| DDI Drug Name |
DDI Drug ID |
Severity |
Mechanism |
Comorbidity |
REF |
| Ivosidenib |
DM8S6T7
|
Major |
Increased risk of prolong QT interval by the combination of Gemifloxacin and Ivosidenib. |
Acute myeloid leukaemia [2A60]
|
[7] |
| Midostaurin |
DMI6E0R
|
Moderate |
Increased risk of prolong QT interval by the combination of Gemifloxacin and Midostaurin. |
Acute myeloid leukaemia [2A60]
|
[6] |
| Arn-509 |
DMT81LZ
|
Moderate |
Increased risk of prolong QT interval by the combination of Gemifloxacin and Arn-509. |
Acute myeloid leukaemia [2A60]
|
[8] |
| Gilteritinib |
DMTI0ZO
|
Moderate |
Increased risk of prolong QT interval by the combination of Gemifloxacin and Gilteritinib. |
Acute myeloid leukaemia [2A60]
|
[9] |
| Oliceridine |
DM6MDCF
|
Moderate |
Increased risk of prolong QT interval by the combination of Gemifloxacin and Oliceridine. |
Acute pain [MG31]
|
[6] |
| Ivabradine |
DM0L594
|
Major |
Increased risk of ventricular arrhythmias by the combination of Gemifloxacin and Ivabradine. |
Angina pectoris [BA40]
|
[8] |
| Bepridil |
DM0RKS4
|
Major |
Increased risk of prolong QT interval by the combination of Gemifloxacin and Bepridil. |
Angina pectoris [BA40]
|
[10] |
| Dronedarone |
DMA8FS5
|
Major |
Increased risk of prolong QT interval by the combination of Gemifloxacin and Dronedarone. |
Angina pectoris [BA40]
|
[11] |
| Cilostazol |
DMZMSCT
|
Moderate |
Increased risk of prolong QT interval by the combination of Gemifloxacin and Cilostazol. |
Arterial occlusive disease [BD40]
|
[6] |
| Posaconazole |
DMUL5EW
|
Moderate |
Increased risk of prolong QT interval by the combination of Gemifloxacin and Posaconazole. |
Aspergillosis [1F20]
|
[6] |
| Levalbuterol |
DM5YBO1
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Gemifloxacin and Levalbuterol. |
Asthma [CA23]
|
[12] |
| Pirbuterol |
DMI5678
|
Moderate |
Increased risk of prolong QT interval by the combination of Gemifloxacin and Pirbuterol. |
Asthma [CA23]
|
[13] |
| Lisdexamfetamine |
DM6W8V5
|
Moderate |
Increased risk of prolong QT interval by the combination of Gemifloxacin and Lisdexamfetamine. |
Attention deficit hyperactivity disorder [6A05]
|
[8] |
| Retigabine |
DMGNYIH
|
Moderate |
Increased risk of prolong QT interval by the combination of Gemifloxacin and Retigabine. |
Behcet disease [4A62]
|
[6] |
| Lomustine |
DMMWSUL
|
Minor |
Decreased absorption of Gemifloxacin due to intestinal mucosa variation caused by Lomustine. |
Brain cancer [2A00]
|
[14] |
| Eribulin |
DM1DX4Q
|
Moderate |
Increased risk of prolong QT interval by the combination of Gemifloxacin and Eribulin. |
Breast cancer [2C60-2C6Y]
|
[11] |
| Lapatinib |
DM3BH1Y
|
Moderate |
Increased risk of prolong QT interval by the combination of Gemifloxacin and Lapatinib. |
Breast cancer [2C60-2C6Y]
|
[6] |
| Thiotepa |
DMIZKOP
|
Minor |
Decreased absorption of Gemifloxacin due to intestinal mucosa variation caused by Thiotepa. |
Breast cancer [2C60-2C6Y]
|
[14] |
| Bosutinib |
DMTI8YE
|
Moderate |
Increased risk of prolong QT interval by the combination of Gemifloxacin and Bosutinib. |
Breast cancer [2C60-2C6Y]
|
[6] |
| PF-04449913 |
DMSB068
|
Moderate |
Increased risk of prolong QT interval by the combination of Gemifloxacin and PF-04449913. |
Chronic myelomonocytic leukaemia [2A40]
|
[15] |
| Olodaterol |
DM62B78
|
Moderate |
