Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TT0K6EO)

DTT Name	Stress-activated protein kinase JNK1 (JNK1) DTT Info
Gene Name	MAPK8

Molecule-Related Drug & Molecule List

Molecule-Related Drug List

Molecule Type:

DTT

DTP

DME

Drug Status:

Preclinical Drug(s)

Clinical Trial Drug(s)

Patented Agent(s)

Investigative Drug(s)

Download the Complete Related Drug List

1 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
NKP-1339	DM5AWK1	Solid tumour/cancer	2A00-2F9Z	Phase 1	[1]
------------------------------------------------------------------------------------

43 Patented Agent(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
7-azaindole derivative 1	DMQL5B7	N. A.	N. A.	Patented	[2]
7-azaindole derivative 2	DMZRM2Q	N. A.	N. A.	Patented	[2]
7-azaindole derivative 3	DMQ7BV4	N. A.	N. A.	Patented	[2]
7-azaindole derivative 5	DMV3H98	N. A.	N. A.	Patented	[2]
PMID25991433-Compound-A1	DM89LF0	N. A.	N. A.	Patented	[2]
PMID25991433-Compound-A10	DM39NBT	N. A.	N. A.	Patented	[2]
PMID25991433-Compound-A11	DMD59C2	N. A.	N. A.	Patented	[2]
PMID25991433-Compound-A2	DMX7MHC	N. A.	N. A.	Patented	[2]
PMID25991433-Compound-A3	DMJ1X53	N. A.	N. A.	Patented	[2]
PMID25991433-Compound-A5	DM5YD1K	N. A.	N. A.	Patented	[2]
PMID25991433-Compound-A6	DMFSB9Y	N. A.	N. A.	Patented	[2]
PMID25991433-Compound-A7	DM2ISDH	N. A.	N. A.	Patented	[2]
PMID25991433-Compound-A8	DMHG4WD	N. A.	N. A.	Patented	[2]
PMID25991433-Compound-A9	DMPYCIM	N. A.	N. A.	Patented	[2]
PMID25991433-Compound-D1	DMXSK8Y	N. A.	N. A.	Patented	[2]
PMID25991433-Compound-D2	DMLWSNA	N. A.	N. A.	Patented	[2]
PMID25991433-Compound-E1	DMKWFVP	N. A.	N. A.	Patented	[2]
PMID25991433-Compound-E2	DM8YR1V	N. A.	N. A.	Patented	[2]
PMID25991433-Compound-E3	DM62XNE	N. A.	N. A.	Patented	[2]
PMID25991433-Compound-E4	DM1VHYX	N. A.	N. A.	Patented	[2]
PMID25991433-Compound-E5	DM2ZCTW	N. A.	N. A.	Patented	[2]
PMID25991433-Compound-Eb	DM536JN	N. A.	N. A.	Patented	[2]
PMID25991433-Compound-F2	DM37VIQ	N. A.	N. A.	Patented	[2]
PMID25991433-Compound-G1	DMHS3ZW	N. A.	N. A.	Patented	[2]
PMID25991433-Compound-G2	DMU3XBH	N. A.	N. A.	Patented	[2]
PMID25991433-Compound-G4	DMACWQY	N. A.	N. A.	Patented	[2]
PMID25991433-Compound-G5	DMRJ1KY	N. A.	N. A.	Patented	[2]
PMID25991433-Compound-H1	DM0Q37R	N. A.	N. A.	Patented	[2]
PMID25991433-Compound-H2	DMZ9BTN	N. A.	N. A.	Patented	[2]
PMID25991433-Compound-H3	DMQKLX0	N. A.	N. A.	Patented	[2]
PMID25991433-Compound-J2	DMZSOCK	N. A.	N. A.	Patented	[2]
PMID25991433-Compound-J3	DM17P3F	N. A.	N. A.	Patented	[2]
PMID25991433-Compound-J5	DMU75ZX	N. A.	N. A.	Patented	[2]
PMID25991433-Compound-K1	DMLT8PA	N. A.	N. A.	Patented	[2]
PMID25991433-Compound-K2	DMBS4LE	N. A.	N. A.	Patented	[2]
PMID25991433-Compound-L1	DM2135Y	N. A.	N. A.	Patented	[2]
PMID25991433-Compound-N1	DMN27QB	N. A.	N. A.	Patented	[2]
PMID25991433-Compound-N3	DMLHC5V	N. A.	N. A.	Patented	[2]
PMID25991433-Compound-O3	DMVOWS5	N. A.	N. A.	Patented	[2]
PMID25991433-Compound-P1	DMD8AX6	N. A.	N. A.	Patented	[2]
PMID25991433-Compound-P4	DMVF1D6	N. A.	N. A.	Patented	[2]
PMID25991433-Compound-P5	DM6FCS9	N. A.	N. A.	Patented	[2]
PMID25991433-Compound-P6	DMNDVC9	N. A.	N. A.	Patented	[2]
------------------------------------------------------------------------------------


