Details of the Drug

General Information of Drug (ID: DMX6OE3)

Drug Name
Dabrafenib
Synonyms
1195765-45-7; Dabrafenib (GSK2118436); Tafinlar; GSK2118436A; UNII-QGP4HA4G1B; GSK 2118436; QGP4HA4G1B; N-(3-(5-(2-aminopyrimidin-4-yl)-2-tert-butylthiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide; CHEBI:75045; N-[3-[5-(2-Amino-4-pyrimidinyl)-2-(tert-butyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide; N-{3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide; GSK-2118436A; Dabrafenib [USAN:INN]; GSK2118436
Indication
Disease Entry ICD 11 Status REF
Melanoma 2C30 Approved [1]
Affected Organisms
Humans and other mammals
ATC Code
L01EC02: Dabrafenib
L01EC: B-Raf serine-threonine kinase (BRAF) inhibitors
L01E: PROTEIN KINASE INHIBITORS
L01: ANTINEOPLASTIC AGENTS
L: ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 2 Molecular Weight (mw) 519.6
Logarithm of the Partition Coefficient (xlogp) 4.8
Rotatable Bond Count (rotbonds) 6
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 11
ADMET Property
Absorption Tmax
The time to maximum plasma concentration (Tmax) is 2 h [2]
BDDCS Class
Biopharmaceutics Drug Disposition Classification System (BDDCS) Class 2: low solubility and high permeability [3]
Bioavailability
The bioavailability of drug is 95% [2]
Clearance
The clearance of drug is 17.0 L/h []
Elimination
Fecal excretion is the major route of elimination accounting for 71% of radioactive dose while urinary excretion accounted for 23% of total radioactivity as metabolites only []
Half-life
The concentration or amount of drug in body reduced by one-half in 8 hours []
Metabolism
The drug is metabolized via the liver [2]
Unbound Fraction
The unbound fraction of drug in plasma is 0.003% [4]
Vd
The volume of distribution (Vd) of drug is 70.3 L []
Chemical Identifiers
Formula
C23H20F3N5O2S2
IUPAC Name
N-[3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide
Canonical SMILES
CC(C)(C)C1=NC(=C(S1)C2=NC(=NC=C2)N)C3=C(C(=CC=C3)NS(=O)(=O)C4=C(C=CC=C4F)F)F
InChI
InChI=1S/C23H20F3N5O2S2/c1-23(2,3)21-30-18(19(34-21)16-10-11-28-22(27)29-16)12-6-4-9-15(17(12)26)31-35(32,33)20-13(24)7-5-8-14(20)25/h4-11,31H,1-3H3,(H2,27,28,29)
InChIKey
BFSMGDJOXZAERB-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
44462760
ChEBI ID
CHEBI:75045
CAS Number
1195765-45-7
UNII
QGP4HA4G1B
DrugBank ID
DB08912
TTD ID
D05ROI
VARIDT ID
DR00164
INTEDE ID
DR0403
ACDINA ID
D00163
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Serine/threonine-protein kinase B-raf (BRAF) TTWCGQT BRAF_HUMAN Inhibitor [5]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [6]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [6]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4)
Main DME 		DE4LYSA CP3A4_HUMAN Substrate [7]
Cytochrome P450 2C8 (CYP2C8)
Main DME 		DES5XRU CP2C8_HUMAN Substrate [8]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2) OTW8V2V1 ABCG2_HUMAN Gene/Protein Processing [9]
Cytochrome P450 1A2 (CYP1A2) OTLLBX48 CP1A2_HUMAN Gene/Protein Processing [9]
Cytochrome P450 2C19 (CYP2C19) OTFMJYYE CP2CJ_HUMAN Gene/Protein Processing [9]
Cytochrome P450 2C8 (CYP2C8) OTHCWT42 CP2C8_HUMAN Gene/Protein Processing [9]
Cytochrome P450 2C9 (CYP2C9) OTGLBN29 CP2C9_HUMAN Gene/Protein Processing [9]
Cytochrome P450 3A4 (CYP3A4) OTQGYY83 CP3A4_HUMAN Gene/Protein Processing [9]
Cytochrome P450 3A5 (CYP3A5) OTSXFBXB CP3A5_HUMAN Gene/Protein Processing [9]
GTPase KRas (KRAS) OT78QCN8 RASK_HUMAN Drug Response [10]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Post-Translational Modifications [11]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Post-Translational Modifications [11]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Melanoma
ICD Disease Classification 2C30
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Serine/threonine-protein kinase B-raf (BRAF) DTT BRAF 3.00E-01 0.1 0.2
P-glycoprotein 1 (ABCB1) DTP P-GP 9.48E-02 1.45E-01 2.92E-01
Breast cancer resistance protein (ABCG2) DTP BCRP 5.25E-11 6.24E-01 9.23E-01
Cytochrome P450 2C8 (CYP2C8) DME CYP2C8 6.39E-01 -5.46E-02 -2.77E-01
Cytochrome P450 3A4 (CYP3A4) DME CYP3A4 1.75E-01 3.78E-02 1.44E-01
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 44 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC1; GDSC2 5.665 7.9598 2.544 1.0568
CHSA8926 GDSC1; GDSC2 -0.3465 7.3692 -2.2173 42.0101
CHSA0011 GDSC1; GDSC2 1.6801 4.6407 1.0541 19.9509
ES1 GDSC1; GDSC2 1.8423 6.8272 0.2228 23.8603
CAL-78 GDSC1; GDSC2 3.7399 12.0196 -0.6837 21.841
TC-71 GDSC1; GDSC2 4.0453 7.7092 1.698 8.3326
EW-11 GDSC1; GDSC2 4.1606 10.9131 0.2006 16.5508
EW-12 GDSC2 4.2718 7.9695 1.7343 7.5775
SJSA-1 GDSC1; GDSC2 4.3097 6.8088 2.3169 3.9982
CHSA0108 GDSC1; GDSC2 4.3866 15.0903 -1.7003 24.0012
ES5 GDSC1; GDSC2 4.45 10.8366 0.4583 14.4687
ES7 GDSC1; GDSC2 4.6525 8.9044 1.5466 7.8534
H-EMC-SS GDSC1; GDSC2 4.7621 7.934 2.077 4.5418
ES6 GDSC1; GDSC2 4.8966 12.296 0.07 15.3581
CADO-ES1 GDSC1; GDSC2 4.9689 7.3608 2.4536 2.1743
U-CH2 GDSC2 5.0128 10.3831 1.0818 9.7483
NOS-1 [Human HNSCC] GDSC1; GDSC2 5.0504 9.1951 1.6705 6.3309
U2OS GDSC1; GDSC2 5.0689 8.3122 2.0885 3.9512
ES8 GDSC1; GDSC2 5.226 7.095 2.6881 0.8648
HuO-3N1 GDSC1; GDSC2 5.2871 12.1881 0.4006 12.8056
MHH-ES-1 GDSC1; GDSC2 5.4655 7.7788 2.5256 1.2962
EW-24 GDSC1; GDSC2 5.5243 7.6273 2.6118 0.9167
EW-3 GDSC1; GDSC2 5.5258 11.1893 1.0383 8.9368
CAL-72 GDSC1; GDSC2 5.5379 12.6767 0.3377 12.5823
EW-22 GDSC1; GDSC2 5.5569 8.1773 2.4071 1.7084
EW-7 GDSC1; GDSC2 5.6374 8.8478 2.1666 2.7311
EW-16 GDSC1; GDSC2 5.7752 11.0578 1.2571 7.289
HuO9 GDSC1; GDSC2 5.7824 11.5985 1.0104 8.5957
EW-18 GDSC1; GDSC2 5.7922 10.5807 1.4861 6.0306
ES4 GDSC1; GDSC2 5.8261 8.0772 2.5683 0.8557
SK-N-MC CTRP2 5.8459 7.2239 5.2821 3.6092
TC71 CTRP2 5.9551 7.8412 5.0705 4.2691
HOS GDSC1; GDSC2; CTRP2 6.0732 7.096 5.5424 2.0553
EW-13 GDSC1 6.1119 8.1439 2.6585 0.5525
EW-1 GDSC1; GDSC2 6.2609 8.1705 2.7049 0.2915
SK-PN-DW GDSC1; GDSC2 6.3388 8.1477 2.7408 0.209
NY GDSC1; GDSC2 6.4847 13.462 0.5827 9.5106
Hs 822.T CTRP2 6.969 7.77 5.7775 0.185
MG-63 GDSC2; CTRP2 7.2896 8.9236 4.511 0.2532
SK-ES-1 GDSC1; GDSC2; CTRP2 8.3281 19.7757 0.9765 16.0454
Hs 888.T CTRP2 8.3957 9.9539 5.5401 0.1685
G-292 clone A141B1 GDSC1; GDSC2; CTRP2 8.8066 10.5895 5.4686 0.1768
A-673 GDSC1; GDSC2; CTRP2 8.82 29.0071 -3.2138 25.6261
SaOS-2 GDSC1; GDSC2; CTRP2 11.5173 23.7422 1.2342 10.8533
⏷ Show the Full List of 44 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 193 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MEC1 CTRP2 5.4958 6.393 5.3243 4.2854
JM1 GDSC1; GDSC2; CTRP2 3.4325 8.1561 2.4309 21.0777
SIG-M5 GDSC2; CTRP2 -13.8101 4.7675 -15.2885 79.9519
OCI-Ly7 GDSC2 -7.6794 -6.1632 -7.6794 98.6076
Pfeiffer CTRP2 -1.2385 3.6847 -1.4058 48.6204
697 GDSC1; GDSC2; CTRP2 -1.0748 3.4429 -1.1999 47.5601
JVM-2 GDSC1; GDSC2 -0.2731 4.0492 -0.8216 38.2601
SU-DHL-16 GDSC1; GDSC2 -0.0686 1.4626 -0.0793 34.0778
L-540 GDSC1; GDSC2 0.2918 3.6677 -0.0854 32.2481
JVM-3 GDSC1; GDSC2 0.4891 7.3847 -1.3747 36.0589
KMS-20 CTRP2 0.5063 4.9312 0.264 37.6061
MEG-01 GDSC1; GDSC2 0.9007 4.7166 0.2011 27.9338
EoL-1 GDSC1; GDSC2; CTRP2 1.0935 2.7335 1.0915 32.9902
MOLM-16 GDSC1; GDSC2 1.2773 4.7489 0.5866 24.2546
HDLM-2 GDSC1; GDSC2 1.304 8.8206 -1.2484 32.1834
TALL-1 [Human adult T-ALL] GDSC2 1.4164 5.1312 0.5719 23.7398
BV-173 GDSC1; GDSC2 1.562 6.9249 -0.096 26.5313
AMO1 GDSC1; GDSC2 1.5925 4.1371 1.1628 19.7005
KE-37 GDSC1; GDSC2 1.6391 4.8466 0.9245 20.8575
IM-9 GDSC1; GDSC2 1.6534 6.925 -0.0069 25.7412
BE-13 GDSC1; GDSC2 1.6789 6.2438 0.3378 23.9083
Karpas-422 GDSC1; GDSC2; CTRP2 1.7026 3.4012 1.697 28.9445
SUP-B8 GDSC1; GDSC2 1.7219 7.0164 0.0164 25.3578
Ku812 GDSC1; GDSC2 1.7278 4.2227 1.274 18.4932
OCI-Ly19 GDSC1; GDSC2; CTRP2 1.9822 7.9585 0.9731 30.4136
NB4 GDSC1; GDSC2 2.0221 6.2724 0.6607 20.8336
RPMI-8226 GDSC1; GDSC2 2.0756 6.9789 0.3735 22.1923
MJ CTRP2 2.0979 17.7093 -3.333 38.707
JURL-MK1 GDSC1; GDSC2 2.1989 4.9949 1.4316 15.6793
MV4-11 GDSC1; GDSC2 2.2266 4.9666 1.4723 15.33
U266B1 GDSC1; GDSC2; CTRP2 2.2339 6.38 1.7896 26.92
Kasumi-2 CTRP2 2.2575 10.8372 0.0539 32.1627
MOLM-13 GDSC1; GDSC2 2.2575 6.1498 0.946 18.3364
BC-1 GDSC1; GDSC2 2.2673 6.2436 0.9103 18.5078
Mono-Mac-6 GDSC1; GDSC2 2.2679 8.1611 -0.0238 23.5077
EM-2 GDSC1; GDSC2 2.3393 4.7623 1.6787 13.6613
LC4-1 GDSC1; GDSC2 2.3834 7.7921 0.2635 21.6545
GDM-1 GDSC1; GDSC2 2.3959 5.5987 1.3428 15.4816
GA-10 GDSC1; GDSC2; CTRP2 2.3964 7.3129 1.6567 26.8775
NU-DHL-1 CTRP2 2.4145 14.6275 -1.5509 35.204
SU-DHL-5 GDSC1; GDSC2 2.4305 5.3101 1.5135 14.3224
WSU-NHL GDSC1; GDSC2 2.4766 5.4794 1.4774 14.3756
NKM-1 GDSC1; GDSC2 2.5567 6.3616 1.1252 16.2204
P32/ISH GDSC1; GDSC2 2.5801 6.2979 1.1781 15.8234
RS4;11 GDSC1; GDSC2 2.6015 7.7387 0.4877 19.7096
HD-MY-Z CTRP2 2.6339 9.2555 1.134 27.9099
Jurkat GDSC1; GDSC2 2.6564 9.1294 -0.1535 22.7871
SU-DHL-6 GDSC1; GDSC2 2.677 4.8802 1.9566 10.7214
MM1.S GDSC2 2.69 4.1784 2.2967 8.5973
DEL GDSC1; GDSC2 2.7507 7.7291 0.6259 18.4491
OCI-AML-2 GDSC1; GDSC2 2.7508 4.3634 2.2727 8.5143
CML-T1 GDSC1; GDSC2 2.8539 6.0625 1.5444 12.6716
LAMA-84 GDSC1; GDSC2 2.9142 8.2338 0.5185 18.5073
CTB-1 GDSC1; GDSC2 2.9831 7.9081 0.7407 17.0503
Karpas-299 GDSC1; GDSC2 3.1188 8.4143 0.6045 17.3872
JJN-3 GDSC1; GDSC2; CTRP2 3.1417 7.479 2.3951 22.0303
Mino CTRP2 3.1491 10.8785 0.9318 27.0832
HAL-01 GDSC1; GDSC2 3.1912 10.1473 -0.2002 21.2922
HC-1 GDSC1; GDSC2 3.1963 12.2621 -1.2533 25.6865
MHH-CALL-4 GDSC2 3.2576 9.3031 0.2776 18.7173
KCL-22 GDSC1; GDSC2 3.2581 5.375 2.2418 7.0264
KG-1 GDSC1; GDSC2 3.2862 8.3475 0.7793 15.8942
Hs 445 GDSC1; GDSC2 3.3016 12.2168 -1.1425 24.9582
NCI-H929 GDSC1; GDSC2 3.3229 7.7327 1.1174 13.8151
ALL-SIL GDSC1; GDSC2 3.3437 7.1917 1.4051 12.0143
OCI-AML-3 GDSC1; GDSC2; CTRP2 3.3543 5.9957 3.1218 18.7333
A3/Kawakami GDSC1; GDSC2; CTRP2 3.4512 10.1425 1.572 24.1458