Increased risk of prolong QT interval by the combination of Gemifloxacin and Olodaterol. |
Chronic obstructive pulmonary disease [CA22]
|
[13] |
| Vilanterol |
DMF5EK1
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Gemifloxacin and Vilanterol. |
Chronic obstructive pulmonary disease [CA22]
|
[12] |
| Indacaterol |
DMQJHR7
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Gemifloxacin and Indacaterol. |
Chronic obstructive pulmonary disease [CA22]
|
[13] |
| Arformoterol |
DMYM974
|
Moderate |
Increased risk of prolong QT interval by the combination of Gemifloxacin and Arformoterol. |
Chronic obstructive pulmonary disease [CA22]
|
[13] |
| Mestranol |
DMG3F94
|
Moderate |
Decreased absorption of Gemifloxacin due to formation of complexes caused by Mestranol. |
Contraceptive management [QA21]
|
[16] |
| Halothane |
DM80OZ5
|
Moderate |
Increased risk of prolong QT interval by the combination of Gemifloxacin and Halothane. |
Corneal disease [9A76-9A78]
|
[6] |
| Sevoflurane |
DMC9O43
|
Moderate |
Increased risk of prolong QT interval by the combination of Gemifloxacin and Sevoflurane. |
Corneal disease [9A76-9A78]
|
[11] |
| Probucol |
DMVZQ2M
|
Moderate |
Increased risk of prolong QT interval by the combination of Gemifloxacin and Probucol. |
Coronary atherosclerosis [BA80]
|
[6] |
| Pasireotide |
DMHM7JS
|
Major |
Increased risk of prolong QT interval by the combination of Gemifloxacin and Pasireotide. |
Cushing syndrome [5A70]
|
[11] |
| Osilodrostat |
DMIJC9X
|
Moderate |
Increased risk of prolong QT interval by the combination of Gemifloxacin and Osilodrostat. |
Cushing syndrome [5A70]
|
[8] |
| Escitalopram |
DMFK9HG
|
Major |
Increased risk of prolong QT interval by the combination of Gemifloxacin and Escitalopram. |
Depression [6A70-6A7Z]
|
[11] |
| Clomipramine |
DMINRKW
|
Moderate |
Increased risk of prolong QT interval by the combination of Gemifloxacin and Clomipramine. |
Depression [6A70-6A7Z]
|
[6] |
| Tetrabenazine |
DMYWQ0O
|
Moderate |
Increased risk of prolong QT interval by the combination of Gemifloxacin and Tetrabenazine. |
Dissociative neurological symptom disorder [6B60]
|
[11] |
| Deutetrabenazine |
DMUPFLI
|
Moderate |
Additive CNS depression effects by the combination of Gemifloxacin and Deutetrabenazine. |
Dystonic disorder [8A02]
|
[17] |
| Ingrezza |
DMVPLNC
|
Moderate |
Increased risk of prolong QT interval by the combination of Gemifloxacin and Ingrezza. |
Dystonic disorder [8A02]
|
[18] |
| Solifenacin |
DMG592Q
|
Moderate |
Increased risk of prolong QT interval by the combination of Gemifloxacin and Solifenacin. |
Functional bladder disorder [GC50]
|
[6] |
| Sunitinib |
DMCBJSR
|
Moderate |
Increased risk of prolong QT interval by the combination of Gemifloxacin and Sunitinib. |
Gastrointestinal stromal tumour [2B5B]
|
[6] |
| Procarbazine |
DMIK367
|
Minor |
Decreased absorption of Gemifloxacin due to intestinal mucosa variation caused by Procarbazine. |
Hodgkin lymphoma [2B30]
|
[14] |
| Saquinavir |
DMG814N
|
Major |
Increased risk of prolong QT interval by the combination of Gemifloxacin and Saquinavir. |
Human immunodeficiency virus disease [1C60-1C62]
|
[19] |
| Lopinavir |
DMITQS0
|
Moderate |
Increased risk of prolong QT interval by the combination of Gemifloxacin and Lopinavir. |
Human immunodeficiency virus disease [1C60-1C62]
|
[11] |
| Rilpivirine |
DMJ0QOW
|
Moderate |
