Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTF10I9)

• DTT Name: Nitric-oxide synthase inducible (NOS2) DTT Info
• Gene Name: NOS2

Molecule-Related Drug & Molecule List

11 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[1]
MPL-S	DMNDCFY	Endotoxic shock	1G41	Phase 3	[2]
SD-6010	DM9DEYL	Osteoarthritis	FA00-FA05	Phase 3	[3]
Pimagedine HCl	DMPWH30	Diabetic kidney disease	GB61.Z	Phase 2/3	[4]
BXT-51072	DMD8GNB	Cardiovascular disease	BA00-BE2Z	Phase 2	[5]
CR-3294	DMHJEZS	Diarrhea	ME05.1	Phase 2	[6]
GW274150	DMZMCB1	Asthma	CA23	Phase 2	[7]
HP-228	DMNZ35F	Postoperative pain	MG30-MG3Z	Phase 2	[8]
KD-7040	DME1WV2	Pain	MG30-MG3Z	Phase 2	[9]
LT-1951	DM5N04G	Coronary artery disease	BA80	Phase 1/2	[10]
Aminoguanidine	DMJQDUC	Diabetic retinopathy	9B71.0	Phase 1	[11]

3 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
NOStentin	DMWDE8K	Artery stenosis	BD52	Discontinued in Phase 1	[12]
ONO-1714	DML7Q56	Sepsis	1G40-1G41	Discontinued in Phase 1	[13]
L-NIL	DM6Y49D	N. A.	N. A.	Terminated	[14]

115 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
((E)-7-But-2-enyl)-azepan-(2Z)-ylideneamine	DMCW65Q	Discovery agent	N.A.	Investigative	[15]
(4S,5R)-4,5-Diethyl-oxazolidin-(2Z)-ylideneamine	DMM6QV5	Discovery agent	N.A.	Investigative	[16]
(4S,5R)-4,5-Dimethyl-oxazolidin-(2Z)-ylideneamine	DM0V9HB	Discovery agent	N.A.	Investigative	[16]
(4S,5R)-4,5-Dipropyl-oxazolidin-(2Z)-ylideneamine	DMDC84U	Discovery agent	N.A.	Investigative	[16]
(4S,5S)-4,5-Diethyl-oxazolidin-(2Z)-ylideneamine	DM1VJUZ	Discovery agent	N.A.	Investigative	[16]
(4S,5S)-4,5-Dipropyl-oxazolidin-(2Z)-ylideneamine	DM5EKF4	Discovery agent	N.A.	Investigative	[16]
(5-Imino-[1,4]thiazepan-3-yl)-methanol	DMBKZDJ	Discovery agent	N.A.	Investigative	[17]
(5S,6R)-[Octahydro-quinolin-(2E)-ylidene]amine	DMT9CXD	Discovery agent	N.A.	Investigative	[18]
(5S,6S)-[Octahydro-quinolin-(2E)-ylidene]amine	DMP4UC1	Discovery agent	N.A.	Investigative	[18]
(6r,1'r,2's)-5,6,7,8 Tetrahydrobiopterin	DMOD9R7	Discovery agent	N.A.	Investigative	[19]
(E)-4-Methyl-6-(prop-1-enyl)pyridin-2-amine	DM75OHG	Discovery agent	N.A.	Investigative	[20]
(R)-3-Propyl-[1,4]thiazepan-(5E)-ylideneamine	DM1Y9MZ	Discovery agent	N.A.	Investigative	[17]
(S)-2-Amino-5-(N-methyl-guanidino)-pentanoic acid	DMZSWDM	Discovery agent	N.A.	Investigative	[21]
(S)-2-Amino-6-[(E)-ethylimino]-hexanoic acid	DMRG80O	Discovery agent	N.A.	Investigative	[21]
(S)-3-Propyl-[1,4]thiazepan-(5E)-ylideneamine	DMIG9H3	Discovery agent	N.A.	Investigative	[17]
(S)-6-Amino-2-(2-imino-ethylamino)-hexanoic acid	DMG58HM	Discovery agent	N.A.	Investigative	[17]
(S)-N-(1-phenylethyl)acetimidamide hydrobromide	DMLR0N3	Discovery agent	N.A.	Investigative	[22]
