Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMXZ9RF)

• Drug Name: JWB-1-84-1 Drug Info
• Synonyms: Choline analogs (neurodegenerative diseases); Choline analogs (neurodegenerative diseases), Medical College of Georgia; JWB-1-B4-1

Indication

Disease Entry	ICD 11	Status	REF
Neurological disorder	6B60	Investigative	[1]

• Cross-matching ID: TTD Drug ID: DMXZ9RF

Molecule-Related Drug Atlas

Drug(s) Targeting Muscarinic acetylcholine receptor M5 (CHRM5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Promazine	DMZAL7W	Acute intermittent hepatic porphyria	5C58.11	Approved	[2]
ACECLIDINE	DMOLNCZ	Glaucoma/ocular hypertension	9C61	Approved	[3]
Pilocarpine	DMV9ADG	Glaucoma/ocular hypertension	9C61	Approved	[4]
Anisodine	DMNOSWU	Central and peripheral nervous disease	8A04-8E7Z	Approved	[5]
Atropine	DMEN6X7	Organophosphate poisoning	NE6Z	Approved	[6]
Propiverine	DMUWBIJ	Urinary incontinence	MF50.2	Approved	[7]
Umeclidinium	DM4E8O9	Chronic obstructive pulmonary disease	CA22	Approved	[8]
Cimetropium bromide	DMZHPNE	Gastric motility disorder	DA21	Approved	[9]
Butylscopolamine	DMZKXB7	Dysmenorrhea	GA34.3	Approved	[10]
Trospium	DMX6RTG	Overactive bladder	GC50.0	Approved	[11]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Muscarinic acetylcholine receptor M5 (CHRM5)	TTH18TF	ACM5_HUMAN	Modulator	[1]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 467).
• [2] Muscarinic cholinergic and histamine H1 receptor binding of phenothiazine drug metabolites. Life Sci. 1988;43(5):405-12.
• [3] Design, synthesis, and neurochemical evaluation of 5-(3-alkyl-1,2,4- oxadiazol-5-yl)-1,4,5,6-tetrahydropyrimidines as M1 muscarinic receptor agonists. J Med Chem. 1993 Apr 2;36(7):842-7.
• [4] Retinoic acid prevents virus-induced airway hyperreactivity and M2 receptor dysfunction via anti-inflammatory and antiviral effects. Am J Physiol Lung Cell Mol Physiol. 2009 Aug;297(2):L340-6.
• [5] Medicinal plants in therapy. Bull World Health Organ. 1985;63(6):965-81.
• [6] Additive protective effects of donepezil and nicotine against salsolinol-induced cytotoxicity in SH-SY5Y cells. Neurotox Res. 2009 Oct;16(3):194-204.
• [7] Affinity profiles of various muscarinic antagonists for cloned human muscarinic acetylcholine receptor (mAChR) subtypes and mAChRs in rat heart and submandibular gland. Life Sci. 1999;64(25):2351-8.
• [8] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7354).
• [9] Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77.
• [10] Comparison of pharmacological effects of L- and DL-n-butyl-scopolamine in rat uterus. Yao Xue Xue Bao. 1994;29(1):24-7.
• [11] Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.