DoHH2 GDSC2 3.4565 7.3166 1.4356 11.5013
OCI-Ly3 CTRP2 3.4862 11.7632 0.8485 26.4329
Daudi GDSC1; GDSC2; CTRP2 3.4999 6.4938 3.1329 18.2554
MY-M12 GDSC2 3.5449 7.3528 1.4892 10.9232
DG-75 GDSC1; GDSC2 3.5557 9.7448 0.3032 17.6978
OCI-Ly10 CTRP2 3.5648 7.6189 2.7902 19.3547
OPM-2 GDSC1; GDSC2; CTRP2 3.6104 6.5008 3.2507 17.4948
SKM-1 GDSC1; GDSC2 3.6924 7.3111 1.6271 9.6702
BL-41 GDSC1; GDSC2 3.7092 6.3396 2.1224 6.5386
H9 GDSC1; GDSC2 3.7175 8.6275 0.9912 13.43
MOLT-4 GDSC1; GDSC2 3.7334 5.9461 2.335 5.1494
MOLT-13 GDSC1; GDSC2 3.8047 7.2525 1.7431 8.6575
MLMA GDSC1; GDSC2 3.8181 11.2164 -0.2198 19.5443
KMOE-2 GDSC1; GDSC2 3.8201 7.7788 1.4938 10.1504
Karpas-1106P GDSC1; GDSC2 3.8622 7.2452 1.7904 8.2182
GR-ST GDSC1; GDSC2 3.867 10.4643 0.1942 17.3782
CRO-AP2 GDSC1; GDSC2 3.8686 7.1003 1.8667 7.7295
NK-92MI GDSC2 3.8706 5.7159 2.5456 3.5303
NOMO-1 GDSC1; GDSC2 3.9437 5.8069 2.5516 3.3379
CTV-1 GDSC1; GDSC2 3.9557 7.6415 1.6649 8.7567
EHEB GDSC1 4.0145 13.0874 -0.9963 25.6959
Karpas-620 GDSC1; GDSC2 4.0247 7.1361 1.9641 6.7493
ME1 GDSC1; GDSC2 4.0347 6.935 2.0694 6.0782
CCRF-CEM GDSC1; GDSC2 4.0465 9.0438 1.0401 12.2663
Karpas-45 GDSC1; GDSC2 4.0798 6.3314 2.3923 4.0126
BC-3 GDSC2 4.1061 8.1797 1.5115 9.3183
SU-DHL-1 GDSC2 4.1111 8.4605 1.377 10.1147
VAL GDSC1; GDSC2 4.1216 10.5552 0.3482 15.893
RPMI-6666 GDSC1; GDSC2; CTRP2 4.1382 11.7743 1.4689 22.7307
MN-60 GDSC1; GDSC2 4.1521 6.7342 2.2482 4.7286
KO52 CTRP2 4.2569 9.0776 2.8654 17.2314
KOPN-8 GDSC1; GDSC2 4.2812 7.5224 1.9574 6.2078
DND-41 GDSC1; GDSC2; CTRP2 4.2892 9.1811 2.8495 17.2128
YT GDSC1; GDSC2 4.3169 6.0697 2.6619 2.0215
MOLT-16 GDSC1; GDSC2 4.3396 9.8586 0.858 12.5633
MOLP-8 GDSC1; GDSC2; CTRP2 4.3434 7.8572 3.5039 14.4889
SR GDSC1; GDSC2 4.3767 8.4512 1.5743 8.3003
Kasumi-1 GDSC1; GDSC2; CTRP2 4.3771 8.2701 3.355 14.9906
Raji GDSC1; GDSC2 4.3849 6.8245 2.3573 3.6198
KY821 GDSC1; GDSC2 4.4006 6.5258 2.5046 2.7525
THP-1 GDSC1; GDSC2 4.4062 6.6064 2.4712 2.9307
MHH-PREB-1 GDSC1; GDSC2 4.4184 10.2371 0.7302 13.0795
QIMR-WIL GDSC1; GDSC2 4.4919 10.3206 0.7433 12.8269
RCH-ACV GDSC1; GDSC2 4.5975 8.485 1.7105 7.0052
Jiyoye GDSC1 4.6419 9.8635 1.0753 12.8889
WSU-DLCL2 GDSC1; GDSC2 4.6543 11.2245 0.4186 14.1742
P31/FUJ GDSC1; GDSC2 4.6738 10.1819 0.9429 11.2834
SUP-T1 GDSC1; GDSC2 4.6842 6.9473 2.4792 2.4412
MC116 GDSC1; GDSC2 4.6909 5.6556 3.008 0.1907
HT GDSC1; GDSC2 4.6941 6.5975 2.6369 1.6222
L-363 GDSC1; GDSC2 4.7055 7.0807 2.4319 2.661
CESS GDSC1; GDSC2 4.7142 9.4424 1.33 8.983
KMS-12-BM GDSC2 4.7314 8.1601 1.9523 5.3172
MHH-CALL-2 GDSC1; GDSC2 4.7422 6.6116 2.6556 1.4733
RPMI-8866 GDSC1; GDSC2 4.7521 12.5592 -0.1658 16.8419
SU-DHL-10 GDSC1; GDSC2 4.7711 8.6277 1.7578 6.3713
BALL-1 GDSC1; GDSC2 4.7777 8.9333 1.617 7.1783
RC-K8 GDSC1; GDSC2 4.8055 6.2476 2.8336 0.6536
JSC-1 GDSC1; GDSC2 4.8126 11.8762 0.2146 14.8398
KMS-11 GDSC1; GDSC2 4.813 8.4935 1.8481 5.7646
WIL2 NS GDSC1; GDSC2 4.8737 9.3607 1.4772 7.7911
TK [Human B-cell lymphoma] GDSC1; GDSC2 4.9008 9.1315 1.604 7.0037
K-562 GDSC1; GDSC2; CTRP2 4.9616 9.1128 3.5352 12.8335
SCC-3 GDSC2 4.9773 6.0738 2.9671 0.1784
SU-DHL-4 GDSC1; GDSC2 4.9958 6.0776 2.9725 0.1623
P30/OHK GDSC1; GDSC2 5.0059 9.4601 1.5172 7.2932
L-1236 GDSC1; GDSC2 5.0172 8.0047 2.1969 3.4446
U-698-M GDSC1; GDSC2 5.0203 10.2772 1.1377 9.4189
BONNA-12 GDSC2 5.0306 10.0863 1.2359 8.844
MOLT-3 CTRP2 5.0393 9.2806 3.5277 12.6837
P12-Ichikawa GDSC1; GDSC2 5.0407 6.3772 2.8825 0.3515
ATN-1 GDSC1; GDSC2 5.0644 10.6339 0.9964 10.1129
ML-2 GDSC1; GDSC2 5.0748 6.6531 2.7934 0.6023
LP-1 GDSC1; GDSC2; CTRP2 5.0852 7.0563 4.6162 8.1544
TUR GDSC1; GDSC2 5.1224 12.4665 0.1494 14.4394
VL51 GDSC1; GDSC2 5.1263 7.4006 2.5177 1.6745
Farage GDSC1; GDSC2 5.1358 7.0084 2.6819 0.9619
Karpas-231 GDSC1; GDSC2 5.1726 6.5557 2.8692 0.3254
EB1 CTRP2 5.2092 21.2301 -2.2552 30.0347
PL-21 GDSC1; GDSC2 5.215 11.7336 0.5701 12.0856
Ramos.2G6.4C10 GDSC1; GDSC2 5.2593 6.9842 2.7452 0.641
KM-H2 GDSC1; GDSC2 5.2747 7.1271 2.697 0.7958
SK-MM-2 GDSC1; GDSC2 5.3001 7.1819 2.6868 0.8134
ARH-77 GDSC1; GDSC2 5.3214 11.1574 0.9191 9.9951
Reh GDSC1; GDSC2 5.338 6.8615 2.8227 0.3699
NU-DUL-1 GDSC1; GDSC2 5.3494 6.9097 2.8096 0.3987
SUP-M2 GDSC1; GDSC2; CTRP2 5.355 7.9073 4.4906 7.996
RPMI-8402 GDSC1; GDSC2 5.3838 11.0605 1.0066 9.3913
TF-1 CTRP2 5.4147 11.3444 2.8529 14.5949
EJM GDSC1; GDSC2; CTRP2 5.4948 10.5658 3.3108 12.568
HEL GDSC1; GDSC2 5.496 12.3443 0.4688 12.0059
Namalwa GDSC1; GDSC2; CTRP2 5.5159 15.1922 1.023 21.0747
SU-DHL-8 GDSC1; GDSC2 5.5549 7.0305 2.8444 0.2382
NALM-6 GDSC1; GDSC2 5.5737 10.2154 1.5219 6.2093
BL-70 CTRP2 5.6029 19.0727 -0.8412 26.1788
ST486 GDSC1; GDSC2; CTRP2 5.6108 11.5475 2.9237 13.8974
RL GDSC1; GDSC2; CTRP2 5.6239 6.5261 5.4016 3.641
A4/Fukuda GDSC1; GDSC2 5.6477 7.263 2.797 0.3054
EB2 GDSC1; GDSC2 5.6566 7.4695 2.726 0.4749
HL-60 GDSC1; GDSC2; CTRP2 5.6814 8.7013 4.4025 7.6357
Sc-1 GDSC1 5.6841 12.6974 0.4266 14.0404
PF-382 GDSC1; GDSC2 5.7563 7.5473 2.7366 0.4027
Toledo CTRP2 5.8096 7.3652 5.1794 4.116
F-36P CTRP2 5.8573 10.9249 3.4465 11.2614
HEL 92.1.7 CTRP2 5.8782 7.2701 5.2881 3.5153
CA46 GDSC1; GDSC2; CTRP2 5.8784 15.1598 1.3477 19.2389
HuT 78 CTRP2 5.9103 8.043 4.9312 4.9443
OCI-AML-5 GDSC1; GDSC2; CTRP2 5.9162 7.2024 5.3553 3.1536
ROS-50 GDSC1; GDSC2 5.9377 8.7729 2.3452 1.6013
Loucy GDSC1; GDSC2 5.9628 15.8176 -0.8853 17.2402
Ci-1 CTRP2 6.1203 7.0593 5.5988 1.7316
OCI-M1 GDSC1; GDSC2; CTRP2 6.1849 7.2564 5.5511 1.8177
SEM CTRP2 6.1866 12.1332 3.1177 11.9633
SET-2 CTRP2 6.2052 7.7392 5.327 2.7193
HH [Human lymphoma] GDSC1; GDSC2; CTRP2 6.22 15.0436 1.6903 17.363
JeKo-1 GDSC1; GDSC2; CTRP2 6.2657 12.5257 2.9863 12.3433
MOTN-1 CTRP2 6.3155 11.2984 3.6398 9.5782
ALL-PO GDSC1; GDSC2 6.413 8.7479 2.5567 0.5663
SUP-B15 GDSC2; CTRP2 6.4675 13.5014 2.6624 13.2488
Granta-519 GDSC1; GDSC2; CTRP2 6.9027 11.7952 3.8492 7.685
SUP-HD1 GDSC1; GDSC2; CTRP2 7.0141 9.7941 4.9031 3.2169
CMK GDSC1; CTRP2 7.0457 11.0755 4.3066 5.5818
DB GDSC1; GDSC2; CTRP2 7.0828 18.9294 0.4455 19.8196
AML-193 CTRP2 7.0849 12.1501 3.8093 7.5528
Hs 611.T CTRP2 8.4047 10.1007 5.4914 0.2361
L-428 GDSC1; GDSC2; CTRP2 9.0047 19.1004 1.7885 12.3117
⏷ Show the Full List of 193 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 27 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE15 CTRP2 8.2406 19.5281 1.0338 16.0022
TE-8 GDSC1; GDSC2 3.8063 8.0973 1.325 11.211
TE-4 GDSC1; GDSC2 4.2088 6.8983 2.2079 4.8515
COLO 680N GDSC1; GDSC2 4.5352 6.9901 2.3732 3.2606
TE-1 GDSC1; GDSC2 4.7918 8.0963 2.0202 4.8132
TE-6 GDSC1; GDSC2 4.8712 9.738 1.2951 8.8437
TE-10 GDSC1; GDSC2 4.9061 7.042 2.5572 1.7459
KYSE-410 GDSC2 5.0519 8.6307 1.9332 4.8411
TE-9 GDSC1; GDSC2 5.0717 6.9475 2.6769 1.0377
TE-15 GDSC1; GDSC2 5.115 13.4655 -0.3442 16.7993
KYSE-270 GDSC1; GDSC2 5.2062 7.5264 2.5049 1.6444
T.T GDSC1; GDSC2 5.3024 13.5796 -0.2647 16.0036
OE19 GDSC1; GDSC2; CTRP2 5.626 7.1909 3.5539 0.5955
KYSE-150 GDSC1; GDSC2; CTRP2 5.7941 6.6184 5.5291 2.7029
KYSE-70 GDSC1; GDSC2 5.8801 7.6959 2.7306 0.367
KYSE-140 GDSC2 5.9656 8.8651 2.3211 1.6745
KYSE-30 CTRP2 6.0028 7.2211 5.4211 2.7015
KYSE-510 GDSC1; GDSC2; CTRP2 6.2853 7.5801 5.4669 2.0001
OE21 GDSC1; GDSC2; CTRP2 6.3364 7.7502 5.421 2.1078
TE-11 GDSC1; GDSC2; CTRP2 6.3852 8.9949 4.8427 4.4306
KYSE-180 GDSC1; GDSC2 6.4125 15.3676 -0.3608 14.0856
KYSE-520 GDSC1; GDSC2; CTRP2 6.4705 8.9045 4.9521 3.8316
KYSE-450 GDSC1; GDSC2; CTRP2 6.6304 8.7325 5.1518 2.7604
TE-5 GDSC1; GDSC2; CTRP2 6.7067 8.5706 5.2815 2.1312
TE-14 CTRP2 6.8574 8.8351 5.2544 2.0401
EC-GI-10 GDSC1; GDSC2; CTRP2 8.3639 19.5054 1.1354 15.4756
OE33 GDSC1; GDSC2; CTRP2 8.6179 16.1074 2.9622 8.619
⏷ Show the Full List of 27 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 34 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
N2a-PK1 CTRP2 7.5637 13.8952 1.6882 5.7087
YAPC GDSC1; GDSC2 1.6023 10.3107 -1.6918 32.4447
BxPC-3 GDSC1; GDSC2 3.6993 12.7504 -1.0816 23.5755
HPAF-II GDSC1; GDSC2 3.886 6.4226 2.2128 5.5413
PSN1 GDSC1; GDSC2; CTRP2 3.8959 10.7185 1.7417 22.3835
HPAC GDSC2 4.2789 9.2764 1.0998 11.3334
MZ-PC-1 GDSC1; GDSC2 4.4024 9.8762 0.8959 12.1955
SUIT-2 GDSC1; GDSC2 4.5595 7.7717 2.0246 5.2289
CFPAC-1 GDSC1; GDSC2 4.8316 9.8876 1.1962 9.4946
PL4 GDSC1; GDSC2 4.8429 8.6425 1.7972 6.0011
KP-1N GDSC1; GDSC2 5.0381 10.1882 1.1922 9.0744
KP-4 GDSC1; GDSC2 5.0753 6.8929 2.7003 0.9414
SU.86.86 GDSC1; GDSC2 5.3003 6.7628 2.8438 0.3334
QGP-1 GDSC1; GDSC2 5.3098 8.0611 2.3321 2.3364
KP-3 GDSC1; GDSC2 5.4059 8.1148 2.3586 2.0935
PaTu 8902 GDSC1; GDSC2 5.4543 9.9928 1.5517 6.2559
HuP-T4 GDSC2 5.5097 7.5594 2.6316 0.8567
Hs 766T GDSC1; GDSC2; CTRP2 5.9636 10.5893 3.7043 9.9817
DAN-G GDSC2; CTRP2 6.3892 7.8461 5.4122 2.0611
AsPC-1 GDSC1; GDSC2; CTRP2 6.4106 11.7804 3.4756 10.0813
Panc 03.27 GDSC1; GDSC2; CTRP2 6.4464 8.0692 5.3443 2.2517
Panc 08.13 GDSC1; GDSC2; CTRP2 6.4543 9.8247 4.4841 5.8084
HuP-T3 GDSC1; GDSC2; CTRP2 6.7019 8.4066 5.356 1.8431
Capan-2 GDSC1; GDSC2; CTRP2 6.7193 8.8973 5.1337 2.7049
KP-2 GDSC1; GDSC2; CTRP2 6.8387 10.856 4.2641 6.0804
Panc 02.03 GDSC1; GDSC2; CTRP2 6.8621 8.9755 5.1914 2.2801
Panc 04.03 GDSC2; CTRP2 7.1235 10.3742 4.6994 3.8785
PK-45H CTRP2 7.2336 18.9813 0.5383 19.2672
Capan-1 GDSC2; CTRP2 7.2394 11.4082 4.2813 5.395
MIA PaCa-2 GDSC1; GDSC2; CTRP2 7.27 11.6366 4.1921 5.7106
Panc 10.05 GDSC1; GDSC2; CTRP2 7.3249 9.519 5.2225 1.6289
PaTu 8988t GDSC1; GDSC2; CTRP2 7.3468 9.4617 5.2602 1.4741
SW1990 GDSC1; GDSC2; CTRP2 7.8787 17.0706 1.9753 13.3797
PaTu 8988s CTRP2 7.9989 20.5303 0.3588 18.4889
⏷ Show the Full List of 34 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 71 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SH4 CTRP2 -7.5108 9.6834 -9.8812 67.2834
WM88 CTRP2 -14.6202 -1.9489 -14.9321 88.8142
WM983B CTRP2 -10.9558 14.7877 -15.4592 68.6771
WT2-iPS GDSC1; GDSC2; CTRP2 -10.6339 3.79 -11.5948 78.2082
