Details of the Drug

General Information of Drug (ID: DMKY8V1)

Drug Name
Propiomazine
Synonyms
Phenoctyl; Propiomazina; Propiomazinum; Propionylpromethazine; Dorevan (TN); Dorevane (TN); Indorm (TN); Largon (TN); Propavan (TN); Propiomazina [INN-Spanish]; Propiomazinum [INN-Latin]; Serentin (TN); Wy-1359; Propiomazine (USAN/INN); Propiomazine [USAN:BAN:INN]; Propiomazine [USAN:INN:BAN]; 1-(10-(2-(Dimethylamino)propyl)phenothiazin-2-yl)-1-propanone; 1-[10-[2-(dimethylamino)propyl]phenothiazin-2-yl]propan-1-one; 1-{10-[2-(dimethylamino)propyl]-10H-phenothiazin-2-yl}propan-1-one; 10-(2-Dimethylaminopropyl)-2-propionylphenothiazine; 10-Dimethylaminoisopropyl-2-propionylphenothiazine; 2-Propionyl-10-(2-(dimethylamino)propyl)phenothiazine; 3-Propionyl-10-dimethylaminoisopropylphenothiazine
Indication
Disease Entry ICD 11 Status REF
Insomnia 7A00-7A0Z Approved [1]
Therapeutic Class
Sedatives and Hypnotics
Affected Organisms
Humans and other mammals
ATC Code
N05CM06: Propiomazine
N05CM: Other hypnotics and sedatives
N05C: HYPNOTICS AND SEDATIVES
N05: PSYCHOLEPTICS
N: NERVOUS SYSTEM
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 340.5
Logarithm of the Partition Coefficient (xlogp) 4.8
Rotatable Bond Count (rotbonds) 5
Hydrogen Bond Donor Count (hbonddonor) 0
Hydrogen Bond Acceptor Count (hbondacc) 4
ADMET Property
Metabolism
The drug is metabolized via the hepatic []
MRTD
The Maximum Recommended Therapeutic Dose (MRTD) of drug that ensured maximising efficacy and moderate side effect is 2.44647 micromolar/kg/day [2]
Chemical Identifiers
Formula
C20H24N2OS
IUPAC Name
1-[10-[2-(dimethylamino)propyl]phenothiazin-2-yl]propan-1-one
Canonical SMILES
CCC(=O)C1=CC2=C(C=C1)SC3=CC=CC=C3N2CC(C)N(C)C
InChI
InChI=1S/C20H24N2OS/c1-5-18(23)15-10-11-20-17(12-15)22(13-14(2)21(3)4)16-8-6-7-9-19(16)24-20/h6-12,14H,5,13H2,1-4H3
InChIKey
UVOIBTBFPOZKGP-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
4940
ChEBI ID
CHEBI:8491
CAS Number
362-29-8
UNII
242Z0PM79Y
DrugBank ID
DB00777
TTD ID
D0R9ZB

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Histamine H1 receptor (H1R) TTTIBOJ HRH1_HUMAN Antagonist [3]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Insomnia
ICD Disease Classification 7A00-7A0Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Histamine H1 receptor (H1R) DTT HRH1 6.74E-01 0.13 0.43
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Same Disease as Propiomazine
DDI Drug Name DDI Drug ID Severity Mechanism Disease REF
ITI-007 DMUQ1DO Moderate Additive anticholinergic effects by the combination of Propiomazine and ITI-007. Insomnia [7A00-7A0Z] [4]
Coadministration of a Drug Treating the Disease Different from Propiomazine (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Oliceridine DM6MDCF Major Additive CNS depression effects by the combination of Propiomazine and Oliceridine. Acute pain [MG31] [5]
Mepyramine DMB4SFH Moderate Additive anticholinergic effects by the combination of Propiomazine and Mepyramine. Allergic/hypersensitivity disorder [4A80-4A8Z] [6]
Phenyltoloxamine DMKAEQW Moderate Additive anticholinergic effects by the combination of Propiomazine and Phenyltoloxamine. Allergic/hypersensitivity disorder [4A80-4A8Z] [6]
Memantine DMD9WSC Moderate Additive anticholinergic effects by the combination of Propiomazine and Memantine. Alzheimer disease [8A20] [4]
