Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMMX2E6)

Drug Name
Pemetrexed Drug Info
Synonyms
Alimta; LYA; LY 231514; LY231514; Alimta (TN); LY 231,514; LY-2315; LY-231514; Pemetrexed (INN); Pemetrexed [INN:BAN]; LY-231,514; N-(4-(2-(2-Amino-3,4-dihydro-4-oxo-7H-pyrrolo(2,3-d)pyrimdin-5-yl)ethyl)benzoyl)glutamic acid; N-{4-[2-(2-amino-4-oxo-4,7-dihydro-1h-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-d-glutamic acid; (2R)-2-[[4-[2-(2-amino-4-oxo-1,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioic acid; (2S)-2-[[4-[2-(2-amino-4-oxo-1,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioic acid; 2-[[4-[2-(2-amino-4-oxo-1,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioic acid; 2-{4-[2-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)-ETHYL]-BENZOYLAMINO}-PENTANEDIOIC ACID
Indication
Disease Entry ICD 11 Status REF
Central nervous system lymphoma 2B33.5 Approved [1]
Epithelioid mesothelioma 2F10 Approved [1]
Lung cancer 2C25.0 Approved [1]
Malignant pleural mesothelioma 2C26.0 Approved [2]
Non-small-cell lung cancer 2C25.Y Approved [1]
Sarcomatoid mesothelioma Approved [1]
Small-cell lung cancer 2C25.Y Approved [1]
Lung neoplasm Investigative [1]
Therapeutic Class
Anticancer Agents
Cross-matching ID
PubChem CID
135410875
ChEBI ID
CHEMBL225072
CAS Number
CAS 137281-23-3
TTD Drug ID
DMMX2E6
VARIDT Drug ID
DR00318

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Candida Thymidylate synthase (Candi TMP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [19]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [20]
Trifluridine DMG2YBD Herpetic keratitis 1F00.10 Approved [21]
Capecitabine DMTS85L Adenocarcinoma 2D40 Approved [22]
Raltitrexed DMT9K8G Rectal adenocarcinoma 2B92 Approved [23]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [24]
Flucytosine DM13VTW Cryptococcal meningitis Approved [25]
Nolatrexed DMOF0CA Solid tumour/cancer 2A00-2F9Z Phase 3 [26]
Plevitrexed (R)-isomer DMTL39C Gastric adenocarcinoma 2B72 Phase 2 [27]
Plevitrexed DM7Y60I Gastric adenocarcinoma 2B72 Phase 2 [27]
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Drug(s) Transported By Multidrug resistance-associated protein 2 (ABCC2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [28]
Methotrexate DM2TEOL Anterior urethra cancer Approved [29]
Folic Acid DMEMBJC Colorectal carcinoma Approved [30]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [31]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [32]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [33]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [34]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [35]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [36]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [37]
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Drug(s) Transported By Breast cancer resistance protein (ABCG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [38]
Methotrexate DM2TEOL Anterior urethra cancer Approved [39]
Folic Acid DMEMBJC Colorectal carcinoma Approved [40]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [41]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [42]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [43]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [44]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [43]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [45]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [46]
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Drug(s) Transported By Multidrug resistance-associated protein 5 (ABCC5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [47]
Folic Acid DMEMBJC Colorectal carcinoma Approved [47]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [48]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [49]
Mercaptopurine DMTM2IK Acute lymphoblastic leukaemia 2A85 Approved [50]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [51]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [52]
FLUORESCEIN DMQTFAO Ocular disease 1F00.1Z Approved [53]
Adenosine DMM2NSK Paroxysmal supraventricular tachycardia BC81.Z Approved [54]
[3H]cAMP DMZRQU7 Discovery agent N.A. Investigative [55]
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Drug(s) Transported By Organic anion transporting polypeptide 2B1 (SLCO2B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [56]
L-Glutamic Acid DM4PUDW Schizophrenia 6A20 Approved [57]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [58]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [59]
Pravastatin DM6A0X7 Adult acute monocytic leukemia Approved [60]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [61]
Cerivastatin DMXCM7H Hyperlipidaemia 5C80 Approved [62]
PITAVASTATIN CALCIUM DM1UJO0 Dyslipidemia 5C80-5C81 Approved [63]
Digoxin DMQCTIH Arrhythmia BC9Z Approved [64]
Rosuvastatin DMMIQ7G Arteriosclerosis BD40 Approved [65]
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Drug(s) Transported By Folate transporter 1 (SLC19A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [4]
Folic Acid DMEMBJC Colorectal carcinoma Approved [4]
Pralatrexate DMAO80I Breast cancer 2C60-2C65 Approved [66]
Drug(s) Transported By Proton-coupled folate transporter (SLC46A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [67]
Folic Acid DMEMBJC Colorectal carcinoma Approved [68]
Pralatrexate DMAO80I Breast cancer 2C60-2C65 Approved [66]
Drug(s) Affected By Reduced folate transporter (SLC19A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Folic Acid DMEMBJC Colorectal carcinoma Approved [69]