SK-MEL-28 GDSC1; GDSC2 -9.9382 10.8443 -13.7243 70.1943
WM115 GDSC1; GDSC2; CTRP2 -9.8654 20.4188 -16.6042 64.4643
UACC-257 GDSC1; GDSC2; CTRP2 -9.3631 29.5035 -20.1208 60.8322
CP50-MEL-B GDSC1; GDSC2 -9.1277 4.5385 -10.6154 75.8766
WM266-4 CTRP2 -9.0697 18.0822 -14.7896 64.5201
UACC-62 GDSC1; GDSC2; CTRP2 -8.3429 14.0236 -12.3793 65.656
SK-MEL-24 GDSC1; GDSC2; CTRP2 -7.6976 9.9459 -10.174 67.4107
G-mel GDSC1; GDSC2 -7.0848 -0.0049 -7.3302 80.9822
COLO 800 GDSC1; GDSC2; CTRP2 -6.9541 7.777 -8.6496 67.8423
M14 GDSC1; GDSC2 -6.7158 6.1294 -8.51 69.3898
A-375 GDSC1; GDSC2 -6.0187 3.6538 -6.9643 71.1345
HT-144 GDSC1; GDSC2; CTRP2 -5.9234 17.701 -11.3538 59.8495
SH-4 GDSC1; GDSC2 -5.8013 1.4731 -6.1975 74.5272
COLO 829 GDSC1; GDSC2; CTRP2 -5.6793 32.5258 -17.8967 55.9451
Mel Ho GDSC1; GDSC2 -5.3668 20.8523 -13.4311 57.5955
WM35 GDSC1; GDSC2 -5.3456 3.8193 -6.2776 68.9087
Malme-3M CTRP2 -5.0464 16.5738 -9.9615 58.6103
COLO 679 GDSC1; GDSC2 -4.5937 20.8494 -12.6756 56.205
451Lu GDSC1; GDSC2 -4.0188 9.2488 -6.8304 59.1463
COLO 783 GDSC1; GDSC2 -3.9999 9.4145 -6.8801 58.9872
Hs 938.T GDSC1; GDSC2 -2.6558 40.2994 -20.3576 51.2655
MZ-MEL-7 GDSC1; GDSC2 -2.5993 19.6635 -10.1883 52.269
SK-MEL-1 GDSC1; GDSC2 -1.9525 2.7433 -2.2872 52.4097
G-361 GDSC1; GDSC2 -1.9038 11.0922 -5.4674 50.9712
MMAc-SF GDSC1; GDSC2 -0.9968 9.9774 -4.0488 46.9319
WM278 GDSC1; GDSC2 -0.159 38.224 -17.1085 47.8668
LOX-IMVI GDSC1; GDSC2; CTRP2 0.8959 12.3113 -1.9889 40.3941
IPC-298 GDSC1; GDSC2 0.9081 5.2733 -0.0175 28.9626
WM793 GDSC1; GDSC2 1.6123 15.1937 -4.0927 37.6811
HMV-II GDSC1; GDSC2 1.8792 6.0336 0.6336 21.5308
A101D GDSC1; GDSC2; CTRP2 2.0144 22.0612 -5.5286 41.0721
MZ-MEL-2 GDSC1; GDSC2 2.8508 9.5434 -0.1896 22.3173
Mel JuSo GDSC1; GDSC2 2.9199 8.3369 0.472 18.7418
A-431 GDSC1; GDSC2 3.018 10.715 -0.6308 23.7628
IGR-37 GDSC1; GDSC2; CTRP2 3.5367 43.4123 -14.7684 43.2532
SK-MEL-31 GDSC1; GDSC2 3.5951 21.2317 -5.4063 34.6339
GAK GDSC1; GDSC2 3.678 6.3791 2.079 6.8903
SK-MEL-5 GDSC1; GDSC2 4.0345 25.7157 -7.2868 36.2275
CHL-1 GDSC1; GDSC2 4.1088 8.4861 1.3626 10.2065
IGR-1 GDSC2; CTRP2 4.3175 40.3024 -12.5441 41.4152
CP66-MEL GDSC1; GDSC2 4.5688 10.0765 0.919 11.6644
LB373-MEL-D GDSC1; GDSC2 4.6502 5.8124 2.9342 0.4143
LB2518-MEL GDSC1; GDSC2 4.7787 6.9258 2.5403 1.9914
IST-MEL1 GDSC1; GDSC2 4.9165 13.9169 -0.7125 18.8903
RVH-421 GDSC1; GDSC2; CTRP2 4.9861 65.6181 -24.6288 44.2209
VMRC-MELG GDSC1; GDSC2 5.2763 13.4564 -0.2233 15.8716
WM1552C GDSC1; GDSC2 5.3598 19.54 -3.1577 26.0977
MeWo GDSC1; GDSC2; CTRP2 5.4691 12.5661 2.2926 16.6718
RPMI-7951 GDSC2 5.647 7.7154 2.6305 0.767
SK-MEL-30 GDSC1; GDSC2 5.7287 12.8637 0.3771 11.9854
CJM [Human melanoma] CTRP2 5.8426 7.8576 4.9646 4.9438
K029AX CTRP2 5.9973 59.3993 -20.6723 42.4467
HMCB CTRP2 6.0396 6.8496 5.6377 1.7187
A-388 GDSC1; GDSC2 6.0515 8.5615 2.4789 1.0054
Hs 294T CTRP2 6.0698 37.4241 -9.6243 37.3758
DJM-1 GDSC1; GDSC2 6.1431 8.1401 2.6718 0.4004
A2058 GDSC2; CTRP2 6.687 8.6262 5.2418 2.3165
SK-MEL-3 GDSC1; GDSC2; CTRP2 7.1273 41.1131 -10.5959 36.7064
Hs 934.T CTRP2 7.1646 20.8864 -0.4649 22.2439
SK-MEL-2 GDSC1; GDSC2; CTRP2 7.2965 8.6317 5.5857 0.4854
IGR-39 CTRP2 7.5036 9.2709 5.4239 0.8091
Hs 839.T CTRP2 7.5656 8.5031 5.7427 0.0793
Hs 688(A).T CTRP2 7.6915 8.8013 5.6847 0.1266
COLO 792 GDSC1; GDSC2; CTRP2 7.9647 9.4516 5.5558 0.2566
Hs 940.T GDSC1; GDSC2; CTRP2 8.8595 21.0637 0.732 15.9825
Hs 895.T CTRP2 9.8111 18.8573 2.439 8.9548
EquiPSC Line K2 GDSC1; GDSC2 -6.1417 9.8842 -9.3213 64.3866
⏷ Show the Full List of 71 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ESO-51 GDSC1; GDSC2 4.2808 7.4586 1.9879 6.0245
FLO-1 GDSC1; GDSC2 4.3339 13.8074 -1.1032 21.9446
KYSE-50 GDSC1; GDSC2 4.4261 8.7294 1.474 8.7847
KYAE-1 GDSC1; GDSC2 4.8344 7.2436 2.4319 2.4702
HCE-4 GDSC1; GDSC2 5.0123 8.3167 2.0531 4.2404
KYSE-220 GDSC1; GDSC2 5.2889 8.0092 2.3434 2.3075
ESO-26 GDSC1; GDSC2 5.5217 7.14 2.7931 0.3638
TE-12 GDSC1; GDSC2 5.6842 12.0831 0.719 10.3234
OACP4 C GDSC1; GDSC2 5.6904 9.2076 2.0398 3.2885
OACM5.1 C GDSC1; GDSC2 6.2216 8.5568 2.5511 0.6748
SK-GT-4 GDSC1; GDSC2 6.4051 9.1417 2.4073 1.0091
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1; GDSC2; CTRP2 6.2341 10.1748 4.1351 7.6643
Cancer Drug Sensitivity Data Curated from 35 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SJNB-6 GDSC2 0.1993 3.6719 -0.1875 33.1879
GI-ME-N GDSC1; GDSC2 3.6641 7.1312 1.6944 9.3287
SJNB-5 GDSC1; GDSC2 3.8563 5.4314 2.6724 2.7938
NB69 GDSC2 3.8769 5.8736 2.4737 3.9553
MHH-NB-11 GDSC2 4.2174 8.2345 1.5661 8.7203
SJNB-14 GDSC1; GDSC2 4.3486 6.9368 2.2818 4.1294
SJNB-13 GDSC1; GDSC2 4.4784 6.4975 2.5629 2.3058
NH-12 GDSC2 4.6213 7.3166 2.2755 3.6633
TGW GDSC1; GDSC2 4.6404 6.7074 2.5607 2.0778
SJNB-10 GDSC1; GDSC2 4.6589 6.6669 2.5884 1.9101
NB(TU)1 GDSC1; GDSC2 4.7129 7.4667 2.262 3.5816
SK-N-MC-IXC GDSC1; GDSC2 4.8119 6.1828 2.8615 0.5499
Kelly GDSC1; GDSC2 5.1037 6.5231 2.854 0.3985
SJNB-12 GDSC1; GDSC2 5.1103 10.2516 1.2103 8.8227
GOTO GDSC1; GDSC2 5.1226 9.2479 1.6914 6.077
CHP-134 GDSC2 5.3216 6.666 2.8863 0.2295
IMR-5 GDSC1; GDSC2 5.3409 7.5346 2.5659 1.2453
CHP-126 GDSC1; GDSC2 5.3826 7.228 2.7044 0.6952
CHP-212 GDSC1; GDSC2; CTRP2 5.389 7.8461 4.5524 7.6624
SJNB-7 GDSC1; GDSC2 5.4166 7.1396 2.7517 0.5263
SK-N-BE(2)-M17 GDSC1; GDSC2 5.446 7.1269 2.7682 0.4636
KP-N-RT-BM-1 GDSC2 5.5156 7.9694 2.4722 1.4707
LA-N-6 GDSC1; GDSC2 5.5703 7.0777 2.8336 0.255
SiMa GDSC1; GDSC2 5.669 7.4375 2.7425 0.4259
SJNB-17 GDSC1; GDSC2 5.7529 7.6902 2.6832 0.5446
KP-N-YS GDSC2 5.8839 7.789 2.6986 0.4419
NB1 GDSC1; GDSC2 5.9791 7.5507 2.8175 0.1727
SK-N-BE(2) CTRP2 6.1473 8.0471 5.1275 3.66
IMR-32 CTRP2 6.3111 7.7324 5.4111 2.1895
SK-N-DZ GDSC1; GDSC2; CTRP2 6.3116 7.7012 5.4268 2.1238
SK-N-AS GDSC1; GDSC2; CTRP2 7.1722 11.3258 4.2743 5.5225
NH-6 CTRP2 7.3841 12.2359 3.9816 6.392
KP-N-YN GDSC1; GDSC2; CTRP2 7.5189 9.1687 4.5102 0.195
SK-N-SH GDSC1; GDSC2; CTRP2 7.6932 15.6932 2.5156 11.6891
SK-N-FI GDSC1; GDSC2; CTRP2 8.211 15.3036 3.0723 8.7732
⏷ Show the Full List of 35 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC1; GDSC2 4.0343 10.1396 0.4871 15.3905
SNU-869 CTRP2 7.4366 8.9987 5.5032 0.6251
Cancer Drug Sensitivity Data Curated from 87 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DU4475 GDSC1; GDSC2; CTRP2 -8.5382 -4.4136 -8.5398 89.8314
Hs 578Bst CTRP2 2.834 25.8343 -6.6388 40.2812
MCF-7 GDSC1; GDSC2 3.8486 6.8367 1.9818 7.0406
OCUB-M GDSC1; GDSC2 3.9906 7.106 1.9541 6.8676
UACC-812 GDSC2 4.4372 7.5802 2.0351 5.4121
HCC1187 GDSC1; GDSC2 4.482 8.371 1.6865 7.37
CAL-51 GDSC1; GDSC2 4.5715 8.4045 1.7315 6.912
HCC2157 GDSC1; GDSC2 4.6425 6.754 2.5413 2.1752
CAL-120 GDSC1; GDSC2 4.7095 11.6273 0.2613 14.8089
CAMA-1 GDSC1; GDSC2 4.7996 8.7482 1.7193 6.5158
JIMT-1 GDSC1; GDSC2 4.8193 6.6527 2.6769 1.283
HDQ-P1 GDSC1; GDSC2 4.8595 9.5275 1.3881 8.3069
EFM-19 GDSC1; GDSC2 4.9371 7.2875 2.4684 2.1351
MDA-MB-231 GDSC1; GDSC2 4.9651 8.2012 2.0776 4.1693
HCC1599 GDSC2 5.1056 6.8261 2.74 0.764
CAL-148 GDSC2 5.1762 6.4969 2.8917 0.2688
HCC1569 GDSC1; GDSC2 5.1965 9.9412 1.4137 7.4804
Evsa-T GDSC1; GDSC2 5.249 6.9949 2.7368 0.6735
MRK-nu-1 GDSC1; GDSC2 5.3336 7.0535 2.75 0.5772
YMB-1-E GDSC2 5.3613 7.4781 2.5978 1.0992
BT-483 GDSC1; GDSC2 5.3747 9.6191 1.6751 5.6955
MDA-MB-436 GDSC1; GDSC2 5.4667 7.4893 2.6401 0.8548
HCC1937 GDSC1; GDSC2 5.603 7.3108 2.7628 0.4024
MDA-MB-175-VII GDSC1; GDSC2 5.7641 8.1599 2.5096 1.1032
HCC70 GDSC1; GDSC2 5.8029 7.2463 2.8591 0.1487
COLO 824 GDSC1; GDSC2 5.8284 12.3715 0.6767 10.2282
HCC2218 GDSC1; GDSC2; CTRP2 5.8557 6.8697 5.4655 2.8237
BT-20 GDSC1; GDSC2; CTRP2 5.8934 7.7961 5.0398 4.5235
HCC1954 GDSC1; GDSC2 5.9902 7.5922 2.8072 0.1853
MFM-223 GDSC1; GDSC2 6.0147 12.21 0.8714 8.8685
HCC1143 GDSC1; GDSC2 6.0282 8.6234 2.445 1.1377
UACC-893 GDSC1; GDSC2 6.1942 8.1537 2.6862 0.3491
HCC1395 GDSC1; GDSC2 6.2793 12.2431 1.0187 7.6414
MDA-MB-415 GDSC1; GDSC2; CTRP2 6.3593 7.6318 5.4954 1.7661
MDA-MB-468 GDSC1; GDSC2; CTRP2 6.4184 11.7233 3.5103 9.9238
MDA-MB-330 GDSC1; GDSC2 6.5 16.3277 -0.761 15.6248
EFM-192A GDSC1; GDSC2; CTRP2 6.5079 8.4372 5.2088 2.7124
HCC1428 GDSC1; GDSC2; CTRP2 6.5511 9.6077 4.6654 4.8887
MDA-MB-453 GDSC1; GDSC2; CTRP2 6.5865 10.5987 4.2017 6.7575
ZR-75-30 GDSC1; GDSC2; CTRP2 6.7141 8.4909 5.3241 1.9527
SK-BR-3 CTRP2 6.9829 9.018 5.2479 1.9109
HCC1419 GDSC1; GDSC2; CTRP2 6.9942 10.4814 4.5589 4.6311
HCC202 GDSC1; CTRP2 7.1553 13.0033 3.4418 8.932
T-47D GDSC1; GDSC2; CTRP2 7.3024 13.4516 3.3297 9.1444
HCC1806 GDSC1; GDSC2 7.4295 15.1224 0.3915 8.8202
MDA-MB-157 GDSC1; GDSC2; CTRP2 7.7146 9.379 5.4787 0.5279
CAL-85-1 GDSC1; GDSC2; CTRP2 7.7557 13.6826 3.5403 7.609
BT-474 GDSC1; GDSC2; CTRP2 7.8104 9.0586 5.6381 0.1654
MDA-MB-361 GDSC1; GDSC2; CTRP2 8.0042 9.6669 5.492 0.3648
HCC1500 GDSC1; GDSC2; CTRP2 8.074 9.6253 5.5354 0.2582
AU565 GDSC2; CTRP2 8.3136 15.2733 3.1566 8.3039
Hs 578T GDSC1; GDSC2; CTRP2 8.3286 10.1291 5.4515 0.3263
HCC38 GDSC1; GDSC2; CTRP2 8.7475 10.5146 5.4731 0.1827
BT-549 GDSC1; GDSC2; CTRP2 10.1988 24.4021 0.0547 16.0326
BT 145 CTRP2 4.3693 8.5006 3.2428 15.4558
BT 286 CTRP2 5.1877 9.8713 3.3773 12.9634
BT 228 CTRP2 5.8031 11.4989 3.1136 12.735
BT 231 CTRP2 5.8416 8.9972 4.3957 7.3313
BT164 CTRP2 5.9985 9.7925 4.132 8.1255
BT 159 CTRP2 6.2075 7.0181 5.6859 1.22
BT 139 CTRP2 6.2316 7.0041 5.7102 1.0821
BT 224 CTRP2 6.2849 9.0988 3.0895 1.6224
BT 428 CTRP2 6.4317 13.9155 2.4267 14.2296
BT 482 CTRP2 6.6421 12.1046 3.4969 9.5776
BT 112 CTRP2 6.6605 10.6633 4.2261 6.5309
BT 179 CTRP2 6.6723 9.4375 4.8384 3.9781
BT 232 CTRP2 6.9089 10.1801 4.6452 4.4074
BT 216 CTRP2 6.9413 10.6318 4.4484 5.1618
BT 239 CTRP2 6.9941 11.8514 3.8893 7.3713
BT 504 CTRP2 7.1071 11.2881 4.2467 5.7323
BT 245 CTRP2 7.2781 9.7656 5.0838 2.1864
BT 422 CTRP2 7.2784 12.7034 3.6789 7.7766