Increased risk of prolong QT interval by the combination of Gemifloxacin and Rilpivirine. |
Human immunodeficiency virus disease [1C60-1C62]
|
[6] |
| Bempedoic acid |
DM1CI9R
|
Major |
Increased risk of tendinitis/tendon rupture by the combination of Gemifloxacin and Bempedoic acid. |
Hyper-lipoproteinaemia [5C80]
|
[20] |
| Polyethylene glycol |
DM4I1JP
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Gemifloxacin and Polyethylene glycol. |
Irritable bowel syndrome [DD91]
|
[11] |
| Phenolphthalein |
DM5SICT
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Gemifloxacin and Phenolphthalein. |
Irritable bowel syndrome [DD91]
|
[11] |
| Crizotinib |
DM4F29C
|
Major |
Increased risk of prolong QT interval by the combination of Gemifloxacin and Crizotinib. |
Lung cancer [2C25]
|
[21] |
| Ceritinib |
DMB920Z
|
Major |
Increased risk of prolong QT interval by the combination of Gemifloxacin and Ceritinib. |
Lung cancer [2C25]
|
[11] |
| Lurbinectedin |
DMEFRTZ
|
Minor |
Decreased absorption of Gemifloxacin due to intestinal mucosa variation caused by Lurbinectedin. |
Lung cancer [2C25]
|
[14] |
| Osimertinib |
DMRJLAT
|
Major |
Increased risk of prolong QT interval by the combination of Gemifloxacin and Osimertinib. |
Lung cancer [2C25]
|
[22] |
| Selpercatinib |
DMZR15V
|
Major |
Increased risk of prolong QT interval by the combination of Gemifloxacin and Selpercatinib. |
Lung cancer [2C25]
|
[8] |
| Lumefantrine |
DM29GAD
|
Major |
Increased risk of prolong QT interval by the combination of Gemifloxacin and Lumefantrine. |
Malaria [1F40-1F45]
|
[23] |
| Halofantrine |
DMOMK1V
|
Major |
Increased risk of prolong QT interval by the combination of Gemifloxacin and Halofantrine. |
Malaria [1F40-1F45]
|
[24] |
| Hydroxychloroquine |
DMSIVND
|
Major |
Increased risk of prolong QT interval by the combination of Gemifloxacin and Hydroxychloroquine. |
Malaria [1F40-1F45]
|
[25] |
| Inotuzumab ozogamicin |
DMAC130
|
Moderate |
Increased risk of prolong QT interval by the combination of Gemifloxacin and Inotuzumab ozogamicin. |
Malignant haematopoietic neoplasm [2B33]
|
[8] |
| Arsenic trioxide |
DM61TA4
|
Major |
Increased risk of prolong QT interval by the combination of Gemifloxacin and Arsenic trioxide. |
Mature B-cell lymphoma [2A85]
|
[26] |
| Vemurafenib |
DM62UG5
|
Major |
Increased risk of prolong QT interval by the combination of Gemifloxacin and Vemurafenib. |
Melanoma [2C30]
|
[11] |
| LGX818 |
DMNQXV8
|
Moderate |
Increased risk of prolong QT interval by the combination of Gemifloxacin and LGX818. |
Melanoma [2C30]
|
[27] |
| Lanthanum carbonate |
DMMJQSH
|
Moderate |
Decreased absorption of Gemifloxacin due to formation of complexes caused by Lanthanum carbonate. |
Mineral absorption/transport disorder [5C64]
|
[11] |
| Panobinostat |
DM58WKG
|
Major |
Increased risk of prolong QT interval by the combination of Gemifloxacin and Panobinostat. |
Multiple myeloma [2A83]
|
[28] |
| Siponimod |
DM2R86O
|
Major |
Increased risk of ventricular arrhythmias by the combination of Gemifloxacin and Siponimod. |
Multiple sclerosis [8A40]
|
[23] |
| Fingolimod |
DM5JVAN
|
Major |
Increased risk of ventricular arrhythmias by the combination of Gemifloxacin and Fingolimod. |
Multiple sclerosis [8A40]
|
[11] |
| Ozanimod |
DMT6AM2
|
Major |
Increased risk of ventricular arrhythmias by the combination of Gemifloxacin and Ozanimod. |