1-(6-Amino-4-methylpyridin-2-yl)propan-2-ol	DMUS9Z3	Discovery agent	N.A.	Investigative	[20]
1400W	DMLZT64	Discovery agent	N.A.	Investigative	[23]
2-(2-Amino-ethyl)-7-imino-azepane	DM3JM7V	Discovery agent	N.A.	Investigative	[15]
2-amino-4-methylpyridine	DM1OED2	Discovery agent	N.A.	Investigative	[24]
2-Amino-5-(N-nitro-guanidino)-pentanoic acid	DMDUZ2H	Discovery agent	N.A.	Investigative	[21]
2-Aminothiazoline	DM9YCAH	Discovery agent	N.A.	Investigative	[25]
2-Methyl-[1,4]thiazepan-(5E)-ylideneamine	DMX1IC4	Discovery agent	N.A.	Investigative	[17]
3,4-Dihydro-1H-quinolin-(2E)-ylideneamine	DM0I6UT	Discovery agent	N.A.	Investigative	[18]
3,4-Dimethyl-pyrrolidin-(2Z)-ylideneamine	DMMO6QI	Discovery agent	N.A.	Investigative	[25]
3-(2-Amino-ethyl)-5-imino-[1,4]oxazepane	DM95R6O	Discovery agent	N.A.	Investigative	[15]
3-(2-Nitro-ethyl)-[1,4]oxazepan-(5Z)-ylideneamine	DMYXQ7L	Discovery agent	N.A.	Investigative	[15]
3-Bromo-1H-indazole-7-carbonitrile	DMZGWL2	Discovery agent	N.A.	Investigative	[26]
3-bromo-7-nitro-1H-indazole	DMM7DHB	Discovery agent	N.A.	Investigative	[19]
3-Butyl-[1,4]oxazepan-(5Z)-ylideneamine	DMRI503	Discovery agent	N.A.	Investigative	[15]
3-Butyl-[1,4]thiazepan-(5E)-ylideneamine	DM6A80U	Discovery agent	N.A.	Investigative	[17]
3-Ethyl-[1,4]thiazepan-(5E)-ylideneamine	DMX2JKQ	Discovery agent	N.A.	Investigative	[17]
3-Isobutyl-[1,4]thiazepan-(5E)-ylideneamine	DMQXP7C	Discovery agent	N.A.	Investigative	[17]
3-Methyl-pyrrolidin-(2Z)-ylideneamine	DMHVUF8	Discovery agent	N.A.	Investigative	[25]
3-Methyl-[1,4]thiazepan-(5E)-ylideneamine	DMCOH46	Discovery agent	N.A.	Investigative	[17]
3-Propyl-[1,4]thiazepan-(5E)-ylideneamine	DMYACO7	Discovery agent	N.A.	Investigative	[17]
4,5,6,7-tetrafluoro-3-methyl-1H-indazole	DMTC7J2	Discovery agent	N.A.	Investigative	[27]
4,5,6,7-tetrafluoro-3-perfluorophenyl-1H-indazole	DMZEY31	Discovery agent	N.A.	Investigative	[27]
4,5-Dimethyl-pyrrolidin-(2Z)-ylideneamine	DMB9CJM	Discovery agent	N.A.	Investigative	[25]
4-(1H-IMIDAZOL-1-YL)PHENOL	DM5JDYO	Discovery agent	N.A.	Investigative	[28]
4-Butyl-thiazolidin-(2E)-ylideneamine	DMKU4TR	Discovery agent	N.A.	Investigative	[25]
4-Ethyl-3-methyl-pyrrolidin-(2Z)-ylideneamine	DM5G3NU	Discovery agent	N.A.	Investigative	[25]
4-Ethyl-5-methyl-pyrrolidin-(2Z)-ylideneamine	DMOAQ1E	Discovery agent	N.A.	Investigative	[25]
4-Ethyl-oxazolidin-(2Z)-ylideneamine	DMG0Y3W	Discovery agent	N.A.	Investigative	[16]
4-Ethyl-pyrrolidin-(2Z)-ylideneamine	DMYIWAH	Discovery agent	N.A.	Investigative	[25]
4-Isopropyl-pyrrolidin-(2Z)-ylideneamine	DMVTEOQ	Discovery agent	N.A.	Investigative	[25]
