Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMUSZHD)

Drug Name
Hydrochlorothiazide Drug Info
Synonyms
Acesistem; Acuilix; Acuretic; Aldazida; Aldoril; Apresazide; Aquarills; Aquarius; Bremil; Briazide; Caplaril; Carozide; Catiazida; Chlorizide; Chlorosulthiadil; Chlorzide; Chlothia; Cidrex; Clorana; Condiuren; Diaqua; Dichlorosal; Dichlorotride; Dichlothiazide; Dichlotiazid; Dichlotride; Diclotride; Dicyclotride; Didral; Dihydran; Dihydrochlorothiazid; Dihydrochlorothiazide; Dihydrochlorothiazidum; Dihydrochlorurit; Dihydrochlorurite; Dihydroxychlorothiazidum; Direma; Disalunil; Disothiazid; Diurogen; Dixidrasi; Drenol; Esidrex; Esidrix; Esoidrina; Fluvin; HCT; HCTZ; HCZ; Hidril; Hidrochlortiazid; Hidroclorotiazida; Hidroronol; Hidrosaluretil; Hidrotiazida; Hyclosid; Hydril; HydroDIURIL; Hydrochlorat; Hydrochlorot; Hydrochlorothiazid; Hydrochlorothiazidum; Hydrochlorthiazide; Hydrochlorthiazidum; Hydrocot; Hydrodiuretic; Hydropres; Hydrosaluric; Hydrothide; Hydrozide; Hypothiazid; Hypothiazide; Hytrid; Idroclorotiazide; Idrotiazide; Indroclor; Ivaugan; Manuril; Maschitt; Medozide; Megadiuril; Microzide; Mictrin; Mikorten; Modurcen; Moduretic; Natrinax; Nefrix; Nefrol; Neoflumen; Newtolide; Novodiurex; Oretic; Pantemon; Panurin; Roxane; Saldiuril; Sectrazide; Selozide; Servithiazid; Spironazide; Tandiur; Thiaretic; Thiuretic; Thlaretic; Timolide; Unazid; Urodiazin; Urozide; Vaseretic; Vetidrex; Aquazide H; Chlorsulfonamidodihydrobenzothiadiazine dioxide; Component of Aldactazide; Component of Aldoril; Component of Butizide Prestabs; Component of Caplaril; Component of Cyclex; Component of Dyazide; Component of Esimil; Concor Plus; Diclot ride; Hydro Par; Hydrochlorothiazide Intensol; Idroclorotiazide [DCIT]; Lotensin HCT; Panurin dichloride; Raunova Plus; Diu 25 Vigt; H 4759; MaybridgeCompound 10; Mazide 25 mg; Su 5879; Aldactazide 25/25; Aldectazide 50/50; Apo-Hydro; Aquazide H (TN); Aquazide-H; Dichlotride (TN); Diu-melusin; Esidrex (TN); Esidrix (TN); HCT-Isis; Hidro-Niagrin; Hidroclorotiazida [INN-Spanish]; Hydrex-semi; Hydro-Aquil; Hydro-D; Hydro-Diuril; Hydro-Saluric; Hydro-T; Hydro-chlor; HydroSaluric (TN); Hydrochlorothiazidum [INN-Latin]; Hydrodiuril (TN); Hydrozide Injection, Veterinary; Jen-Diril; Microzide (TN); Neo-Flumen; Neo-Minzil; Neo-codema; Oretic (TN); Ro-hydrazide; AF-614/30832002; Apo-Hydro (TN); Hydrochlorothiazide [INN:BAN:JAN]; Hydrochlorothiazide (JP15/USP/INN); Dro-2H-1,2,4-benzothiadiazine 1,1-dioxide; 3,4-Dihydro-6-chloro-7-sulfamyl-1,2, 4-benzothi; 3,4-Dihydrochlorothiazide; 6-Chloro-7-sulfamoyl-3, 4-dihy
Indication
Disease Entry ICD 11 Status REF
Chronic heart failure BD1Z Approved [1]
Edema MG29 Approved [1]
Hypertension BA00-BA04 Approved [2]
Malignant essential hypertension BA00 Approved [1]
Prediabetes syndrome Approved [1]
Therapeutic Class
Diuretics
Cross-matching ID
PubChem CID
3639
ChEBI ID
CHEMBL435
CAS Number
CAS 58-93-5
TTD Drug ID
DMUSZHD
VARIDT Drug ID
DR00460
ACDINA Drug ID
D00312

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Angiotensin-converting enzyme (ACE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Enalapril DMNFUZR Congestive heart failure BD10 Approved [9]
Spirapril DM5XLTY Hypertension BA00-BA04 Approved [10]
Captopril DM458UM Chronic heart failure BD1Z Approved [11]
Benazepril DMH1M9B Hypertension BA00-BA04 Approved [12]
Moexipril DM26E4B Hypertension BA00-BA04 Approved [13]
Ramipril DM2R68E Acute heart failure BD10-BD13 Approved [14]
Perindopril DMOPZDT Hypertension BA00-BA04 Approved [15]
Trandolapril DM4L6EU Chronic heart failure BD1Z Approved [16]
Fosinopril DM9NJ52 Chronic heart failure BD1Z Approved [17]
Lisinopril DMUOK4C Chronic heart failure BD1Z Approved [18]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Renin (REN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [19]
Acebutolol DM0TI4U Hypertension BA00-BA04 Approved [20]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [21]
Reboxetine DM26PRD Depression 6A70-6A7Z Approved [22]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [23]