Rivastigmine DMG629M Moderate Antagonize the effect of Propiomazine when combined with Rivastigmine. Alzheimer disease [8A20] [7]
Donepezil DMIYG7Z Moderate Antagonize the effect of Propiomazine when combined with Donepezil. Alzheimer disease [8A20] [7]
Isosorbide dinitrate DMBI4JG Moderate Additive hypotensive effects by the combination of Propiomazine and Isosorbide dinitrate. Anal fissure/fistula [DB50] [8]
Amyl nitrite DMJKO05 Moderate Additive hypotensive effects by the combination of Propiomazine and Amyl nitrite. Angina pectoris [BA40] [8]
Nifedipine DMSVOZT Moderate Additive hypotensive effects by the combination of Propiomazine and Nifedipine. Angina pectoris [BA40] [8]
Ephedrine DMMV0KW Moderate Antagonize the effect of Propiomazine when combined with Ephedrine. Asthma [CA23] [9]
Lisdexamfetamine DM6W8V5 Moderate Antagonize the effect of Propiomazine when combined with Lisdexamfetamine. Attention deficit hyperactivity disorder [6A05] [9]
Desipramine DMT2FDC Moderate Increased plasma concentrations of Propiomazine and Desipramine due to competitive inhibition of the same metabolic pathway. Attention deficit hyperactivity disorder [6A05] [10]
Cariprazine DMJYDVK Moderate Additive anticholinergic effects by the combination of Propiomazine and Cariprazine. Bipolar disorder [6A60] [4]
Loperamide DMOJZQ9 Moderate Additive antimotility effects by the combination of Propiomazine and Loperamide. Bowel habit change [ME05] [11]
Umeclidinium DM4E8O9 Moderate Additive anticholinergic effects by the combination of Propiomazine and Umeclidinium. Chronic obstructive pulmonary disease [CA22] [12]
Tiotropium DMFDC0Q Moderate Additive anticholinergic effects by the combination of Propiomazine and Tiotropium. Chronic obstructive pulmonary disease [CA22] [12]
Revefenacin DMMP5SI Moderate Additive anticholinergic effects by the combination of Propiomazine and Revefenacin. Chronic obstructive pulmonary disease [CA22] [12]
Dihydrocodeine DMB0FWL Major Additive CNS depression effects by the combination of Propiomazine and Dihydrocodeine. Chronic pain [MG30] [5]
Propofol DMB4OLE Moderate Additive cardiorespiratory depression effects by the combination of Propiomazine and Propofol. Corneal disease [9A76-9A78] [13]
Alfentanil DMVO0UB Major Additive CNS depression effects by the combination of Propiomazine and Alfentanil. Corneal disease [9A76-9A78] [14]
Remifentanil DMZTXCH Major Additive CNS depression effects by the combination of Propiomazine and Remifentanil. Corneal disease [9A76-9A78] [14]
Cyclobenzaprine DM1YBRM Moderate Additive anticholinergic effects by the combination of Propiomazine and Cyclobenzaprine. Depression [6A70-6A7Z] [4]
Isocarboxazid DMAF1NB Moderate Additive hypotensive effects by the combination of Propiomazine and Isocarboxazid. Depression [6A70-6A7Z] [15]
OPC-34712 DMHG57U Moderate Additive anticholinergic effects by the combination of Propiomazine and OPC-34712. Depression [6A70-6A7Z] [4]
Phenelzine DMHIDUE Moderate Additive hypotensive effects by the combination of Propiomazine and Phenelzine. Depression [6A70-6A7Z] [15]
Clomipramine DMINRKW Moderate Increased plasma concentrations of Propiomazine and Clomipramine due to competitive inhibition of the same metabolic pathway. Depression [6A70-6A7Z] [10]