4-Methyl-5-propyl-pyrrolidin-(2Z)-ylideneamine	DMN8Z3C	Discovery agent	N.A.	Investigative	[25]
4-Methyl-6-(2-methylprop-1-enyl)pyridin-2-amine	DMW7YHS	Discovery agent	N.A.	Investigative	[20]
4-methyl-6-propylpyridin-2-amine	DMY04D1	Discovery agent	N.A.	Investigative	[29]
4-Methyl-oxazolidin-(2Z)-ylideneamine	DME7W0Q	Discovery agent	N.A.	Investigative	[16]
4-Methyl-piperidin-(2E)-ylideneamine	DMNMXCE	Discovery agent	N.A.	Investigative	[18]
4-Methyl-pyrrolidin-(2Z)-ylideneamine	DM0YS36	Discovery agent	N.A.	Investigative	[25]
4-[(2-Methyl-1H-imidazol-1-yl)methyl]pyridine	DM8BPTQ	Discovery agent	N.A.	Investigative	[22]
4r-Fluoro-N6-Ethanimidoyl-L-Lysine	DMUGFS3	Discovery agent	N.A.	Investigative	[19]
5-Bromomethyl-oxazolidin-(2Z)-ylideneamine	DMH908V	Discovery agent	N.A.	Investigative	[16]
5-Ethyl-4-methyl-pyrrolidin-(2Z)-ylideneamine	DMQWOIG	Discovery agent	N.A.	Investigative	[25]
5-Ethyl-4-propyl-pyrrolidin-(2Z)-ylideneamine	DMSA8X2	Discovery agent	N.A.	Investigative	[25]
5-Ethyl-oxazolidin-(2Z)-ylideneamine	DM8Y4G5	Discovery agent	N.A.	Investigative	[16]
5-Methyl-4-propyl-pyrrolidin-(2Z)-ylideneamine	DM6DEOC	Discovery agent	N.A.	Investigative	[25]
5-Methyl-oxazolidin-(2Z)-ylideneamine	DMBQS31	Discovery agent	N.A.	Investigative	[16]
5-Methyl-pyrrolidin-(2Z)-ylideneamine	DM4QB3G	Discovery agent	N.A.	Investigative	[25]
5-Nitroindazole	DMH7SIX	Discovery agent	N.A.	Investigative	[19]
6-(2-Fluoropropyl)-4-methylpyridin-2-amine	DME1JLM	Discovery agent	N.A.	Investigative	[20]
6-(3-Fluoropropyl)-4-methylpyridin-2-amine	DMTJPZU	Discovery agent	N.A.	Investigative	[20]
6-(4-Fluorobutyl)-4-methylpyridin-2-amine	DM3EDBO	Discovery agent	N.A.	Investigative	[20]
6-isobutyl-4-methylpyridin-2-amine	DM2XB68	Discovery agent	N.A.	Investigative	[20]
6-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine	DMSLT3I	Discovery agent	N.A.	Investigative	[30]
6-Nitroindazole	DM2WZCX	Discovery agent	N.A.	Investigative	[19]
7,8-dihydrobiopterin	DMQU4XM	Discovery agent	N.A.	Investigative	[31]
7-(2-Nitro-ethyl)-azepan-(2Z)-ylideneamine	DMK28IS	Discovery agent	N.A.	Investigative	[15]
7-Butyl-azepan-(2Z)-ylideneamine	DMVTK0A	Discovery agent	N.A.	Investigative	[15]
7-Methyl-[1,4]thiazepan-(5E)-ylideneamine	DMUCJA6	Discovery agent	N.A.	Investigative	[17]
7-nitro-1H-indazole	DMW4XKQ	Discovery agent	N.A.	Investigative	[19]
Aminothiazoline	DMGEVBH	Discovery agent	N.A.	Investigative	[32]
AR-C102222	DMWVULN	Discovery agent	N.A.	Investigative	[29]
AR-C133057XX	DM71WQT	Discovery agent	N.A.	Investigative	[29]
Azepan-(2Z)-ylideneamine	DMZHV39	Discovery agent	N.A.	Investigative	[15]
Azocan-(2Z)-ylideneamine	DMQ13PZ	Discovery agent	N.A.	Investigative	[15]