Ramipril DM2R68E Acute heart failure BD10-BD13 Approved [24]
Rhucin DM3ADGP Erectile dysfunction HA01.1 Approved [25]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [26]
Epinephrine DM3KJBC Acute asthma CA23 Approved [27]
Chlorthalidone DM4DMBT Edema MG29 Approved [28]
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Drug(s) Affected By Vasopressin-neurophysin 2-copeptin (AVP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [29]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [30]
Oxprenolol DM51OQW Anxiety Approved [31]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [32]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [33]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [34]
Luvox DMJKROX Anxiety disorder 6B00-6B0Z Approved [35]
Sodium chloride DMM3950 Skin burns ME65.0 Approved [36]
Levodopa DMN3E57 Parkinson disease 8A00.0 Approved [30]
Chlorpropamide DMPHZQE Non-insulin dependent diabetes 5A11 Approved [37]
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Drug(s) Affected By HLA class I histocompatibility antigen, alpha chain E (HLA-E)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [5]
Clindamycin DM15HL8 Acne vulgaris ED80 Approved [5]
Selenium DM25CGV N. A. N. A. Approved [38]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [5]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [5]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [39]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [40]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [41]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [5]
Testosterone DM7HUNW Hot flushes GA30 Approved [42]
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Drug(s) Affected By HLA class II histocompatibility antigen, DP alpha 1 chain (HLA-DPA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [38]
Fluoxetine DM3PD2C Bipolar depression Approved [5]
Cinoxacin DM4EWNS Urinary tract infection GC08 Approved [5]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [40]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [43]
Testosterone DM7HUNW Hot flushes GA30 Approved [42]
Valdecoxib DMAY7H4 Osteoarthritis FA00-FA05 Approved [5]
Testosterone enanthate DMB6871 N. A. N. A. Approved [44]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [45]
Cephalexin DMD5JU8 Acute otitis media AB00 Approved [5]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By HLA class I histocompatibility antigen, alpha chain F (HLA-F)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gefitinib DM15F0X Colon adenocarcinoma Approved [5]
Selenium DM25CGV N. A. N. A. Approved [38]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [5]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [46]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [47]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [40]
Repaglinide DM5SXUV Diabetic complication 5A2Y Approved [5]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [48]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [49]
Saquinavir DMG814N Human immunodeficiency virus infection 1C62 Approved [5]
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Drug(s) Affected By Major histocompatibility complex class I-related gene protein (MR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gefitinib DM15F0X Colon adenocarcinoma Approved [5]
Quercetin DM3NC4M Obesity 5B81 Approved [50]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [5]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [51]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [5]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [52]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [5]
Bupropion DM5PCS7 Depression 6A70-6A7Z Approved [5]
Repaglinide DM5SXUV Diabetic complication 5A2Y Approved [5]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [53]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sodium channel protein type 5 subunit alpha (SCN5A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Disopyramide DM5SYZP Long QT syndrome BC65.0 Approved [6]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [54]