Doxepin DMPI98T Moderate Increased plasma concentrations of Propiomazine and Doxepin due to competitive inhibition of the same metabolic pathway. Depression [6A70-6A7Z] [10]
Maprotiline DMPWB7T Moderate Additive anticholinergic effects by the combination of Propiomazine and Maprotiline. Depression [6A70-6A7Z] [4]
Esketamine DMVU687 Moderate Additive CNS depression effects by the combination of Propiomazine and Esketamine. Depression [6A70-6A7Z] [16]
Mepenzolate DM8YU2F Moderate Additive anticholinergic effects by the combination of Propiomazine and Mepenzolate. Digestive system disease [DE2Z] [6]
Oxybutynine DMJPBAX Moderate Additive anticholinergic effects by the combination of Propiomazine and Oxybutynine. Discovery agent [N.A.] [4]
Tetrabenazine DMYWQ0O Major Increased risk of prolong QT interval by the combination of Propiomazine and Tetrabenazine. Dissociative neurological symptom disorder [6B60] [17]
Deutetrabenazine DMUPFLI Major Additive antidopaminergic effects by the combination of Propiomazine and Deutetrabenazine. Dystonic disorder [8A02] [18]
Zonisamide DM0DTF7 Major Increased risk of hyperpyrexia by the combination of Propiomazine and Zonisamide. Epilepsy/seizure [8A61-8A6Z] [19]
Diphenhydramine DMKQTBA Moderate Additive anticholinergic effects by the combination of Propiomazine and Diphenhydramine. Episodic vestibular syndrome [AB31] [4]
Ethacrynic acid DM60QMR Moderate Additive hypotensive effects by the combination of Propiomazine and Ethacrynic acid. Essential hypertension [BA00] [20]
Phenoxybenzamine DM8KSQH Moderate Additive hypotensive effects by the combination of Propiomazine and Phenoxybenzamine. Essential hypertension [BA00] [8]
Nadolol DMW6GVL Moderate Additive hypotensive effects by the combination of Propiomazine and Nadolol. Essential hypertension [BA00] [8]
Solifenacin DMG592Q Moderate Additive anticholinergic effects by the combination of Propiomazine and Solifenacin. Functional bladder disorder [GC50] [4]
Tolterodine DMSHPW8 Moderate Additive anticholinergic effects by the combination of Propiomazine and Tolterodine. Functional bladder disorder [GC50] [4]
Terbinafine DMI6HUW Moderate Decreased metabolism of Propiomazine caused by Terbinafine mediated inhibition of CYP450 enzyme. Fungal infection [1F29-1F2F] [21]
Propantheline DM2EN6G Moderate Additive anticholinergic effects by the combination of Propiomazine and Propantheline. Gastric ulcer [DA60] [4]
Pilocarpine DMV9ADG Moderate Antagonize the effect of Propiomazine when combined with Pilocarpine. Glaucoma [9C61] [22]
Carvedilol DMHTEAO Moderate Additive hypotensive effects by the combination of Propiomazine and Carvedilol. Heart failure [BD10-BD1Z] [8]
Chlorothiazide DMLHESP Moderate Additive hypotensive effects by the combination of Propiomazine and Chlorothiazide. Heart failure [BD10-BD1Z] [8]
Bumetanide DMRV7H0 Moderate Additive hypotensive effects by the combination of Propiomazine and Bumetanide. Heart failure [BD10-BD1Z] [8]
Procarbazine DMIK367 Moderate Additive hypotensive effects by the combination of Propiomazine and Procarbazine. Hodgkin lymphoma [2B30] [15]
Isosorbide mononitrate DMYLMU0 Moderate Additive hypotensive effects by the combination of Propiomazine and Isosorbide mononitrate. Hydrocephalus [8D64] [8]
Cinacalcet DMCX0K3 Moderate Decreased metabolism of Propiomazine caused by Cinacalcet mediated inhibition of CYP450 enzyme. Hyper-parathyroidism [5A51] [16]