BT 359 CTRP2 7.3001 10.6068 4.7056 3.615
BT 271 CTRP2 7.3643 10.3496 4.8671 2.9057
BT 498 CTRP2 7.3905 8.7292 5.5895 0.4228
BT 131 CTRP2 7.5557 8.8769 5.6038 0.3119
BT 320 CTRP2 7.5703 8.5202 5.7384 0.0832
BT 444 CTRP2 7.5999 10.1334 5.1045 1.7722
BT 416 CTRP2 7.6382 24.2224 -1.7529 24.5403
BT 248 CTRP2 7.7105 9.3702 5.4803 0.5259
BT 333 CTRP2 7.7571 8.9672 5.6505 0.1602
BT 340 CTRP2 7.7715 8.8035 5.713 0.0781
BT 440 CTRP2 8.1573 14.3812 3.4782 7.2809
BT 172 CTRP2 8.2599 15.932 2.8031 9.7287
BT 328 CTRP2 10.0555 19.4905 2.2977 9.1421
BT 330 CTRP2 10.2872 20.4514 1.9952 9.8854
BT147 CTRP2 10.3099 25.8517 -0.569 17.5738
⏷ Show the Full List of 87 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 61 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DBTRG-05MG GDSC1; GDSC2 0.2895 15.9098 -5.6487 43.4462
KG-1-C CTRP2 0.3145 17.117 -4.7745 44.6406
NMC-G1 GDSC1; GDSC2 1.2437 12.0834 -2.8919 36.7176
H4 GDSC1; GDSC2 1.2669 8.4663 -1.1141 31.8767
MOG-G-UVW GDSC1; GDSC2 1.4324 7.0274 -0.2711 27.8629
GI-1 GDSC1 3.0386 11.8339 -1.1724 29.6891
D-247MG GDSC1; GDSC2 3.4332 8.7965 0.6768 16.0351
D-336MG GDSC1; GDSC2 3.6115 13.6557 -1.6057 25.7407
ONS-76 GDSC1; GDSC2 4.0382 10.3765 0.3723 15.9891
U-87MG ATCC GDSC1; GDSC2 4.1366 6.4752 2.3616 4.0791
LN-18 GDSC1; GDSC2 4.1596 5.7172 2.7294 1.9036
D-566MG GDSC1; GDSC2 4.3478 11.9448 -0.1672 17.8676
D-245MG GDSC2 4.4738 8.9882 1.3819 9.2193
LNZTA3WT4 GDSC1 4.4749 7.1348 2.2693 4.9292
KNS-81-FD GDSC1; GDSC2 4.5622 8.1223 1.86 6.1941
AM-38 GDSC1; GDSC2 5.005 12.2834 0.1547 14.6847
SF295 GDSC1; GDSC2 5.0636 15.3323 -1.3007 20.8959
Onda 10 GDSC1; GDSC2 5.2841 11.6478 0.659 11.4678
KINGS-1 GDSC1; GDSC2 5.3482 11.8668 0.5975 11.6537
SK-MG-1 GDSC1; GDSC2 5.3705 7.4085 2.6294 0.9702
CAS-1 GDSC1; GDSC2 5.3734 6.589 2.9317 0.1345
D-263MG GDSC1; GDSC2 5.4778 7.1026 2.7896 0.3916
GB-1 GDSC1; GDSC2 5.5857 7.2952 2.7617 0.4143
M059J GDSC1; GDSC2 5.5869 9.0522 2.0515 3.3701
D-542MG GDSC1; GDSC2 5.589 7.1997 2.7974 0.3265
D-502MG GDSC1; GDSC2 5.6017 11.4227 0.9774 9.1169
LN-229 GDSC1; GDSC2 5.6723 7.4405 2.7427 0.424
Onda 11 GDSC1; GDSC2 5.7683 8.43 2.4044 1.5145
8-MG-BA GDSC1; GDSC2; CTRP2 5.8934 6.765 5.5516 2.3826
PFSK-1 GDSC2 5.9191 7.871 2.6826 0.4667
GaMG GDSC1; GDSC2 5.9193 7.3942 2.8497 0.1391
SW1088 GDSC1; GDSC2 5.9479 7.8639 2.6963 0.4205
SF126 GDSC1; GDSC2 5.9593 8.5965 2.4251 1.2684
LN-405 GDSC1; GDSC2 5.9961 7.5593 2.8205 0.1645
SF268 GDSC1; GDSC2; CTRP2 6.0334 7.985 5.0649 4.1385
KALS-1 GDSC1; GDSC2 6.0602 9.0029 2.3096 1.6349
D283 Med GDSC1; GDSC2; CTRP2 6.062 7.1116 5.5254 2.1476
Daoy GDSC1; GDSC2 6.0984 7.7352 2.7967 0.1777
D-423MG GDSC1; GDSC2 6.2125 9.1863 2.3061 1.516
MOG-G-CCM GDSC1; GDSC2 6.4138 8.3732 2.69 0.275
KS-1 [Human Krukenberg tumour] GDSC1; GDSC2 6.4229 8.7977 2.5425 0.5986
DK-MG GDSC1; GDSC2; CTRP2 6.5153 8.0099 5.421 1.8387
D-392MG GDSC1; GDSC2 6.5382 8.6056 2.6545 0.3044
SW1783 GDSC1; GDSC2; CTRP2 6.5394 9.5368 3.888 2.8075
U-251MG GDSC1; GDSC2; CTRP2 6.7295 8.5903 5.2871 2.078
Becker GDSC1; GDSC2; CTRP2 6.8352 9.1745 5.0792 2.7605
SF539 GDSC1; GDSC2; CTRP2 7.1985 11.4258 4.2443 5.605
Hs 683 GDSC1; GDSC2; CTRP2 7.2227 8.8339 5.4661 0.8927
SNB-75 GDSC1; GDSC2; CTRP2 7.5755 9.469 5.377 0.8976
CCF-STTG1 CTRP2 7.6131 8.7267 5.6817 0.1495
U-118MG GDSC1; GDSC2; CTRP2 7.6135 9.2822 5.4713 0.6036
GMS-10 CTRP2 7.6427 8.8948 5.6324 0.2231
T98G GDSC1; GDSC2; CTRP2 7.8665 13.245 3.826 6.3217
YH-13 GDSC1; GDSC2; CTRP2 7.9926 9.3887 5.5894 0.1928
M059K CTRP2 8.0329 9.3175 5.6295 0.1277
KNS-42 GDSC1; GDSC2; CTRP2 8.3272 9.5028 5.6698 0.0497
YKG-1 GDSC1; GDSC2; CTRP2 8.3886 9.5941 5.6603 0.0506
A-172 GDSC1; GDSC2; CTRP2 8.4156 18.6526 1.5906 13.8751
GOS-3 CTRP2 9.4031 16.7111 3.1824 6.7947
TM-31 CTRP2 9.8583 17.8649 2.9292 7.1675
42-MG-BA GDSC1; GDSC2; CTRP2 13.5514 32.4098 -1.5302 15.9252
⏷ Show the Full List of 61 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ETK-1 GDSC1; GDSC2 4.5704 9.3758 1.2618 9.7008
TGBC1TKB GDSC1; GDSC2 5.1621 6.9516 2.716 0.8115
TGBC24TKB GDSC1; GDSC2 5.7745 7.5988 2.7251 0.4234
Cancer Drug Sensitivity Data Curated from 12 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KLE GDSC1; GDSC2 4.81 11.0916 0.5966 12.8626
RL95-2 GDSC1; GDSC2 5.5656 7.0182 2.8527 0.2191
JHUEM-1 CTRP2 6.0784 7.4338 5.3778 2.7369
HEC-1-A CTRP2 6.0811 7.4975 5.3482 2.8563
MFE-280 GDSC1; GDSC2 6.141 8.3742 2.5862 0.6177
MFE-319 GDSC1; GDSC2; CTRP2 6.6531 11.2377 3.936 7.7472
JHUEM-7 CTRP2 6.681 8.1117 5.4809 1.3851
EN GDSC1; GDSC2; CTRP2 7.0547 9.1483 5.2317 1.8879
ESS-1 GDSC1; GDSC2; CTRP2 7.3349 10.9354 4.5727 4.0931
AN3-CA GDSC1; GDSC2; CTRP2 7.5822 12.8507 3.8219 6.7418
JHUEM-3 CTRP2 7.9791 10.0986 5.313 0.8113
MFE-296 GDSC1; GDSC2; CTRP2 9.7355 17.9946 2.7936 7.7949
⏷ Show the Full List of 12 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KTCTL-140 GDSC1; GDSC2 1.3655 9.1409 -1.3443 32.2568
769-P GDSC1; GDSC2 1.5039 5.4629 0.5172 23.6688
LB996-RCC GDSC1; GDSC2 1.9776 8.647 -0.5298 26.8697
KTCTL-13 GDSC1; GDSC2 2.2044 10.1943 -1.0849 28.2601
KTCTL-26A GDSC1; GDSC2 2.7493 9.6367 -0.3245 23.2739
SW156 GDSC1; GDSC2 2.8887 9.5394 -0.1549 22.0303
KTCTL-21 GDSC1; GDSC2 3.1259 8.8736 0.3811 18.5781
LB2241-RCC GDSC1; GDSC2 3.7719 9.4666 0.616 15.4047
LB1047-RCC GDSC1; GDSC2 3.9426 12.0695 -0.5459 20.6805
A-704 GDSC1; GDSC2 3.9628 12.5627 -0.7758 21.6101
SN12C GDSC1; GDSC2 3.9633 8.3275 1.3315 10.7608
RXF 393L GDSC1; GDSC2 4.0769 12.0167 -0.4134 19.7243
HA7-RCC GDSC1; GDSC2 4.3693 13.9029 -1.123 21.9301
NCC010 GDSC1; GDSC2 4.4616 10.4191 0.6725 13.2891
BFTC-909 GDSC1; GDSC2 4.5688 11.067 0.4331 14.3072
KTCTL-1M GDSC1; GDSC2 4.6933 11.0418 0.5366 13.4582
KMRC-20 GDSC1; GDSC2 4.8168 10.1925 1.0386 10.42
SW13 GDSC1; GDSC2 4.8708 11.1182 0.6271 12.5586
BB65-RCC GDSC1; GDSC2 4.8851 10.2286 1.0686 10.0997
TK-10 GDSC1; GDSC2 5.0748 9.8312 1.3866 7.8997
A-498 GDSC1; GDSC2 5.2335 11.4573 0.7161 11.2734
NCC021 GDSC1; GDSC2 5.2427 15.4901 -1.245 20.2643
VMRC-RCW GDSC2 5.3769 12.4896 0.3171 13.0325
KTCTL-195 GDSC1; GDSC2 5.3852 7.7501 2.4995 1.4816
UO-31 GDSC1; GDSC2; CTRP2 6.1366 21.1234 -1.4184 26.4801
OS-RC-2 GDSC1; GDSC2 6.1571 10.6176 1.678 4.4671
786-O GDSC1; GDSC2; CTRP2 6.4884 11.8325 3.5115 9.7918
RCC10RGB GDSC1; GDSC2; CTRP2 7.9052 9.0394 5.6796 0.0923
KMRC-3 CTRP2 7.9369 17.4227 1.8451 13.7495
ACHN GDSC1; GDSC2; CTRP2 8.0341 17.6421 1.8086 13.7217
KMRC-1 GDSC2; CTRP2 8.0821 9.7604 5.4889 0.3414
TUHR14TKB CTRP2 8.3235 15.7165 2.9506 16.8067
CAL-54 GDSC1; GDSC2; CTRP2 8.3659 16.2024 2.7458 9.79
Caki-2 CTRP2 8.5696 21.7487 0.1845 18.0735
VMRC-RCZ GDSC1; GDSC2; CTRP2 9.9512 18.7562 2.5743 8.3084
Caki-1 GDSC1; GDSC2; CTRP2 10.3628 20.9612 1.8045 10.428
KMRC-2 CTRP2 11.6207 21.6871 2.2363 7.5763
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 55 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO205 GDSC1; GDSC2 -7.5028 9.9414 -10.7827 67.068
HT-29 GDSC1; GDSC2 -0.61 14.3726 -5.7453 46.2574
MDST8 GDSC1; GDSC2 -0.3602 8.6065 -2.7844 42.8486
LoVo GDSC1; GDSC2 1.3906 6.3149 0.0181 26.6064
LS411N GDSC1; GDSC2 1.4886 15.8753 -4.5412 38.6559
RKO GDSC1; GDSC2 1.6584 10.4976 -1.7317 32.2853
HCT 116 GDSC1; GDSC2 1.9609 7.4536 0.0354 24.2708
NCI-H508 GDSC1; GDSC2 3.3399 8.6337 0.681 16.2366
KM12 GDSC1; GDSC2 3.9891 7.3307 1.8428 7.5547
SNU-407 GDSC1; GDSC2 4.0355 7.2232 1.9293 6.9138
CL-11 GDSC1; GDSC2 4.2235 8.158 1.6079 8.4249
HT115 GDSC1; GDSC2 4.2245 5.828 2.7172 1.86
SW1417 GDSC1; GDSC2; CTRP2 4.3433 26.0519 -6.0492 35.1294
LS513 GDSC1; GDSC2 4.445 7.5756 2.0425 5.3336
SW1463 GDSC1; GDSC2 4.4814 6.9817 2.3443 3.5066
SW1116 GDSC1; GDSC2 4.5164 6.5875 2.5444 2.3389
NCI-H747 GDSC1; GDSC2; CTRP2 4.5935 7.4707 3.9295 12.1553
SNU-175 GDSC2 4.6645 7.4071 2.2602 3.662
SW620 GDSC1; GDSC2 4.6749 7.375 2.2811 3.5267
SNU-C5 GDSC1; GDSC2 4.9011 20.4598 -3.9691 29.0164
SNU-1040 GDSC1; GDSC2 4.9171 9.2259 1.57 7.1431
SK-CO-1 GDSC1; GDSC2 4.9477 10.4425 1.0086 10.2655
COLO 320HSR GDSC1; GDSC2 5.1057 6.9195 2.7035 0.9001
LS123 GDSC1; GDSC2 5.1794 8.5914 2.0269 4.0949
CaR-1 GDSC1; GDSC2 5.2466 7.0242 2.7245 0.7167
HT-55 GDSC2 5.2732 11.0632 0.9318 9.9945
SNU-61 GDSC1 5.31 7.2363 2.67 1.0798
HCC2998 GDSC1; GDSC2 5.3109 7.8274 2.4314 1.8576
SNU-81 GDSC1; GDSC2 5.4689 6.9602 2.8373 0.2811
SW48 GDSC1; GDSC2 5.6177 8.1478 2.4479 1.4701
SNU-283 GDSC2 5.6562 7.6189 2.6706 0.6341
GP5d GDSC1; GDSC2 5.7241 7.1505 2.864 0.1585
T84 GDSC1; GDSC2; CTRP2 5.7884 7.4388 5.1238 4.3937
CCK-81 GDSC1; GDSC2 5.8465 7.6587 2.7312 0.3775
GP2d CTRP2 5.8671 12.0409 2.8972 13.4799
LS180 GDSC1; GDSC2 5.9108 7.4792 2.8177 0.1873
NCI-H716 GDSC1; GDSC2; CTRP2 5.9243 11.2334 3.3492 11.5291
SW626 GDSC1; GDSC2 5.9573 7.8011 2.7223 0.3566
SW837 GDSC1; GDSC2 6.142 7.79 2.7934 0.1727
SNU-1033 CTRP2 6.2165 8.5914 4.9113 4.4408
LS1034 GDSC1; GDSC2; CTRP2 6.2437 8.0431 5.2059 3.1583
CW-2 GDSC1; GDSC2 6.2712 8.8908 2.4463 0.9643
SNU-C4 CTRP2 6.3096 7.7166 5.4177 2.1643
C2BBe1 GDSC1; GDSC2; CTRP2 6.3105 8.6631 4.9497 4.1127
SW948 GDSC1; GDSC2; CTRP2 6.3209 7.5129 5.5259 1.7003
HCT 8 CTRP2 6.5197 7.708 5.5675 1.2513
SNU-C1 GDSC1; GDSC2; CTRP2 6.5824 12.3709 3.3176 10.4166
RCM-1 [Human ESC] GDSC1; GDSC2; CTRP2 6.6569 10.6892 4.2106 6.6012
SNU-C2B GDSC1; GDSC2 6.9233 9.8939 2.3385 0.9102
COLO 678 GDSC1; GDSC2; CTRP2 6.9362 11.4549 3.2451 4.9178
COLO 320 CTRP2 6.9779 20.721 -0.5312 22.754
HCT 15 GDSC1; GDSC2; CTRP2 7.2242 15.1326 2.4422 12.7461
HCC-56 CTRP2 7.5036 8.6623 5.6626 0.2141
DiFi GDSC1; GDSC2 7.8239 17.8723 -0.6313 12.6391
SNU-503 CTRP2 8.6224 10.3779 5.4749 0.2072
⏷ Show the Full List of 55 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1; GDSC2 3.9662 9.0822 0.9596 12.9418
Cancer Drug Sensitivity Data Curated from 19 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Hep 3B2.1-7 GDSC1; GDSC2 3.3667 4.7096 2.665 4.031
JHH-7 GDSC1; GDSC2 4.1409 8.9176 1.1739 11.2446