Methotrexate DM2TEOL Anterior urethra cancer Approved [17]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [70]
Selenium DM25CGV N. A. N. A. Approved [71]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [72]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [73]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [74]
Ethanol DMDRQZU Chronic pain MG30 Approved [73]
Atenolol DMNKG1Z Angina pectoris BA40 Approved [73]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [75]
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Drug(s) Affected By ATP-binding cassette sub-family C member 5 (ABCC5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [76]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [48]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [77]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [78]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [79]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [80]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [81]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [82]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [83]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [84]
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Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [85]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [86]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [87]
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [88]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [89]
Selenium DM25CGV N. A. N. A. Approved [90]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [85]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [91]
Methotrexate DM2TEOL Anterior urethra cancer Approved [92]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [91]
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Drug(s) Affected By DNA excision repair protein ERCC-1 (ERCC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [71]
Quercetin DM3NC4M Obesity 5B81 Approved [93]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [94]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [95]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [96]
Melatonin DMKWFBT Depression 6A70-6A7Z Approved [97]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [98]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [75]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [99]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [100]
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Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [101]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [102]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [103]
Methotrexate DM2TEOL Anterior urethra cancer Approved [104]
Epinephrine DM3KJBC Acute asthma CA23 Approved [105]
Quercetin DM3NC4M Obesity 5B81 Approved [106]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [107]
Fructose DM43AN2 Vomiting MD90 Approved [108]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [101]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [109]
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Drug(s) Affected By Bcl-2-binding component 3, isoforms 3/4 (BBC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [70]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [103]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [110]
Methotrexate DM2TEOL Anterior urethra cancer Approved [111]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [112]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [113]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [114]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [115]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [116]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [117]
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Drug(s) Affected By Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial (MTHFD2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [110]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [72]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [109]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [109]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [118]
Leflunomide DMR8ONJ Arthritis FA20 Approved [119]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [95]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [109]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [120]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [121]
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Drug(s) Affected By Splicing factor 45 (RBM17)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [122]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [81]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [74]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [121]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [123]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [124]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [70]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [125]
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [18]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [18]
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Drug(s) Affected By ATP-binding cassette sub-family C member 11 (ABCC11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [126]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [127]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [128]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [74]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [129]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [130]