Acebutolol DM0TI4U Moderate Additive hypotensive effects by the combination of Propiomazine and Acebutolol. Hypertension [BA00-BA04] [8]
Captopril DM458UM Moderate Additive hypotensive effects by the combination of Propiomazine and Captopril. Hypertension [BA00-BA04] [8]
Methyldopa DM5I621 Moderate Additive hypotensive effects by the combination of Propiomazine and Methyldopa. Hypertension [BA00-BA04] [8]
Nebivolol DM7F1PA Moderate Additive hypotensive effects by the combination of Propiomazine and Nebivolol. Hypertension [BA00-BA04] [8]
Levamlodipine DM92S6N Moderate Additive hypotensive effects by the combination of Propiomazine and Levamlodipine. Hypertension [BA00-BA04] [8]
TAK-491 DMCF6SX Moderate Additive hypotensive effects by the combination of Propiomazine and TAK-491. Hypertension [BA00-BA04] [8]
Pindolol DMD2NV7 Moderate Additive hypotensive effects by the combination of Propiomazine and Pindolol. Hypertension [BA00-BA04] [8]
Fenoldopam DMFAOKP Moderate Additive hypotensive effects by the combination of Propiomazine and Fenoldopam. Hypertension [BA00-BA04] [8]
Indapamide DMGN1PW Moderate Additive hypotensive effects by the combination of Propiomazine and Indapamide. Hypertension [BA00-BA04] [8]
Diazoxide DML1538 Moderate Additive hypotensive effects by the combination of Propiomazine and Diazoxide. Hypertension [BA00-BA04] [8]
Perindopril DMOPZDT Moderate Additive hypotensive effects by the combination of Propiomazine and Perindopril. Hypertension [BA00-BA04] [8]
Quinapril DMR8H31 Moderate Additive hypotensive effects by the combination of Propiomazine and Quinapril. Hypertension [BA00-BA04] [8]
Telmisartan DMS3GX2 Moderate Additive hypotensive effects by the combination of Propiomazine and Telmisartan. Hypertension [BA00-BA04] [8]
Irbesartan DMTP1DC Moderate Additive hypotensive effects by the combination of Propiomazine and Irbesartan. Hypertension [BA00-BA04] [8]
Hydralazine DMU8JGH Moderate Additive hypotensive effects by the combination of Propiomazine and Hydralazine. Hypertension [BA00-BA04] [8]
Clevidipine butyrate DMW4M97 Moderate Additive hypotensive effects by the combination of Propiomazine and Clevidipine butyrate. Hypertension [BA00-BA04] [8]
Belladonna DM2RBWK Moderate Additive anticholinergic effects by the combination of Propiomazine and Belladonna. Infectious gastroenteritis/colitis [1A40] [4]
Amantadine DMS3YE9 Moderate Additive anticholinergic effects by the combination of Propiomazine and Amantadine. Influenza [1E30-1E32] [23]
Polyethylene glycol DM4I1JP Moderate Increased risk of lowers seizure threshold by the combination of Propiomazine and Polyethylene glycol. Irritable bowel syndrome [DD91] [24]
Dicyclomine DMZSDGX Moderate Additive anticholinergic effects by the combination of Propiomazine and Dicyclomine. Irritable bowel syndrome [DD91] [4]
Physostigmine DM2N0TO Moderate Antagonize the effect of Propiomazine when combined with Physostigmine. Lips/oral mucosa miscellaneous disorder [DA02] [7]
Allopregnanolone DMNLHAC Moderate Additive CNS depression effects by the combination of Propiomazine and Allopregnanolone. Mental/behavioural/neurodevelopmental disorder [6E20-6E8Z] [25]
Lasmiditan DMXLVDT Moderate Additive CNS depression effects by the combination of Propiomazine and Lasmiditan. Migraine [8A80] [26]