Azonan-(2Z)-ylideneamine	DMTQSNK	Discovery agent	N.A.	Investigative	[21]
B-Octylglucoside	DMMO75G	Discovery agent	N.A.	Investigative	[19]
BYK-191023	DMAWMDN	Inflammation	1A00-CA43.1	Investigative	[33]
CDDO	DM03NUV	Discovery agent	N.A.	Investigative	[34]
Ethylisothiourea	DMV9OCU	N. A.	N. A.	Investigative	[19]
Heme	DMGC287	Discovery agent	N.A.	Investigative	[28]
Hexahydro-cyclopenta[c]pyrrol-(1Z)-ylideneamine	DMG0UVT	Discovery agent	N.A.	Investigative	[25]
KD-7332	DMJ2X64	Inflammation	1A00-CA43.1	Investigative	[33]
L-NIO	DME9FAV	Discovery agent	N.A.	Investigative	[35]
L-Thiocitrulline	DMP8O6R	Discovery agent	N.A.	Investigative	[19]
N,N-dimethylarginine	DM0Y8OW	Discovery agent	N.A.	Investigative	[36]
N-(5-Amino-6-oxo-heptyl)-acetamidine	DM47XR8	Discovery agent	N.A.	Investigative	[25]
N-benzylacetimidamide hydrobromide	DM26R4P	Discovery agent	N.A.	Investigative	[22]
N-omega-allyl-L-arginine	DM0BPCT	Discovery agent	N.A.	Investigative	[35]
N-Omega-Hydroxy-L-Arginine	DMOXQ3N	Discovery agent	N.A.	Investigative	[19]
N-omega-propargyl-L-arginine	DM9X3B7	Discovery agent	N.A.	Investigative	[35]
N-Omega-Propyl-L-Arginine	DM4X0WY	Discovery agent	N.A.	Investigative	[19]
N5-(1-iminobut-3-enyl)-L-ornithine	DMB62OI	Discovery agent	N.A.	Investigative	[35]
N5-(1-iminobutyl)-L-ornithine	DMT893N	Discovery agent	N.A.	Investigative	[35]
N5-(1-iminopropyl)-L-ornithine	DM05O7J	Discovery agent	N.A.	Investigative	[35]
Octahydro-isoindol-(1Z)-ylideneamine	DM4C70S	Discovery agent	N.A.	Investigative	[25]
Oxazolidin-(2Z)-ylideneamine	DM8109D	Discovery agent	N.A.	Investigative	[16]
PIBTU	DMQBAM6	Discovery agent	N.A.	Investigative	[37]
Piperidin-(2E)-ylideneamine	DMN8OR2	Discovery agent	N.A.	Investigative	[18]
Pyrrolidin-(2Z)-ylideneamine	DMS4ZFU	Discovery agent	N.A.	Investigative	[25]
Resveratrol Potassium4,-Sulfate	DMMFP57	Discovery agent	N.A.	Investigative	[38]
SKLB-010	DMUVAFO	Inflammation	1A00-CA43.1	Investigative	[33]
THIOCITRULLINE	DM7X8MH	Discovery agent	N.A.	Investigative	[39]
Thiocoumarin	DMPTSN0	Discovery agent	N.A.	Investigative	[28]
[1,3]Oxazinan-(2E)-ylideneamine	DMDX6W4	Discovery agent	N.A.	Investigative	[21]
[1,3]Thiazinan-(2E)-ylideneamine	DMOEIHC	Discovery agent	N.A.	Investigative	[21]
[1,4]Oxazepan-(3E)-ylideneamine	DMX58NK	Discovery agent	N.A.	Investigative	[17]
[1,4]Oxazepan-(5E)-ylideneamine	DMMUZVS	Discovery agent	N.A.	Investigative	[17]
[1,4]Thiazepan-(3E)-ylideneamine	DMCBFJQ	Discovery agent	N.A.	Investigative	[17]
[1,4]Thiazepan-(5E)-ylideneamine	DMFQ0Z4	Discovery agent	N.A.	Investigative	[17]
[1,5]Thiazocan-(4E)-ylideneamine	DMF62JR	Discovery agent	N.A.	Investigative	[15]

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