Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMQKSGI)

Drug Name

Myo-inositol Drug Info

Synonyms

Scyllo-inositol; inositol; Muco-Inositol; epi-Inositol; i-Inositol; meso-Inositol; Allo-inositol; 87-89-8; 1D-Chiro-inositol; 1L-Chiro-inositol; 488-59-5; Scyllitol; 643-12-9; D-(+)-chiro-Inositol; cis-Inositol; mesoinositol; Quercinitol; Myoinosite; Dambose; Cyclohexane-1,2,3,4,5,6-hexaol; Neo-inositol; Meat sugar; 6917-35-7; Phaseomannite; Inositina; Cocositol; D-chiro-Inositol; Inositene; Inosital; Iso-inositol; cyclohexane-1,2,3,4,5,6-hexol; Phaseomannitol; Cyclohexitol; Mesoinosit; Scyllite; Mesoinosite; Inosite

Indication

Disease Entry	ICD 11	Status	REF
Alzheimer disease	8A20	Phase 2	[1]

Cross-matching ID

PubChem CID: 892
ChEBI ID: CHEBI:17268
CAS Number: CAS 551-72-4
TTD Drug ID: DMQKSGI
VARIDT Drug ID: DR00122
INTEDE Drug ID: DR2160

Molecule-Related Drug Atlas

Molecule Type:

DTT

DTP

DME

Drug Status:

Investigative Drug(s)

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Mycobacterium CDP-diacylglycerol-inositol phosphatidyltransferase (MycB pssA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zn2+	DMEC1I9	Discovery agent	N.A.	Investigative	[2]
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Drug(s) Targeting Amyloid beta A4 protein (APP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nirogacestat	DMUP5Z0	Desmoid tumour	2F7C	Approved	[6]
Aducanumab	DM51JW4	Alzheimer disease	8A20	Approved	[7]
Lecanemab	DMW03YD	Alzheimer disease	8A20	Approved	[8]
Florbetapir F-18	DMJ8A3Z	Diagnostic imaging	N.A.	Approved	[9]
GV-971	DMTMA5W	Alzheimer disease	8A20	Approved in China	[10]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[11]
Solanezumab	DM0HIU5	Alzheimer disease	8A20	Phase 3	[12]
Tramiprosate	DM7BSRH	Alzheimer disease	8A20	Phase 3	[13]
Bapineuzumab	DMHQ5GK	Alzheimer disease	8A20	Phase 3	[14]
ALZT-OP1	DMG5BTD	Alzheimer disease	8A20	Phase 3	[15]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Amyloid beta A4 protein (APP)	TTE4KHA	A4_HUMAN	Inhibitor	[1]
Mycobacterium CDP-diacylglycerol-inositol phosphatidyltransferase (MycB pssA)	TTI0TCK	PSS_MYCTU	Inhibitor	[2]

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Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Sodium/myo-inositol cotransporter (SLC5A3)	DT8ACN1	SC5A3_HUMAN	Substrate	[3]
Sodium/myo-inositol cotransporter 2 (SLC5A11)	DT2CAPQ	SC5AB_HUMAN	Substrate	[4]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Inositol dehydrogenase (idh)	DE0J45Y	A0A0J9X1Y2_LACCB	Substrate	[5]
Inositol dehydrogenase (idh)	DEDUGWF	IOLG_LACCA	Substrate	[5]

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References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2	Phosphatidylinositol synthesis in mycobacteria. Biochim Biophys Acta. 1999 Jan 4;1436(3):437-50.
3	Identification of a novel Na+/myo-inositol cotransporter. J Biol Chem. 2002 Sep 20;277(38):35219-24.
4	The sodium/glucose cotransport family SLC5. Pflugers Arch. 2004 Feb;447(5):510-8.
5	Purification, crystallization and room-temperature X-ray diffraction of inositol dehydrogenase LcIDH2 from Lactobacillus casei BL23. Acta Crystallogr F Struct Biol Commun. 2014 Jul;70(Pt 7):979-83.
6	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
7	Passive anti-amyloid immunotherapy in Alzheimer's disease: What are the most promising targets . Immun Ageing. 2013; 10: 18.
8	The murine version of BAN2401 (mAb158) selectively reduces amyloid-beta protofibrils in brain and cerebrospinal fluid of tg-ArcSwe mice. J Alzheimers Dis. 2015;43(2):575-88.
9	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
10	Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression. Cell Res. 2019 Oct;29(10):787-803.
11	Curcumin and dehydrozingerone derivatives: synthesis, radiolabeling, and evaluation for beta-amyloid plaque imaging. J Med Chem. 2006 Oct 5;49(20):6111-9.
12	Phase 3 trials of solanezumab for mild-to-moderate Alzheimer's disease. N Engl J Med. 2014 Jan 23;370(4):311-21.
13	Targeting soluble Abeta peptide with Tramiprosate for the treatment of brain amyloidosis. Neurobiol Aging. 2007 Apr;28(4):537-47.
14	Bapineuzumab: anti-beta-amyloid monoclonal antibodies for the treatment of Alzheimer's disease. Immunotherapy. 2010 Nov;2(6):767-82.
15	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)