Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMTCNOM)

Drug Name
Fasudil Drug Info
Synonyms
103745-39-7; HA1077; ha-1077; HA 1077; Fasudil [INN]; AT 877; Fasudilum [INN-Latin]; 1-(5-Isoquinolinesulfonyl)homopiperazine; 1H-1,4-Diazepine, hexahydro-1-(5-isoquinolinylsulfonyl)-; UNII-Q0CH43PGXS; 5-(1,4-diazepane-1-sulfonyl)isoquinoline; 5-(1,4-diazepan-1-ylsulfonyl)isoquinoline; (5-ISOQUINOLINESULFONYL)HOMOPIPERAZINE; AT-877; AT877; Q0CH43PGXS; 5-(1,4-DIAZEPAN-1-SULFONYL)ISOQUINOLINE; CHEMBL38380; Hexahydro-1-(5-isoquinolinylsulfonyl)-1H-1,4-diazepine; Fasudil (INN); Fasudilhydrochloride
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
3547
CAS Number
CAS 103745-39-7
TTD Drug ID
DMTCNOM
VARIDT Drug ID
DR00792

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Rho-associated protein kinase 1 (ROCK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Netarsudil DM0LPI9 Open-angle glaucoma 9C61 Approved [5]
SAR-407899 DMF95KD Diabetic nephropathy GB61.Z Phase 2 [6]
H-1152 DM8XH3S Pulmonary arterial hypertension BB01.0 Phase 2 [7]
INS-117548 DMA46DO Glaucoma/ocular hypertension 9C61 Phase 1 [8]
GSK269962A DM5I2HL Inflammation 1A00-CA43.1 Clinical trial [9]
PMID28048944-Compound-19 DMPT3V9 N. A. N. A. Patented [10]
PMID28048944-Compound-3 DM1BN74 N. A. N. A. Patented [10]
PMID28048944-Compound-7 DMXZ368 N. A. N. A. Patented [10]
PMID28048944-Compound-4 DMJAUWG N. A. N. A. Patented [10]
PMID28048944-Compound-5 DMAB987 N. A. N. A. Patented [10]
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Drug(s) Affected By Ribosomal protein S6 kinase alpha-5 (RPS6KA5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [11]
Quercetin DM3NC4M Obesity 5B81 Approved [12]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [13]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [14]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [15]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [16]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [17]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [18]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [19]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [20]
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Drug(s) Affected By Ribosomal protein S6 kinase beta-1 (RPS6KB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [21]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [22]
Gefitinib DM15F0X Colon adenocarcinoma Approved [23]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [24]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [25]
Quercetin DM3NC4M Obesity 5B81 Approved [3]
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [26]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [27]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [28]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [29]
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Drug(s) Affected By Ribosomal protein S6 kinase alpha-1 (RPS6KA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [11]
Selenium DM25CGV N. A. N. A. Approved [30]
Quercetin DM3NC4M Obesity 5B81 Approved [31]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [14]
Testosterone DM7HUNW Hot flushes GA30 Approved [32]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [32]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [33]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [18]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [20]
Pioglitazone DMKJ485 Amyotrophic lateral sclerosis 8B60.0 Approved [34]
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Drug(s) Affected By Serine/threonine-protein kinase N2 (PKN2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [30]
Quercetin DM3NC4M Obesity 5B81 Approved [35]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [14]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [36]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [37]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [18]
Folic Acid DMEMBJC Colorectal carcinoma Approved [38]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [20]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [39]
Ximelegatran DMU8ANS Myocardial infarction BA41-BA43 Approved [3]
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Drug(s) Affected By Rho guanine nucleotide exchange factor 11 (ARHGEF11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [40]
Tacrolimus DMZ7XNQ Graft-versus-host disease 4B24 Approved [41]
Urethane DM7NSI0 N. A. N. A. Phase 4 [42]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [35]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [35]
Drug(s) Affected By Cofilin-1 (CFL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [43]
Etretinate DM2CZFA Keratosis ED56 Approved [44]
Quercetin DM3NC4M Obesity 5B81 Approved [45]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [14]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [46]
Haloperidol DM96SE0 Delirium Approved [47]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [48]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [49]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [18]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [50]
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Drug(s) Affected By Solute carrier family 12 member 2 (SLC12A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [51]
Quercetin DM3NC4M Obesity 5B81 Approved [31]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [14]
Estrone DM5T6US Acne vulgaris ED80 Approved [52]
Ethacrynic acid DM60QMR Edema MG29 Approved [53]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [54]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [49]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [18]
Furosemide DMMQ8ZG Congestive heart failure BD10 Approved [53]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [52]
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Drug(s) Affected By Transforming protein RhoA (RHOA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [55]
Methotrexate DM2TEOL Anterior urethra cancer Approved [56]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [57]
Quercetin DM3NC4M Obesity 5B81 Approved [58]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [59]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [59]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [60]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [61]
Pamidronate DMB4AVP Bone Paget disease Approved [62]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [63]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Rho-associated protein kinase 1 (ROCK1) TTZN7RP ROCK1_HUMAN Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Cofilin-1 (CFL1) OTT6D5MH COF1_HUMAN Gene/Protein Processing [2]
Rho guanine nucleotide exchange factor 11 (ARHGEF11) OTDOMEH6 ARHGB_HUMAN Gene/Protein Processing [2]
Ribosomal protein S6 kinase alpha-1 (RPS6KA1) OTDOTWU4 KS6A1_HUMAN Gene/Protein Processing [3]
Ribosomal protein S6 kinase alpha-5 (RPS6KA5) OTAVZJ3J KS6A5_HUMAN Gene/Protein Processing [3]
Ribosomal protein S6 kinase beta-1 (RPS6KB1) OTAELNGX KS6B1_HUMAN Gene/Protein Processing [3]
Serine/threonine-protein kinase N2 (PKN2) OTW0SOID PKN2_HUMAN Gene/Protein Processing [3]
Solute carrier family 12 member 2 (SLC12A2) OT3ZJ3LH S12A2_HUMAN Gene/Protein Processing [4]
Transforming protein RhoA (RHOA) OT6YOJ9N RHOA_HUMAN Gene/Protein Processing [2]

References

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