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[8]
Pemetrexed	DMMX2E6	Central nervous system lymphoma	2B33.5	Approved	[9]
Trifluridine	DMG2YBD	Herpetic keratitis	1F00.10	Approved	[10]
Capecitabine	DMTS85L	Adenocarcinoma	2D40	Approved	[11]
Raltitrexed	DMT9K8G	Rectal adenocarcinoma	2B92	Approved	[12]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[13]
Flucytosine	DM13VTW	Cryptococcal meningitis		Approved	[14]
Nolatrexed	DMOF0CA	Solid tumour/cancer	2A00-2F9Z	Phase 3	[15]
Plevitrexed (R)-isomer	DMTL39C	Gastric adenocarcinoma	2B72	Phase 2	[16]

Drug(s) Metabolized By Thymidylate synthase (TYMS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[17]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[18]

Drug(s) Affected By ATP-binding cassette sub-family C member 5 (ABCC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[19]
Pemetrexed	DMMX2E6	Central nervous system lymphoma	2B33.5	Approved	[4]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[20]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[21]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[22]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[23]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[24]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[25]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[27]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial Deoxyuridine triphosphate nucleotidohydrolase (Bact dut)	TTY8KJS	DUT_ECOLI	Inhibitor	[1]
Candida Thymidylate synthase (Candi TMP1)	TTU6BFZ	TYSY_CANAL	Inhibitor	[1]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Thymidylate synthase (TYMS)	DEASG0Q	TYSY_HUMAN	Substrate	[2]
Thymidylate synthase (thyA)	DEH4O6C	TYSY_LACCA	Substrate	[3]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
ATP-binding cassette sub-family C member 5 (ABCC5)	OT34G4US	MRP5_HUMAN	Regulation of Drug Effects	[4]

References

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• [16] Cooperative inhibition of human thymidylate synthase by mixtures of active site binding and allosteric inhibitors. Biochemistry. 2007 Mar 13;46(10):2823-30.
• [17] The pharmacogenetics of methotrexate. Rheumatology (Oxford). 2007 Oct;46(10):1520-4.
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• [22] Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses. PLoS One. 2010 Dec 17;5(12):e14352. doi: 10.1371/journal.pone.0014352.
• [23] ATP binding cassette multidrug transporters limit the anti-HIV activity of zidovudine and indinavir in infected human macrophages. Antivir Ther. 2004 Aug;9(4):519-28.
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