Details of Disease

General Information of Disease (ID: DIS0U6CJ)

Disease Name Diabetes insipidus
Disease Class 5A60-5A61: Pituitary gland disorder
Definition
A disorder characterized by excretion of large amounts of urine, accompanied by excessive thirst. Causes include deficiency of antidiuretic hormone or failure of the kidneys to respond to antidiuretic hormone. It may also be drug-related.
Disease Hierarchy
DISXWP4P: Nephropathy
DIS0U6CJ: Diabetes insipidus
ICD Code
ICD-11
ICD-11: 5A61.5
ICD-10
ICD-10: E23.2
Disease Identifiers
MONDO ID
MONDO_0004782
MESH ID
D003919
UMLS CUI
C0011848
MedGen ID
8349
HPO ID
HP:0000873
SNOMED CT ID
15771004

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 1 Approved Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Vasopressin DMQ2FPC Approved Small molecular drug [1]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 6 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
AVP TTJ8EWH Limited Biomarker [2]
KCNJ5 TTEO25X Limited Genetic Variation [3]
AVPR2 TTK8R02 Strong Biomarker [4]
LNPEP TTY2KP7 Strong Biomarker [5]
PCSK1 TTED9LZ Strong Genetic Variation [6]
POMC TT21AKM Strong Biomarker [7]
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⏷ Show the Full List of 6 DTT(s)
This Disease Is Related to 4 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
ENDOV OTX2GXXX Limited Biomarker [8]
CISD2 OTVS7S2H Strong Genetic Variation [9]
HAS2 OTTD3PAL Strong Biomarker [10]
PRPS1 OTN3A6CN Strong Biomarker [11]
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References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2168).
2 Copeptin in the differential diagnosis of hypotonic polyuria.J Endocrinol Invest. 2020 Jan;43(1):21-30. doi: 10.1007/s40618-019-01087-6. Epub 2019 Jul 31.
3 A case of severe hyperaldosteronism caused by a de novo mutation affecting a critical salt bridge Kir3.4 residue.J Clin Endocrinol Metab. 2015 Jan;100(1):E114-8. doi: 10.1210/jc.2014-3636.
4 Failure to thrive: the importance of measuring the electrolytes.J Biol Regul Homeost Agents. 2019 Sep-Oct;33(5 Suppl. 1):3-5. Special Issue: Focus on Pediatric Nephrology.
5 Other Pituitary Conditions and Pregnancy.Endocrinol Metab Clin North Am. 2019 Sep;48(3):583-603. doi: 10.1016/j.ecl.2019.05.005. Epub 2019 Jun 18.
6 Severe obesity and diabetes insipidus in a patient with PCSK1 deficiency.Mol Genet Metab. 2013 Sep-Oct;110(1-2):191-4. doi: 10.1016/j.ymgme.2013.04.005. Epub 2013 Apr 17.
7 Postoperative Diabetes Insipidus and Hyponatremia in Children after Transsphenoidal Surgery for Adrenocorticotropin Hormone and Growth Hormone Secreting Adenomas.J Pediatr. 2018 Apr;195:169-174.e1. doi: 10.1016/j.jpeds.2017.11.042. Epub 2018 Feb 1.
8 Application of single nucleotide extension and MALDI-TOF mass spectrometry in proofreading and DNA repair assay.DNA Repair (Amst). 2018 Jan;61:63-75. doi: 10.1016/j.dnarep.2017.11.011. Epub 2017 Dec 2.
9 Correction: Genetic and clinical aspects of Wolfram syndrome 1, a severe neurodegenerative disease.Pediatr Res. 2018 Nov;84(5):787. doi: 10.1038/s41390-018-0146-1.
10 Expression of type II hyaluronan-synthase gene in kidneys Wistar and Brattleboro rats with diabetes insipidus: effect of vasopressin and its analogues.Dokl Biochem Biophys. 2009 Mar-Apr;425:61-4. doi: 10.1134/s160767290902001x.
11 Association of PRPS1 Mutations with Disease Phenotypes.Dis Markers. 2015;2015:127013. doi: 10.1155/2015/127013. Epub 2015 May 24.