Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTQ5LRD)

DTT Name	Cellular inhibitor of apoptosis 1 (BIRC2) DTT Info
Gene Name	BIRC2

Molecule-Related Drug & Molecule List

Molecule-Related Drug List

Molecule Type:

DTT

DTP

DME

Drug Status:

Clinical Trial Drug(s)

Patented Agent(s)

Investigative Drug(s)

Download the Complete Related Drug List

2 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AT-406	DMVJW0S	Squamous head and neck cell carcinom	2D60.0	Phase 3	[1]
Birinapant	DM6PBUM	Lymphoma	2A80-2A86	Phase 2	[2]
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21 Patented Agent(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID25980951-Compound-1	DMYPT2H	N. A.	N. A.	Patented	[3]
PMID25980951-Compound-16	DM1J3LE	N. A.	N. A.	Patented	[3]
PMID25980951-Compound-17	DMSC8B6	N. A.	N. A.	Patented	[3]
PMID25980951-Compound-18	DMC3NHJ	N. A.	N. A.	Patented	[3]
PMID25980951-Compound-19	DMGIV0M	N. A.	N. A.	Patented	[3]
PMID25980951-Compound-20	DMM45AC	N. A.	N. A.	Patented	[3]
PMID25980951-Compound-21	DMIE0MR	N. A.	N. A.	Patented	[3]
PMID25980951-Compound-22	DM6OEHK	N. A.	N. A.	Patented	[3]
PMID25980951-Compound-27	DMXAH9F	N. A.	N. A.	Patented	[3]
PMID25980951-Compound-3	DMPSWXU	N. A.	N. A.	Patented	[3]
PMID25980951-Compound-36	DMBD4K9	N. A.	N. A.	Patented	[3]
PMID25980951-Compound-37	DMHP6J2	N. A.	N. A.	Patented	[3]
PMID25980951-Compound-38	DMEUBDA	N. A.	N. A.	Patented	[3]
PMID25980951-Compound-4	DM9RZSH	N. A.	N. A.	Patented	[3]
PMID25980951-Compound-41	DMNROIP	N. A.	N. A.	Patented	[3]
PMID25980951-Compound-42	DM8XESD	N. A.	N. A.	Patented	[3]
PMID25980951-Compound-43	DMTJRCS	N. A.	N. A.	Patented	[3]
PMID25980951-Compound-44	DMS5896	N. A.	N. A.	Patented	[3]
PMID25980951-Compound-5	DMB3IZT	N. A.	N. A.	Patented	[3]
PMID25980951-Compound-6	DMVSW5N	N. A.	N. A.	Patented	[3]
PMID25980951-Compound-7	DMF8V5J	N. A.	N. A.	Patented	[3]
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⏷ Show the Full List of 21 Patented Agent(s)

3 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AZD5582	DMPIHN6	Discovery agent	N.A.	Investigative	[4]
BV-6	DMDTV7A	Discovery agent	N.A.	Investigative	[5]
EAPB0203	DMB7685	T-cell leukaemia	2A90	Investigative	[6]
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Molecule Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

References

1	Debio 1143, an antagonist of multiple inhibitor-of-apoptosis proteins, activates apoptosis and enhances radiosensitization of non-small cell lung c... Am J Cancer Res. 2014 Nov 19;4(6):943-51.
2	cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1- and RIPK3-dependent manner. Blood. 2014 Apr 17;123(16):2562-72.
3	Small molecule inhibitor of apoptosis proteins antagonists: a patent review.Expert Opin Ther Pat. 2015 Jul;25(7):755-74.
4	Discovery of a novel class of dimeric Smac mimetics as potent IAP antagonists resulting in a clinical candidate for the treatment of cancer (AZD5582). J Med Chem. 2013 Dec 27;56(24):9897-919.
5	IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis. Cell. 2007 Nov 16;131(4):669-81.
6	EAPB0203, a member of the imidazoquinoxaline family, inhibits growth and induces caspase-dependent apoptosis in T-cell lymphomas and HTLV-I-associated adult T-cell leukemia/lymphoma. Blood. 2008 Apr 1;111(7):3770-7.