Flibanserin DM70DTN Moderate Additive CNS depression effects by the combination of Propiomazine and Flibanserin. Mood disorder [6A60-6E23] [27]
Thalidomide DM70BU5 Moderate Additive CNS depression effects by the combination of Propiomazine and Thalidomide. Multiple myeloma [2A83] [28]
Ozanimod DMT6AM2 Moderate Additive hypotensive effects by the combination of Propiomazine and Ozanimod. Multiple sclerosis [8A40] [15]
Dextroamphetamine DMMIHVP Moderate Antagonize the effect of Propiomazine when combined with Dextroamphetamine. Narcolepsy [7A20] [9]
Dimenhydrinate DM264B3 Moderate Additive anticholinergic effects by the combination of Propiomazine and Dimenhydrinate. Nausea/vomiting [MD90] [4]
Promethazine DM6I5GR Moderate Additive anticholinergic effects by the combination of Propiomazine and Promethazine. Nausea/vomiting [MD90] [4]
Metoclopramide DMFA5MY Major Additive antidopaminergic effects by the combination of Propiomazine and Metoclopramide. Nausea/vomiting [MD90] [29]
Bupropion DM5PCS7 Major Decreased metabolism of Propiomazine caused by Bupropion mediated inhibition of CYP450 enzyme. Nicotine use disorder [6C4A] [30]
Phendimetrazine DM6TS1N Moderate Antagonize the effect of Propiomazine when combined with Phendimetrazine. Obesity [5B80-5B81] [9]
Amfepramone DM9YSNQ Moderate Antagonize the effect of Propiomazine when combined with Amfepramone. Obesity [5B80-5B81] [9]
Benzphetamine DMIJATC Moderate Antagonize the effect of Propiomazine when combined with Benzphetamine. Obesity [5B80-5B81] [9]
Polythiazide DMCH80F Moderate Additive hypotensive effects by the combination of Propiomazine and Polythiazide. Oedema [MG29] [20]
Lofexidine DM1WXA6 Moderate Additive hypotensive effects by the combination of Propiomazine and Lofexidine. Opioid use disorder [6C43] [8]
Apraclonidine DMO4PVE Moderate Additive CNS depression effects by the combination of Propiomazine and Apraclonidine. Optic nerve disorder [9C40] [31]
Oxymorphone DM65AGJ Major Additive CNS depression effects by the combination of Propiomazine and Oxymorphone. Pain [MG30-MG3Z] [14]
Levorphanol DMGS80V Major Additive CNS depression effects by the combination of Propiomazine and Levorphanol. Pain [MG30-MG3Z] [14]
Flavoxate DMKV4NL Moderate Additive anticholinergic effects by the combination of Propiomazine and Flavoxate. Pain [MG30-MG3Z] [4]
Nalbuphine DMOSQGU Major Additive CNS depression effects by the combination of Propiomazine and Nalbuphine. Pain [MG30-MG3Z] [14]
Methamphetamine DMPM4SK Moderate Antagonize the effect of Propiomazine when combined with Methamphetamine. Pain [MG30-MG3Z] [32]
Buprenorphine DMPRI8G Major Additive CNS depression effects by the combination of Propiomazine and Buprenorphine. Pain [MG30-MG3Z] [33]
Safinamide DM0YWJC Moderate Additive hypotensive effects by the combination of Propiomazine and Safinamide. Parkinsonism [8A00] [15]
Pergolide DM14MAE Moderate Antagonize the effect of Propiomazine when combined with Pergolide. Parkinsonism [8A00] [34]
Opicapone DM1BKA6 Moderate Antagonize the effect of Propiomazine when combined with Opicapone. Parkinsonism [8A00] [35]
Rasagiline DM3WKQ4 Moderate Additive hypotensive effects by the combination of Propiomazine and Rasagiline. Parkinsonism [8A00] [15]
Biperiden DME78OA Moderate Additive anticholinergic effects by the combination of Propiomazine and Biperiden. Parkinsonism [8A00] [6]