SNU-398 GDSC1; GDSC2 4.7852 6.9125 2.5496 1.9366
Huh-7 GDSC1; GDSC2 4.8912 10.8435 0.7751 11.7122
Hep-G2/C3A GDSC1; GDSC2 5.1784 6.8783 2.7514 0.6743
PLC/PRF/5 CTRP2 5.2207 10.269 3.2117 13.5664
JHH-5 CTRP2 5.776 7.3292 5.1666 4.2428
SK-HEP-1 GDSC1; GDSC2; CTRP2 5.8588 16.8836 0.4693 22.0969
HLE GDSC1; GDSC2 5.9468 7.8437 2.7032 0.4045
SNU-475 CTRP2 6.4813 17.8896 0.4818 20.8298
JHH-1 GDSC1; GDSC2; CTRP2 6.7148 11.3698 3.9177 7.7173
JHH-4 GDSC1; GDSC2; CTRP2 6.9467 12.9973 3.2883 9.8989
HuH-1 GDSC1; GDSC2; CTRP2 7.0512 11.3183 4.1922 6.0408
SNU-423 GDSC1; GDSC2; CTRP2 7.1241 8.6851 4.5332 0.2644
JHH-6 GDSC1; GDSC2; CTRP2 7.2776 12.8067 3.6278 7.9845
SNU-449 GDSC1; GDSC2; CTRP2 7.4266 16.1903 2.0723 13.7784
SNU-387 GDSC1; GDSC2; CTRP2 7.9313 10.2067 5.2461 1.0341
HLF CTRP2 8.6837 21.4884 0.3963 17.2722
JHH-2 GDSC1; GDSC2; CTRP2 12.0338 26.6524 0.2018 13.2701
⏷ Show the Full List of 19 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 202 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H209 GDSC1; GDSC2 -0.4901 3.5571 -0.9048 39.8084
NCI-H1792 GDSC1; GDSC2 0.6445 3.9241 0.2159 29.0597
EBC-1 GDSC1; GDSC2 0.8436 20.3849 -7.3538 43.1808
NCI-H2030 GDSC1; GDSC2 1.1195 5.2585 0.2093 26.9105
A-427 GDSC1; GDSC2 1.9333 5.7969 0.7974 20.4055
NCI-H1299 GDSC1; GDSC2 2.0249 8.8823 -0.6015 26.9982
NCI-H2795 GDSC1; GDSC2 2.1176 8.4886 -0.3229 25.45
NCI-H1755 GDSC1; GDSC2 2.1895 9.6807 -0.8444 27.3937
NCI-H1975 GDSC1; GDSC2 2.2023 7.1861 0.3925 21.6255
Calu-6 GDSC1; GDSC2 2.4331 10.036 -0.8019 26.381
NCI-H358 GDSC1; GDSC2 2.8028 8.9798 0.0496 21.316
LOU-NH91 GDSC1; GDSC2 2.9563 10.9314 -0.7916 24.6281
NCI-H322M GDSC1; GDSC2 3.1503 8.9482 0.3645 18.59
NCI-H2405 GDSC1; GDSC2 3.2688 9.9335 -0.0282 20.2286
NCI-H460 GDSC1; GDSC2 3.3603 8.4094 0.8101 15.4974
NCI-H2087 GDSC1; GDSC2 3.5416 10.1235 0.1024 18.7678
LC-2/ad GDSC1; GDSC2 3.6822 9.1862 0.6844 15.277
NCI-H727 GDSC1; GDSC2 3.7488 6.4259 2.1097 6.5178
BEN GDSC1; GDSC2 3.7628 4.9262 2.8508 1.9185
Lu-99A GDSC1; GDSC2 3.8355 9.1642 0.8169 14.1074
EPLC-272H GDSC1; GDSC2 3.8989 9.072 0.9125 13.3914
UMC-11 GDSC1; GDSC2 4.0357 6.9969 2.04 6.257
NCI-H510A GDSC2 4.0724 6.7533 2.1843 5.2899
NCI-H1573 GDSC1; GDSC2 4.0786 5.9704 2.5627 3.0011
NCI-H196 GDSC1; GDSC2 4.13 7.9394 1.6471 8.4382
SBC-3 GDSC1; GDSC2 4.145 9.4255 0.926 12.6691
NCI-H2023 GDSC1; GDSC2 4.2331 6.6974 2.3198 4.133
NCI-H2369 GDSC1; GDSC2 4.2482 5.9057 2.6959 1.9447
SBC-5 GDSC1; GDSC2 4.3322 5.3607 2.9712 0.5136
EMC-BAC-2 GDSC1; GDSC2 4.419 9.6695 1.0095 11.5104
NCI-H250 GDSC2 4.4311 6.704 2.4415 3.0556
NCI-H64 GDSC2 4.4562 10.274 0.7399 12.9324
NCI-H1993 GDSC1; GDSC2 4.4716 8.4137 1.6588 7.5829
COR-L303 GDSC2 4.4735 6.2571 2.6665 1.7656
SBC-1 GDSC1; GDSC2 4.5105 6.8813 2.4082 3.1066
NCI-H3122 GDSC1; GDSC2 4.5759 7.9585 1.9469 5.6535
COR-L23 GDSC1; GDSC2 4.5842 13.2903 -0.6533 19.4578
NCI-H1155 GDSC1; GDSC2 4.638 9.0871 1.4487 8.4587
NCI-H2085 GDSC1; GDSC2 4.6543 6.6772 2.5814 1.9517
SHP-77 GDSC1; GDSC2 4.6544 6.4042 2.6985 1.3744
NCI-H290 GDSC1; GDSC2 4.6744 7.9133 2.0317 4.9655
A-549 GDSC1; GDSC2 4.677 11.764 0.1701 15.3913
NCI-H1435 GDSC1; GDSC2 4.6892 7.9263 2.035 4.9181
ABC-1 GDSC1; GDSC2 4.7032 8.1928 1.919 5.5655
NCI-H2291 GDSC1; GDSC2 4.7456 7.4848 2.2732 3.4644
HCC44 GDSC1; GDSC2 4.756 7.548 2.2506 3.5724
NCI-H526 GDSC1; GDSC2 4.7611 6.8736 2.5536 1.9485
NCI-H524 GDSC1; GDSC2 4.7645 12.7114 -0.2315 17.1196
NCI-H345 GDSC1; GDSC2 4.7823 5.6705 3.0363 0.108
NCI-H292 GDSC1; GDSC2 4.7964 7.9911 2.0718 4.5099
NCI-H1836 GDSC1; GDSC2 4.8083 6.4929 2.7372 1.0344
NCI-H513 GDSC1; GDSC2 4.815 7.6115 2.2567 3.4413
NCI-H1781 GDSC1; GDSC2 4.8163 6.2407 2.841 0.6185
Lu-165 GDSC1; GDSC2 4.8292 7.5401 2.2971 3.197
NCI-H2347 GDSC1; GDSC2 4.8688 9.2444 1.5294 7.4997
NCI-H650 GDSC1; GDSC2 4.8807 10.3503 1.0067 10.4562
NCI-H2444 GDSC1; GDSC2 4.8827 6.6088 2.7253 1.0132
NCI-H2171 GDSC2; CTRP2 4.8876 7.157 4.3688 9.6495
NCI-H740 GDSC2 4.8996 8.1078 2.081 4.2764
NCI-H1666 GDSC1; GDSC2 4.8999 13.1752 -0.3595 17.3795
NCI-H187 GDSC1 4.9151 6.0732 2.9439 0.3131
NCI-H1581 GDSC1; GDSC2 4.9305 9.7316 1.3382 8.4714
NCI-H1436 GDSC1; GDSC2 4.9375 6.6627 2.7291 0.9472
NCI-H2818 GDSC1; GDSC2 4.9431 13.3828 -0.4297 17.5926
NCI-H23 GDSC1; GDSC2; CTRP2 4.9758 10.1709 3.0346 14.8336
COR-L311 GDSC2 4.999 7.1744 2.5486 1.6762
HCC827 GDSC1; GDSC2 5.0028 6.9128 2.6587 1.1783
NCI-H2066 GDSC1; GDSC2 5.0047 10.7324 0.9081 10.7301
NCI-H146 GDSC1; GDSC2 5.023 7.9041 2.2451 3.1771
NCI-H3255 GDSC1; GDSC2 5.0389 10.0884 1.2405 8.8006
NCI-H720 GDSC1; GDSC2 5.0435 10.1136 1.2315 8.8419
HCC15 GDSC1; GDSC2 5.0626 12.0051 0.3316 13.6613
NCI-H2803 GDSC1; GDSC2 5.0772 7.0982 2.6186 1.2764
COR-L279 GDSC1; GDSC2 5.1128 11.6683 0.5306 12.5194
LK2 CTRP2 5.1532 9.03 3.7565 11.4836
NCI-H596 GDSC1; GDSC2 5.1848 6.6757 2.8301 0.4239
LCLC-103H GDSC1; GDSC2 5.1856 8.8913 1.8944 4.8268
COR-L321 GDSC1; GDSC2 5.1935 6.8601 2.7647 0.6195
NCI-H2461 GDSC1; GDSC2 5.1989 12.9896 -0.051 15.2383
NCI-H2227 GDSC1; GDSC2 5.2007 10.1846 1.3016 8.127
NCI-H1304 GDSC1 5.2094 6.9819 2.7248 0.9275
NCI-H1048 GDSC1; GDSC2 5.2242 6.6721 2.847 0.3588
NCI-H2122 GDSC1; GDSC2 5.2283 6.7395 2.824 0.4188
PC-14 GDSC1; GDSC2 5.2446 10.161 1.3413 7.8179
NCI-H847 GDSC1; GDSC2 5.2486 11.9165 0.505 12.352
EMC-BAC-1 GDSC1; GDSC2 5.2515 10.8125 1.037 9.4952
NCI-H1770 GDSC1; GDSC2 5.2631 6.9221 2.7703 0.5582
NCI-H1734 GDSC2 5.2643 7.4409 2.5679 1.309
Lu-134-A GDSC1; GDSC2 5.2717 8.6705 2.0447 3.8674
NCI-H226 GDSC1; GDSC2 5.3045 10.8156 1.0706 9.2018
NCI-H2591 GDSC1; GDSC2 5.309 8.9434 1.9437 4.353
NCI-H748 GDSC2 5.3106 7.4538 2.5843 1.1978
Ms-1 GDSC1; GDSC2 5.324 6.92 2.7957 0.449
COR-L32 GDSC1; GDSC2 5.3378 7.461 2.594 1.1348
NCI-H446 GDSC1; GDSC2 5.3556 7.6709 2.5177 1.4331
NCI-H2731 GDSC1; GDSC2 5.3584 9.5991 1.6744 5.747
DMS 53 GDSC1; GDSC2; CTRP2 5.3753 8.5516 4.1973 9.1593
NCI-H661 GDSC1; GDSC2 5.3815 10.8317 1.1135 8.8116
CAL-12T GDSC1; GDSC2 5.3961 13.5144 -0.1663 15.3362
DV-90 CTRP2 5.4033 7.9784 4.5022 7.836
NCI-H1838 GDSC1; GDSC2 5.4048 11.5281 0.798 10.4741
NCI-H2869 GDSC1; GDSC2 5.4287 9.7188 1.6621 5.6931
NCI-H1876 GDSC1; GDSC2 5.4309 7.2178 2.7284 0.5884
HCC366 GDSC1; GDSC2 5.4452 7.2149 2.7353 0.5592
LCLC-97TM1 GDSC1; GDSC2 5.4517 13.5373 -0.1381 15.0807
NCI-H2810 GDSC1; GDSC2 5.4567 11.2607 0.9596 9.5
NCI-H1703 GDSC1; GDSC2; CTRP2 5.4796 9.1718 3.9882 9.7968
DMS 79 GDSC1; GDSC2 5.4799 7.4919 2.6448 0.8318
NCI-H82 GDSC1; GDSC2 5.4809 7.1578 2.7707 0.4396
NCI-H2009 GDSC1; GDSC2 5.4977 11.461 0.8915 9.7838
NCI-H2373 GDSC1; GDSC2 5.5037 9.8166 1.6624 5.5631
Lu-139 GDSC1; GDSC2 5.51 7.0525 2.8199 0.3054
SK-LU-1 GDSC1; GDSC2 5.5115 12.4589 0.4243 12.2001
LXF 289 GDSC1; GDSC2 5.5163 7.4097 2.6915 0.6524
NCI-H2722 GDSC1; GDSC2 5.5555 10.4803 1.3887 6.9698
SW1573 GDSC1; GDSC2 5.5652 8.7888 2.154 2.8848
LB647-SCLC GDSC1; GDSC2 5.5892 7.6403 2.6346 0.7914
NCI-H2135 GDSC1; GDSC2 5.5955 7.4156 2.7216 0.5177
HARA [Human squamous cell lung carcinoma] GDSC1; GDSC2 5.6228 8.0754 2.4794 1.3418
NCI-H810 GDSC1; GDSC2; CTRP2 5.6371 6.6516 5.3586 3.7788
HCC78 GDSC1; GDSC2 5.6386 7.2572 2.7956 0.3118
Calu-3 GDSC1; GDSC2 5.6702 7.7326 2.6336 0.7418
CPC-N GDSC1; GDSC2 5.7194 7.5806 2.7102 0.4872
NCI-H2172 GDSC1; GDSC2 5.7317 7.0736 2.8927 0.1174
Lu-135 GDSC1; GDSC2 5.7607 7.704 2.6813 0.546
HCC4006 CTRP2 5.7718 6.7604 5.4398 3.1214
NCI-H1688 GDSC1; GDSC2 5.7867 7.4379 2.787 0.2786
NCI-H69 GDSC1; GDSC2 5.7921 8.0089 2.5799 0.8392
NCI-H1793 GDSC1; GDSC2; CTRP2 5.7936 6.6032 5.5359 2.6761
HCC33 GDSC2 5.7947 7.2277 2.8625 0.146
SW1271 GDSC1; GDSC2 5.831 13.1903 0.2896 12.2116
NCI-H1648 GDSC1; GDSC2 5.8348 8.6229 2.3577 1.6456
NCI-H2081 GDSC1; GDSC2; CTRP2 5.8373 7.3514 5.2112 3.9236
RERF-LC-MS GDSC1; GDSC2; CTRP2 5.9099 9.3919 4.2573 7.7745
NCI-H1568 GDSC1; GDSC2; CTRP2 5.9303 6.8706 5.5327 2.3817
NCI-H441 GDSC1; GDSC2 5.9809 9.8493 1.9172 3.512
NCI-H211 GDSC1; GDSC2 6.022 7.8675 2.723 0.332
NCI-H1355 GDSC1; GDSC2 6.0618 8.6642 2.4437 1.1212
NCI-H1437 GDSC1; GDSC2 6.0702 7.6741 2.8075 0.1678
KNS-62 GDSC1; GDSC2; CTRP2 6.0814 6.8899 5.652 1.5793
NCI-H1341 GDSC1; GDSC2; CTRP2 6.0955 7.1975 5.5098 2.1504
EKVX GDSC1; GDSC2; CTRP2 6.098 10.3706 3.9258 8.7965
IST-SL1 GDSC1; GDSC2 6.1119 7.9669 2.7214 0.3055
LC-1/sq-SF CTRP2 6.1237 7.457 5.403 2.5469
NCI-H838 GDSC1; GDSC2; CTRP2 6.1244 7.5093 5.3775 2.6527
LK-2 GDSC1; GDSC2 6.1483 8.0182 2.7168 0.3029
NCI-H835 GDSC1; GDSC2 6.1533 8.3861 2.5867 0.61
NCI-H1944 GDSC1; GDSC2; CTRP2 6.1585 9.3517 4.4848 6.3383
NCI-H1869 GDSC1; GDSC2; CTRP2 6.1679 7.3879 5.4726 2.1754
NCI-H841 GDSC1; GDSC2; CTRP2 6.1719 7.4388 5.4504 2.2613
RERF-LC-KJ GDSC1; GDSC2 6.1743 8.4216 2.582 0.6125
LC-1/sq GDSC1; GDSC2 6.1749 8.214 2.6574 0.4209
COR-L88 GDSC1; GDSC2; CTRP2 6.1769 12.2852 3.0337 12.3219
NCI-H1092 GDSC1; GDSC2; CTRP2 6.2076 7.7164 5.3403 2.6593
NCI-H2804 GDSC1; GDSC2 6.2311 9.2497 2.2894 1.5651
NCI-H2141 GDSC1; GDSC2; CTRP2 6.2432 10.1203 4.1697 7.5024
NCI-H1650 GDSC2 6.3026 8.1357 2.732 0.2319
Lu-65 GDSC1; GDSC2; CTRP2 6.3048 14.5253 2.019 16.007
NCI-H2110 GDSC1; GDSC2; CTRP2 6.3201 11.9268 3.3297 10.8472
T3M-10 CTRP2 6.3635 8.0451 5.2959 2.5811
HCC1438 CTRP2 6.3947 7.8567 5.411 2.0576
NCI-H1693 GDSC1; GDSC2; CTRP2 6.408 12.6448 3.0421 11.8516
ChaGo-K-1 GDSC1; GDSC2; CTRP2 6.4423 11.7966 3.4928 9.9523
NCI-H2595 GDSC1; GDSC2 6.4431 8.5363 2.6438 0.3544
COLO 668 GDSC1; GDSC2; CTRP2 6.4452 9.6011 4.588 5.3903
COR-L51 CTRP2 6.4733 8.767 5.0219 3.5377
VMRC-LCD GDSC1; GDSC2; CTRP2 6.4777 9.2077 4.8077 4.4195
NCI-H522 GDSC1; GDSC2; CTRP2 6.5018 14.4783 2.2023 14.9495
PaCa-3 GDSC1; GDSC2 6.5322 8.9427 2.5325 0.5748
NCI-H2228 GDSC2 6.5612 9.2716 2.4231 0.8646
NCI-H1339 CTRP2 6.5664 8.114 5.4056 1.8287
HOP-62 GDSC1; GDSC2; CTRP2 6.6334 10.7456 4.1648 6.8315
IST-SL2 GDSC1; GDSC2 6.6746 16.6039 -0.7756 15.3421
NCI-H2196 GDSC2; CTRP2 6.6852 8.1854 5.4491 1.5019
LUDLU-1 CTRP2 6.6913 8.327 5.3867 1.737
