Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMVEK07)

Drug Name
Magnesium Sulfate Drug Info
Synonyms
Magnesiumsulfat; Bitter salt; Epsom salt; Hair salt; Heptahydrate Magnesium Sulfate; Kieserite [as monohydrate]; Magnesium Sulfate In Plastic Container; Magnesium Sulphate Hydrate; Magnesium bisulfate; Magnesium hydrogensulphate; Magnesium sulfate anhydrous; Magnesium sulfate dried; Magnesium sulfate hexahydrate; Magnesium sulfate solution; Magnesium sulphate; Sal Angalis; Sal De sedlitz; Sal amarum; Sal anglicum; Sal catharticum; Sal seidlitense; Salts of england; Sulfuric acid magnesium salt; Tomix OT; MgSO4; Epsom Sa (TN); Magnesium Sulfate, Heptahydrate; Magnesium sulfate in dextrose 5% in plastic container; Magnesium(II) sulfate; OT-S; Sel d'angleterre; Sulfate, Magnesium; Sulfuric acid magnesium salt (VAN); Sulfuric acid, magnesium salt; Magnesium sulfate (1:1); Magnesium(2+) ion sulfate; OT-S (drying agent); SDA 15-062-07; Sulfuric acid magnesium salt (1:1); Sulfuric acid, C10-16 alkyl ester, magnesium salt; Sulfuric acid, magnesium salt (1:1); Sulfuric acid, mono-C10-16-alkyl esters, magnesium salts; (C10-C16) Alkylalcohol sulfuric acid, magnesium salt
Indication
Disease Entry ICD 11 Status REF
Acute pain MG31 Approved [1]
Familial primary hypomagnesemia Approved [2]
Hypertension, pregnancy-induced Approved [2]
Mild pre-eclampsia Approved [2]
Non-arteritic anterior ischemic optic neuropathy 9C40.40 Approved [2]
Pain MG30-MG3Z Approved [2]
Severe pre-eclampsia Approved [2]
Traumatic brain injury NA07.Z Approved [2]
Therapeutic Class
Analgesics
Cross-matching ID
PubChem CID
24083
ChEBI ID
CHEBI:32599
CAS Number
CAS 7487-88-9
TTD Drug ID
DMVEK07

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting N-methyl-D-aspartate receptor (NMDAR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
L-Glutamic Acid DM4PUDW Schizophrenia 6A20 Approved [7]
Cycloserine DMT1I52 Bacterial infection 1A00-1C4Z Approved [8]
Benzphetamine DMIJATC Obesity 5B81 Approved [9]
Ketamine DMT5HA4 Anaesthesia 9A78.6 Approved [10]
Felbamate DM1V5ZS Epilepsy 8A60-8A68 Approved [11]
Memantine DMD9WSC Alzheimer disease 8A20 Approved [12]
Huperzine A DMMAWLU Alzheimer disease 8A20 Approved [13]
Levorphanol DMGS80V Pain MG30-MG3Z Approved [14]
Magnesium DMU4ORS Ischemic stroke 8B11.5Z Approved [1]
Orphenadrine DMW542E Parkinson disease 8A00.0 Approved [15]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Kallikrein-8 (KLK8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Panobinostat DM58WKG Chronic graft versus host disease Approved [16]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [17]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [18]
Potassium Chloride DMMTAJC Hypokalemia 5C77 Approved [5]
Arsenic DMTL2Y1 N. A. N. A. Approved [19]
Magnesium DMU4ORS Ischemic stroke 8B11.5Z Approved [5]
Permethrin DMZ0Q1G Pediculus capitis infestation 1G00.0 Approved [20]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [21]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [22]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [16]
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Drug(s) Affected By Renin (REN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [23]
Acebutolol DM0TI4U Hypertension BA00-BA04 Approved [24]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [25]
Reboxetine DM26PRD Depression 6A70-6A7Z Approved [26]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [27]
Ramipril DM2R68E Acute heart failure BD10-BD13 Approved [28]
Rhucin DM3ADGP Erectile dysfunction HA01.1 Approved [29]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [30]
Epinephrine DM3KJBC Acute asthma CA23 Approved [31]
Chlorthalidone DM4DMBT Edema MG29 Approved [32]
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Drug(s) Affected By Interleukin-1 beta (IL1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [33]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [34]
Gefitinib DM15F0X Colon adenocarcinoma Approved [35]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [36]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [37]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [36]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [38]
Selenium DM25CGV N. A. N. A. Approved [39]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [4]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [40]
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Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [41]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [42]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [43]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [44]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [45]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [34]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [36]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [37]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [46]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [36]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
N-methyl-D-aspartate receptor (NMDAR) TT9IK2Z NOUNIPROTAC Antagonist [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Interleukin-1 beta (IL1B) OT0DWXXB IL1B_HUMAN Gene/Protein Processing [4]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Gene/Protein Processing [4]
Kallikrein-8 (KLK8) OTGVGHXY KLK8_HUMAN Gene/Protein Processing [5]
Renin (REN) OT52GZR2 RENI_HUMAN Gene/Protein Processing [6]