Levodopa DMN3E57 Moderate Antagonize the effect of Propiomazine when combined with Levodopa. Parkinsonism [8A00] [34]
Bromocriptine DMVE3TK Moderate Antagonize the effect of Propiomazine when combined with Bromocriptine. Parkinsonism [8A00] [34]
Orphenadrine DMW542E Moderate Additive anticholinergic effects by the combination of Propiomazine and Orphenadrine. Parkinsonism [8A00] [4]
Methylscopolamine DM5VWOB Moderate Additive anticholinergic effects by the combination of Propiomazine and Methylscopolamine. Peptic ulcer [DA61] [4]
ABIRATERONE DM8V75C Moderate Decreased metabolism of Propiomazine caused by ABIRATERONE mediated inhibition of CYP450 enzyme. Prostate cancer [2C82] [36]
Terazosin DM3JCVS Moderate Additive hypotensive effects by the combination of Propiomazine and Terazosin. Prostate hyperplasia [GA90] [8]
Silodosin DMJSBT6 Moderate Additive hypotensive effects by the combination of Propiomazine and Silodosin. Prostate hyperplasia [GA90] [8]
Neupro DMHEAB1 Moderate Antagonize the effect of Propiomazine when combined with Neupro. Restless legs syndrome [7A80] [34]
Quetiapine DM1N62C Moderate Additive anticholinergic effects by the combination of Propiomazine and Quetiapine. Schizophrenia [6A20] [4]
Mesoridazine DM2ZGAN Moderate Additive anticholinergic effects by the combination of Propiomazine and Mesoridazine. Schizophrenia [6A20] [6]
Aripiprazole DM3NUMH Moderate Additive anticholinergic effects by the combination of Propiomazine and Aripiprazole. Schizophrenia [6A20] [4]
Iloperidone DM6AUFY Moderate Additive anticholinergic effects by the combination of Propiomazine and Iloperidone. Schizophrenia [6A20] [4]
Perphenazine DMA4MRX Moderate Additive anticholinergic effects by the combination of Propiomazine and Perphenazine. Schizophrenia [6A20] [4]
Molindone DMAH70G Moderate Additive anticholinergic effects by the combination of Propiomazine and Molindone. Schizophrenia [6A20] [4]
Thiothixene DMDINC4 Moderate Additive anticholinergic effects by the combination of Propiomazine and Thiothixene. Schizophrenia [6A20] [4]
Trifluoperazine DMKBYWI Moderate Additive anticholinergic effects by the combination of Propiomazine and Trifluoperazine. Schizophrenia [6A20] [4]
Asenapine DMSQZE2 Moderate Additive anticholinergic effects by the combination of Propiomazine and Asenapine. Schizophrenia [6A20] [4]
Pimozide DMW83TP Moderate Additive anticholinergic effects by the combination of Propiomazine and Pimozide. Schizophrenia [6A20] [4]
Fentanyl DM8WAHT Major Additive CNS depression effects by the combination of Propiomazine and Fentanyl. Sensation disturbance [MB40] [14]
Papaverine DMCA9QP Moderate Additive hypotensive effects by the combination of Propiomazine and Papaverine. Tonus and reflex abnormality [MB47] [8]
Chlorpheniramine DM5URA2 Moderate Additive anticholinergic effects by the combination of Propiomazine and Chlorpheniramine. Vasomotor/allergic rhinitis [CA08] [4]
Brompheniramine DMFOVSD Moderate Additive anticholinergic effects by the combination of Propiomazine and Brompheniramine. Vasomotor/allergic rhinitis [CA08] [4]
Acrivastine DMTIGA0 Moderate Additive anticholinergic effects by the combination of Propiomazine and Acrivastine. Vasomotor/allergic rhinitis [CA08] [6]
⏷ Show the Full List of 120 DDI Information of This Drug

References

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