Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMQ4Z6E)

• Drug Name: ISORHAMNETIN Drug Info
• Synonyms: Isorhamnetin; 480-19-3; 3-Methylquercetin; Isorhamnetol; 3'-Methoxyquercetin; 3'-Methoxy-3,4',5,7-tetrahydroxyflavone; isorhamnetine; 3'-Methylquercetin; C.I. 75680; 3-Methylquercetine; UNII-07X3IB4R4Z; CCRIS 3791; C16H12O7; EINECS 207-545-5; Flavone, 3'-methoxy-3,4',5,7-tetrahydroxy-; BRN 0044723; 3,5,7,4'-Tetrahydroxy-3'-methoxyflavone; CHEMBL379064; CHEBI:6052; 07X3IB4R4Z

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 5281654
  ChEBI ID: CHEMBL379064
  CAS Number: CAS 480-19-3
  TTD Drug ID: DMQ4Z6E

Molecule-Related Drug Atlas

Drug(s) Targeting Plasmodium Enoyl-ACP reductase (Malaria fabI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[5]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[6]
Nicotinamide-Adenine-Dinucleotide	DM9LRKB	N. A.	N. A.	Investigative	[7]
Beta-D-Glucose	DM5IHYP	Discovery agent	N.A.	Investigative	[7]
MORIN	DM2OGZ5	Discovery agent	N.A.	Investigative	[2]
3,7,3',4'-TETRAHYDROXYFLAVONE	DMES906	Discovery agent	N.A.	Investigative	[2]
(-)-CATECHINGALLATE	DMZOGSK	Discovery agent	N.A.	Investigative	[2]
Thiolactomycin	DMBAWDG	Malaria	1F40-1F45	Investigative	[5]
GALLOCATECHIN GALLATE	DMX2084	Discovery agent	N.A.	Investigative	[2]
Diazaborines	DM5UFZX	Discovery agent	N.A.	Investigative	[8]

Drug(s) Targeting Plasmodium Oxoacyl-[acyl-carrier protein] reductase (Malaria fabG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[2]
Chrysin	DM7V2LG	Discovery agent	N.A.	Investigative	[2]
KAEMPFEROL	DMHEMUB	Discovery agent	N.A.	Investigative	[2]
MORIN	DM2OGZ5	Discovery agent	N.A.	Investigative	[2]
3,7,3',4'-TETRAHYDROXYFLAVONE	DMES906	Discovery agent	N.A.	Investigative	[2]
(-)-CATECHINGALLATE	DMZOGSK	Discovery agent	N.A.	Investigative	[2]
2-Hexadecynoic acid	DMTFIPZ	Discovery agent	N.A.	Investigative	[9]
GALLOCATECHIN GALLATE	DMX2084	Discovery agent	N.A.	Investigative	[2]
NADPH	DM75Q34	Discovery agent	N.A.	Investigative	[10]

Drug(s) Targeting Cytochrome P450 1B1 (CYP1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PINOCEMBRIN	DM96VWD	N. A.	N. A.	Phase 2	[1]
NARINGENIN	DMHAZLM	N. A.	N. A.	Phase 1	[1]
Chrysin	DM7V2LG	Discovery agent	N.A.	Investigative	[1]
APIGENIN	DMI3491	Discovery agent	N.A.	Investigative	[1]
KAEMPFEROL	DMHEMUB	Discovery agent	N.A.	Investigative	[1]
ACACETIN	DMQOB0X	Discovery agent	N.A.	Investigative	[1]
TRISMETHOXYRESVERATROL	DM6USPC	Discovery agent	N.A.	Investigative	[11]
Galangin	DM5TQ2O	Discovery agent	N.A.	Investigative	[1]
CHRYSOERIOL	DM96ECL	Discovery agent	N.A.	Investigative	[1]
DIOSMETIN	DM4KXIM	Discovery agent	N.A.	Investigative	[1]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[12]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[13]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[14]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[15]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[16]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[17]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[18]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[19]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[20]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[18]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[21]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[22]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[23]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[24]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[25]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[26]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[25]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[27]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[28]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[29]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[30]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[31]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[24]
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[33]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[34]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[35]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[36]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[38]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cytochrome P450 1B1 (CYP1B1)	TTI84H7	CP1B1_HUMAN	Inhibitor	[1]
Plasmodium Enoyl-ACP reductase (Malaria fabI)	TTNX2CS	Q965D5_PLAFA	Inhibitor	[2]
Plasmodium Oxoacyl-[acyl-carrier protein] reductase (Malaria fabG)	TTBE4IR	Q965D6_PLAFA	Inhibitor	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Gene/Protein Processing	[3]
Bcl-2-like protein 1 (BCL2L1)	OTRC5K9O	B2CL1_HUMAN	Gene/Protein Processing	[4]
Poly polymerase 1 (PARP1)	OT310QSG	PARP1_HUMAN	Protein Interaction/Cellular Processes	[4]

References

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