Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTTRP0H)

• DTT Name: Kinesin-like protein KIF11 (KIF11) DTT Info
• Gene Name: KIF11

Molecule-Related Drug & Molecule List

8 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ARRY-520	DMTOI7S	Multiple myeloma	2A83	Phase 2	[1]
AZD-4877	DMFVL5J	Acute myeloid leukaemia	2A60	Phase 2	[2]
Ispinesib	DMP2BWX	Head and neck cancer	2D42	Phase 2	[3]
LY2523355	DMCV602	Acute myeloid leukaemia	2A60	Phase 2	[2]
SB-743921	DM6XJ9S	Solid tumour/cancer	2A00-2F9Z	Phase 2	[4]
4SC-205	DMG75P3	Lymphoma	2A80-2A86	Phase 1	[5]
ARQ 621	DMCRLQZ	Haematological malignancy	2B33.Y	Phase 1	[2]
MK-0731	DM2TAUR	Solid tumour/cancer	2A00-2F9Z	Phase 1	[2]

1 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Monastrol	DMLSEJN	Discovery agent	N.A.	Investigative	[6]

References

• [1] Inhibition of KSP by ARRY-520 induces cell cycle block and cell death via the mitochondrial pathway in AML cells. Leukemia. 2009 Oct;23(10):1755-62.
• [2] Kinesins and cancer. Nat Rev Cancer. 2012 Jul 24;12(8):527-39.
• [3] Initial testing (stage 1) of the kinesin spindle protein inhibitor ispinesib by the pediatric preclinical testing program. Pediatr Blood Cancer. 2009 Dec 15;53(7):1255-63.
• [4] Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2009 Jan-Feb;31(1):47-57.
• [5] 2011 Pipeline of 4SC AG.
• [6] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.