Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM6Q7U4)

Drug Name
Lenalidomide Drug Info
Synonyms
Revamid; Revimid; Revlimid; Celgene brand of lenalidomide; Lenalidomide [USAN]; CC 5013; CC5013; CDC 501; IMiD3; IMiD3cpd; ALBB-015321; CC-5013; CDC-501; CDC-5013; ENMD-0997; IMID-5013; Revlimid (Celgene); Revlimid (TN); Thalidomide analog CC-5013; Lenalidomide (USAN/INN); CC-5013, Revlimid, Lenalidomide; 3-(4-Amino-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione; 3-(4-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(7-Amino-3-oxo-1H-isoindol-2-yl)-piperidine-2,6-dione; 3-(7-amino-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione; Lenalidomide (Immunomodulator)
Indication
Disease Entry ICD 11 Status REF
Adult T-cell leukemia/lymphoma Approved [1]
Advanced cancer 2A00-2F9Z Approved [1]
Complex regional pain syndrome type 1 Approved [1]
Hepatosplenic T-cell lymphoma Approved [1]
Large granular lymphocytic leukemia 2A90.1 Approved [1]
Leukemia Approved [1]
MALT lymphoma Approved [1]
Multiple myeloma 2A83 Approved [2]
Nodal marginal zone lymphoma 2A85.0 Approved [1]
Pain MG30-MG3Z Approved [1]
Plasma cell myeloma 2A83.1 Approved [1]
Primary cutaneous peripheral T-cell lymphoma not otherwise specified Approved [1]
Prolymphocytic leukaemia 2A82.1 Approved [1]
Recurrent adult burkitt lymphoma 2A85.6 Approved [1]
Small intestine lymphoma Approved [1]
Splenic marginal zone lymphoma Approved [1]
Testicular lymphoma Approved [1]
Urinary bladder neoplasm Approved [1]
Waldenstrom macroglobulinemia 2A85.4 Approved [1]
Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 3 [3]
Colon cancer 2B90.Z Investigative [1]
Therapeutic Class
Anticancer Agents
Cross-matching ID
PubChem CID
216326
ChEBI ID
CHEMBL848
CAS Number
CAS 191732-72-6
TTD Drug ID
DM6Q7U4
VARIDT Drug ID
DR00261
ACDINA Drug ID
D00353

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Tumor necrosis factor (TNF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [9]
Nafamostat DMU1XOD Pancreatitis DC31-DC34 Approved [10]
Pentoxifylline DMU3DNC Alcoholic hepatitis DB94.1 Approved [11]
Enbrel DM7RNP3 Arthritis FA20 Approved [12]
Golimumab DMHZV7X Psoriatic arthritis FA21 Approved [13]
Certolizumab DM5CL9Z Rheumatoid arthritis FA20 Approved [14]
Etanercept DMCV109 Arthritis FA20 Approved [15]
Adalimumab DMQMV1B Crohn disease DD70 Approved [16]
Infliximab DMH7OIA Crohn disease DD70 Approved [17]
Golnerminogene pradenovac DMKWV4B Esophageal cancer 2B70 Phase 3 [18]
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Drug(s) Transported By P-glycoprotein 1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [19]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [20]
Methotrexate DM2TEOL Anterior urethra cancer Approved [21]
Folic Acid DMEMBJC Colorectal carcinoma Approved [22]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [21]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [21]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [23]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [21]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [24]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [25]
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Drug(s) Affected By Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [26]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [27]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [28]
Methotrexate DM2TEOL Anterior urethra cancer Approved [29]
Quercetin DM3NC4M Obesity 5B81 Approved [30]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [31]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [32]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [33]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [34]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [35]
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Drug(s) Affected By Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gefitinib DM15F0X Colon adenocarcinoma Approved [36]
Quercetin DM3NC4M Obesity 5B81 Approved [37]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [38]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [39]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [35]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [7]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [40]
Ethanol DMDRQZU Chronic pain MG30 Approved [41]
Menthol DMG2KW7 Back pain ME84.Z Approved [42]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [43]
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Drug(s) Affected By Interleukin-6 receptor subunit beta (IL6ST)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [44]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [45]
Selenium DM25CGV N. A. N. A. Approved [46]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [38]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [48]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [49]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [7]
Testosterone DM7HUNW Hot flushes GA30 Approved [50]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [50]
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Drug(s) Affected By DNA damage-binding protein 1 (DDB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [51]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [52]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [53]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [54]
Arsenic DMTL2Y1 N. A. N. A. Approved [55]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [56]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [57]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [58]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [59]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [60]
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Drug(s) Affected By Sal-like protein 4 (SALL4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [48]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [8]
Testosterone DM7HUNW Hot flushes GA30 Approved [61]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [62]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [63]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [64]
Pomalidomide DMTGBAX Plasma cell myeloma 2A83.1 Approved [8]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [65]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [66]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [67]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Tumor necrosis factor (TNF) TTF8CQI TNFA_HUMAN Inhibitor [4]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [5]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
DNA damage-binding protein 1 (DDB1) OTTR2L3Z DDB1_HUMAN Protein Interaction/Cellular Processes [6]
Interleukin-6 receptor subunit beta (IL6ST) OT1N9C70 IL6RB_HUMAN Gene/Protein Processing [7]
Sal-like protein 4 (SALL4) OTC08PR5 SALL4_HUMAN Protein Interaction/Cellular Processes [8]
Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A) OT2D9DOV TNR1A_HUMAN Gene/Protein Processing [7]
Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B) OTDS2EAR TNR1B_HUMAN Gene/Protein Processing [7]