NCI-H1105 GDSC1; GDSC2; CTRP2 6.891 10.4549 4.4987 5.0335
NCI-H2029 GDSC1; GDSC2; CTRP2 6.9285 8.2813 5.5484 0.8753
IA-LM GDSC1; GDSC2; CTRP2 6.9378 12.6574 3.4497 9.2602
DMS 454 CTRP2 6.9773 8.9143 5.2923 1.7499
HCC2935 CTRP2 7.0022 8.6372 5.4324 1.2085
RERF-LC-Ad2 CTRP2 7.0103 15.1404 2.2741 13.7523
RERF-LC-Sq1 GDSC1; GDSC2 7.1666 9.8534 2.4483 0.5177
NCI-H1915 GDSC1; GDSC2; CTRP2 7.341 18.9506 0.6374 18.7728
NCI-H1694 GDSC1; CTRP2 7.36 9.1259 5.4127 0.9519
NCI-H520 GDSC1; GDSC2; CTRP2 7.4556 12.7851 3.7655 7.1556
NCI-H1623 GDSC1; GDSC2; CTRP2 7.558 9.4139 3.4951 0.1054
NCI-H1563 GDSC1; GDSC2; CTRP2 7.5608 9.1521 5.4991 0.5606
Calu-1 CTRP2 7.6645 13.1234 3.7472 6.9202
NCI-H2170 GDSC1; GDSC2; CTRP2 7.8441 16.268 2.3438 12.0901
COR-L95 GDSC1; CTRP2 7.9633 9.4857 5.5428 0.2807
COR-L47 CTRP2 7.9676 18.8586 1.1609 16.0338
NCI-H1395 CTRP2 7.9706 10.1671 4.3251 0.3722
NCI-H322 CTRP2 8.1189 14.1233 3.5756 6.9549
NCI-H647 GDSC1; GDSC2; CTRP2 8.1263 17.604 1.8945 13.2715
DMS 273 GDSC1; GDSC2; CTRP2 8.1572 9.5882 5.5804 0.166
SK-MES-1 GDSC1; GDSC2; CTRP2 8.2084 16.1345 2.6692 10.3101
NCI-H2342 GDSC1; GDSC2; CTRP2 8.3565 10.2537 5.4167 0.3823
DMS 114 GDSC1; GDSC2; CTRP2 8.8456 16.437 2.9562 8.3329
NCI-H1651 GDSC1; GDSC2; CTRP2 9.9429 24.471 -0.1568 16.9803
COR-L105 GDSC1; GDSC2; CTRP2 10.6473 23.9353 0.583 13.901
HOP-92 GDSC1; GDSC2; CTRP2 12.051 31.1709 -1.934 18.6003
Hs 888.Lu CTRP2 9.6859 21.2351 1.2278 13.2094
⏷ Show the Full List of 202 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1; GDSC2 5.1029 13.6212 -0.4294 17.2117
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Thigh Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
H-STS CTRP2 4.0537 7.0354 3.539 15.1378
SYO-1 CTRP2 7.6037 11.4817 4.4894 4.067
P-STS CTRP2 7.6989 10.209 5.1256 1.6063
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Aska-SS CTRP2 7.0912 8.8672 5.3804 1.3034
Yamato-SS CTRP2 7.7222 9.1826 5.5576 0.3412
Hs 633.T GDSC1; GDSC2 1.2717 6.483 -0.1778 28.1105
RKN GDSC1; GDSC2 3.3829 6.4787 1.7941 9.4863
EW-8 GDSC1; GDSC2 3.72 9.207 0.7042 15.0607
SW872 GDSC1; GDSC2 4.9805 15.9823 -1.6848 22.4891
SW684 GDSC1; GDSC2 5.1002 6.5747 2.8335 0.4597
STS-0421 GDSC1; GDSC2 5.1957 9.6648 1.5429 6.7789
Rh41 GDSC1; GDSC2 5.302 7.0171 2.7506 0.5965
Rh18 GDSC1 5.3265 11.3089 0.8502 12.465
KYM-1 GDSC1; GDSC2; CTRP2 5.7875 8.4377 4.6275 6.471
Rh30 GDSC1; GDSC2 5.8051 7.395 2.8088 0.2311
VA-ES-BJ GDSC1; GDSC2 5.8306 11.4185 1.1244 7.8997
HT-1080 GDSC1; GDSC2; CTRP2 6.0264 12.0001 3.0516 12.5418
A-204 GDSC1; GDSC2; CTRP2 6.0618 15.3763 1.3929 18.7142
MFH-ino GDSC1; GDSC2 6.0968 7.8492 2.7569 0.243
SK-LMS-1 GDSC1; GDSC2; CTRP2 6.2295 16.3219 1.0591 19.5009
MES-SA GDSC1; GDSC2; CTRP2 6.2771 7.5014 5.4995 1.8784
GCT GDSC1; GDSC2; CTRP2 6.349 22.3789 -1.8704 27.0665
Tm87-16 CTRP2 6.8023 8.8822 5.1965 2.339
G-402 GDSC1; GDSC2; CTRP2 7.1276 16.395 1.7418 15.4876
G-401 GDSC1; GDSC2; CTRP2 7.2068 14.6574 1.8989 10.0646
BT-12 CTRP2 7.2166 8.033 5.779 0.1034
RD GDSC1; GDSC2; CTRP2 7.2867 16.4772 1.8237 14.9171
TTC-709 CTRP2 7.4219 13.0443 3.6154 7.8099
BT-16 CTRP2 7.7269 8.6818 5.7386 0.0597
TE 617.T CTRP2 7.8211 14.4751 3.2023 8.843
TE 441.T GDSC2; CTRP2 7.869 8.8987 5.7148 0.063
SK-UT-1 GDSC1; GDSC2; CTRP2 9.0252 16.9894 2.8121 8.627
SW982 GDSC1; GDSC2; CTRP2 9.7799 24.7411 -0.4033 17.8831
Hs 729.T CTRP2 13.4293 26.5141 1.1119 9.1703
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Clivus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U-CH1 CTRP2 7.3834 9.1396 5.4188 0.914
Cancer Drug Sensitivity Data Curated from 36 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
2004 CTRP2 8.8217 28.5575 -2.9896 25.2019
ES-2 GDSC1; GDSC2 -1.2918 12.9003 -5.7009 48.6396
OV-90 GDSC1; GDSC2; CTRP2 0.5184 16.5523 -4.3096 43.7899
OVTOKO GDSC1; GDSC2 1.5619 6.8718 -0.0711 26.4141
SK-OV-3 GDSC1; GDSC2 2.5092 7.129 0.7049 18.8243
IGROV-1 GDSC1; GDSC2 3.9776 10.3694 0.3286 16.3813
JHOS-4 GDSC1; GDSC2 4.2676 7.2441 2.082 5.4851
FU-OV-1 GDSC1; GDSC2 4.4563 6.7821 2.4209 3.128
A2780 GDSC1; GDSC2 4.5507 7.6226 2.0891 4.8682
OVK18 GDSC1; GDSC2 4.5703 6.7045 2.5228 2.3802
RMG-I GDSC1; GDSC2 4.856 12.8717 -0.2426 16.9483
OVKATE GDSC1; GDSC2 4.8792 7.7336 2.239 3.4341
OVISE GDSC1; GDSC2 5.1334 6.3872 2.9146 0.2346
DOV13 GDSC1; GDSC2 5.1443 10.1428 1.2845 8.3364
OC 314 GDSC1; GDSC2; CTRP2 5.2971 11.4464 2.6978 15.4651
OVCAR-3 GDSC1; GDSC2 5.6011 7.6257 2.6452 0.7481
Kuramochi GDSC1; GDSC2 5.8811 7.8377 2.6799 0.491
Caov-3 GDSC2 5.9018 18.1411 -2.063 21.6967
OVCAR-8 GDSC1; GDSC2 6.0668 7.8933 2.7306 0.3015
OV56 GDSC1; GDSC2; CTRP2 6.2011 8.0107 5.1886 3.3061
JHOM-1 CTRP2 6.2927 8.8494 4.8431 4.5901
OVCAR-4 GDSC1; GDSC2 6.3773 8.3164 2.6965 0.2735
Caov-4 GDSC1; GDSC2 6.5046 8.5156 2.6735 0.2794
TYK-nu GDSC1; GDSC2 6.5395 16.9378 -1.027 16.6235
EFO-21 GDSC1; GDSC2; CTRP2 6.8779 11.0589 4.1933 6.3093
TOV-112D GDSC1; GDSC2; CTRP2 7.0661 9.3123 5.1631 2.1346
COV434 CTRP2 7.304 19.7539 0.209 20.1236
TOV-21G GDSC1; GDSC2; CTRP2 7.3439 19.3472 0.4425 19.3617
OAW42 GDSC1; GDSC2; CTRP2 7.9693 13.1038 3.9611 5.6526
OVCAR-5 GDSC1; GDSC2; CTRP2 7.9814 17.45 1.8643 13.6096
COV644 CTRP2 8.2867 13.8429 3.818 5.794
OAW28 GDSC1; GDSC2; CTRP2 8.4387 10.4492 5.3773 0.4298
JHOS-2 GDSC1; GDSC2; CTRP2 8.6501 16.1127 2.9812 8.5033
EFO-27 GDSC1; GDSC2; CTRP2 8.8526 15.1146 3.5812 5.9864
COV362 CTRP2 9.9321 20.9818 1.5143 11.9428
OV7 CTRP2 10.9202 23.9894 0.7374 13.0892
⏷ Show the Full List of 36 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H2452 GDSC1; GDSC2 2.4576 8.4003 0.0308 22.5725
NCI-H28 GDSC1; GDSC2 2.8019 7.6663 0.7025 17.8519
MSTO-211H GDSC2 4.1116 7.5636 1.8177 7.4421
NCI-H2052 GDSC2 5.4528 10.8924 1.1311 8.5743
MPP 89 GDSC1; GDSC2; CTRP2 6.9684 11.2501 4.1657 6.2786
JL-1 CTRP2 8.1569 9.3243 5.6712 0.0658
IST-Mes1 GDSC1; GDSC2; CTRP2 8.4145 9.98 5.5379 0.1675
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H660 GDSC2 4.4325 6.3138 2.6188 2.0762
LNCaP clone FGC GDSC1; GDSC2; CTRP2 5.8593 11.4029 3.2094 12.2314
DU145 GDSC1; GDSC2; CTRP2 5.8988 7.3564 5.2634 3.5749
22Rv1 GDSC1; GDSC2 6.0952 8.0432 2.6882 0.3814
PC-3 GDSC1; GDSC2 6.3203 8.8713 2.4741 0.8487
VCaP GDSC1; GDSC2; CTRP2 6.3396 11.2529 2.9421 7.0839
PaCa-3 CTRP2 6.3874 7.6552 5.5038 1.6895
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC1; GDSC2; CTRP2 6.655 8.6842 5.1922 2.5612
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1; GDSC2 3.7717 5.9987 2.3374 5.0413
Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NUGC-3 GDSC1; GDSC2 1.6827 6.4318 0.2539 24.3268
SCH GDSC1; GDSC2 1.926 8.6987 -0.603 27.3691
NCI-N87 GDSC1; GDSC2 3.2517 7.8619 0.9932 14.7622
Fu97 GDSC1; GDSC2 3.8964 6.9432 1.9649 7.0527
AGS GDSC2 4.0693 6.7705 2.1738 5.3605
RF-48 GDSC1 4.1172 6.1441 2.5058 4.061
ECC12 GDSC2 4.2266 6.814 2.2601 4.5014
SNU-5 GDSC1; GDSC2 4.3168 6.4044 2.5097 2.8682
MKN45 GDSC1; GDSC2 4.3332 12.6806 -0.5436 19.6245
SK-GT-2 GDSC1; GDSC2 4.5561 10.5395 0.6829 13.0016
SNU-16 GDSC1; GDSC2; CTRP2 4.647 8.6808 3.4359 13.9903
MKN28 GDSC2 4.8226 9.9553 1.1573 9.7355
MKN1 GDSC1; GDSC2 4.9934 8.1184 2.1319 3.8362
HSC-39 GDSC1; GDSC2 5.0271 14.9251 -1.1271 20.315
SNU-1 GDSC1; GDSC2; CTRP2 5.2068 10.1858 3.24 13.482
TGBC11TKB GDSC1; GDSC2 5.3166 10.864 1.0556 9.2595
OCUM-1 GDSC1; GDSC2 5.3935 7.5883 2.5687 1.1869
23132/87 GDSC1; GDSC2 5.5157 7.1711 2.7795 0.4004
HGC-27 GDSC1; GDSC2; CTRP2 5.6972 16.1772 0.6858 21.7673
GCIY GDSC2 5.7042 7.4137 2.7646 0.3571
ECC10 GDSC1; GDSC2 5.7228 11.8426 0.8578 9.5186
TMK-1 GDSC1; GDSC2 5.7874 8.0375 2.567 0.886
RERF-GC-1B GDSC1; GDSC2 6.0085 8.3166 2.5539 0.7868
HuG1-N CTRP2 6.0678 7.2807 5.4457 2.4718
SH-10-TC CTRP2 6.127 6.9491 5.6589 1.4676
SNU-601 CTRP2 6.1591 7.1973 5.5605 1.8231
NUGC-4 GDSC1; GDSC2 6.2248 7.7219 2.8449 0.0958
SNU-216 CTRP2 6.2449 16.557 0.9542 19.8119
Hs 746.T GDSC1; GDSC2; CTRP2 6.4762 8.1581 5.3222 2.2966
KATO III GDSC1; GDSC2; CTRP2 6.5949 11.3333 3.8436 8.2309
MKN7 GDSC1; GDSC2; CTRP2 7.4728 15.5626 2.4169 12.4219
IM95 GDSC2; CTRP2 7.549 10.4544 4.9313 2.4489
KE-39 CTRP2 8.063 16.4151 2.4299 11.4261
MKN74 CTRP2 8.358 20.7218 0.5333 17.3779
LMSU CTRP2 9.362 15.795 3.5779 5.4078
SNG-M GDSC1; GDSC2 3.3252 7.8852 1.0431 14.2488
SNU-685 CTRP2 6.9883 16.6145 1.5239 16.5006
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 18 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
K5 GDSC1; GDSC2 -3.4822 10.3789 -6.7557 56.8251
BHT-101 GDSC1; GDSC2 -0.4283 11.1905 -4.0513 44.5896
HTC-C3 GDSC1; GDSC2 0.3573 10.8898 -3.1477 40.4404
IHH-4 GDSC1; GDSC2 0.5198 15.4467 -5.2092 42.3747
8305C GDSC1; GDSC2 1.5826 14.1303 -3.5924 36.9307
8505C GDSC1; GDSC2 2.095 10.5892 -1.3788 29.6835
B-CPAP GDSC1; GDSC2 2.7023 11.0455 -1.0676 26.5275
KMH-2 GDSC1; GDSC2 3.7345 7.7887 1.4224 10.8132
ASH-3 GDSC1; GDSC2 3.7628 6.1624 2.2503 5.6055
CAL-62 GDSC1; GDSC2 4.1957 8.6173 1.3624 9.9935
TT GDSC1; GDSC2 4.9603 9.2617 1.5813 7.016
CGTH-W-1 GDSC1; GDSC2 5.001 6.6647 2.757 0.7852
WRO GDSC1; GDSC2 5.261 7.0583 2.7176 0.7332
TT2609-C02 GDSC1; GDSC2; CTRP2 5.5803 14.6688 1.3396 19.8838
ML-1 [Human leukemia] GDSC1; GDSC2 5.7968 14.7232 -0.4711 15.8388
SW579 CTRP2 6.402 7.9079 5.3912 2.1276
FTC-133 GDSC1; GDSC2; CTRP2 6.5377 12.2214 3.3567 10.3374
FTC-238 CTRP2 6.5743 8.6094 5.1722 2.7611
⏷ Show the Full List of 18 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 48 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HSC-3 GDSC1; GDSC2 0.2019 10.1119 -2.9274 40.7107
BB49-HNC GDSC1; GDSC2 1.5099 12.1614 -2.6859 35.3566
DOK GDSC1; GDSC2 1.8458 7.1339 0.0797 24.5656
PCI-04B GDSC1; GDSC2 2.347 8.9188 -0.3255 24.6432
HO-1-N-1 GDSC1; GDSC2 3.954 10.056 0.466 15.7191
SAS GDSC1; GDSC2 3.9936 7.4211 1.8016 7.8234
SAT [Human HNSCC] GDSC1; GDSC2 4.0812 10.8185 0.1861 16.8365
HSC-4 GDSC1; GDSC2 4.139 6.4247 2.3872 3.9211
KOSC-2 GDSC1; GDSC2 4.2093 11.2 0.0958 16.9509