Methotrexate DM2TEOL Anterior urethra cancer Approved [10]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [130]
Urethane DM7NSI0 N. A. N. A. Phase 4 [131]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [132]
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Drug(s) Affected By Folylpolyglutamate synthase, mitochondrial (FPGS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone DM7HUNW Hot flushes GA30 Approved [133]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [121]
Folic Acid DMEMBJC Colorectal carcinoma Approved [134]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [135]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [136]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [125]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [137]
Warfarin DMJYCVW Atrial fibrillation BC81.3 Approved [138]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [139]
Urethane DM7NSI0 N. A. N. A. Phase 4 [131]
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Drug(s) Affected By CASP8 and FADD-like apoptosis regulator (CFLAR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [101]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [140]
Methotrexate DM2TEOL Anterior urethra cancer Approved [141]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [142]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [143]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [145]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [146]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [147]
Ethacrynic acid DM60QMR Edema MG29 Approved [148]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Candida Thymidylate synthase (Candi TMP1) TTU6BFZ TYSY_CANAL Inhibitor [3]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Folate transporter 1 (SLC19A1) DTOSN46 S19A1_HUMAN Substrate [4]
Proton-coupled folate transporter (SLC46A1) DTDJEMI PCFT_HUMAN Substrate [5]
Multidrug resistance-associated protein 5 (ABCC5) DTYVM24 MRP5_HUMAN Substrate [6]
Multidrug resistance-associated protein 2 (ABCC2) DTFI42L MRP2_HUMAN Substrate [7]
Organic anion transporting polypeptide 2B1 (SLCO2B1) DTPFTEQ SO2B1_HUMAN Substrate [8]
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [9]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
ATP-binding cassette sub-family C member 11 (ABCC11) OTVHL7OR MRP8_HUMAN Drug Response [10]
ATP-binding cassette sub-family C member 5 (ABCC5) OT34G4US MRP5_HUMAN Drug Response [11]
Bcl-2-binding component 3, isoforms 3/4 (BBC3) OTUAXDAY BBC3B_HUMAN Gene/Protein Processing [12]
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial (MTHFD2) OT1LQSGX MTDC_HUMAN Drug Response [13]
CASP8 and FADD-like apoptosis regulator (CFLAR) OTX14BAS CFLAR_HUMAN Drug Response [14]
DNA excision repair protein ERCC-1 (ERCC1) OTNPYQHI ERCC1_HUMAN Gene/Protein Processing [15]
Folylpolyglutamate synthase, mitochondrial (FPGS) OTW3F1ZE FOLC_HUMAN Drug Response [16]
Reduced folate transporter (SLC19A1) OTWB0BTO S19A1_HUMAN Drug Response [17]
Splicing factor 45 (RBM17) OT9ROJCL SPF45_HUMAN Drug Response [18]
Thymidine phosphorylase OT6BQTMR TYPH_HUMAN Drug Response [16]

References

1 Pemetrexed FDA Label
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6837).
3 Updated clinical information on multitargeted antifolates in lung cancer. Clin Lung Cancer. 2009 Mar;10 Suppl 1:S35-40.
4 Biology of the major facilitative folate transporters SLC19A1 and SLC46A1. Curr Top Membr. 2014;73:175-204.
5 The proton-coupled folate transporter: impact on pemetrexed transport and on antifolates activities compared with the reduced folate carrier. Mol Pharmacol. 2008 Sep;74(3):854-62.
6 Kinetic validation of the use of carboxydichlorofluorescein as a drug surrogate for MRP5-mediated transport. Eur J Pharm Sci. 2006 Apr;27(5):524-32.
7 Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007.
8 Substrate- and pH-specific antifolate transport mediated by organic anion-transporting polypeptide 2B1 (OATP2B1-SLCO2B1). Mol Pharmacol. 2012 Feb;81(2):134-42.
9 pH-Dependent transport of pemetrexed by breast cancer resistance protein. Drug Metab Dispos. 2011 Sep;39(9):1478-85.
10 ABCC11/MRP8 confers pemetrexed resistance in lung cancer. Cancer Sci. 2010 Nov;101(11):2404-10.
11 The multidrug resistance protein 5 (ABCC5) confers resistance to 5-fluorouracil and transports its monophosphorylated metabolites. Mol Cancer Ther. 2005 May;4(5):855-63.
12 Xanthohumol inhibits non-small cell lung cancer by activating PUMA-mediated apoptosis. Toxicology. 2022 Mar 30;470:153141. doi: 10.1016/j.tox.2022.153141. Epub 2022 Mar 5.
13 KRAS mutation status is associated with enhanced dependency on folate metabolism pathways in non-small cell lung cancer cells. Mol Cancer Ther. 2014 Jun;13(6):1611-24. doi: 10.1158/1535-7163.MCT-13-0649. Epub 2014 Mar 31.
14 Death receptor 5 and cellular FLICE-inhibitory protein regulate pemetrexed-induced apoptosis in human lung cancer cells. Eur J Cancer. 2011 Nov;47(16):2471-8. doi: 10.1016/j.ejca.2011.06.003. Epub 2011 Jul 2.
15 Pemetrexed downregulates ERCC1 expression and enhances cytotoxicity effected by resveratrol in human nonsmall cell lung cancer cells. Naunyn Schmiedebergs Arch Pharmacol. 2013 Dec;386(12):1047-59. doi: 10.1007/s00210-013-0905-9. Epub 2013 Aug 3.
16 A randomized, double-blind, phase II study of two doses of pemetrexed as first-line chemotherapy for advanced breast cancer. Clin Cancer Res. 2007 Jun 15;13(12):3652-9. doi: 10.1158/1078-0432.CCR-06-2377.