References

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3 Low-dose Lenalidomide for Non-severe COVID-19 Treatment Trial (GETAFE)
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7 Circulating endothelial progenitor cells in multiple myeloma: implications and significance. Blood. 2005 Apr 15;105(8):3286-94. doi: 10.1182/blood-2004-06-2101. Epub 2004 Dec 23.
8 Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome. Elife. 2018 Aug 1;7:e38430. doi: 10.7554/eLife.38430.
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25 Association of genetic polymorphisms in the influx transporter SLCO1B3 and the efflux transporter ABCB1 with imatinib pharmacokinetics in patients with chronic myeloid leukemia. Ther Drug Monit. 2011 Apr;33(2):244-50.
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27 Transcriptomic Analysis of Stem Cells Treated with Moringin or Cannabidiol: Analogies and Differences in Inflammation Pathways. Int J Mol Sci. 2019 Nov 30;20(23):6039. doi: 10.3390/ijms20236039.
28 Iron-mediated H2O2 production as a mechanism for cell type-specific inhibition of tumor necrosis factor alpha-induced but not interleukin-1beta-induced IkappaB kinase complex/nuclear factor-kappaB activation. J Biol Chem. 2005 Jan 28;280(4):2912-23. doi: 10.1074/jbc.M409524200. Epub 2004 Nov 17.
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32 Motexafin gadolinium and zinc induce oxidative stress responses and apoptosis in B-cell lymphoma lines. Cancer Res. 2005 Dec 15;65(24):11676-88.
33 Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol. 2011 Dec;28(4):1225-54.
34 Lunasin, a novel seed peptide, sensitizes human breast cancer MDA-MB-231 cells to aspirin-arrested cell cycle and induced apoptosis. Chem Biol Interact. 2010 Jul 30;186(2):127-34. doi: 10.1016/j.cbi.2010.04.027. Epub 2010 May 21.
35 Hydroquinone Exposure Worsens Rheumatoid Arthritis through the Activation of the Aryl Hydrocarbon Receptor and Interleukin-17 Pathways. Antioxidants (Basel). 2021 Jun 7;10(6):929. doi: 10.3390/antiox10060929.
36 Identification of genes linked to gefitinib treatment in prostate cancer cell lines with or without resistance to androgen: a clue to application of gefitinib to hormone-resistant prostate cancer. Oncol Rep. 2006 Jun;15(6):1453-60.
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44 Cannabidiol Modulates the Immunophenotype and Inhibits the Activation of the Inflammasome in Human Gingival Mesenchymal Stem Cells. Front Physiol. 2016 Nov 24;7:559. doi: 10.3389/fphys.2016.00559. eCollection 2016.
45 Chronic senescent human mesenchymal stem cells as possible contributor to the wound healing disorder after exposure to the alkylating agent sulfur mustard. Arch Toxicol. 2021 Feb;95(2):727-747. doi: 10.1007/s00204-020-02946-5. Epub 2021 Jan 25.
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53 Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
54 Identification of biomarkers and outcomes of endocrine disruption in human ovarian cortex using In Vitro Models. Toxicology. 2023 Feb;485:153425. doi: 10.1016/j.tox.2023.153425. Epub 2023 Jan 5.
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62 Integrative "-Omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
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67 Inhibiting ubiquitination causes an accumulation of SUMOylated newly synthesized nuclear proteins at PML bodies. J Biol Chem. 2019 Oct 18;294(42):15218-15234. doi: 10.1074/jbc.RA119.009147. Epub 2019 Jul 8.