Details of the Drug Reposition

General Information of This Drug (ID: DMVN5OH)

• Drug Name: Minocycline (DMVN5OH)
• Synonyms: Borymycin; MINO; MIY; Minociclina; Minociclinum; Minocin; Minocline; Minocyclin; Minocyclinum; Minocycline Monohydrochloride; CL 59806; Lactoferrin B & Minocycline; Lactoferrin H & Minocycline; Minociclina [INN-Spanish]; Minocin (Hydrochloride); Minocin (TN); Minocyclinum [INN-Latin]; Vectrin (Hydrochloride); CRL-1605 & Minocycline; Minocycline (USAN/INN); Minocycline [USAN:BAN:INN]; (2Z,4S,4aS,5aR,12aS)-2-[amino(hydroxy)methylidene]-4,7-bis(dimethylamino)-10,11,12a-trihydroxy-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione; (4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2-CARBOXAMIDE; 4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide; 7-Dimethylamino-6-demethyl-6-deoxytetracycline
• Therapeutic Class: Antibiotics
• Drug Type: Small molecular drug

Information on Drug Reposition of This Drug

23 Approved Indication(s)

Indication Name	Indication ID	ICD-11	Status	REF
Yaws	DISLTH3X	N.A.	Approved	[1]
Typhus	DISJ5JX1	N.A.	Approved	[1]
Trachoma	DIS2WZUR	N.A.	Approved	[1]
Syphilis	DISJ73BS	N.A.	Approved	[1]
Rocky mountain spotted fever	DISFN72S	N.A.	Approved	[1]
Rickettsialpox	DISEMENW	N.A.	Approved	[1]
Relapsing fever	DISEA4L7	N.A.	Approved	[1]
Q fever	DISK1S90	N.A.	Approved	[1]
Ornithosis	DIS4YMZ8	N.A.	Approved	[1]
Lymphogranuloma venereum	DIS0MMFT	N.A.	Approved	[1]
Listeriosis	DISKMQBM	N.A.	Approved	[1]
Chancroid	DISMVLOF	N.A.	Approved	[1]
Brucellosis	DISEAYGH	N.A.	Approved	[1]
Bartonellosis	DISMKP1N	N.A.	Approved	[1]
Acute gonococcal cervicitis	DIS4LKDT	N.A.	Approved	[1]
Actinomycosis	DIS7YFRP	N.A.	Approved	[1]
Bacterial infection	DIS5QJ9S	1A00-1C4Z	Approved	[2]
Tularemia	DISF94A2	1B94	Approved	[1]
Bronchitis	DISBM6EQ	CA20	Approved	[1]
Pneumonia	DIS8EF3M	CA40	Approved	[1]
Periodontitis	DISI9JOI	DA0C	Approved	[1]
Acne vulgaris	DISKW8PI	ED80	Approved	[1]
Urinary tract infection	DISMT6UV	GC08	Approved	[1]

1 Phase 2 Indication(s)

Indication Name	Indication ID	ICD-11	Status	REF
Rosacea	DIS02PWG	ED90.0	Phase 2	[3]

2 Withdrawn Indication(s)

Indication Name	Indication ID	ICD-11	Status	REF
Acute gonococcal endometritis	DISZ8BW7	N.A.	Withdrawn	[4]
Carotid stenosis	DISZA8D0	N.A.	Withdrawn	[5]

3 Discontinued in Phase 2 Indication(s)

Indication Name	Indication ID	ICD-11	Status	REF
Granuloma inguinale	DISRKXBH	N.A.	Discontinued in Phase 2	[6]
Gonorrhea	DISQ5AO6	1A7Z	Discontinued in Phase 2	[7]
Pharyngitis	DISSN548	CA02.Z	Discontinued in Phase 2	[8]

1 Discontinued in Phase 1 Indication(s)

Indication Name	Indication ID	ICD-11	Status	REF
Campylobacter fetus infectious disease	DISTKT4M	N.A.	Discontinued in Phase 1	[9]

3 Investigative Indication(s)

Indication Name	Indication ID	ICD-11	Status	REF
Plague	DISY1PBI	N.A.	Investigative	[1]
Vibrio cholerae infection	DISW7E3U	1A00	Investigative	[1]
Sinusitis	DISX5NCF	CA0A.Z	Investigative	[1]

References

• [1] Minocycline FDA Label
• [2] Emerging disease-modifying therapies for the treatment of motor neuron disease/amyotropic lateral sclerosis. Expert Opin Emerg Drugs. 2007 May;12(2):229-52.
• [3] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [4] The Role of Maintenance Oral Clofarabine in Older Adults With Acute Myeloid Leukemia
• [5] Efficacy and Safety Study of Sorafenib to Treat Advanced Medullary Thyroid Carcinoma
• [6] A 3-arm Proof of Concept Study of AIN457, ACZ885 or Corticosteroids in Patients With Polymyalgia Rheumatica
• [7] Rituximab, Combination Chemotherapy, and 90-Yttrium Ibritumomab Tiuxetan for Patients With Stage I or II Non-Hodgkin's Lymphoma
• [8] Temsirolimus (Torisel) and Erlotinib (Tarceva) in Platinum-Refractory/Ineligible, Advanced, Squamous Cell Carcinoma
• [9] Treated Blood Cells, Cyclophosphamide, Fludarabine Phosphate, and Aldesleukin in Treating Patients With Cancer