Flecainide DMSQDLE Tachyarrhythmias BC71 Approved [55]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [56]
Meloxicam DM2AR7L Arthritis FA20 Approved [57]
Quercetin DM3NC4M Obesity 5B81 Approved [58]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [59]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [60]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [61]
Retigabine DMGNYIH Behcet disease 4A62 Approved [62]
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Drug(s) Affected By ATP-binding cassette sub-family C member 4 (ABCC4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [63]
Quercetin DM3NC4M Obesity 5B81 Approved [64]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [65]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [66]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [67]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [68]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [69]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [70]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [71]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [72]
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Drug(s) Affected By Prostaglandin E2 receptor EP1 subtype (PTGER1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Carbachol DMX9K8F Glaucoma/ocular hypertension 9C61 Approved [6]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Angiotensin-converting enzyme (ACE) TTL69WB ACE_HUMAN Modulator [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
ATP-binding cassette sub-family C member 4 (ABCC4) OTO27PAL MRP4_HUMAN Regulation of Drug Effects [4]
HLA class I histocompatibility antigen, alpha chain E (HLA-E) OTX1CTFB HLAE_HUMAN Gene/Protein Processing [5]
HLA class I histocompatibility antigen, alpha chain F (HLA-F) OT76CM19 HLAF_HUMAN Gene/Protein Processing [5]
HLA class II histocompatibility antigen, DP alpha 1 chain (HLA-DPA1) OT7OG7Y2 DPA1_HUMAN Gene/Protein Processing [5]
Major histocompatibility complex class I-related gene protein (MR1) OTZU3XX7 HMR1_HUMAN Gene/Protein Processing [5]
Prostaglandin E2 receptor EP1 subtype (PTGER1) OTZV8W66 PE2R1_CANLF Drug Response [6]
Renin (REN) OT52GZR2 RENI_HUMAN Gene/Protein Processing [7]
Sodium channel protein type 5 subunit alpha (SCN5A) OTGYZWR6 SCN5A_HUMAN Drug Response [6]
Vasopressin-neurophysin 2-copeptin (AVP) OTAVZ76K NEU2_HUMAN Protein Interaction/Cellular Processes [8]

References

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42 The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
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51 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
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54 Ethnic-Related Sodium Voltage-Gated Channel Subunit 5 Polymorphisms Shape the In Vitro Pharmacological Action of Amiodarone upon Na(v)1.5. Mol Pharmacol. 2021 Jun;99(6):448-459. doi: 10.1124/molpharm.120.000176. Epub 2021 Apr 6.
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59 Multi-parameter in vitro toxicity testing of crizotinib, sunitinib, erlotinib, and nilotinib in human cardiomyocytes. Toxicol Appl Pharmacol. 2013 Oct 1;272(1):245-55.
60 Evaluation of nefazodone-induced cardiotoxicity in human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2016 Apr 1;296:42-53. doi: 10.1016/j.taap.2016.01.015. Epub 2016 Jan 25.
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68 Robustness testing and optimization of an adverse outcome pathway on cholestatic liver injury. Arch Toxicol. 2020 Apr;94(4):1151-1172. doi: 10.1007/s00204-020-02691-9. Epub 2020 Mar 10.
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70 Prolonged use of aspirin alters human and rat intestinal cells and thereby limits the absorption of clopidogrel. Clin Pharmacol Ther. 2011 Oct;90(4):612-9. doi: 10.1038/clpt.2011.163. Epub 2011 Sep 7.
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72 Stem cell transcriptome responses and corresponding biomarkers that indicate the transition from adaptive responses to cytotoxicity. Chem Res Toxicol. 2017 Apr 17;30(4):905-922.