Detroit 562 GDSC1; GDSC2 4.3614 9.7341 0.9355 12.0721
BICR 78 GDSC1; GDSC2 4.4065 7.3868 2.1067 5.0492
Ca9-22 GDSC1; GDSC2 4.4999 8.4263 1.6723 7.4411
KON GDSC1; GDSC2 4.5659 10.346 0.7849 12.4178
SCC-25 GDSC1; GDSC2 4.7216 7.5657 2.222 3.7912
JHU-022 GDSC1; GDSC2 4.7337 9.7012 1.2184 9.583
PCI-38 GDSC1 4.9012 11.5264 0.4498 15.9925
PCI-15A GDSC1; GDSC2 4.9075 9.1607 1.5946 7.0447
JHU-029 GDSC1; GDSC2 5.2148 10.2113 1.2982 8.1178
JHU-011 GDSC2 5.2658 10.3476 1.2669 8.1917
BICR 10 GDSC1; GDSC2 5.295 8.4867 2.1394 3.3315
BICR 18 CTRP2 5.3064 10.0335 2.7646 9.7174
SCC-15 GDSC1; GDSC2 5.3391 11.5418 0.7472 10.8825
OSC-19 GDSC1; GDSC2 5.5053 7.6083 2.6108 0.9342
HO-1-u-1 GDSC1; GDSC2 5.5773 12.9419 0.237 13.0004
BHY GDSC1; GDSC2 5.6075 7.3047 2.7667 0.3921
BB30-HNC GDSC1; GDSC2 5.6218 15.0239 -0.7407 17.38
NCI-H3118 GDSC1; GDSC2 5.7252 10.2419 1.6002 5.5304
PCI-30 GDSC1; GDSC2 5.7379 10.4444 1.5159 5.9617
HSC-2 GDSC1; GDSC2; CTRP2 5.7579 7.3352 5.147 4.3641
UPCI-SCC-090 GDSC1; GDSC2 5.8425 7.6919 2.7177 0.4125
PCI-06A GDSC1; GDSC2 5.8511 7.6868 2.7228 0.3967
OSC-20 GDSC1; GDSC2 5.8774 7.8744 2.665 0.5323
SCC-4 GDSC1; GDSC2; CTRP2 6.039 12.4828 2.8207 13.444
LB771-HNC GDSC1; GDSC2 6.0782 13.1329 0.4793 10.7774
FaDu GDSC2; CTRP2 6.1882 9.3167 4.5265 6.1079
SKN-3 GDSC1; GDSC2 6.3511 8.1619 2.7403 0.2069
BICR 6 CTRP2 6.3954 8.4037 5.1429 3.1633
BICR 22 GDSC1; GDSC2; CTRP2 6.4117 7.6644 5.5163 1.6031
PE/CA-PJ49 CTRP2 6.7066 8.0254 5.5362 1.1458
BICR 31 GDSC2; CTRP2 6.7463 14.5905 1.6047 11.9952
PE/CA-PJ15 GDSC1; GDSC2; CTRP2 6.8571 13.504 2.9684 11.3359
SCC-9 GDSC1; GDSC2; CTRP2 7.005 8.9753 5.281 1.76
CAL-27 GDSC1; GDSC2; CTRP2 7.0354 10.4372 4.609 4.3672
CAL-33 GDSC1; GDSC2; CTRP2 7.0924 10.1946 4.7643 3.6621
PE/CA-PJ34 (clone C12) CTRP2 7.1987 8.7393 5.4939 0.8234
PE/CA-PJ41 (clone D2) CTRP2 7.3752 11.1375 4.5033 4.3138
BICR 56 CTRP2 8.0987 9.5284 5.5797 0.1806
BICR 16 CTRP2 8.2927 9.7822 5.5623 0.1609
⏷ Show the Full List of 48 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KU-19-19 GDSC1; GDSC2 2.7889 5.3038 1.858 10.9417
BFTC-905 GDSC1; GDSC2 3.5825 8.7424 0.8257 14.7627
RT-4 GDSC1; GDSC2 4.2424 10.5486 0.4441 15.0723
CAL-29 GDSC1; GDSC2 4.3267 8.4902 1.5198 8.7411
SW1710 GDSC1; GDSC2 4.355 8.7851 1.3961 9.4114
RT-112 GDSC1; GDSC2 4.4001 6.2764 2.617 2.1349
639V GDSC1; GDSC2 4.4468 5.4908 2.9708 0.4272
UM-UC-3 GDSC1; GDSC2 5.1927 7.5057 2.5068 1.6506
TCCSUP GDSC1; GDSC2 5.2737 6.483 2.9325 0.157
HT-1376 GDSC1; GDSC2 5.4112 10.931 1.0859 8.9035
SW780 GDSC1; GDSC2 5.4646 7.4191 2.6662 0.7688
HT-1197 GDSC1; GDSC2; CTRP2 5.4975 20.9494 -1.8686 28.6939
5637 GDSC1; GDSC2 5.7773 11.2736 1.1585 7.8145
KMBC-2 CTRP2 5.9916 6.876 5.5838 2.0403
SCaBER CTRP2 6.3188 9.8547 4.3628 6.5554
UM-UC-1 CTRP2 6.5764 10.3787 4.3031 6.353
J82 GDSC1; GDSC2; CTRP2 6.5845 7.9911 5.476 1.5257
BC-3C CTRP2 6.7611 8.7746 5.2204 2.2998
647V GDSC1; GDSC2; CTRP2 7.0522 8.5495 5.4985 0.9319
U-BLC1 CTRP2 10.295 21.7583 1.3848 11.8848
T24 GDSC1; GDSC2; CTRP2 11.6331 23.6468 1.3499 10.3637
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KGN GDSC1; GDSC2 0.684 12.0854 -3.4142 39.6398
ACC-OV7 GDSC1; GDSC2 1.5847 9.9255 -1.5198 31.9816
HEY GDSC1; GDSC2 2.5877 6.3774 1.1461 15.9888
ME-180 GDSC1; GDSC2 2.6634 9.3118 -0.2381 23.1609
C-4-I GDSC2 4.1048 7.6924 1.7498 7.8732
OVCA433 GDSC1; GDSC2 4.1964 6.811 2.2414 4.6766
OVCA420 GDSC1; GDSC2 4.3578 8.233 1.6669 7.7884
CAL-39 GDSC1; GDSC2 4.3941 8.2035 1.7066 7.4689
C-33 A GDSC1; GDSC2 4.4454 9.0258 1.3434 9.5116
NEC8 GDSC2 4.5914 7.9053 1.9822 5.4146
SiSo GDSC1; GDSC2 4.7338 8.0074 2.0253 4.891
TC-YIK GDSC1; GDSC2 4.7718 7.2634 2.3881 2.795
JAR GDSC1; GDSC2 4.8015 9.518 1.3534 8.6578
HEC-1 GDSC1; GDSC2 4.8421 7.6668 2.2475 3.4477
MS751 GDSC1; GDSC2 4.8979 6.7108 2.6911 1.1434
SiHa GDSC1; GDSC2 4.9473 6.304 2.8721 0.4303
NCC-IT GDSC2 5.1123 6.9272 2.7034 0.8982
UWB1.289 GDSC1; GDSC2 5.1709 10.547 1.1098 9.2586
BPH-1 GDSC1; GDSC2 5.2146 8.879 1.9173 4.6516
PA-1 GDSC2 5.2149 6.9248 2.7491 0.6573
SW756 GDSC1; GDSC2 5.2627 6.5956 2.8892 0.2434
PEO1 GDSC1; GDSC2 5.2917 10.4372 1.2415 8.2823
NT2-D1 GDSC1; GDSC2 5.3036 12.9282 0.0534 14.4986
SW954 GDSC1; GDSC2 5.3037 13.118 -0.0388 14.9422
JEG-3 GDSC1; GDSC2 5.3476 9.18 1.8593 4.7492
PWR-1E GDSC1; GDSC2 5.3709 7.2428 2.6938 0.7389
OMC-1 [Human cervical carcinoma] GDSC1; GDSC2 5.4037 13.3671 -0.0893 14.9577
SKN GDSC1; GDSC2 5.5448 7.9497 2.4937 1.354
SKG-IIIa GDSC1; GDSC2 5.5449 7.1604 2.7946 0.3505
HT-3 GDSC1; GDSC2 5.5699 7.673 2.6138 0.8762
DoTc2 4510 GDSC1; GDSC2 5.587 7.6942 2.613 0.8669
LB831-BLC GDSC1; GDSC2 5.5962 8.2319 2.4036 1.6839
SW962 GDSC1; GDSC2 5.7333 7.8682 2.6087 0.7827
OV17R GDSC1; GDSC2 5.8923 10.2086 1.7113 4.6824
OVMIU GDSC1; GDSC2 5.9834 9.0022 2.274 1.8547
JHOS-3 GDSC1; GDSC2 5.986 8.5886 2.44 1.1919
Ca Ski GDSC1; GDSC2 6.1655 8.7032 2.4732 0.9481
DSH1 GDSC1; GDSC2 6.408 8.2992 2.7135 0.2362
HeLa GDSC1; GDSC2; CTRP2 7.3126 8.3417 5.7044 0.2014
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Same Disease as Dabrafenib
DDI Drug Name DDI Drug ID Severity Mechanism Disease REF
Selumetinib DMC7W6R Major Increased metabolism of Dabrafenib caused by Selumetinib mediated induction of CYP450 enzyme. Melanoma [2C30] [12]
LGX818 DMNQXV8 Major Increased metabolism of Dabrafenib caused by LGX818 mediated induction of CYP450 enzyme. Melanoma [2C30] [13]
Coadministration of a Drug Treating the Disease Different from Dabrafenib (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Ivosidenib DM8S6T7 Moderate Increased metabolism of Dabrafenib caused by Ivosidenib mediated induction of CYP450 enzyme. Acute myeloid leukaemia [2A60] [14]
Arn-509 DMT81LZ Moderate Increased metabolism of Dabrafenib caused by Arn-509 mediated induction of CYP450 enzyme. Acute myeloid leukaemia [2A60] [15]
Gilteritinib DMTI0ZO Moderate Increased metabolism of Dabrafenib caused by Gilteritinib mediated induction of CYP450 enzyme. Acute myeloid leukaemia [2A60] [14]
Oliceridine DM6MDCF Major Increased metabolism of Dabrafenib caused by Oliceridine mediated induction of CYP450 enzyme. Acute pain [MG31] [16]
Ivabradine DM0L594 Moderate Increased metabolism of Dabrafenib caused by Ivabradine mediated induction of CYP450 enzyme. Angina pectoris [BA40] [14]
Troleandomycin DMUZNIG Moderate Decreased metabolism of Dabrafenib caused by Troleandomycin mediated inhibition of CYP450 enzyme. Bacterial infection [1A00-1C4Z] [15]
Erdafitinib DMI782S Major Increased metabolism of Dabrafenib caused by Erdafitinib mediated induction of CYP450 enzyme. Bladder cancer [2C94] [17]
Pexidartinib DMS2J0Z Moderate Increased metabolism of Dabrafenib caused by Pexidartinib mediated induction of CYP450 enzyme. Bone/articular cartilage neoplasm [2F7B] [18]
HKI-272 DM6QOVN Major Increased metabolism of Dabrafenib caused by HKI-272 mediated induction of CYP450 enzyme. Breast cancer [2C60-2C6Y] [15]
LY2835219 DM93VBZ Moderate Increased metabolism of Dabrafenib caused by LY2835219 mediated induction of CYP450 enzyme. Breast cancer [2C60-2C6Y] [14]
Esterified estrogens DM9KZDO Moderate Increased metabolism of Dabrafenib caused by Esterified estrogens mediated induction of CYP450 enzyme. Breast cancer [2C60-2C6Y] [19]
Tucatinib DMBESUA Moderate Decreased metabolism of Dabrafenib caused by Tucatinib mediated inhibition of CYP450 enzyme. Breast cancer [2C60-2C6Y] [15]
Palbociclib DMD7L94 Moderate Increased metabolism of Dabrafenib caused by Palbociclib mediated induction of CYP450 enzyme. Breast cancer [2C60-2C6Y] [15]
PF-04449913 DMSB068 Major Increased metabolism of Dabrafenib caused by PF-04449913 mediated induction of CYP450 enzyme. Chronic myelomonocytic leukaemia [2A40] [20]
Revefenacin DMMP5SI Moderate Decreased clearance of Dabrafenib due to the transporter inhibition by Revefenacin. Chronic obstructive pulmonary disease [CA22] [21]
Levonorgestrel DM1DP7T Major Increased metabolism of Dabrafenib caused by Levonorgestrel mediated induction of CYP450 enzyme. Contraceptive management [QA21] [22]
Osilodrostat DMIJC9X Moderate Increased metabolism of Dabrafenib caused by Osilodrostat mediated induction of CYP450 enzyme. Cushing syndrome [5A70] [23]
MK-8228 DMOB58Q Moderate Decreased metabolism of Dabrafenib caused by MK-8228 mediated inhibition of CYP450 enzyme. Cytomegaloviral disease [1D82] [15]
Polatuzumab vedotin DMF6Y0L Moderate Increased metabolism of Dabrafenib caused by Polatuzumab vedotin mediated induction of CYP450 enzyme. Diffuse large B-cell lymphoma [2A81] [14]
SODIUM CITRATE DMHPD2Y Moderate Decreased absorption of Dabrafenib due to altered gastric pH caused by SODIUM CITRATE. Discovery agent [N.A.] [15]
Oestradiol valerate and dienogest DMZK0FQ Major Increased metabolism of Dabrafenib caused by Oestradiol valerate and dienogest mediated induction of CYP450 enzyme. Endometriosis [GA10] [24]
Stiripentol DMMSDOY Moderate Increased metabolism of Dabrafenib caused by Stiripentol mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [14]
Bay 80-6946 DMLOS5R Moderate Increased metabolism of Dabrafenib caused by Bay 80-6946 mediated induction of CYP450 enzyme. Follicular lymphoma [2A80] [14]
Tazemetostat DMWP1BH Major Increased metabolism of Dabrafenib caused by Tazemetostat mediated induction of CYP450 enzyme. Follicular lymphoma [2A80] [25]
Ripretinib DM958QB Moderate Increased metabolism of Dabrafenib caused by Ripretinib mediated induction of CYP450 enzyme. Gastrointestinal stromal tumour [2B5B] [15]
Avapritinib DMK2GZX Major Increased metabolism of Dabrafenib caused by Avapritinib mediated induction of CYP450 enzyme. Gastrointestinal stromal tumour [2B5B] [14]
Daclatasvir DMSFK9V Major Increased metabolism of Dabrafenib caused by Daclatasvir mediated induction of CYP450 enzyme. Hepatitis virus infection [1E50-1E51] [14]