Multiple sclerosis [8A40]
|
[29] |
| Deflazacort |
DMV0RNS
|
Major |
Increased risk of tendinitis/tendon rupture by the combination of Gemifloxacin and Deflazacort. |
Muscular dystrophy [8C70]
|
[30] |
| Romidepsin |
DMT5GNL
|
Moderate |
Increased risk of prolong QT interval by the combination of Gemifloxacin and Romidepsin. |
Mycosis fungoides [2B01]
|
[6] |
| Nilotinib |
DM7HXWT
|
Major |
Increased risk of prolong QT interval by the combination of Gemifloxacin and Nilotinib. |
Myeloproliferative neoplasm [2A20]
|
[11] |
| Dasatinib |
DMJV2EK
|
Moderate |
Increased risk of prolong QT interval by the combination of Gemifloxacin and Dasatinib. |
Myeloproliferative neoplasm [2A20]
|
[6] |
| Bupropion |
DM5PCS7
|
Major |
Increased risk of lowers seizure threshold by the combination of Gemifloxacin and Bupropion. |
Nicotine use disorder [6C4A]
|
[31] |
| Entrectinib |
DMMPTLH
|
Moderate |
Increased risk of prolong QT interval by the combination of Gemifloxacin and Entrectinib. |
Non-small cell lung cancer [2C25]
|
[23] |
| Levomethadyl Acetate |
DM06HG5
|
Major |
Increased risk of prolong QT interval by the combination of Gemifloxacin and Levomethadyl Acetate. |
Opioid use disorder [6C43]
|
[8] |
| Lofexidine |
DM1WXA6
|
Moderate |
Increased risk of prolong QT interval by the combination of Gemifloxacin and Lofexidine. |
Opioid use disorder [6C43]
|
[11] |
| Rucaparib |
DM9PVX8
|
Moderate |
Increased risk of prolong QT interval by the combination of Gemifloxacin and Rucaparib. |
Ovarian cancer [2C73]
|
[6] |
| Triclabendazole |
DMPWGBR
|
Moderate |
Increased risk of prolong QT interval by the combination of Gemifloxacin and Triclabendazole. |
Parasitic worm infestation [1F90]
|
[6] |
| Pimavanserin |
DMR7IVC
|
Moderate |
Increased risk of prolong QT interval by the combination of Gemifloxacin and Pimavanserin. |
Parkinsonism [8A00]
|
[32] |
| Macimorelin |
DMQYJIR
|
Major |
Increased risk of prolong QT interval by the combination of Gemifloxacin and Macimorelin. |
Pituitary gland disorder [5A60-5A61]
|
[33] |
| Lefamulin |
DME6G97
|
Major |
Increased risk of prolong QT interval by the combination of Gemifloxacin and Lefamulin. |
Pneumonia [CA40]
|
[34] |
| Choline salicylate |
DM8P137
|
Moderate |
Additive CNS depression effects by the combination of Gemifloxacin and Choline salicylate. |
Postoperative inflammation [1A00-CA43]
|
[35] |
| Degarelix |
DM3O8QY
|
Moderate |
Increased risk of prolong QT interval by the combination of Gemifloxacin and Degarelix. |
Prostate cancer [2C82]
|
[8] |
| ABIRATERONE |
DM8V75C
|
Moderate |
Increased risk of prolong QT interval by the combination of Gemifloxacin and ABIRATERONE. |
Prostate cancer [2C82]
|
[8] |
| Enzalutamide |
DMGL19D
|
Moderate |
Increased risk of prolong QT interval by the combination of Gemifloxacin and Enzalutamide. |
Prostate cancer [2C82]
|
[8] |
| Relugolix |
DMK7IWL
|
Moderate |
Increased risk of prolong QT interval by the combination of Gemifloxacin and Relugolix. |
Prostate cancer [2C82]
|
[8] |
| Levomepromazine |
DMIKFEL
|
Moderate |
Increased risk of prolong QT interval by the combination of Gemifloxacin and Levomepromazine. |
Psychotic disorder [6A20-6A25]
|
[6] |
| Salsalate |
DM13P4C
|
Moderate |
Additive CNS depression effects by the combination of Gemifloxacin and Salsalate. |
Rheumatoid arthritis [FA20]
