Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMTU05Y)

Drug Name
ISOPENTENYL PYROPHOSPHATE Drug Info
Synonyms
isopentenyl pyrophosphate; isopentenyl diphosphate; 3-Methyl-3-butenyl pyrophosphate; IPPP; Mono(3-methyl-3-butenyl) diphosphate; delta3-Isopentenyl diphosphate; isopentenyl-pp; Diphosphoric acid mono(3-methyl-3-butenyl) ester; delta-3-Isopentenyl pyrophosphat; Isopentenyl-diphosphate; CHEBI:16584; delta3-methyl-3-butenyl diphosphate; 3-methylbut-3-enyl phosphono hydrogen phosphate; 358-71-4; delta-3-Isopentenyl pyrophosphate; 3-methylbut-3-en-1-yl trihydrogen diphosphate; 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
1195
ChEBI ID
CHEBI:16584
CAS Number
CAS 358-71-4
TTD Drug ID
DMTU05Y

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Investigative Drug(s)
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting Bacterial Undecaprenyl pyrophosphate synthetase (Bact ispU)
Drug Name Drug ID Indication ICD 11 Highest Status REF
E-pentenylbutanedioic acid 32 DMT7RXZ Discovery agent N.A. Investigative [7]
Drug(s) Targeting Geranyltranstransferase (FDPS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [8]
Minodronate DM50PMY Osteoporosis FB83.0 Approved [9]
Ibandronate DM0QZBN Hypercalcaemia 5B91.0 Approved [8]
Alendronate DMY2KX9 Bone Paget disease Approved [8]
Pamidronate DMB4AVP Bone Paget disease Approved [10]
Incadronate DM3DSVJ Hypercalcaemia 5B91.0 Approved [11]
Risedronate DM5FLTY Bone Paget disease Approved [12]
NERIDRONIC ACID DMMPG5V Bone disease FC0Z Approved [13]
Zarnestra DMF30HL Acute myeloid leukaemia 2A60 Phase 3 [14]
GERANYLGERANYL DIPHOSPHATE DMJZ0AM Discovery agent N.A. Investigative [2]
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Drug(s) Affected By Mevalonate kinase (MVK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [15]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [16]
Fluoxetine DM3PD2C Bipolar depression Approved [17]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [18]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [19]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [20]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [21]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [22]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [23]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [24]
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Drug(s) Affected By Interferon gamma (IFNG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [25]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [26]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [27]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [28]
Methotrexate DM2TEOL Anterior urethra cancer Approved [29]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [30]
Quercetin DM3NC4M Obesity 5B81 Approved [31]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [33]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [34]
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Drug(s) Affected By Interleukin-2 receptor subunit alpha (IL2RA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [35]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [30]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [36]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [37]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [38]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [39]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [40]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [41]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [42]
Folic Acid DMEMBJC Colorectal carcinoma Approved [43]
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Drug(s) Affected By Fibroblast growth factor 9 (FGF9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [44]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [45]
Panobinostat DM58WKG Chronic graft versus host disease Approved [46]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [47]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [48]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [49]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [50]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [51]
Arsenic DMTL2Y1 N. A. N. A. Approved [52]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [53]
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Drug(s) Affected By C-C chemokine receptor type 5 (CCR5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [54]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [55]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [56]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [57]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [58]
I3C DMIGFOR Breast cancer 2C60-2C65 Phase 3 [59]
DNCB DMDTVYC Immune System disease 4A01-4B41 Phase 2 [60]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [61]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [58]
EUGENOL DM7US1H Discovery agent N.A. Patented [55]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Bacterial Undecaprenyl pyrophosphate synthetase (Bact ispU) TT5VER7 UPPS_ECOLI Inhibitor [2]
Geranyltranstransferase (FDPS) TTIKWV4 FPPS_HUMAN Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
C-C chemokine receptor type 5 (CCR5) OTP5FMZ4 CCR5_HUMAN Gene/Protein Processing [3]
Fibroblast growth factor 9 (FGF9) OT2SKDGM FGF9_HUMAN Gene/Protein Processing [4]
Interferon gamma (IFNG) OTXG9JM7 IFNG_HUMAN Gene/Protein Processing [5]
Interleukin-2 receptor subunit alpha (IL2RA) OT0MWCHG IL2RA_HUMAN Gene/Protein Processing [5]
Mevalonate kinase (MVK) OTHJCUKT KIME_HUMAN Gene/Protein Processing [6]
Vitamin D3 receptor OTFC7K35 VDR_HUMAN Gene/Protein Processing [5]

References

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23 The proapoptotic effect of zoledronic acid is independent of either the bone microenvironment or the intrinsic resistance to bortezomib of myeloma cells and is enhanced by the combination with arsenic trioxide. Exp Hematol. 2011 Jan;39(1):55-65.
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30 Simvastatin inhibits IL-17 secretion by targeting multiple IL-17-regulatory cytokines and by inhibiting the expression of IL-17 transcription factor RORC in CD4+ lymphocytes. J Immunol. 2008 May 15;180(10):6988-96. doi: 10.4049/jimmunol.180.10.6988.
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