⏷ Show the Full List of 43 Patented Agent(s)

1 Preclinical Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
COR-D	DMLXMCB	T-cell leukaemia	2A90	Preclinical	[3]
------------------------------------------------------------------------------------

25 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2,6-Dihydroanthra/1,9-Cd/Pyrazol-6-One	DMDN12L	Discovery agent	N.A.	Investigative	[4]
2-(2-(butylamino)pyrimidin-4-ylamino)benzoic acid	DMZA8M7	Discovery agent	N.A.	Investigative	[5]
2-(2-(pentyloxy)pyrimidin-4-ylamino)benzoic acid	DM4KS27	Discovery agent	N.A.	Investigative	[5]
2-(2-(phenylamino)pyrimidin-4-ylamino)benzamide	DM5GAOZ	Discovery agent	N.A.	Investigative	[5]
2-(2-butoxypyrimidin-4-ylamino)benzoic acid	DMLTU3J	Discovery agent	N.A.	Investigative	[5]
2-(2-phenoxypyrimidin-4-ylamino)benzoic acid	DME0HPA	Discovery agent	N.A.	Investigative	[5]
2-(2-propoxypyrimidin-4-ylamino)benzoic acid	DMGVCKZ	Discovery agent	N.A.	Investigative	[5]
2-(2-sec-butoxypyrimidin-4-ylamino)benzoic acid	DMB4W68	Discovery agent	N.A.	Investigative	[5]
4,5,6,7-tetrabromo-1H-benzo[d][1,2,3]triazole	DMN9YOB	Discovery agent	N.A.	Investigative	[6]
Aminopyridine deriv. 2	DM94KQP	Discovery agent	N.A.	Investigative	[7]
AS-601245	DMQ95EB	Discovery agent	N.A.	Investigative	[8]
Bisindolylmaleimide-I	DMOQJZC	Discovery agent	N.A.	Investigative	[9]
CI-1040	DMF3DZX	Discovery agent	N.A.	Investigative	[9]
JNK-IN-8	DMLWYJB	Discovery agent	N.A.	Investigative	[10]
KN-62	DMLZ89P	Discovery agent	N.A.	Investigative	[9]
KT-5720	DM9J50F	Discovery agent	N.A.	Investigative	[9]
N-(4-amino-5-cyano-6-ethoxypyridin-2-yl)acetamide	DMY1FMG	Discovery agent	N.A.	Investigative	[11]
N-(4-amino-5-cyano-6-phenylpyridin-2-yl)acetamide	DMUFVM6	Discovery agent	N.A.	Investigative	[7]
N-(4-amino-6-butoxy-5-cyanopyridin-2-yl)acetamide	DMSAD87	Discovery agent	N.A.	Investigative	[7]
N-(6-ethoxypyridin-2-yl)acetamide	DM90KGB	Discovery agent	N.A.	Investigative	[7]
NM-PP1	DMS8H5Q	Discovery agent	N.A.	Investigative	[8]
Phylomers	DMU30IO	Brain injury	NA07.Z	Investigative	[1]
RO-316233	DMAGLPW	Discovery agent	N.A.	Investigative	[9]
Ro31-8220	DMDJLF0	Discovery agent	N.A.	Investigative	[9]
STAUROSPORINONE	DMU2H4K	Discovery agent	N.A.	Investigative	[9]
------------------------------------------------------------------------------------


⏷ Show the Full List of 25 Investigative Drug(s)

Molecule Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1496).
2	c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72.
3	Corchorusin-D directed apoptosis of K562 cells occurs through activation of mitochondrial and death receptor pathways and suppression of AKT/PKB pathway. Cell Physiol Biochem. 2012;30(4):915-26.
4	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
5	Discovery of a new class of 4-anilinopyrimidines as potent c-Jun N-terminal kinase inhibitors: Synthesis and SAR studies. Bioorg Med Chem Lett. 2007 Feb 1;17(3):668-72.
6	Optimization of protein kinase CK2 inhibitors derived from 4,5,6,7-tetrabromobenzimidazole. J Med Chem. 2004 Dec 2;47(25):6239-47.
7	Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity. J Med Chem. 2006 Jun 15;49(12):3563-80.
8	The selectivity of protein kinase inhibitors: a further update. Biochem J. 2007 Dec 15;408(3):297-315.
9	Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105.
10	Discovery of potent and selective covalent inhibitors of JNK. Chem Biol. 2012 Jan 27;19(1):140-54.
11	Discovery of potent, highly selective, and orally bioavailable pyridine carboxamide c-Jun NH2-terminal kinase inhibitors. J Med Chem. 2006 Jul 27;49(15):4455-8.