|
[35] |
| Dexamethasone |
DMMWZET
|
Major |
Increased risk of tendinitis/tendon rupture by the combination of Gemifloxacin and Dexamethasone. |
Rheumatoid arthritis [FA20]
|
[30] |
| Quetiapine |
DM1N62C
|
Moderate |
Increased risk of prolong QT interval by the combination of Gemifloxacin and Quetiapine. |
Schizophrenia [6A20]
|
[11] |
| Aripiprazole |
DM3NUMH
|
Moderate |
Increased risk of prolong QT interval by the combination of Gemifloxacin and Aripiprazole. |
Schizophrenia [6A20]
|
[23] |
| Iloperidone |
DM6AUFY
|
Major |
Increased risk of prolong QT interval by the combination of Gemifloxacin and Iloperidone. |
Schizophrenia [6A20]
|
[11] |
| Amisulpride |
DMSJVAM
|
Major |
Increased risk of prolong QT interval by the combination of Gemifloxacin and Amisulpride. |
Schizophrenia [6A20]
|
[36] |
| Asenapine |
DMSQZE2
|
Moderate |
Increased risk of prolong QT interval by the combination of Gemifloxacin and Asenapine. |
Schizophrenia [6A20]
|
[11] |
| Ifosfamide |
DMCT3I8
|
Minor |
Decreased absorption of Gemifloxacin due to intestinal mucosa variation caused by Ifosfamide. |
Solid tumour/cancer [2A00-2F9Z]
|
[14] |
| Docetaxel |
DMDI269
|
Minor |
Decreased absorption of Gemifloxacin due to intestinal mucosa variation caused by Docetaxel. |
Solid tumour/cancer [2A00-2F9Z]
|
[14] |
| Mitoxantrone |
DMM39BF
|
Minor |
Decreased absorption of Gemifloxacin due to intestinal mucosa variation caused by Mitoxantrone. |
Solid tumour/cancer [2A00-2F9Z]
|
[14] |
| LEE011 |
DMMX75K
|
Moderate |
Increased risk of prolong QT interval by the combination of Gemifloxacin and LEE011. |
Solid tumour/cancer [2A00-2F9Z]
|
[6] |
| Vandetanib |
DMRICNP
|
Major |
Increased risk of prolong QT interval by the combination of Gemifloxacin and Vandetanib. |
Solid tumour/cancer [2A00-2F9Z]
|
[11] |
| Taxol |
DMUOT9V
|
Minor |
Decreased absorption of Gemifloxacin due to intestinal mucosa variation caused by Taxol. |
Solid tumour/cancer [2A00-2F9Z]
|
[14] |
| Pitolisant |
DM8RFNJ
|
Moderate |
Increased risk of prolong QT interval by the combination of Gemifloxacin and Pitolisant. |
Somnolence [MG42]
|
[8] |
| Telavancin |
DM58VQX
|
Moderate |
Increased risk of prolong QT interval by the combination of Gemifloxacin and Telavancin. |
Staphylococcal/streptococcal disease [1B5Y]
|
[6] |
| Plicamycin |
DM7C8YV
|
Minor |
Decreased absorption of Gemifloxacin due to intestinal mucosa variation caused by Plicamycin. |
Testicular cancer [2C80]
|
[14] |
| Lenvatinib |
DMB1IU4
|
Moderate |
Increased risk of prolong QT interval by the combination of Gemifloxacin and Lenvatinib. |
Thyroid cancer [2D10]
|
[6] |
| Cabozantinib |
DMIYDT4
|
Major |
Increased risk of prolong QT interval by the combination of Gemifloxacin and Cabozantinib. |
Thyroid cancer [2D10]
|
[8] |
| Trimeprazine |
DMEMV9D
|
Moderate |
Increased risk of prolong QT interval by the combination of Gemifloxacin and Trimeprazine. |
Vasomotor/allergic rhinitis [CA08]
|
[6] |
| Propafenone |
DMPIBJK
|
Moderate |
Increased risk of prolong QT interval by the combination of Gemifloxacin and Propafenone. |
Ventricular tachyarrhythmia [BC71]
|
[6] |
| Flecainide |
DMSQDLE
|
Moderate |
Increased risk of prolong QT interval by the combination of Gemifloxacin and Flecainide. |
Ventricular tachyarrhythmia [BC71]
|
[6] |
| ----------- |
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