References

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2 Magnesium Sulfate FDA Label
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19 Arsenic alters transcriptional responses to Pseudomonas aeruginosa infection and decreases antimicrobial defense of human airway epithelial cells. Toxicol Appl Pharmacol. 2017 Sep 15;331:154-163.
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29 Inhibition of cGMP-specific phosphodiesterase type 5 reduces sodium excretion and arterial blood pressure in patients with NaCl retention and ascites. Am J Physiol Renal Physiol. 2005 May;288(5):F1044-52. doi: 10.1152/ajprenal.00142.2004. Epub 2004 Dec 21.
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33 Cannabidiol Modulates the Immunophenotype and Inhibits the Activation of the Inflammasome in Human Gingival Mesenchymal Stem Cells. Front Physiol. 2016 Nov 24;7:559. doi: 10.3389/fphys.2016.00559. eCollection 2016.
34 ERE-independent ERalpha target genes differentially expressed in human breast tumors. Mol Cell Endocrinol. 2005 Dec 21;245(1-2):53-9. doi: 10.1016/j.mce.2005.10.003. Epub 2005 Nov 17.
35 Reactive metabolite of gefitinib activates inflammasomes: implications for gefitinib-induced idiosyncratic reaction. J Toxicol Sci. 2020;45(11):673-680. doi: 10.2131/jts.45.673.
36 An in vitro coculture system of human peripheral blood mononuclear cells with hepatocellular carcinoma-derived cells for predicting drug-induced liver injury. Arch Toxicol. 2021 Jan;95(1):149-168. doi: 10.1007/s00204-020-02882-4. Epub 2020 Aug 20.
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38 (9)-Tetrahydrocannabinol Suppresses Monocyte-Mediated Astrocyte Production of Monocyte Chemoattractant Protein 1 and Interleukin-6 in a Toll-Like Receptor 7-Stimulated Human Coculture. J Pharmacol Exp Ther. 2019 Oct;371(1):191-201. doi: 10.1124/jpet.119.260661. Epub 2019 Aug 5.
39 Changes in gene expression profiles in response to selenium supplementation among individuals with arsenic-induced pre-malignant skin lesions. Toxicol Lett. 2007 Mar 8;169(2):162-76. doi: 10.1016/j.toxlet.2007.01.006. Epub 2007 Jan 19.
40 Spironolactone induces apoptosis in human mononuclear cells. Association between apoptosis and cytokine suppression. Apoptosis. 2006 Apr;11(4):573-9. doi: 10.1007/s10495-006-4919-3.
41 Monomeric and oligomeric flavanols maintain the endogenous glucocorticoid response in human macrophages in pro-oxidant conditions in vitro. Chem Biol Interact. 2018 Aug 1;291:237-244.
42 Nicotine up-regulates IL-8 expression in human gingival epithelial cells following stimulation with IL-1 or P. gingivalis lipopolysaccharide via nicotinic acetylcholine receptor signalling. Arch Oral Biol. 2012 May;57(5):483-90. doi: 10.1016/j.archoralbio.2011.10.007. Epub 2011 Nov 25.
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44 Calcium pantothenate modulates gene expression in proliferating human dermal fibroblasts. Exp Dermatol. 2009 Nov;18(11):969-78. doi: 10.1111/j.1600-0625.2009.00884.x. Epub 2009 Apr 8.
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