17 The inverse relationship between reduced folate carrier function and pemetrexed activity in a human colon cancer cell line. Mol Cancer Ther. 2006 Feb;5(2):438-49. doi: 10.1158/1535-7163.MCT-05-0243.
18 Human splicing factor SPF45 (RBM17) confers broad multidrug resistance to anticancer drugs when overexpressed--a phenotype partially reversed by selective estrogen receptor modulators. Cancer Res. 2005 Aug 1;65(15):6593-600. doi: 10.1158/0008-5472.CAN-03-3675.
19 The efficacy of the combination therapy of 5-fluorouracil, cisplatin and leucovorin for hepatocellular carcinoma and its predictable factors. Cancer Chemother Pharmacol. 2004 Apr;53(4):296-304.
20 Loss of folylpoly-gamma-glutamate synthetase activity is a dominant mechanism of resistance to polyglutamylation-dependent novel antifolates in multiple human leukemia sublines. Int J Cancer. 2003 Feb 20;103(5):587-99.
21 Trifluorothymidine induces cell death independently of p53. Nucleosides Nucleotides Nucleic Acids. 2008 Jun;27(6):699-703.
22 UGT1A7 and UGT1A9 polymorphisms predict response and toxicity in colorectal cancer patients treated with capecitabine/irinotecan. Clin Cancer Res. 2005 Feb 1;11(3):1226-36.
23 DNA damage and homologous recombination signaling induced by thymidylate deprivation. Biochem Pharmacol. 2008 Oct 15;76(8):987-96.
24 Antisense down-regulation of thymidylate synthase to suppress growth and enhance cytotoxicity of 5-FUdR, 5-FU and Tomudex in HeLa cells. Br J Pharmacol. 1999 Aug;127(8):1777-86.
25 Antifungal agents: mode of action in yeast cells. Rev Esp Quimioter. 2006 Jun;19(2):130-9.
26 A phase I study of the lipophilic thymidylate synthase inhibitor Thymitaq (nolatrexed dihydrochloride) given by 10-day oral administration. Br J Cancer. 1999 Feb;79(5-6):915-20.
27 Cooperative inhibition of human thymidylate synthase by mixtures of active site binding and allosteric inhibitors. Biochemistry. 2007 Mar 13;46(10):2823-30.
28 Involvement of the drug transporters p glycoprotein and multidrug resistance-associated protein Mrp2 in telithromycin transport. Antimicrob Agents Chemother. 2006 Jan;50(1):80-7.
29 Dose-dependent disposition of methotrexate in Abcc2 and Abcc3 gene knockout murine models. Drug Metab Dispos. 2011 Nov;39(11):2155-61.
30 Mammalian multidrug-resistance proteins (MRPs). Essays Biochem. 2011 Sep 7;50(1):179-207.
31 Enhancing chemosensitivity in oral squamous cell carcinoma by lentivirus vector-mediated RNA interference targeting EGFR and MRP2. Oncol Lett. 2016 Sep;12(3):2107-2114.
32 Multidrug resistance associated protein 2 mediates transport of prostaglandin E2. Liver Int. 2006 Apr;26(3):362-8.
33 Lentivirus-mediated RNAi silencing targeting ABCC2 increasing the sensitivity of a human nasopharyngeal carcinoma cell line against cisplatin. J Transl Med. 2008 Oct 4;6:55.
34 Effect of acetaminophen on expression and activity of rat liver multidrug resistance-associated protein 2 and P-glycoprotein. Biochem Pharmacol. 2004 Aug 15;68(4):791-8.
35 Small intestinal efflux mediated by MRP2 and BCRP shifts sulfasalazine intestinal permeability from high to low, enabling its colonic targeting. Am J Physiol Gastrointest Liver Physiol. 2009 Aug;297(2):G371-7.
36 Delineating the contribution of secretory transporters in the efflux of etoposide using Madin-Darby canine kidney (MDCK) cells overexpressing P-glycoprotein (Pgp), multidrug resistance-associated protein (MRP1), and canalicular multispecific organic anion transporter (cMOAT). Drug Metab Dispos. 2002 Apr;30(4):457-63.
37 Multidrug Resistance-Associated Protein 2 (MRP2) Mediated Transport of Oxaliplatin-Derived Platinum in Membrane Vesicles. PLoS One. 2015 Jul 1;10(7):e0130727.
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