MK-1439 DM215WE Major Increased metabolism of Dabrafenib caused by MK-1439 mediated induction of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [14]
Fostemsavir DM50ILT Minor Increased metabolism of Dabrafenib caused by Fostemsavir mediated induction of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [26]
Cobicistat DM6L4H2 Moderate Decreased metabolism of Dabrafenib caused by Cobicistat mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [15]
Elvitegravir DMG9B1U Moderate Increased metabolism of Dabrafenib caused by Elvitegravir mediated induction of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [15]
Levamlodipine DM92S6N Moderate Increased metabolism of Dabrafenib caused by Levamlodipine mediated induction of CYP450 enzyme. Hypertension [BA00-BA04] [14]
Tasimelteon DMLOQ1V Moderate Increased metabolism of Dabrafenib caused by Tasimelteon mediated induction of CYP450 enzyme. Insomnia [7A00-7A0Z] [27]
Naloxegol DML0B41 Moderate Increased metabolism of Dabrafenib caused by Naloxegol mediated induction of CYP450 enzyme. Large intestine motility disorder [DB32] [28]
Pemigatinib DM819JF Major Increased metabolism of Dabrafenib caused by Pemigatinib mediated induction of CYP450 enzyme. Liver cancer [2C12] [14]
Brigatinib DM7W94S Major Increased metabolism of Dabrafenib caused by Brigatinib mediated induction of CYP450 enzyme. Lung cancer [2C25] [15]
Ceritinib DMB920Z Moderate Decreased metabolism of Dabrafenib caused by Ceritinib mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [15]
Lurbinectedin DMEFRTZ Major Decreased metabolism of Dabrafenib caused by Lurbinectedin mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [29]
PF-06463922 DMKM7EW Major Increased metabolism of Dabrafenib caused by PF-06463922 mediated induction of CYP450 enzyme. Lung cancer [2C25] [30]
Osimertinib DMRJLAT Moderate Increased metabolism of Dabrafenib caused by Osimertinib mediated induction of CYP450 enzyme. Lung cancer [2C25] [14]
Pralsetinib DMWU0I2 Moderate Increased metabolism of Dabrafenib caused by Pralsetinib mediated induction of CYP450 enzyme. Lung cancer [2C25] [31]
Capmatinib DMYCXKL Major Increased metabolism of Dabrafenib caused by Capmatinib mediated induction of CYP450 enzyme. Lung cancer [2C25] [32]
Selpercatinib DMZR15V Major Increased metabolism of Dabrafenib caused by Selpercatinib mediated induction of CYP450 enzyme. Lung cancer [2C25] [14]
Idelalisib DM602WT Moderate Decreased metabolism of Dabrafenib caused by Idelalisib mediated inhibition of CYP450 enzyme. Mature B-cell leukaemia [2A82] [15]
GDC-0199 DMH0QKA Major Increased metabolism of Dabrafenib caused by GDC-0199 mediated induction of CYP450 enzyme. Mature B-cell leukaemia [2A82] [33]
IPI-145 DMWA24P Moderate Increased metabolism of Dabrafenib caused by IPI-145 mediated induction of CYP450 enzyme. Mature B-cell leukaemia [2A82] [14]
Acalabrutinib DM7GCVW Moderate Increased metabolism of Dabrafenib caused by Acalabrutinib mediated induction of CYP450 enzyme. Mature B-cell lymphoma [2A85] [14]
Ubrogepant DM749I3 Moderate Increased metabolism of Dabrafenib caused by Ubrogepant mediated induction of CYP450 enzyme. Migraine [8A80] [34]
Rimegepant DMHOAUG Major Increased metabolism of Dabrafenib caused by Rimegepant mediated induction of CYP450 enzyme. Migraine [8A80] [35]
Deflazacort DMV0RNS Major Increased metabolism of Dabrafenib caused by Deflazacort mediated induction of CYP450 enzyme. Muscular dystrophy [8C70] [14]
Fedratinib DM4ZBK6 Major Increased metabolism of Dabrafenib caused by Fedratinib mediated induction of CYP450 enzyme. Myeloproliferative neoplasm [2A20] [14]
Entrectinib DMMPTLH Major Increased metabolism of Dabrafenib caused by Entrectinib mediated induction of CYP450 enzyme. Non-small cell lung cancer [2C25] [36]
S-297995 DM26IH8 Moderate Increased metabolism of Dabrafenib caused by S-297995 mediated induction of CYP450 enzyme. Opioid use disorder [6C43] [14]
Olaparib DM8QB1D Moderate Increased metabolism of Dabrafenib caused by Olaparib mediated induction of CYP450 enzyme. Ovarian cancer [2C73] [15]
Istradefylline DM20VSK Moderate Increased metabolism of Dabrafenib caused by Istradefylline mediated induction of CYP450 enzyme. Parkinsonism [8A00] [14]
Abametapir DM2RX0I Moderate Decreased metabolism of Dabrafenib caused by Abametapir mediated inhibition of CYP450 enzyme. Pediculosis [1G00] [37]
Macimorelin DMQYJIR Moderate Increased metabolism of Dabrafenib caused by Macimorelin mediated induction of CYP450 enzyme. Pituitary gland disorder [5A60-5A61] [38]
Lefamulin DME6G97 Major Increased metabolism of Dabrafenib caused by Lefamulin mediated induction of CYP450 enzyme. Pneumonia [CA40] [39]
Darolutamide DMV7YFT Moderate Increased metabolism of Dabrafenib caused by Darolutamide mediated induction of CYP450 enzyme. Prostate cancer [2C82] [14]
Upadacitinib DM32B5U Moderate Increased metabolism of Dabrafenib caused by Upadacitinib mediated induction of CYP450 enzyme. Rheumatoid arthritis [FA20] [40]
Voxelotor DMCS6M5 Major Increased metabolism of Dabrafenib caused by Voxelotor mediated induction of CYP450 enzyme. Sickle-cell disorder [3A51] [41]
LDE225 DMM9F25 Major Increased metabolism of Dabrafenib caused by LDE225 mediated induction of CYP450 enzyme. Skin cancer [2C30-2C37] [42]
Larotrectinib DM26CQR Moderate Increased metabolism of Dabrafenib caused by Larotrectinib mediated induction of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [14]
LEE011 DMMX75K Moderate Increased metabolism of Dabrafenib caused by LEE011 mediated induction of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [15]
Fostamatinib DM6AUHV Moderate Increased metabolism of Dabrafenib caused by Fostamatinib mediated induction of CYP450 enzyme. Thrombocytopenia [3B64] [14]
As-1670542 DMV05SW Major Increased metabolism of Dabrafenib caused by As-1670542 mediated induction of CYP450 enzyme. Thrombocytopenia [3B64] [43]
Elagolix DMB2C0E Moderate Increased metabolism of Dabrafenib caused by Elagolix mediated induction of CYP450 enzyme. Uterine fibroid [2E86] [14]
⏷ Show the Full List of 67 DDI Information of This Drug

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG
DIG Name DIG ID PubChem CID Functional Classification
Eisenoxyd E00585 56841934 Colorant
Hypromellose E00634 Not Available Coating agent
Magnesium stearate E00208 11177 lubricant
Silicon dioxide E00670 Not Available Anticaking agent; Opacifying agent; Viscosity-controlling agent
Titanium dioxide E00322 26042 Coating agent; Colorant; Opacifying agent
Haematite red E00236 14833 Colorant
Hydrophobic colloidal silica E00285 24261 Anticaking agent; Emulsion stabilizing agent; Glidant; Suspending agent; Viscosity-controlling agent
Cellulose microcrystalline E00698 Not Available Adsorbent; Suspending agent; Diluent
⏷ Show the Full List of 8 Pharmaceutical Excipients of This Drug
Pharmaceutical Formulation
Formulation Name Drug Dosage Dosage Form Route
Dabrafenib Mesylate eq 50mg base capsule eq 50mg base Capsule Oral
Dabrafenib Mesylate eq 75mg base capsule eq 75mg base Capsule Oral
Dabrafenib 50 mg capsule 50 mg Oral Capsule Oral
Dabrafenib 75 mg capsule 75 mg Oral Capsule Oral
Jump to Detail Pharmaceutical Formulation Page of This Drug

References

1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
2 Dabrafenib
3 BDDCS predictions, self-correcting aspects of BDDCS assignments, BDDCS assignment corrections, and classification for more than 175 additional drugs
4 Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds
5 Clinical pipeline report, company report or official report of GlaxoSmithKline (2011).
6 Mechanisms limiting distribution of the threonine-protein kinase B-RaF(V600E) inhibitor dabrafenib to the brain: implications for the treatment of melanoma brain metastases. J Pharmacol Exp Ther. 2013 Mar;344(3):655-64.
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21 Product Information. Nexletol (bempedoic acid). Esperion Therapeutics, Ann Arbor, MI.
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23 Product Information. Isturisa (osilodrostat). Recordati Rare Diseases Inc, Lebanon, NJ.
24 Faculty of Sexual & Reproductive Healthcare "FSRH Clinical Guidance: Drug Interactions with Hormonal Contraception.".
25 Product Information. Tazverik (tazemetostat). Epizyme, Inc, Cambridge, MA.
26 Product Information. Rukobia (fostemsavir). ViiV Healthcare, Research Triangle Park, NC.
27 Product Information. Hetlioz (tasimelteon). Vanda Pharmaceuticals Inc, Rockville, MD.
28 Product Information. Movantik (naloxegol). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
29 Product Information. Zepzelca (lurbinectedin). Jazz Pharmaceuticals, Palo Alto, CA.
30 Product Information. Lorbrena (lorlatinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
31 Product Information. Gavreto (pralsetinib). Blueprint Medicines Corporation, Cambridge, MA.
32 Product Information. Tabrecta (capmatinib). Novartis Pharmaceuticals, East Hanover, NJ.
33 Product Information. Venclexta (venetoclax). AbbVie US LLC, North Chicago, IL.
34 Product Information. Ubrelvy (ubrogepant). Allergan Inc, Irvine, CA.
35 Product Information. Nurtec ODT (rimegepant). Biohaven Pharmaceuticals, New Haven, CT.
36 Product Information. Rozlytrek (entrectinib). Genentech, South San Francisco, CA.
37 Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
38 Product Information. Macrilen (macimorelin). Aeterna Zentaris, Charleston, SC.
39 Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
40 Product Information. Rinvoq (upadacitinib). AbbVie US LLC, North Chicago, IL.
41 Product Information. Oxbryta (voxelotor). Global Blood Therapeutics, Inc., South San Francisco, CA.
42 Product Information. Odomzo (sonidegib). Novartis Pharmaceuticals, East Hanover, NJ.
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